{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:44:53Z","timestamp":1781660693238,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7356","license":[{"start":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T00:00:00Z","timestamp":1305072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1038\/nature10116","type":"journal-article","created":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T04:39:19Z","timestamp":1305088759000},"page":"386-389","source":"Crossref","is-referenced-by-count":757,"title":["Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors"],"prefix":"10.1038","volume":"475","author":[{"given":"Pengyu","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changcheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijian","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,5,11]]},"reference":[{"key":"BFnature10116_CR1","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1053\/j.gastro.2009.01.019","volume":"136","author":"MA Zern","year":"2009","unstructured":"Zern, M. A. Cell transplantation to replace whole liver transplantation. Gastroenterology 136, 767\u2013769 (2009)","journal-title":"Gastroenterology"},{"key":"BFnature10116_CR2","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1038\/nbt1258","volume":"24","author":"V Gouon-Evans","year":"2006","unstructured":"Gouon-Evans, V. et al. BMP-4 is required for hepatic specification of mouse embryonic stem cell\u2013derived definitive endoderm. Nature Biotechnol. 24, 1402\u20131411 (2006)","journal-title":"Nature Biotechnol."},{"key":"BFnature10116_CR3","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1038\/nbt1257","volume":"24","author":"A Soto-Guti\u00e9rrez","year":"2006","unstructured":"Soto-Guti\u00e9rrez, A. et al. Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell-derived hepatocytes. Nature Biotechnol. 24, 1412\u20131419 (2006)","journal-title":"Nature Biotechnol."},{"key":"BFnature10116_CR4","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1634\/stemcells.2007-0291","volume":"25","author":"Y Duan","year":"2007","unstructured":"Duan, Y. et al. Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo . Stem Cells 25, 3058\u20133068 (2007)","journal-title":"Stem Cells"},{"key":"BFnature10116_CR5","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1053\/j.gastro.2008.10.047","volume":"136","author":"H Basma","year":"2009","unstructured":"Basma, H. et al. Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology 136, 990\u2013999 (2009)","journal-title":"Gastroenterology"},{"key":"BFnature10116_CR6","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/hep.23354","volume":"51","author":"K Si-Tayeb","year":"2010","unstructured":"Si-Tayeb, K. et al. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology 51, 297\u2013305 (2010)","journal-title":"Hepatology"},{"key":"BFnature10116_CR7","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/hep.23335","volume":"51","author":"GJ Sullivan","year":"2010","unstructured":"Sullivan, G. J. et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 51, 329\u2013335 (2010)","journal-title":"Hepatology"},{"key":"BFnature10116_CR8","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1053\/j.gastro.2010.08.042","volume":"139","author":"F Li","year":"2010","unstructured":"Li, F. et al. Hepatoblast-like progenitor cells derived from embryonic stem cells can repopulate livers of mice. Gastroenterology 139, 2158\u20132169 (2010)","journal-title":"Gastroenterology"},{"key":"BFnature10116_CR9","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/35046522","volume":"2","author":"CN Shen","year":"2000","unstructured":"Shen, C. N., Slack, J. M. & Tosh, D. Molecular basis of transdifferentiation of pancreas to liver. Nature Cell Biol. 2, 879\u2013887 (2000)","journal-title":"Nature Cell Biol."},{"key":"BFnature10116_CR10","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/S0092-8674(04)00419-2","volume":"117","author":"H Xie","year":"2004","unstructured":"Xie, H., Ye, M., Feng, R. & Graf, T. Stepwise reprogramming of B cells into macrophages. Cell 117, 663\u2013676 (2004)","journal-title":"Cell"},{"key":"BFnature10116_CR11","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nature07314","volume":"455","author":"Q Zhou","year":"2008","unstructured":"Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D. A. In vivo reprogramming of adult pancreatic exocrine cells to \u03b2-cells. Nature 455, 627\u2013632 (2008)","journal-title":"Nature"},{"key":"BFnature10116_CR12","doi-asserted-by":"publisher","first-page":"6057","DOI":"10.1073\/pnas.0711961105","volume":"105","author":"R Feng","year":"2008","unstructured":"Feng, R. et al. PU.1 and C\/EBP\u03b1\/\u03b2 convert fibroblasts into macrophage-like cells. Proc. Natl Acad. Sci. USA 105, 6057\u20136062 (2008)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature10116_CR13","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/nature08797","volume":"463","author":"T Vierbuchen","year":"2010","unstructured":"Vierbuchen, T. et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035\u20131041 (2010)","journal-title":"Nature"},{"key":"BFnature10116_CR14","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.cell.2010.07.002","volume":"142","author":"M Ieda","year":"2010","unstructured":"Ieda, M. et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142, 375\u2013386 (2010)","journal-title":"Cell"},{"key":"BFnature10116_CR15","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/nature09591","volume":"468","author":"E Szabo","year":"2010","unstructured":"Szabo, E. et al. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 468, 521\u2013526 (2010)","journal-title":"Nature"},{"key":"BFnature10116_CR16","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1101\/gad.390906","volume":"20","author":"I Kyrmizi","year":"2006","unstructured":"Kyrmizi, I. et al. Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 20, 2293\u20132305 (2006)","journal-title":"Genes Dev."},{"key":"BFnature10116_CR17","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nrg2318","volume":"9","author":"KS Zaret","year":"2008","unstructured":"Zaret, K. S. Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation. Nature Rev. Genet. 9, 329\u2013340 (2008)","journal-title":"Nature Rev. Genet."},{"key":"BFnature10116_CR18","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1124\/pr.54.1.129","volume":"54","author":"H Schrem","year":"2002","unstructured":"Schrem, H., Klempnauer, J. & Borlak, J. Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expression. Pharmacol. Rev. 54, 129\u2013158 (2002)","journal-title":"Pharmacol. Rev."},{"key":"BFnature10116_CR19","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1124\/pr.56.2.5","volume":"56","author":"H Schrem","year":"2004","unstructured":"Schrem, H., Klempnauer, J. & Borlak, J. Liver-enriched transcription factors in liver function and development. Part II: the C\/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation. Pharmacol. Rev. 56, 291\u2013330 (2004)","journal-title":"Pharmacol. Rev."},{"key":"BFnature10116_CR20","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1002\/hep.20084","volume":"39","author":"M Mikula","year":"2004","unstructured":"Mikula, M. et al. Immortalized p19ARF null hepatocytes restore liver injury and generate hepatic progenitors after transplantation. Hepatology 39, 628\u2013634 (2004)","journal-title":"Hepatology"},{"key":"BFnature10116_CR21","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1101\/gad.7.12a.2298","volume":"7","author":"M Grompe","year":"1993","unstructured":"Grompe, M. et al. Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice. Genes Dev. 7 (12A). 2298\u20132307 (1993)","journal-title":"Genes Dev."},{"key":"BFnature10116_CR22","doi-asserted-by":"publisher","first-page":"11881","DOI":"10.1073\/pnas.1734199100","volume":"100","author":"X Wang","year":"2003","unstructured":"Wang, X. et al. The origin and liver repopulating capacity of murine oval cells. Proc. Natl Acad. Sci. USA 100 (Suppl. 1). 11881\u201311888 (2003)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature10116_CR23","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/ng0895-453","volume":"10","author":"M Grompe","year":"1995","unstructured":"Grompe, M. et al. Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I. Nature Genet. 10, 453\u2013460 (1995)","journal-title":"Nature Genet."},{"key":"BFnature10116_CR24","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/ng0396-266","volume":"12","author":"K Overturf","year":"1996","unstructured":"Overturf, K. et al. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I. Nature Genet. 12, 266\u2013273 (1996)","journal-title":"Nature Genet."},{"key":"BFnature10116_CR25","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1101\/sqb.2008.73.040","volume":"73","author":"KS Zaret","year":"2008","unstructured":"Zaret, K. S. et al. Pioneer factors, genetic competence, and inductive signaling: programming liver and pancreas progenitors from the endoderm. Cold Spring Harb. Symp. Quant. Biol. 73, 119\u2013126 (2008)","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"BFnature10116_CR26","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S1097-2765(02)00459-8","volume":"9","author":"LA Cirillo","year":"2002","unstructured":"Cirillo, L. A. et al. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol. Cell 9, 279\u2013289 (2002)","journal-title":"Mol. Cell"},{"key":"BFnature10116_CR27","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1126\/science.1089769","volume":"303","author":"DT Odom","year":"2004","unstructured":"Odom, D. T. et al. Control of pancreas and liver gene expression by HNF transcription factors. Science 303, 1378\u20131381 (2004)","journal-title":"Science"},{"key":"BFnature10116_CR28","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1038\/nature08290","volume":"460","author":"H Li","year":"2009","unstructured":"Li, H. et al. The Ink4\/Arf locus is a barrier for iPS cell reprogramming. Nature 460, 1136\u20131139 (2009)","journal-title":"Nature"},{"key":"BFnature10116_CR29","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/ng2033","volume":"39","author":"L Hui","year":"2007","unstructured":"Hui, L. et al. p38\u03b1 suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nature Genet. 39, 741\u2013749 (2007)","journal-title":"Nature Genet."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature10116.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature10116","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature10116.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:52:33Z","timestamp":1684417953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature10116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,11]]},"references-count":29,"journal-issue":{"issue":"7356","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["BFnature10116"],"URL":"https:\/\/doi.org\/10.1038\/nature10116","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.10539956.12264054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.10539956.11402054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.10539956.11741063","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.10539956.11392058","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,11]]}}}