{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:23:57Z","timestamp":1783776237511,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"7525","license":[{"start":{"date-parts":[[2014,8,24]],"date-time":"2014-08-24T00:00:00Z","timestamp":1408838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1038\/nature13663","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T15:05:10Z","timestamp":1408633510000},"page":"125-129","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":388,"title":["PLETHORA gradient formation mechanism separates auxin responses"],"prefix":"10.1038","volume":"515","author":[{"given":"Ari Pekka","family":"M\u00e4h\u00f6nen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten ten","family":"Tusscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Siligato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ond\u0159ej","family":"Smetana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"D\u00edaz-Trivi\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarkko","family":"Saloj\u00e4rvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Wachsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalika","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renze","family":"Heidstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Scheres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,24]]},"reference":[{"key":"BFnature13663_CR1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1242\/dev.119.1.71","volume":"119","author":"L Dolan","year":"1993","unstructured":"Dolan, L. et al. Cellular organisation of the Arabidopsis thaliana root. Development 119, 71\u201384 (1993)","journal-title":"Development"},{"key":"BFnature13663_CR2","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1104\/pp.124.4.1718","volume":"124","author":"GT Beemster","year":"2000","unstructured":"Beemster, G. T. & Baskin, T. I. Stunted plant 1 mediates effects of cytokinin, but not of auxin, on cell division and expansion in the root of Arabidopsis. Plant Physiol. 124, 1718\u20131727 (2000)","journal-title":"Plant Physiol."},{"key":"BFnature13663_CR3","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0092-8674(00)81535-4","volume":"99","author":"S Sabatini","year":"1999","unstructured":"Sabatini, S. et al. An auxin-dependent distal organizer of pattern and polarity in the Arabidopsis root. Cell 99, 463\u2013472 (1999)","journal-title":"Cell"},{"key":"BFnature13663_CR4","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1038\/nature06215","volume":"449","author":"VA Grieneisen","year":"2007","unstructured":"Grieneisen, V. A., Xu, J., Maree, A. F., Hogeweg, P. & Scheres, B. Auxin transport is sufficient to generate a maximum and gradient guiding root growth. Nature 449, 1008\u20131013 (2007)","journal-title":"Nature"},{"key":"BFnature13663_CR5","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1105\/tpc.109.066480","volume":"21","author":"SV Petersson","year":"2009","unstructured":"Petersson, S. V. et al. An auxin gradient and maximum in the Arabidopsis root apex shown by high-resolution cell-specific analysis of IAA distribution and synthesis. Plant Cell 21, 1659\u20131668 (2009)","journal-title":"Plant Cell"},{"key":"BFnature13663_CR6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature10791","volume":"482","author":"G Brunoud","year":"2012","unstructured":"Brunoud, G. et al. A novel sensor to map auxin response and distribution at high spatio-temporal resolution. Nature 482, 103\u2013106 (2012)","journal-title":"Nature"},{"key":"BFnature13663_CR7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1242\/dev.035840","volume":"137","author":"T Ishida","year":"2010","unstructured":"Ishida, T. et al. Auxin modulates the transition from the mitotic cycle to the endocycle in Arabidopsis. Development 137, 63\u201371 (2010)","journal-title":"Development"},{"key":"BFnature13663_CR8","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.cell.2004.09.018","volume":"119","author":"M Aida","year":"2004","unstructured":"Aida, M. et al. The PLETHORA genes mediate patterning of the Arabidopsis root stem cell niche. Cell 119, 109\u2013120 (2004)","journal-title":"Cell"},{"key":"BFnature13663_CR9","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1038\/nature06206","volume":"449","author":"C Galinha","year":"2007","unstructured":"Galinha, C. et al. PLETHORA proteins as dose-dependent master regulators of Arabidopsis root development. Nature 449, 1053\u20131057 (2007)","journal-title":"Nature"},{"key":"BFnature13663_CR10","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nature03184","volume":"433","author":"I Blilou","year":"2005","unstructured":"Blilou, I. et al. The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots. Nature 433, 39\u201344 (2005)","journal-title":"Nature"},{"key":"BFnature13663_CR11","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1105\/tpc.113.119495","volume":"26","author":"LR Band","year":"2014","unstructured":"Band, L. R. et al. Systems analysis of auxin transport in the Arabidopsis root apex. Plant Cell 26, 862\u2013875 (2014)","journal-title":"Plant Cell"},{"key":"BFnature13663_CR12","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.cub.2013.04.048","volume":"23","author":"H Hofhuis","year":"2013","unstructured":"Hofhuis, H. et al. Phyllotaxis and rhizotaxis in Arabidopsis are modified by three PLETHORA transcription factors. Curr. Biol. 23, 956\u2013962 (2013)","journal-title":"Curr. Biol."},{"key":"BFnature13663_CR13","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/415806a","volume":"415","author":"J Friml","year":"2002","unstructured":"Friml, J., Wisniewska, J., Benkova, E., Mendgen, K. & Palme, K. Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis. Nature 415, 806\u2013809 (2002)","journal-title":"Nature"},{"key":"BFnature13663_CR14","doi-asserted-by":"publisher","first-page":"4668","DOI":"10.1073\/pnas.1201498109","volume":"109","author":"LR Band","year":"2012","unstructured":"Band, L. R. et al. Root gravitropism is regulated by a transient lateral auxin gradient controlled by a tipping-point mechanism. Proc. Natl Acad. Sci. USA 109, 4668\u20134673 (2012)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13663_CR15","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1126\/science.1118875","volume":"311","author":"AP M\u00e4h\u00f6nen","year":"2006","unstructured":"M\u00e4h\u00f6nen, A. P. et al. Cytokinin signaling and its inhibitor AHP6 regulate cell fate during vascular development. Science 311, 94\u201398 (2006)","journal-title":"Science"},{"key":"BFnature13663_CR16","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0092-8674(00)81536-6","volume":"99","author":"MM Lee","year":"1999","unstructured":"Lee, M. M. & Schiefelbein, J. WEREWOLF, a MYB-related protein in Arabidopsis, is a position-dependent regulator of epidermal cell patterning. Cell 99, 473\u2013483 (1999)","journal-title":"Cell"},{"key":"BFnature13663_CR17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/nature02085","volume":"426","author":"J Friml","year":"2003","unstructured":"Friml, J. et al. Efflux-dependent auxin gradients establish the apical\u2013basal axis of Arabidopsis. Nature 426, 147\u2013153 (2003)","journal-title":"Nature"},{"key":"BFnature13663_CR18","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1016\/j.cub.2006.08.091","volume":"16","author":"U Fischer","year":"2006","unstructured":"Fischer, U. et al. Vectorial information for Arabidopsis planar polarity is mediated by combined AUX1, EIN2, and GNOM activity. Curr. Biol. 16, 2143\u20132149 (2006)","journal-title":"Curr. Biol."},{"key":"BFnature13663_CR19","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.pbi.2012.09.010","volume":"15","author":"S Wu","year":"2012","unstructured":"Wu, S. & Gallagher, K. L. Transcription factors on the move. Curr. Opin. Plant Biol. 15, 645\u2013651 (2012)","journal-title":"Curr. Opin. Plant Biol."},{"key":"BFnature13663_CR20","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1101\/gad.305504","volume":"18","author":"R Heidstra","year":"2004","unstructured":"Heidstra, R., Welch, D. & Scheres, B. Mosaic analyses using marked activation and deletion clones dissect Arabidopsis SCARECROW action in asymmetric cell division. Genes Dev. 18, 1964\u20131969 (2004)","journal-title":"Genes Dev."},{"key":"BFnature13663_CR21","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1126\/science.1191132","volume":"329","author":"Y Matsuzaki","year":"2010","unstructured":"Matsuzaki, Y., Ogawa-Ohnishi, M., Mori, A. & Matsubayashi, Y. Secreted peptide signals required for maintenance of root stem cell niche in Arabidopsis. Science 329, 1065\u20131067 (2010)","journal-title":"Science"},{"key":"BFnature13663_CR22","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1046\/j.1365-313x.1999.00620.x","volume":"20","author":"A Col\u00f3n-Carmona","year":"1999","unstructured":"Col\u00f3n-Carmona, A., You, R., Haimovitch-Gal, T. & Doerner, P. Technical advance: spatio-temporal analysis of mitotic activity with a labile cyclin\u2013GUS fusion protein. Plant J. 20, 503\u2013508 (1999)","journal-title":"Plant J."},{"key":"BFnature13663_CR23","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1105\/tpc.018903","volume":"16","author":"K Culligan","year":"2004","unstructured":"Culligan, K., Tissier, A. & Britt, A. ATR regulates a G2-phase cell-cycle checkpoint in Arabidopsis thaliana. Plant Cell 16, 1091\u20131104 (2004)","journal-title":"Plant Cell"},{"key":"BFnature13663_CR24","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nature08391","volume":"461","author":"SR Yu","year":"2009","unstructured":"Yu, S. R. et al. Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Nature 461, 533\u2013536 (2009)","journal-title":"Nature"},{"key":"BFnature13663_CR25","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1242\/dev.021246","volume":"136","author":"V Wilson","year":"2009","unstructured":"Wilson, V., Olivera-Martinez, I. & Storey, K. G. Stem cells, signals and vertebrate body axis extension. Development 136, 1591\u20131604 (2009)","journal-title":"Development"},{"key":"BFnature13663_CR26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/msb4100098","volume":"2","author":"M Iba\u00f1es","year":"2006","unstructured":"Iba\u00f1es, M., Kawakami, Y., Rasskin-Gutman, D. & Izpisua Belmonte, J. C. Cell lineage transport: a mechanism for molecular gradient formation. Mol. Syst. Biol. 2, 57 (2006)","journal-title":"Mol. Syst. Biol."},{"key":"BFnature13663_CR27","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1021\/cb200404c","volume":"7","author":"K Hayashi","year":"2012","unstructured":"Hayashi, K. et al. Rational design of an auxin antagonist of the SCFTIR1 auxin receptor complex. ACS Chem. Biol. 7, 590\u2013598 (2012)","journal-title":"ACS Chem. Biol."},{"key":"BFnature13663_CR28","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1126\/science.279.5355.1371","volume":"279","author":"D Rouse","year":"1998","unstructured":"Rouse, D., Mackay, P., Stirnberg, P., Estelle, M. & Leyser, O. Changes in auxin response from mutations in an AUX\/IAA gene. Science 279, 1371\u20131373 (1998)","journal-title":"Science"},{"key":"BFnature13663_CR29","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1146\/annurev-cellbio-101011-155741","volume":"28","author":"M Vanstraelen","year":"2012","unstructured":"Vanstraelen, M. & Benkova, E. Hormonal interactions in the regulation of plant development. Annu. Rev. Cell Dev. Biol. 28, 463\u2013487 (2012)","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"BFnature13663_CR30","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1073\/pnas.1213497110","volume":"110","author":"V Pinon","year":"2013","unstructured":"Pinon, V., Prasad, K., Grigg, S. P., Sanchez-Perez, G. F. & Scheres, B. Local auxin biosynthesis regulation by PLETHORA transcription factors controls phyllotaxis in Arabidopsis. Proc. Natl Acad. Sci. USA 110, 1107\u20131112 (2013)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13663_CR31","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1016\/j.cub.2005.09.052","volume":"15","author":"MG Heisler","year":"2005","unstructured":"Heisler, M. G. et al. Patterns of auxin transport and gene expression during primordium development revealed by live imaging of the Arabidopsis inflorescence meristem. Curr. Biol. 15, 1899\u20131911 (2005)","journal-title":"Curr. Biol."},{"key":"BFnature13663_CR32","doi-asserted-by":"publisher","first-page":"6055","DOI":"10.1073\/pnas.0510607103","volume":"103","author":"JY Lee","year":"2006","unstructured":"Lee, J. Y. et al. Transcriptional and posttranscriptional regulation of transcription factor expression in Arabidopsis roots. Proc. Natl Acad. Sci. USA 103, 6055\u20136060 (2006)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13663_CR33","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1105\/tpc.006437","volume":"14","author":"HT Cho","year":"2002","unstructured":"Cho, H. T. & Cosgrove, D. J. Regulation of root hair initiation and expansin gene expression in Arabidopsis. Plant Cell 14, 3237\u20133253 (2002)","journal-title":"Plant Cell"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature13663.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature13663","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature13663.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:24:08Z","timestamp":1684434248000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature13663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,24]]},"references-count":33,"journal-issue":{"issue":"7525","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["BFnature13663"],"URL":"https:\/\/doi.org\/10.1038\/nature13663","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,24]]},"assertion":[{"value":"6 February 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}