{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:39:17Z","timestamp":1781534357996,"version":"3.54.5"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"7645","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1038\/nature21695","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T19:04:30Z","timestamp":1488222270000},"page":"443-446","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":437,"title":["Cytosolic proteostasis through importing of misfolded proteins into mitochondria"],"prefix":"10.1038","volume":"543","author":[{"given":"Linhao","family":"Ruan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuankai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erli","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Kucharavy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Florens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"BFnature21695_CR1","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nature05292","volume":"443","author":"MT Lin","year":"2006","unstructured":"Lin, M. T. & Beal, M. F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787\u2013795 (2006)","journal-title":"Nature"},{"key":"BFnature21695_CR2","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1126\/science.1141448","volume":"319","author":"WE Balch","year":"2008","unstructured":"Balch, W. E., Morimoto, R. I., Dillin, A. & Kelly, J. W. Adapting proteostasis for disease intervention. Science 319, 916\u2013919 (2008)","journal-title":"Science"},{"key":"BFnature21695_CR3","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nature10317","volume":"475","author":"FU Hartl","year":"2011","unstructured":"Hartl, F. U., Bracher, A. & Hayer-Hartl, M. Molecular chaperones in protein folding and proteostasis. Nature 475, 324\u2013332 (2011)","journal-title":"Nature"},{"key":"BFnature21695_CR4","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/S0140-6736(11)61305-6","volume":"379","author":"AH Schapira","year":"2012","unstructured":"Schapira, A. H. Mitochondrial diseases. Lancet 379, 1825\u20131834 (2012)","journal-title":"Lancet"},{"key":"BFnature21695_CR5","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"C L\u00f3pez-Ot\u00edn","year":"2013","unstructured":"L\u00f3pez-Ot\u00edn, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153, 1194\u20131217 (2013)","journal-title":"Cell"},{"key":"BFnature21695_CR6","doi-asserted-by":"publisher","first-page":"13145","DOI":"10.1073\/pnas.0806192105","volume":"105","author":"CA Hansson Petersen","year":"2008","unstructured":"Hansson Petersen, C. A. et al. The amyloid \u03b2-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc. Natl Acad. Sci. USA 105, 13145\u201313150 (2008)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature21695_CR7","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/372475a0","volume":"372","author":"DA Parsell","year":"1994","unstructured":"Parsell, D. A., Kowal, A. S., Singer, M. A. & Lindquist, S. Protein disaggregation mediated by heat-shock protein Hsp104. Nature 372, 475\u2013478 (1994)","journal-title":"Nature"},{"key":"BFnature21695_CR8","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/nrm3660","volume":"14","author":"SM Doyle","year":"2013","unstructured":"Doyle, S. M., Genest, O. & Wickner, S. Protein rescue from aggregates by powerful molecular chaperone machines. Nat. Rev. Mol. Cell Biol. 14, 617\u2013629 (2013)","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFnature21695_CR9","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.cell.2014.09.026","volume":"159","author":"C Zhou","year":"2014","unstructured":"Zhou, C. et al. Organelle-based aggregation and retention of damaged proteins in asymmetrically dividing cells. Cell 159, 530\u2013542 (2014)","journal-title":"Cell"},{"key":"BFnature21695_CR10","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.jmb.2015.02.006","volume":"427","author":"SB Miller","year":"2015","unstructured":"Miller, S. B., Mogk, A. & Bukau, B. Spatially organized aggregation of misfolded proteins as cellular stress defense strategy. J. Mol. Biol. 427, 1564\u20131574 (2015)","journal-title":"J. Mol. Biol."},{"key":"BFnature21695_CR11","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/nmeth.1697","volume":"8","author":"R Gupta","year":"2011","unstructured":"Gupta, R. et al. Firefly luciferase mutants as sensors of proteome stress. Nat. Methods 8, 879\u2013884 (2011)","journal-title":"Nat. Methods"},{"key":"BFnature21695_CR12","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.cell.2015.08.041","volume":"162","author":"EW Wallace","year":"2015","unstructured":"Wallace, E. W. et al. Reversible, specific, active aggregates of endogenous proteins assemble upon heat stress. Cell 162, 1286\u20131298 (2015)","journal-title":"Cell"},{"key":"BFnature21695_CR13","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1146\/annurev.biochem.76.052705.163409","volume":"76","author":"W Neupert","year":"2007","unstructured":"Neupert, W. & Herrmann, J. M. Translocation of proteins into mitochondria. Annu. Rev. Biochem. 76, 723\u2013749 (2007)","journal-title":"Annu. Rev. Biochem."},{"key":"BFnature21695_CR14","doi-asserted-by":"crossref","first-page":"18051","DOI":"10.1016\/S0021-9258(18)55235-2","volume":"266","author":"J Martin","year":"1991","unstructured":"Martin, J., Mahlke, K. & Pfanner, N. Role of an energized inner membrane in mitochondrial protein import. \u0394\u03a8 drives the movement of presequences. J. Biol. Chem. 266, 18051\u201318057 (1991)","journal-title":"J. Biol. Chem."},{"key":"BFnature21695_CR15","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1432-1033.1977.tb11861.x","volume":"80","author":"R Serrano","year":"1977","unstructured":"Serrano, R. Energy requirements for maltose transport in yeast. Eur. J. Biochem. 80, 97\u2013102 (1977)","journal-title":"Eur. J. Biochem."},{"key":"BFnature21695_CR16","doi-asserted-by":"publisher","first-page":"17563","DOI":"10.1074\/jbc.M700454200","volume":"282","author":"HC Stevens","year":"2007","unstructured":"Stevens, H. C. & Nichols, J. W. The proton electrochemical gradient across the plasma membrane of yeast is necessary for phospholipid flip. J. Biol. Chem. 282, 17563\u201317567 (2007)","journal-title":"J. Biol. Chem."},{"key":"BFnature21695_CR17","doi-asserted-by":"publisher","first-page":"4641","DOI":"10.1128\/MCB.00876-13","volume":"33","author":"G Pareek","year":"2013","unstructured":"Pareek, G., Krishnamoorthy, V. & D\u2019Silva, P. Molecular insights revealing interaction of Tim23 and channel subunits of presequence translocase. Mol. Cell. Biol. 33, 4641\u20134659 (2013)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature21695_CR18","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nbt1044","volume":"23","author":"S Cabantous","year":"2005","unstructured":"Cabantous, S., Terwilliger, T. C. & Waldo, G. S. Protein tagging and detection with engineered self-assembling fragments of green fluorescent protein. Nat. Biotechnol. 23, 102\u2013107 (2005)","journal-title":"Nat. Biotechnol."},{"key":"BFnature21695_CR19","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1016\/j.cub.2004.11.004","volume":"14","author":"KL Fehrenbacher","year":"2004","unstructured":"Fehrenbacher, K. L., Yang, H. C., Gay, A. C., Huckaba, T. M. & Pon, L. A. Live cell imaging of mitochondrial movement along actin cables in budding yeast. Curr. Biol. 14, 1996\u20132004 (2004)","journal-title":"Curr. Biol."},{"key":"BFnature21695_CR20","doi-asserted-by":"publisher","first-page":"R46","DOI":"10.1093\/hmg\/ddq137","volume":"19","author":"C Lagier-Tourenne","year":"2010","unstructured":"Lagier-Tourenne, C., Polymenidou, M. & Cleveland, D. W. TDP-43 and FUS\/TLS: emerging roles in RNA processing and neurodegeneration. Hum. Mol. Genet. 19 (R1), R46\u2013R64 (2010)","journal-title":"Hum. Mol. Genet."},{"key":"BFnature21695_CR21","doi-asserted-by":"publisher","first-page":"4378","DOI":"10.1128\/MCB.16.8.4378","volume":"16","author":"J Becker","year":"1996","unstructured":"Becker, J., Walter, W., Yan, W. & Craig, E. A. Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo . Mol. Cell. Biol. 16, 4378\u20134386 (1996)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature21695_CR22","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.febslet.2013.02.011","volume":"587","author":"E Kummer","year":"2013","unstructured":"Kummer, E., Oguchi, Y., Seyffer, F., Bukau, B. & Mogk, A. Mechanism of Hsp104\/ClpB inhibition by prion curing guanidinium hydrochloride. FEBS Lett. 587, 810\u2013817 (2013)","journal-title":"FEBS Lett."},{"key":"BFnature21695_CR23","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0091-679X(01)65012-X","volume":"65","author":"MT Ryan","year":"2001","unstructured":"Ryan, M. T., Voos, W. & Pfanner, N. Assaying protein import into mitochondria. Methods Cell Biol. 65, 189\u2013215 (2001)","journal-title":"Methods Cell Biol."},{"key":"BFnature21695_CR24","doi-asserted-by":"publisher","first-page":"9089","DOI":"10.1074\/jbc.M710012200","volume":"283","author":"L Devi","year":"2008","unstructured":"Devi, L., Raghavendran, V., Prabhu, B. M., Avadhani, N. G. & Anandatheerthavarada, H. K. Mitochondrial import and accumulation of \u03b1-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J. Biol. Chem. 283, 9089\u20139100 (2008)","journal-title":"J. Biol. Chem."},{"key":"BFnature21695_CR25","doi-asserted-by":"publisher","first-page":"a007559","DOI":"10.1101\/cshperspect.a007559","volume":"3","author":"MJ Baker","year":"2011","unstructured":"Baker, M. J., Tatsuta, T. & Langer, T. Quality control of mitochondrial proteostasis. Cold Spring Harb. Perspect. Biol. 3, a007559 (2011)","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"BFnature21695_CR26","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1126\/science.274.5284.103","volume":"274","author":"M Rep","year":"1996","unstructured":"Rep, M. et al. Promotion of mitochondrial membrane complex assembly by a proteolytically inactive yeast Lon. Science 274, 103\u2013106 (1996)","journal-title":"Science"},{"key":"BFnature21695_CR27","doi-asserted-by":"publisher","first-page":"27280","DOI":"10.1074\/jbc.271.44.27280","volume":"271","author":"DH Lee","year":"1996","unstructured":"Lee, D. H. & Goldberg, A. L. Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae . J. Biol. Chem. 271, 27280\u201327284 (1996)","journal-title":"J. Biol. Chem."},{"key":"BFnature21695_CR28","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1002\/yea.1805","volume":"27","author":"GA Collins","year":"2010","unstructured":"Collins, G. A., Gomez, T. A., Deshaies, R. J. & Tansey, W. P. Combined chemical and genetic approach to inhibit proteolysis by the proteasome. Yeast 27, 965\u2013974 (2010)","journal-title":"Yeast"},{"key":"BFnature21695_CR29","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nrn2417","volume":"9","author":"AB Knott","year":"2008","unstructured":"Knott, A. B., Perkins, G., Schwarzenbacher, R. & Bossy-Wetzel, E. Mitochondrial fragmentation in neurodegeneration. Nat. Rev. Neurosci. 9, 505\u2013518 (2008)","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnature21695_CR30","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/nrm2993","volume":"11","author":"J Tyedmers","year":"2010","unstructured":"Tyedmers, J., Mogk, A. & Bukau, B. Cellular strategies for controlling protein aggregation. Nat. Rev. Mol. Cell Biol. 11, 777\u2013788 (2010)","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFnature21695_CR31","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1002\/(SICI)1097-0061(199807)14:10<953::AID-YEA293>3.0.CO;2-U","volume":"14","author":"MS Longtine","year":"1998","unstructured":"Longtine, M. S. et al. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae . Yeast 14, 953\u2013961 (1998)","journal-title":"Yeast"},{"key":"BFnature21695_CR32","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0378-1119(95)00037-7","volume":"156","author":"D Mumberg","year":"1995","unstructured":"Mumberg, D., M\u00fcller, R. & Funk, M. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 156, 119\u2013122 (1995)","journal-title":"Gene"},{"key":"BFnature21695_CR33","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/nature02026","volume":"425","author":"WK Huh","year":"2003","unstructured":"Huh, W. K. et al. Global analysis of protein localization in budding yeast. Nature 425, 686\u2013691 (2003)","journal-title":"Nature"},{"key":"BFnature21695_CR34","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.ymeth.2003.11.017","volume":"33","author":"PT Tran","year":"2004","unstructured":"Tran, P. T., Paoletti, A. & Chang, F. Imaging green fluorescent protein fusions in living fission yeast cells. Methods 33, 220\u2013225 (2004)","journal-title":"Methods"},{"key":"BFnature21695_CR35","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.cell.2011.11.002","volume":"147","author":"C Zhou","year":"2011","unstructured":"Zhou, C. et al. Motility and segregation of Hsp104-associated protein aggregates in budding yeast. Cell 147, 1186\u20131196 (2011)","journal-title":"Cell"},{"key":"BFnature21695_CR36","doi-asserted-by":"publisher","first-page":"15651","DOI":"10.1073\/pnas.0904764106","volume":"106","author":"H Imamura","year":"2009","unstructured":"Imamura, H. et al. Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators. Proc. Natl Acad. Sci. USA 106, 15651\u201315656 (2009)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature21695_CR37","first-page":"159","volume":"328","author":"L Florens","year":"2006","unstructured":"Florens, L. & Washburn, M. P. Proteomic analysis by multidimensional protein identification technology. Methods Mol. Biol. 328, 159\u2013175 (2006)","journal-title":"Methods Mol. Biol."},{"key":"BFnature21695_CR38","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/85686","volume":"19","author":"MP Washburn","year":"2001","unstructured":"Washburn, M. P., Wolters, D. & Yates, J. R., III . Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat. Biotechnol. 19, 242\u2013247 (2001)","journal-title":"Nat. Biotechnol."},{"key":"BFnature21695_CR39","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/1044-0305(94)80016-2","volume":"5","author":"JK Eng","year":"1994","unstructured":"Eng, J. K., McCormack, A. L. & Yates, J. R. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J. Am. Soc. Mass Spectrom. 5, 976\u2013989 (1994)","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"BFnature21695_CR40","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1021\/pr015504q","volume":"1","author":"DL Tabb","year":"2002","unstructured":"Tabb, D. L., McDonald, W. H. & Yates, J. R., III . DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics. J. Proteome Res. 1, 21\u201326 (2002)","journal-title":"J. Proteome Res."},{"key":"BFnature21695_CR41","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1021\/ac9023999","volume":"82","author":"Y Zhang","year":"2010","unstructured":"Zhang, Y., Wen, Z., Washburn, M. P. & Florens, L. Refinements to label free proteome quantitation: how to deal with peptides shared by multiple proteins. Anal. Chem. 82, 2272\u20132281 (2010)","journal-title":"Anal. Chem."},{"key":"BFnature21695_CR42","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1021\/pr050477f","volume":"5","author":"J Reinders","year":"2006","unstructured":"Reinders, J., Zahedi, R. P., Pfanner, N., Meisinger, C. & Sickmann, A. Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5, 1543\u20131554 (2006)","journal-title":"J. Proteome Res."},{"key":"BFnature21695_CR43","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nmeth.3179","volume":"12","author":"SS Lam","year":"2015","unstructured":"Lam, S. S. et al. Directed evolution of APEX2 for electron microscopy and proximity labeling. Nat. Methods 12, 51\u201354 (2015)","journal-title":"Nat. Methods"},{"key":"BFnature21695_CR44","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0091-679X(06)80002-6","volume":"80","author":"IR Boldogh","year":"2007","unstructured":"Boldogh, I. R. & Pon, L. A. Purification and subfractionation of mitochondria from the yeast Saccharomyces cerevisiae . Methods Cell Biol. 80, 45\u201364 (2007)","journal-title":"Methods Cell Biol."},{"key":"BFnature21695_CR45","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/S0091-679X(06)80036-1","volume":"80","author":"D Stojanovski","year":"2007","unstructured":"Stojanovski, D., Pfanner, N. & Wiedemann, N. Import of proteins into mitochondria. Methods Cell Biol. 80, 783\u2013806 (2007)","journal-title":"Methods Cell Biol."},{"key":"BFnature21695_CR46","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.cell.2012.09.038","volume":"151","author":"ME DeSantis","year":"2012","unstructured":"DeSantis, M. E. et al. Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients. Cell 151, 778\u2013793 (2012)","journal-title":"Cell"},{"key":"BFnature21695_CR47","doi-asserted-by":"publisher","first-page":"25547","DOI":"10.1074\/jbc.M111.231365","volume":"286","author":"JA Fern\u00e1ndez-Higuero","year":"2011","unstructured":"Fern\u00e1ndez-Higuero, J. A. et al. Allosteric communication between the nucleotide binding domains of caseinolytic peptidase B. J. Biol. Chem. 286, 25547\u201325555 (2011)","journal-title":"J. Biol. Chem."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature21695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature21695","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature21695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:00:31Z","timestamp":1684418431000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature21695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":47,"journal-issue":{"issue":"7645","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["BFnature21695"],"URL":"https:\/\/doi.org\/10.1038\/nature21695","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727347900.793529728","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.727347900.793530068","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.727347900.793530814","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"19 June 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}