{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:21:43Z","timestamp":1779366103647,"version":"3.53.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"7632","license":[{"start":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T00:00:00Z","timestamp":1480464000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1038\/nature20158","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T15:12:34Z","timestamp":1480432354000},"page":"296-300","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":151,"title":["Capturing pairwise and multi-way chromosomal conformations using chromosomal walks"],"prefix":"10.1038","volume":"540","author":[{"given":"Pedro","family":"Olivares-Chauvet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohar","family":"Mukamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviezer","family":"Lifshitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Schwartzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa Oded","family":"Elkayam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniv","family":"Lubling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gintaras","family":"Deikus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Sebra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Tanay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,30]]},"reference":[{"key":"BFnature20158_CR1","doi-asserted-by":"publisher","first-page":"a003889","DOI":"10.1101\/cshperspect.a003889","volume":"2","author":"T Cremer","year":"2010","unstructured":"Cremer, T. & Cremer, M. Chromosome territories. Cold Spring Harb. Perspect. Biol . 2, a003889 (2010)","journal-title":"Cold Spring Harb. Perspect. Biol"},{"key":"BFnature20158_CR2","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/nrg3454","volume":"14","author":"J Dekker","year":"2013","unstructured":"Dekker, J., Marti-Renom, M. A. & Mirny, L. A. Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data. Nature Rev. Genet. 14, 390\u2013403 (2013)","journal-title":"Nature Rev. Genet."},{"key":"BFnature20158_CR3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nature14222","volume":"518","author":"JR Dixon","year":"2015","unstructured":"Dixon, J. R. et al. Chromatin architecture reorganization during stem cell differentiation. Nature 518, 331\u2013336 (2015)","journal-title":"Nature"},{"key":"BFnature20158_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature12593","volume":"502","author":"T Nagano","year":"2013","unstructured":"Nagano, T. et al. Single-cell Hi-C reveals cell-to-cell variability in chromosome structure. Nature 502, 59\u201364 (2013)","journal-title":"Nature"},{"key":"BFnature20158_CR5","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.celrep.2015.02.004","volume":"10","author":"M Vietri Rudan","year":"2015","unstructured":"Vietri Rudan, M. et al. Comparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture. Cell Reports 10, 1297\u20131309 (2015)","journal-title":"Cell Reports"},{"key":"BFnature20158_CR6","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature11082","volume":"485","author":"JR Dixon","year":"2012","unstructured":"Dixon, J. R. et al. Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature 485, 376\u2013380 (2012)","journal-title":"Nature"},{"key":"BFnature20158_CR7","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.cell.2012.01.010","volume":"148","author":"T Sexton","year":"2012","unstructured":"Sexton, T. et al. Three-dimensional folding and functional organization principles of the Drosophila genome. Cell 148, 458\u2013472 (2012)","journal-title":"Cell"},{"key":"BFnature20158_CR8","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nature11049","volume":"485","author":"EP Nora","year":"2012","unstructured":"Nora, E. P. et al. Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature 485, 381\u2013385 (2012)","journal-title":"Nature"},{"key":"BFnature20158_CR9","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1073\/pnas.1317788111","volume":"111","author":"J Zuin","year":"2014","unstructured":"Zuin, J. et al. Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells. Proc. Natl Acad. Sci. USA 111, 996\u20131001 (2014)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature20158_CR10","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1038\/emboj.2013.237","volume":"32","author":"S Sofueva","year":"2013","unstructured":"Sofueva, S. et al. Cohesin-mediated interactions organize chromosomal domain architecture. EMBO J . 32, 3119\u20133129 (2013)","journal-title":"EMBO J"},{"key":"BFnature20158_CR11","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1016\/j.cell.2014.11.021","volume":"159","author":"SSP Rao","year":"2014","unstructured":"Rao, S. S. P. et al. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell 159, 1665\u20131680 (2014)","journal-title":"Cell"},{"key":"BFnature20158_CR12","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/nature12716","volume":"504","author":"Y Zhang","year":"2013","unstructured":"Zhang, Y. et al. Chromatin connectivity maps reveal dynamic promoter\u2013enhancer long-range associations. Nature 504, 306\u2013310 (2013)","journal-title":"Nature"},{"key":"BFnature20158_CR13","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/j.cell.2013.04.053","volume":"153","author":"JE Phillips-Cremins","year":"2013","unstructured":"Phillips-Cremins, J. E. et al. Architectural protein subclasses shape 3D organization of genomes during lineage commitment. Cell 153, 1281\u20131295 (2013)","journal-title":"Cell"},{"key":"BFnature20158_CR14","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1016\/j.cell.2015.11.024","volume":"163","author":"Z Tang","year":"2015","unstructured":"Tang, Z. et al. CTCF-mediated human 3D genome architecture reveals chromatin topology for transcription. Cell 163, 1611\u20131627 (2015)","journal-title":"Cell"},{"key":"BFnature20158_CR15","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s13059-015-0753-7","volume":"16","author":"T Nagano","year":"2015","unstructured":"Nagano, T. et al. Comparison of Hi-C results using in-solution versus in-nucleus ligation. Genome Biol. 16, 175 (2015)","journal-title":"Genome Biol."},{"key":"BFnature20158_CR16","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12864-015-1236-7","volume":"16","author":"F Ay","year":"2015","unstructured":"Ay, F. et al. Identifying multi-locus chromatin contacts in human cells using tethered multiple 3C. BMC Genomics 16, 121 (2015)","journal-title":"BMC Genomics"},{"key":"BFnature20158_CR17","doi-asserted-by":"publisher","first-page":"1234167","DOI":"10.1126\/science.1234167","volume":"340","author":"G Andrey","year":"2013","unstructured":"Andrey, G. et al. A switch between topological domains underlies HoxD genes collinearity in mouse limbs. Science 340, 1234167 (2013)","journal-title":"Science"},{"key":"BFnature20158_CR18","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1016\/j.celrep.2016.04.085","volume":"15","author":"G Fudenberg","year":"2016","unstructured":"Fudenberg, G. et al. Formation of chromosomal domains by loop extrusion. Cell Reports 15, 2038\u20132049 (2016)","journal-title":"Cell Reports"},{"key":"BFnature20158_CR19","doi-asserted-by":"publisher","first-page":"E6456","DOI":"10.1073\/pnas.1518552112","volume":"112","author":"AL Sanborn","year":"2015","unstructured":"Sanborn, A. L. et al. Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes. Proc. Natl Acad. Sci. USA 112, E6456\u2013E6465 (2015)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature20158_CR20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.gde.2013.11.016","volume":"25","author":"T Cheutin","year":"2014","unstructured":"Cheutin, T. & Cavalli, G. Polycomb silencing: from linear chromatin domains to 3D chromosome folding. Curr. Opin. Genet. Dev. 25, 30\u201337 (2014)","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFnature20158_CR21","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.celrep.2014.08.072","volume":"9","author":"B Schuettengruber","year":"2014","unstructured":"Schuettengruber, B. et al. Cooperativity, specificity, and evolutionary stability of Polycomb targeting in Drosophila. Cell Reports 9, 219\u2013233 (2014)","journal-title":"Cell Reports"},{"key":"BFnature20158_CR22","doi-asserted-by":"publisher","first-page":"13964","DOI":"10.1073\/pnas.1517972112","volume":"112","author":"PJ Fabre","year":"2015","unstructured":"Fabre, P. J. et al. Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states. Proc. Natl Acad. Sci. USA 112, 13964\u201313969 (2015)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature20158_CR23","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/nature16496","volume":"529","author":"AN Boettiger","year":"2016","unstructured":"Boettiger, A. N. et al. Super-resolution imaging reveals distinct chromatin folding for different epigenetic states. Nature 529, 418\u2013422 (2016)","journal-title":"Nature"},{"key":"BFnature20158_CR24","doi-asserted-by":"publisher","first-page":"1237973","DOI":"10.1126\/science.1237973","volume":"341","author":"JM Engreitz","year":"2013","unstructured":"Engreitz, J. M. et al. The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome. Science 341, 1237973 (2013)","journal-title":"Science"},{"key":"BFnature20158_CR25","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1101\/gad.251694.114","volume":"28","author":"I Williamson","year":"2014","unstructured":"Williamson, I. et al. Spatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization. Genes Dev. 28, 2778\u20132791 (2014)","journal-title":"Genes Dev."},{"key":"BFnature20158_CR26","doi-asserted-by":"publisher","first-page":"3031","DOI":"10.1016\/j.febslet.2015.09.004","volume":"589","author":"MV Imakaev","year":"2015","unstructured":"Imakaev, M. V., Fudenberg, G. & Mirny, L. A. Modeling chromosomes: Beyond pretty pictures. FEBS Lett . 589, 3031\u20133036 (2015)","journal-title":"FEBS Lett"},{"key":"BFnature20158_CR27","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.cell.2014.03.025","volume":"157","author":"L Giorgetti","year":"2014","unstructured":"Giorgetti, L. et al. Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription. Cell 157, 950\u2013963 (2014)","journal-title":"Cell"},{"key":"BFnature20158_CR28","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1126\/science.1261417","volume":"347","author":"S Geula","year":"2015","unstructured":"Geula, S. et al. m6A mRNA methylation facilitates resolution of na\u00efve pluripotency toward differentiation. Science 347, 1002\u20131006 (2015)","journal-title":"Science"},{"key":"BFnature20158_CR29","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nmeth.3922","volume":"13","author":"O Schwartzman","year":"2016","unstructured":"Schwartzman, O. et al. UMI-4C for quantitative and targeted chromosomal contact profiling. Nature Methods 13, 685\u2013691 (2016)","journal-title":"Nature Methods"},{"key":"BFnature20158_CR30","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/nprot.2011.328","volume":"6","author":"T Ryba","year":"2011","unstructured":"Ryba, T., Battaglia, D., Pope, B. D., Hiratani, I. & Gilbert, D. M. Genome-scale analysis of replication timing: from bench to bioinformatics. Nature Protocols 6, 870\u2013895 (2011)","journal-title":"Nature Protocols"},{"key":"BFnature20158_CR31","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1073\/pnas.0912402107","volume":"107","author":"RS Hansen","year":"2010","unstructured":"Hansen, R. S. et al. Sequencing newly replicated DNA reveals widespread plasticity in human replication timing. Proc. Natl Acad. Sci. USA 107, 139\u2013144 (2010)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature20158_CR32","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1101\/gad.399506","volume":"20","author":"E Splinter","year":"2006","unstructured":"Splinter, E. et al. CTCF mediates long-range chromatin looping and local histone modification in the \u03b2-globin locus. Genes Dev. 20, 2349\u20132354 (2006)","journal-title":"Genes Dev."},{"key":"BFnature20158_CR33","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.cell.2014.05.050","volume":"158","author":"W Deng","year":"2014","unstructured":"Deng, W. et al. Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell 158, 849\u2013860 (2014)","journal-title":"Cell"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature20158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature20158","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature20158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:57:05Z","timestamp":1684432625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature20158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,30]]},"references-count":33,"journal-issue":{"issue":"7632","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["BFnature20158"],"URL":"https:\/\/doi.org\/10.1038\/nature20158","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,30]]},"assertion":[{"value":"25 December 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}