{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:20:08Z","timestamp":1780352408272,"version":"3.54.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7310","license":[{"start":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T00:00:00Z","timestamp":1278806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1038\/nature09271","type":"journal-article","created":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T21:38:04Z","timestamp":1278884284000},"page":"1105-1109","source":"Crossref","is-referenced-by-count":848,"title":["A novel pathway regulates memory and plasticity via SIRT1 and miR-134"],"prefix":"10.1038","volume":"466","author":[{"given":"Jun","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Wei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Gr\u00e4ff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Song","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Mak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dohoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C.","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Huei","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,7,11]]},"reference":[{"key":"BFnature09271_CR1","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nature08197","volume":"460","author":"T Finkel","year":"2009","unstructured":"Finkel, T., Deng, C. X. & Mostoslavsky, R. Recent progress in the biology and physiology of sirtuins. Nature 460, 587\u2013591 (2009)","journal-title":"Nature"},{"key":"BFnature09271_CR2","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1101\/gad.13.19.2570","volume":"13","author":"M Kaeberlein","year":"1999","unstructured":"Kaeberlein, M., McVey, M. & Guarente, L. The SIR2\/3\/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570\u20132580 (1999)","journal-title":"Genes Dev."},{"key":"BFnature09271_CR3","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cell.2008.07.002","volume":"134","author":"Y Nakahata","year":"2008","unstructured":"Nakahata, Y. et al. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134, 329\u2013340 (2008)","journal-title":"Cell"},{"key":"BFnature09271_CR4","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1126\/science.1170803","volume":"324","author":"Y Nakahata","year":"2009","unstructured":"Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M. & Sassone-Corsi, P. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science 324, 654\u2013657 (2009)","journal-title":"Science"},{"key":"BFnature09271_CR5","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1038\/sj.emboj.7601758","volume":"26","author":"D Kim","year":"2007","unstructured":"Kim, D. et al. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer\u2019s disease and amyotrophic lateral sclerosis. EMBO J. 26, 3169\u20133179 (2007)","journal-title":"EMBO J."},{"key":"BFnature09271_CR6","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.neuron.2009.03.026","volume":"62","author":"W Renthal","year":"2009","unstructured":"Renthal, W. et al. Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron 62, 335\u2013348 (2009)","journal-title":"Neuron"},{"key":"BFnature09271_CR7","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1101\/gad.1839209","volume":"23","author":"DE Cohen","year":"2009","unstructured":"Cohen, D. E., Supinski, A. M., Bonkowski, M. S., Donmez, G. & Guarente, L. P. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev. 23, 2812\u20132817 (2009)","journal-title":"Genes Dev."},{"key":"BFnature09271_CR8","doi-asserted-by":"publisher","first-page":"10794","DOI":"10.1073\/pnas.1934713100","volume":"100","author":"HL Cheng","year":"2003","unstructured":"Cheng, H. L. et al. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl Acad. Sci. USA 100, 10794\u201310799 (2003)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature09271_CR9","doi-asserted-by":"publisher","first-page":"14515","DOI":"10.1073\/pnas.0406344101","volume":"101","author":"NJ Broadbent","year":"2004","unstructured":"Broadbent, N. J., Squire, L. R. & Clark, R. E. Spatial memory, recognition memory, and the hippocampus. Proc. Natl Acad. Sci. USA 101, 14515\u201314520 (2004)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature09271_CR10","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/BF02284844","volume":"25","author":"ME Calhoun","year":"1996","unstructured":"Calhoun, M. E. et al. Comparative evaluation of synaptophysin-based methods for quantification of synapses. J. Neurocytol. 25, 821\u2013828 (1996)","journal-title":"J. Neurocytol."},{"key":"BFnature09271_CR11","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1126\/science.7886457","volume":"267","author":"H Kang","year":"1995","unstructured":"Kang, H. & Schuman, E. M. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267, 1658\u20131662 (1995)","journal-title":"Science"},{"key":"BFnature09271_CR12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0092-8674(94)90394-8","volume":"79","author":"DA Frank","year":"1994","unstructured":"Frank, D. A. & Greenberg, M. E. CREB: a mediator of long-term memory from mollusks to mammals. Cell 79, 5\u20138 (1994)","journal-title":"Cell"},{"key":"BFnature09271_CR13","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1146\/annurev.neuro.31.060407.125631","volume":"31","author":"SW Flavell","year":"2008","unstructured":"Flavell, S. W. & Greenberg, M. E. Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. Annu. Rev. Neurosci. 31, 563\u2013590 (2008)","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnature09271_CR14","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0896-6273(00)81010-7","volume":"20","author":"X Tao","year":"1998","unstructured":"Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J. & Greenberg, M. E. Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20, 709\u2013726 (1998)","journal-title":"Neuron"},{"key":"BFnature09271_CR15","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.neuron.2008.09.024","volume":"60","author":"EJ Hong","year":"2008","unstructured":"Hong, E. J., McCord, A. E. & Greenberg, M. E. A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. Neuron 60, 610\u2013624 (2008)","journal-title":"Neuron"},{"key":"BFnature09271_CR16","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/0896-6273(93)90335-O","volume":"10","author":"T Timmusk","year":"1993","unstructured":"Timmusk, T. et al. Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10, 475\u2013489 (1993)","journal-title":"Neuron"},{"key":"BFnature09271_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.mcn.2007.08.011","volume":"37","author":"C Chiaruttini","year":"2008","unstructured":"Chiaruttini, C., Sonego, M., Baj, G., Simonato, M. & Tongiorgi, E. BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae. Mol. Cell. Neurosci. 37, 11\u201319 (2008)","journal-title":"Mol. Cell. Neurosci."},{"key":"BFnature09271_CR18","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215\u2013233 (2009)","journal-title":"Cell"},{"key":"BFnature09271_CR19","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.bbagrm.2007.12.006","volume":"1779","author":"R Fiore","year":"2008","unstructured":"Fiore, R., Siegel, G. & Schratt, G. MicroRNA function in neuronal development, plasticity and disease. Biochim. Biophys. Acta 1779, 471\u2013478 (2008)","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnature09271_CR20","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.conb.2008.07.001","volume":"18","author":"N Bushati","year":"2008","unstructured":"Bushati, N. & Cohen, S. M. MicroRNAs in neurodegeneration. Curr. Opin. Neurobiol. 18, 292\u2013296 (2008)","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnature09271_CR21","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nature04367","volume":"439","author":"GM Schratt","year":"2006","unstructured":"Schratt, G. M. et al. A brain-specific microRNA regulates dendritic spine development. Nature 439, 283\u2013289 (2006)","journal-title":"Nature"},{"key":"BFnature09271_CR22","doi-asserted-by":"publisher","first-page":"10841","DOI":"10.1074\/jbc.C700018200","volume":"282","author":"E van der Veer","year":"2007","unstructured":"van der Veer, E. et al. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J. Biol. Chem. 282, 10841\u201310845 (2007)","journal-title":"J. Biol. Chem."},{"key":"BFnature09271_CR23","first-page":"F49","volume":"1332","author":"Y Shi","year":"1997","unstructured":"Shi, Y., Lee, J. S. & Galvin, K. M. Everything you have ever wanted to know about Yin Yang 1. Biochim. Biophys. Acta 1332, F49\u2013F66 (1997)","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnature09271_CR24","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1749-6632.2003.tb07077.x","volume":"985","author":"MS Fanselow","year":"2003","unstructured":"Fanselow, M. S. & Gale, G. D. The amygdala, fear, and memory. Ann. NY Acad. Sci. 985, 125\u2013134 (2003)","journal-title":"Ann. NY Acad. Sci."},{"key":"BFnature09271_CR25","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/nature05772","volume":"447","author":"A Fischer","year":"2007","unstructured":"Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M. & Tsai, L. H. Recovery of learning and memory is associated with chromatin remodelling. Nature 447, 178\u2013182 (2007)","journal-title":"Nature"},{"key":"BFnature09271_CR26","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1101\/gad.1839209","volume":"23","author":"DE Cohen","year":"2009","unstructured":"Cohen, D. E., Supinski, A. M., Bonkowski, M. S., Donmez, G. & Guarente, L. P. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev. 23, 2812\u20132817 (2009)","journal-title":"Genes Dev."},{"key":"BFnature09271_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature07925","volume":"459","author":"JS Guan","year":"2009","unstructured":"Guan, J. S. et al. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459, 55\u201360 (2009)","journal-title":"Nature"},{"key":"BFnature09271_CR28","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.neuron.2005.10.033","volume":"48","author":"A Fischer","year":"2005","unstructured":"Fischer, A., Sananbenesi, F., Pang, P. T., Lu, B. & Tsai, L. H. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron 48, 825\u2013838 (2005)","journal-title":"Neuron"},{"key":"BFnature09271_CR29","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1101\/gad.1184404","volume":"18","author":"JG Doench","year":"2004","unstructured":"Doench, J. G. & Sharp, P. A. Specificity of microRNA target selection in translational repression. Genes Dev. 18, 504\u2013511 (2004)","journal-title":"Genes Dev."},{"key":"BFnature09271_CR30","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/297681a0","volume":"297","author":"RG Morris","year":"1982","unstructured":"Morris, R. G., Garrud, P., Rawlins, J. N. & O'Keefe, J. Place navigation impaired in rats with hippocampal lesions. Nature 297, 681\u2013683 (1982)","journal-title":"Nature"},{"key":"BFnature09271_CR31","doi-asserted-by":"publisher","first-page":"9447","DOI":"10.1073\/pnas.0903964106","volume":"106","author":"DP Stefanko","year":"2009","unstructured":"Stefanko, D. P., Barrett, R. M., Ly, A. R., Reolon, G. K. & Wood, M. A. Modulation of long-term memory for object recognition via HDAC inhibition. Proc. Natl Acad. Sci. USA 106, 9447\u20139452 (2009)","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature09271.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature09271","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature09271.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:35:44Z","timestamp":1684420544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature09271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,11]]},"references-count":31,"journal-issue":{"issue":"7310","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["BFnature09271"],"URL":"https:\/\/doi.org\/10.1038\/nature09271","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.4568958.4439060","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,11]]}}}