{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:58:41Z","timestamp":1776124721018,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7503","license":[{"start":{"date-parts":[[2014,5,25]],"date-time":"2014-05-25T00:00:00Z","timestamp":1400976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1038\/nature13404","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T05:40:20Z","timestamp":1401082820000},"page":"103-108","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":550,"title":["Accurate design of co-assembling multi-component protein nanomaterials"],"prefix":"10.1038","volume":"510","author":[{"given":"Neil P.","family":"King","sequence":"first","affiliation":[]},{"given":"Jacob B.","family":"Bale","sequence":"additional","affiliation":[]},{"given":"William","family":"Sheffler","sequence":"additional","affiliation":[]},{"given":"Dan E.","family":"McNamara","sequence":"additional","affiliation":[]},{"given":"Shane","family":"Gonen","sequence":"additional","affiliation":[]},{"given":"Tamir","family":"Gonen","sequence":"additional","affiliation":[]},{"given":"Todd O.","family":"Yeates","sequence":"additional","affiliation":[]},{"given":"David","family":"Baker","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,5,25]]},"reference":[{"key":"BFnature13404_CR1","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.copbio.2011.05.003","volume":"22","author":"S Howorka","year":"2011","unstructured":"Howorka, S. Rationally engineering natural protein assemblies in nanobiotechnology. Curr. Opin. Biotechnol. 22, 485\u2013491 (2011)","journal-title":"Curr. Opin. Biotechnol."},{"key":"BFnature13404_CR2","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1126\/science.1123223","volume":"312","author":"T Douglas","year":"2006","unstructured":"Douglas, T. & Young, M. Viruses: making friends with old foes. Science 312, 873\u2013875 (2006)","journal-title":"Science"},{"key":"BFnature13404_CR3","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.tcb.2012.08.004","volume":"22","author":"YT Lai","year":"2012","unstructured":"Lai, Y. T., King, N. P. & Yeates, T. O. Principles for designing ordered protein assemblies. Trends Cell Biol. 22, 653\u2013661 (2012)","journal-title":"Trends Cell Biol."},{"key":"BFnature13404_CR4","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.sbi.2013.06.002","volume":"23","author":"NP King","year":"2013","unstructured":"King, N. P. & Lai, Y. T. Practical approaches to designing novel protein assemblies. Curr. Opin. Struct. Biol. 23, 632\u2013638 (2013)","journal-title":"Curr. Opin. Struct. Biol."},{"key":"BFnature13404_CR5","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.cbpa.2013.10.004","volume":"17","author":"JC Sinclair","year":"2013","unstructured":"Sinclair, J. C. Constructing arrays of proteins. Curr. Opin. Chem. Biol. 17, 946\u2013951 (2013)","journal-title":"Curr. Opin. Chem. Biol."},{"key":"BFnature13404_CR6","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1021\/ar900273t","volume":"43","author":"EN Salgado","year":"2010","unstructured":"Salgado, E. N., Radford, R. J. & Tezcan, F. A. Metal-directed protein self-assembly. Acc. Chem. Res. 43, 661\u2013672 (2010)","journal-title":"Acc. Chem. Res."},{"key":"BFnature13404_CR7","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1126\/science.1219364","volume":"336","author":"NP King","year":"2012","unstructured":"King, N. P. et al. Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science 336, 1171\u20131174 (2012)","journal-title":"Science"},{"key":"BFnature13404_CR8","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/nchem.1290","volume":"4","author":"JD Brodin","year":"2012","unstructured":"Brodin, J. D. et al. Metal-directed, chemically tunable assembly of one-, two- and three-dimensional crystalline protein arrays. Nature Chem. 4, 375\u2013382 (2012)","journal-title":"Nature Chem."},{"key":"BFnature13404_CR9","doi-asserted-by":"publisher","first-page":"7304","DOI":"10.1073\/pnas.1112595109","volume":"109","author":"CJ Lanci","year":"2012","unstructured":"Lanci, C. J. et al. Computational design of a protein crystal. Proc. Natl Acad. Sci. USA 109, 7304\u20137309 (2012)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13404_CR10","doi-asserted-by":"publisher","first-page":"20562","DOI":"10.1073\/pnas.1115124108","volume":"108","author":"PB Stranges","year":"2011","unstructured":"Stranges, P. B., Machius, M., Miley, M. J., Tripathy, A. & Kuhlman, B. Computational design of a symmetric homodimer using beta-strand assembly. Proc. Natl Acad. Sci. USA 108, 20562\u201320567 (2011)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13404_CR11","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/nnano.2011.122","volume":"6","author":"JC Sinclair","year":"2011","unstructured":"Sinclair, J. C., Davies, K. M., Venien-Bryan, C. & Noble, M. E. Generation of protein lattices by fusing proteins with matching rotational symmetry. Nature Nanotechnol. 6, 558\u2013562 (2011)","journal-title":"Nature Nanotechnol."},{"key":"BFnature13404_CR12","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1126\/science.1219351","volume":"336","author":"YT Lai","year":"2012","unstructured":"Lai, Y. T., Cascio, D. & Yeates, T. O. Structure of a 16-nm cage designed by using protein oligomers. Science 336, 1129 (2012)","journal-title":"Science"},{"key":"BFnature13404_CR13","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1021\/ja208015j","volume":"134","author":"BS Der","year":"2012","unstructured":"Der, B. S. et al. Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer. J. Am. Chem. Soc. 134, 375\u2013385 (2012)","journal-title":"J. Am. Chem. Soc."},{"key":"BFnature13404_CR14","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1126\/science.1233936","volume":"340","author":"JM Fletcher","year":"2013","unstructured":"Fletcher, J. M. et al. Self-assembling cages from coiled-coil peptide modules. Science 340, 595\u2013599 (2013)","journal-title":"Science"},{"key":"BFnature13404_CR15","doi-asserted-by":"publisher","first-page":"15457","DOI":"10.1021\/ja3053943","volume":"134","author":"AL Boyle","year":"2012","unstructured":"Boyle, A. L. et al. Squaring the circle in peptide assembly: from fibers to discrete nanostructures by de novo design. J. Am. Chem. Soc. 134, 15457\u201315467 (2012)","journal-title":"J. Am. Chem. Soc."},{"key":"BFnature13404_CR16","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1126\/science.1198841","volume":"332","author":"G Grigoryan","year":"2011","unstructured":"Grigoryan, G. et al. Computational design of virus-like protein assemblies on carbon nanotube surfaces. Science 332, 1071\u20131076 (2011)","journal-title":"Science"},{"key":"BFnature13404_CR17","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1146\/annurev-biochem-060308-102244","volume":"79","author":"NC Seeman","year":"2010","unstructured":"Seeman, N. C. Nanomaterials based on DNA. Annu. Rev. Biochem. 79, 65\u201387 (2010)","journal-title":"Annu. Rev. Biochem."},{"key":"BFnature13404_CR18","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/nature04586","volume":"440","author":"PW Rothemund","year":"2006","unstructured":"Rothemund, P. W. Folding DNA to create nanoscale shapes and patterns. Nature 440, 297\u2013302 (2006)","journal-title":"Nature"},{"key":"BFnature13404_CR19","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1126\/science.1227268","volume":"338","author":"Y Ke","year":"2012","unstructured":"Ke, Y., Ong, L. L., Shih, W. M. & Yin, P. Three-dimensional structures self-assembled from DNA bricks. Science 338, 1177\u20131183 (2012)","journal-title":"Science"},{"key":"BFnature13404_CR20","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1126\/science.1232252","volume":"339","author":"D Han","year":"2013","unstructured":"Han, D. et al. DNA gridiron nanostructures based on four-arm junctions. Science 339, 1412\u20131415 (2013)","journal-title":"Science"},{"key":"BFnature13404_CR21","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1073\/pnas.041614998","volume":"98","author":"JE Padilla","year":"2001","unstructured":"Padilla, J. E., Colovos, C. & Yeates, T. O. Nanohedra: using symmetry to design self assembling protein cages, layers, crystals, and filaments. Proc. Natl Acad. Sci. USA 98, 2217\u20132221 (2001)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13404_CR22","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1002\/pro.106","volume":"18","author":"K Usui","year":"2009","unstructured":"Usui, K. et al. Nanoscale elongating control of the self-assembled protein filament with the cysteine-introduced building blocks. Protein Sci. 18, 960\u2013969 (2009)","journal-title":"Protein Sci."},{"key":"BFnature13404_CR23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1146\/annurev.biophys.29.1.105","volume":"29","author":"DS Goodsell","year":"2000","unstructured":"Goodsell, D. S. & Olson, A. J. Structural symmetry and protein function. Annu. Rev. Biophys. Biomol. Struct. 29, 105\u2013153 (2000)","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"BFnature13404_CR24","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1017\/S0033583508004708","volume":"41","author":"J Janin","year":"2008","unstructured":"Janin, J., Bahadur, R. P. & Chakrabarti, P. Protein-protein interaction and quaternary structure. Q. Rev. Biophys. 41, 133\u2013180 (2008)","journal-title":"Q. Rev. Biophys."},{"key":"BFnature13404_CR25","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1110\/ps.073125207","volume":"16","author":"PS Huang","year":"2007","unstructured":"Huang, P. S., Love, J. J. & Mayo, S. L. A de novo designed protein protein interface. Protein Sci. 16, 2770\u20132774 (2007)","journal-title":"Protein Sci."},{"key":"BFnature13404_CR26","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jmb.2010.05.006","volume":"400","author":"RK Jha","year":"2010","unstructured":"Jha, R. K. et al. Computational design of a PAK1 binding protein. J. Mol. Biol. 400, 257\u2013270 (2010)","journal-title":"J. Mol. Biol."},{"key":"BFnature13404_CR27","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.molcel.2011.03.010","volume":"42","author":"J Karanicolas","year":"2011","unstructured":"Karanicolas, J. et al. A de novo protein binding pair by computational design and directed evolution. Mol. Cell 42, 250\u2013260 (2011)","journal-title":"Mol. Cell"},{"key":"BFnature13404_CR28","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1126\/science.1202617","volume":"332","author":"SJ Fleishman","year":"2011","unstructured":"Fleishman, S. J. et al. Computational design of proteins targeting the conserved stem region of influenza hemagglutinin. Science 332, 816\u2013821 (2011)","journal-title":"Science"},{"key":"BFnature13404_CR29","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.febslet.2012.12.009","volume":"587","author":"SD Khare","year":"2013","unstructured":"Khare, S. D. & Fleishman, S. J. Emerging themes in the computational design of novel enzymes and protein-protein interfaces. FEBS Lett. 587, 1147\u20131154 (2013)","journal-title":"FEBS Lett."},{"key":"BFnature13404_CR30","doi-asserted-by":"publisher","first-page":"10383","DOI":"10.1073\/pnas.97.19.10383","volume":"97","author":"B Kuhlman","year":"2000","unstructured":"Kuhlman, B. & Baker, D. Native protein sequences are close to optimal for their structures. Proc. Natl Acad. Sci. USA 97, 10383\u201310388 (2000)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13404_CR31","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/B978-0-12-381270-4.00019-6","volume":"487","author":"A Leaver-Fay","year":"2011","unstructured":"Leaver-Fay, A. et al. ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules. Methods Enzymol. 487, 545\u2013574 (2011)","journal-title":"Methods Enzymol."},{"key":"BFnature13404_CR32","doi-asserted-by":"publisher","first-page":"e20450","DOI":"10.1371\/journal.pone.0020450","volume":"6","author":"F DiMaio","year":"2011","unstructured":"DiMaio, F., Leaver-Fay, A., Bradley, P., Baker, D. & Andre, I. Modeling symmetric macromolecular structures in Rosetta3. PLoS ONE 6, e20450 (2011)","journal-title":"PLoS ONE"},{"key":"BFnature13404_CR33","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1006\/jmbi.1993.1648","volume":"234","author":"MC Lawrence","year":"1993","unstructured":"Lawrence, M. C. & Colman, P. M. Shape complementarity at protein\/protein interfaces. J. Mol. Biol. 234, 946\u2013950 (1993)","journal-title":"J. Mol. Biol."},{"key":"BFnature13404_CR34","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S1367-5931(99)80010-6","volume":"3","author":"FH Arnold","year":"1999","unstructured":"Arnold, F. H. & Volkov, A. A. Directed evolution of biocatalysts. Curr. Opin. Chem. Biol. 3, 54\u201359 (1999)","journal-title":"Curr. Opin. Chem. Biol."},{"key":"BFnature13404_CR35","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1146\/annurev.biophys.37.032807.125832","volume":"37","author":"C J\u00e4ckel","year":"2008","unstructured":"J\u00e4ckel, C., Kast, P. & Hilvert, D. Protein design by directed evolution. Annu. Rev. Biophys. 37, 153\u2013173 (2008)","journal-title":"Annu. Rev. Biophys."},{"key":"BFnature13404_CR36","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1021\/ja211011k","volume":"134","author":"B W\u00f6rsd\u00f6rfer","year":"2012","unstructured":"W\u00f6rsd\u00f6rfer, B., Pianowski, Z. & Hilvert, D. Efficient in vitro encapsulation of protein cargo by an engineered protein container. J. Am. Chem. Soc. 134, 909\u2013911 (2012)","journal-title":"J. Am. Chem. Soc."},{"key":"BFnature13404_CR37","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1126\/science.1199081","volume":"331","author":"B W\u00f6rsd\u00f6rfer","year":"2011","unstructured":"W\u00f6rsd\u00f6rfer, B., Woycechowsky, K. J. & Hilvert, D. Directed evolution of a protein container. Science 331, 589\u2013592 (2011)","journal-title":"Science"},{"key":"BFnature13404_CR38","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1002\/prot.21133","volume":"65","author":"P Bradley","year":"2006","unstructured":"Bradley, P. & Baker, D. Improved beta-protein structure prediction by multilevel optimization of nonlocal strand pairings and local backbone conformation. Proteins 65, 922\u2013929 (2006)","journal-title":"Proteins"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature13404.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature13404","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature13404.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:21:46Z","timestamp":1684419706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature13404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,25]]},"references-count":38,"journal-issue":{"issue":"7503","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["BFnature13404"],"URL":"https:\/\/doi.org\/10.1038\/nature13404","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718424093.793496720","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,25]]},"assertion":[{"value":"7 January 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}