{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:22:00Z","timestamp":1777368120710,"version":"3.51.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"7662","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1038\/nature22969","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T16:05:10Z","timestamp":1498665910000},"page":"173-178","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":567,"title":["Fine-mapping inflammatory bowel disease loci to single-variant resolution"],"prefix":"10.1038","volume":"547","author":[{"name":"International Inflammatory Bowel Disease Genetics Consortium","sequence":"first","affiliation":[]},{"given":"Hailiang","family":"Huang","sequence":"first","affiliation":[]},{"given":"Ming","family":"Fang","sequence":"additional","affiliation":[]},{"given":"Luke","family":"Jostins","sequence":"additional","affiliation":[]},{"given":"Ma\u0161a","family":"Umi\u0107evi\u0107 Mirkov","sequence":"additional","affiliation":[]},{"given":"Gabrielle","family":"Boucher","sequence":"additional","affiliation":[]},{"given":"Carl A.","family":"Anderson","sequence":"additional","affiliation":[]},{"given":"Vibeke","family":"Andersen","sequence":"additional","affiliation":[]},{"given":"Isabelle","family":"Cleynen","sequence":"additional","affiliation":[]},{"given":"Adrian","family":"Cortes","sequence":"additional","affiliation":[]},{"given":"Fran\u00e7ois","family":"Crins","sequence":"additional","affiliation":[]},{"given":"Mauro","family":"D\u2019Amato","sequence":"additional","affiliation":[]},{"given":"Val\u00e9rie","family":"Deffontaine","sequence":"additional","affiliation":[]},{"given":"Julia","family":"Dmitrieva","sequence":"additional","affiliation":[]},{"given":"Elisa","family":"Docampo","sequence":"additional","affiliation":[]},{"given":"Mahmoud","family":"Elansary","sequence":"additional","affiliation":[]},{"given":"Kyle Kai-How","family":"Farh","sequence":"additional","affiliation":[]},{"given":"Andre","family":"Franke","sequence":"additional","affiliation":[]},{"given":"Ann-Stephan","family":"Gori","sequence":"additional","affiliation":[]},{"given":"Philippe","family":"Goyette","sequence":"additional","affiliation":[]},{"given":"Jonas","family":"Halfvarson","sequence":"additional","affiliation":[]},{"given":"Talin","family":"Haritunians","sequence":"additional","affiliation":[]},{"given":"Jo","family":"Knight","sequence":"additional","affiliation":[]},{"given":"Ian C.","family":"Lawrance","sequence":"additional","affiliation":[]},{"given":"Charlie W.","family":"Lees","sequence":"additional","affiliation":[]},{"given":"Edouard","family":"Louis","sequence":"additional","affiliation":[]},{"given":"Rob","family":"Mariman","sequence":"additional","affiliation":[]},{"given":"Theo","family":"Meuwissen","sequence":"additional","affiliation":[]},{"given":"Myriam","family":"Mni","sequence":"additional","affiliation":[]},{"given":"Yukihide","family":"Momozawa","sequence":"additional","affiliation":[]},{"given":"Miles","family":"Parkes","sequence":"additional","affiliation":[]},{"given":"Sarah L.","family":"Spain","sequence":"additional","affiliation":[]},{"given":"Emilie","family":"Th\u00e9\u00e2tre","sequence":"additional","affiliation":[]},{"given":"Gosia","family":"Trynka","sequence":"additional","affiliation":[]},{"given":"Jack","family":"Satsangi","sequence":"additional","affiliation":[]},{"given":"Suzanne","family":"van Sommeren","sequence":"additional","affiliation":[]},{"given":"Severine","family":"Vermeire","sequence":"additional","affiliation":[]},{"given":"Ramnik J.","family":"Xavier","sequence":"additional","affiliation":[]},{"given":"Rinse K.","family":"Weersma","sequence":"additional","affiliation":[]},{"given":"Richard H.","family":"Duerr","sequence":"additional","affiliation":[]},{"given":"Christopher G.","family":"Mathew","sequence":"additional","affiliation":[]},{"given":"John D.","family":"Rioux","sequence":"additional","affiliation":[]},{"given":"Dermot P. B.","family":"McGovern","sequence":"additional","affiliation":[]},{"given":"Judy H.","family":"Cho","sequence":"additional","affiliation":[]},{"given":"Michel","family":"Georges","sequence":"additional","affiliation":[]},{"given":"Mark J.","family":"Daly","sequence":"additional","affiliation":[]},{"given":"Jeffrey C.","family":"Barrett","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"key":"BFnature22969_CR1","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1053\/j.gastro.2008.09.012","volume":"135","author":"MD Kappelman","year":"2008","unstructured":"Kappelman, M. D. et al. Direct health care costs of Crohn\u2019s disease and ulcerative colitis in US children and adults. Gastroenterology 135, 1907\u20131913 (2008)","journal-title":"Gastroenterology"},{"key":"BFnature22969_CR2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","volume":"142","author":"NA Molodecky","year":"2012","unstructured":"Molodecky, N. A. et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 142, 46\u201354.e42 (2012)","journal-title":"Gastroenterology"},{"key":"BFnature22969_CR3","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/nature11582","volume":"491","author":"L Jostins","year":"2012","unstructured":"Jostins, L. et al. Host\u2013microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491, 119\u2013124 (2012)","journal-title":"Nature"},{"key":"BFnature22969_CR4","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/ng.3359","volume":"47","author":"JZ Liu","year":"2015","unstructured":"Liu, J. Z. et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat. Genet. 47, 979\u2013986 (2015)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR5","doi-asserted-by":"publisher","first-page":"e1005535","DOI":"10.1371\/journal.pgen.1005535","volume":"11","author":"M van de Bunt","year":"2015","unstructured":"van de Bunt, M., Cortes, A., Brown, M. A., Morris, A. P. & McCarthy, M. I. Evaluating the performance of fine-mapping strategies at common variant GWAS loci. PLoS Genet. 11, e1005535 (2015)","journal-title":"PLoS Genet."},{"key":"BFnature22969_CR6","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1038\/ng.2435","volume":"44","author":"JB Maller","year":"2012","unstructured":"Maller, J. B. et al. Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat. Genet. 44, 1294\u20131301 (2012)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR7","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nature11401","volume":"490","author":"J Yang","year":"2012","unstructured":"Yang, J. et al. FTO genotype is associated with phenotypic variability of body mass index. Nature 490, 267\u2013272 (2012)","journal-title":"Nature"},{"key":"BFnature22969_CR8","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1038\/ng.2770","volume":"45","author":"AH Beecham","year":"2013","unstructured":"Beecham, A. H. et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat. Genet. 45, 1353\u20131360 (2013)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR9","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/ng.3245","volume":"47","author":"S Onengut-Gumuscu","year":"2015","unstructured":"Onengut-Gumuscu, S. et al. Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat. Genet. 47, 381\u2013386 (2015)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR10","doi-asserted-by":"crossref","unstructured":"The 1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes. Nature 491, 56\u201365 (2012)","DOI":"10.1038\/nature11632"},{"key":"BFnature22969_CR11","doi-asserted-by":"crossref","unstructured":"The 1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature 467, 1061\u20131073 (2010)","DOI":"10.1038\/nature09534"},{"key":"BFnature22969_CR12","unstructured":"Jostins, L. Using Next-Generation Genomic Datasets in Disease Association. PhD thesis, Univ. Cambridge (2012)"},{"key":"BFnature22969_CR13","doi-asserted-by":"publisher","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","volume":"5","author":"BN Howie","year":"2009","unstructured":"Howie, B. N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009)","journal-title":"PLoS Genet."},{"key":"BFnature22969_CR14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1534\/g3.111.001198","volume":"1","author":"B Howie","year":"2011","unstructured":"Howie, B., Marchini, J. & Stephens, M. Genotype imputation with thousands of genomes. G3 1, 457\u2013470 (2011)","journal-title":"G3"},{"key":"BFnature22969_CR15","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/ng.3176","volume":"47","author":"P Goyette","year":"2015","unstructured":"Goyette, P. et al. High-density mapping of the MHC identifies a shared role for HLA-DRB101:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat. Genet. 47, 172\u2013179 (2015)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR16","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1038\/ng.952","volume":"43","author":"MA Rivas","year":"2011","unstructured":"Rivas, M. A. et al. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat. Genet. 43, 1066\u20131073 (2011)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR17","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/ng.823","volume":"43","author":"J Yang","year":"2011","unstructured":"Yang, J. et al. Genome partitioning of genetic variation for complex traits using common SNPs. Nat. Genet. 43, 519\u2013525 (2011)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR18","doi-asserted-by":"publisher","first-page":"e1002177","DOI":"10.1371\/journal.pgen.1002177","volume":"7","author":"H Huang","year":"2011","unstructured":"Huang, H., Chanda, P., Alonso, A., Bader, J. S. & Arking, D. E. Gene-based tests of association. PLoS Genet. 7, e1002177 (2011)","journal-title":"PLoS Genet."},{"key":"BFnature22969_CR19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/ng.733","volume":"43","author":"Y Momozawa","year":"2011","unstructured":"Momozawa, Y. et al. Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nat. Genet. 43, 43\u201347 (2011)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR20","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.1093\/nar\/gkt1249","volume":"42","author":"P Kheradpour","year":"2014","unstructured":"Kheradpour, P. & Kellis, M. Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments. Nucleic Acids Res. 42, 2976\u20132987 (2014)","journal-title":"Nucleic Acids Res."},{"key":"BFnature22969_CR21","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/ni.2641","volume":"14","author":"R Nechanitzky","year":"2013","unstructured":"Nechanitzky, R. et al. Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells. Nat. Immunol. 14, 867\u2013875 (2013)","journal-title":"Nat. Immunol."},{"key":"BFnature22969_CR22","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/ng.2504","volume":"45","author":"G Trynka","year":"2013","unstructured":"Trynka, G. et al. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat. Genet. 45, 124\u2013130 (2013)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR23","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature13835","volume":"518","author":"KK-H Farh","year":"2015","unstructured":"Farh, K. K.-H. et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 518, 337\u2013343 (2015)","journal-title":"Nature"},{"key":"BFnature22969_CR24","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1038\/nbt1010-1045","volume":"28","author":"BE Bernstein","year":"2010","unstructured":"Bernstein, B. E. et al. The NIH Roadmap Epigenomics Mapping Consortium. Nat. Biotechnol. 28, 1045\u20131048 (2010)","journal-title":"Nat. Biotechnol."},{"key":"BFnature22969_CR25","doi-asserted-by":"publisher","first-page":"e1000895","DOI":"10.1371\/journal.pgen.1000895","volume":"6","author":"AC Nica","year":"2010","unstructured":"Nica, A. C. et al. Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations. PLoS Genet. 6, e1000895 (2010)","journal-title":"PLoS Genet."},{"key":"BFnature22969_CR26","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nature12531","volume":"501","author":"T Lappalainen","year":"2013","unstructured":"Lappalainen, T. et al. Transcriptome and genome sequencing uncovers functional variation in humans. Nature 501, 506\u2013511 (2013)","journal-title":"Nature"},{"key":"BFnature22969_CR27","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1093\/hmg\/dds098","volume":"21","author":"C Wallace","year":"2012","unstructured":"Wallace, C. et al. Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes. Hum. Mol. Genet. 21, 2815\u20132824 (2012)","journal-title":"Hum. Mol. Genet."},{"key":"BFnature22969_CR28","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/ng.543","volume":"42","author":"PCA Dubois","year":"2010","unstructured":"Dubois, P. C. A. et al. Multiple common variants for celiac disease influencing immune gene expression. Nat. Genet. 42, 295\u2013302 (2010)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR29","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/ng.2951","volume":"46","author":"FA Wright","year":"2014","unstructured":"Wright, F. A. et al. Heritability and genomics of gene expression in peripheral blood. Nat. Genet. 46, 430\u2013437 (2014)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR30","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1038\/ng.2756","volume":"45","author":"H-J Westra","year":"2013","unstructured":"Westra, H.-J. et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat. Genet. 45, 1238\u20131243 (2013)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR31","doi-asserted-by":"publisher","first-page":"1246949","DOI":"10.1126\/science.1246949","volume":"343","author":"BP Fairfax","year":"2014","unstructured":"Fairfax, B. P. et al. Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science 343, 1246949 (2014)","journal-title":"Science"},{"key":"BFnature22969_CR32","doi-asserted-by":"crossref","unstructured":"Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421\u2013427 (2014)","DOI":"10.1038\/nature13595"},{"key":"BFnature22969_CR33","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/ng.717","volume":"42","author":"A Franke","year":"2010","unstructured":"Franke, A. et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn\u2019s disease susceptibility loci. Nat. Genet. 42, 1118\u20131125 (2010)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR34","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1126\/science.1167728","volume":"324","author":"S Nejentsev","year":"2009","unstructured":"Nejentsev, S., Walker, N., Riches, D., Egholm, M. & Todd, J. A. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 324, 387\u2013389 (2009)","journal-title":"Science"},{"key":"BFnature22969_CR35","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/ejhg.2012.3","volume":"20","author":"J Huang","year":"2012","unstructured":"Huang, J., Ellinghaus, D., Franke, A., Howie, B. & Li, Y. 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 data. Eur. J. Hum. Genet. 20, 801\u2013805 (2012)","journal-title":"Eur. J. Hum. Genet."},{"key":"BFnature22969_CR36","doi-asserted-by":"publisher","first-page":"R111","DOI":"10.1093\/hmg\/ddv260","volume":"24","author":"SL Spain","year":"2015","unstructured":"Spain, S. L. & Barrett, J. C. Strategies for fine-mapping complex traits. Hum. Mol. Genet. 24 (R1), R111\u2013R119 (2015)","journal-title":"Hum. Mol. Genet."},{"key":"BFnature22969_CR37","doi-asserted-by":"crossref","unstructured":"The 1000 Genomes Project Consortium. A global reference for human genetic variation. Nature 526, 68\u201374 (2015)","DOI":"10.1038\/nature15393"},{"key":"BFnature22969_CR38","doi-asserted-by":"crossref","unstructured":"The UK10K Consortium. The UK10K project identifies rare variants in health and disease. Nature 526, 82\u201390 (2015)","DOI":"10.1038\/nature14962"},{"key":"BFnature22969_CR39","unstructured":"Roadmap Epigenomics Consortium et al. Integrative analysis of 111 reference human epigenomes. Nature 518, 317\u2013330 (2015)"},{"key":"BFnature22969_CR40","unstructured":"Shah, T. S. et al. optiCall: a robust genotype-calling algorithm for rare, low-frequency and common variants. 28, 1598\u20131603 (2012)"},{"key":"BFnature22969_CR41","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ajhg.2008.06.005","volume":"83","author":"AL Price","year":"2008","unstructured":"Price, A. L. et al. Long-range LD can confound genome scans in admixed populations. Am. J. Hum. Genet. 83, 132\u2013135 (2008)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature22969_CR42","doi-asserted-by":"crossref","unstructured":"Anderson, E . et al. LAPACK Users\u2019 Guide (Society for Industrial and Applied Mathematics, 1999)","DOI":"10.1137\/1.9780898719604"},{"key":"BFnature22969_CR43","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/ejhg.2011.39","volume":"19","author":"J Yang","year":"2011","unstructured":"Yang, J. et al. Genomic inflation factors under polygenic inheritance. Eur. J. Hum. Genet. 19, 807\u2013812 (2011)","journal-title":"Eur. J. Hum. Genet."},{"key":"BFnature22969_CR44","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ng.3211","volume":"47","author":"BK Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan, B. K. et al. LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291\u2013295 (2015)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR45","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/ng.3760","volume":"49","author":"KM de Lange","year":"2017","unstructured":"de Lange, K. M. et al. Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. Nat. Genet. 49, 256\u2013261 (2017)","journal-title":"Nat. Genet."},{"key":"BFnature22969_CR46","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nmeth.1785","volume":"9","author":"O Delaneau","year":"2011","unstructured":"Delaneau, O., Marchini, J. & Zagury, J.-F. A linear complexity phasing method for thousands of genomes. Nat. Methods 9, 179\u2013181 (2011)","journal-title":"Nat. Methods"},{"key":"BFnature22969_CR47","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nmeth.2307","volume":"10","author":"O Delaneau","year":"2013","unstructured":"Delaneau, O., Zagury, J.-F. & Marchini, J. Improved whole-chromosome phasing for disease and population genetic studies. Nat. Methods 10, 5\u20136 (2013)","journal-title":"Nat. Methods"},{"key":"BFnature22969_CR48","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1093\/bioinformatics\/btq280","volume":"26","author":"JA Morris","year":"2010","unstructured":"Morris, J. A., Randall, J. C., Maller, J. B. & Barrett, J. C. Evoker: a visualization tool for genotype intensity data. Bioinformatics 26, 1786\u20131787 (2010)","journal-title":"Bioinformatics"},{"key":"BFnature22969_CR49","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1093\/bioinformatics\/btw075","volume":"32","author":"L Jostins","year":"2016","unstructured":"Jostins, L. & McVean, G. Trinculo: Bayesian and frequentist multinomial logistic regression for genome-wide association studies of multi-category phenotypes. Bioinformatics 32, 1898\u20131900 (2016)","journal-title":"Bioinformatics"},{"key":"BFnature22969_CR50","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","volume":"88","author":"J Yang","year":"2011","unstructured":"Yang, J., Lee, S. H., Goddard, M. E. & Visscher, P. M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76\u201382 (2011)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature22969_CR51","first-page":"137","volume-title":"DMU-a package for analyzing multivariate mixed models","author":"P Madsen","year":"2010","unstructured":"Madsen, P ., Su, G ., Labouriau, R . & Christensen, F. DMU-a package for analyzing multivariate mixed models. In Proc. 9th World Congress on Genetics Applied to Livestock Production 137 (Gesellschaft f\u00fcr Tierzuchtwissenschaften 2010), p. 137"},{"key":"BFnature22969_CR52","doi-asserted-by":"crossref","unstructured":"Cox, D. R . & Snell, E. J. Analysis of Binary Data 2nd edn, Ch. 2 (CRC, 1989)","DOI":"10.2307\/2531476"},{"key":"BFnature22969_CR53","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nbt0406-423","volume":"24","author":"P D\u2019haeseleer","year":"2006","unstructured":"D\u2019haeseleer, P. What are DNA sequence motifs? Nat. Biotechnol 24, 423\u2013425 (2006)","journal-title":"Nat. Biotechnol"},{"key":"BFnature22969_CR54","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","volume":"26","author":"AR Quinlan","year":"2010","unstructured":"Quinlan, A. R. & Hall, I. M. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics 26, 841\u2013842 (2010)","journal-title":"Bioinformatics"},{"key":"BFnature22969_CR55","doi-asserted-by":"crossref","unstructured":"The International HapMap Consortium. The International HapMap Project. Nature 426, 789\u2013796 (2003)","DOI":"10.1038\/nature02168"},{"key":"BFnature22969_CR56","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1093\/nar\/gkm1075","volume":"36","author":"SM Lin","year":"2008","unstructured":"Lin, S. M., Du, P., Huber, W. & Kibbe, W. A. Model-based variance-stabilizing transformation for Illumina microarray data. Nucleic Acids Res. 36, e11 (2008)","journal-title":"Nucleic Acids Res."},{"key":"BFnature22969_CR57","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","volume":"19","author":"BM Bolstad","year":"2003","unstructured":"Bolstad, B. M., Irizarry, R. A., Astrand, M. & Speed, T. P. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19, 185\u2013193 (2003)","journal-title":"Bioinformatics"},{"key":"BFnature22969_CR58","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1093\/bioinformatics\/btn224","volume":"24","author":"P Du","year":"2008","unstructured":"Du, P., Kibbe, W. A. & Lin, S. M. lumi: a pipeline for processing Illumina microarray. Bioinformatics 24, 1547\u20131548 (2008)","journal-title":"Bioinformatics"},{"key":"BFnature22969_CR59","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/1467-9868.00346","volume":"64","author":"JD Storey","year":"2002","unstructured":"Storey, J. D. A direct approach to false discovery rates. J. Roy. Stat. Soc. B 64, 479\u2013498 (2002)","journal-title":"J. Roy. Stat. Soc. B"},{"key":"BFnature22969_CR60","doi-asserted-by":"publisher","first-page":"e1004383","DOI":"10.1371\/journal.pgen.1004383","volume":"10","author":"C Giambartolomei","year":"2014","unstructured":"Giambartolomei, C. et al. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet. 10, e1004383 (2014)","journal-title":"PLoS Genet."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature22969.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature22969","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nature22969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/nature22969.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:02:55Z","timestamp":1684418575000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature22969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,28]]},"references-count":60,"journal-issue":{"issue":"7662","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["BFnature22969"],"URL":"https:\/\/doi.org\/10.1038\/nature22969","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727756334.793535004","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.727756334.793573427","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/028688","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,28]]},"assertion":[{"value":"17 October 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2017","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The equation at the end Methods section \u2018Establishing a P value threshold\u2019 was corrected.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}