{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T20:51:00Z","timestamp":1776199860959,"version":"3.50.1"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"7666","license":[{"start":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:00:00Z","timestamp":1501632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:00:00Z","timestamp":1501632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2017,8,10]]},"DOI":"10.1038\/nature23320","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T12:21:00Z","timestamp":1501590060000},"page":"244-247","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":249,"title":["Proteins evolve on the edge of supramolecular self-assembly"],"prefix":"10.1038","volume":"548","author":[{"given":"Hector","family":"Garcia-Seisdedos","sequence":"first","affiliation":[]},{"given":"Charly","family":"Empereur-Mot","sequence":"additional","affiliation":[]},{"given":"Nadav","family":"Elad","sequence":"additional","affiliation":[]},{"given":"Emmanuel D.","family":"Levy","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,8,2]]},"reference":[{"key":"BFnature23320_CR1","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1016\/j.jmb.2006.11.020","volume":"365","author":"DB Lukatsky","year":"2007","unstructured":"Lukatsky, D. B., Shakhnovich, B. E., Mintseris, J. & Shakhnovich, E. I. Structural similarity enhances interaction propensity of proteins. J. Mol. Biol. 365, 1596\u20131606 (2007)","journal-title":"J. Mol. Biol."},{"key":"BFnature23320_CR2","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1038\/nature06942","volume":"453","author":"ED Levy","year":"2008","unstructured":"Levy, E. D., Boeri Erba, E., Robinson, C. V. & Teichmann, S. A. Assembly reflects evolution of protein complexes. Nature 453, 1262\u20131265 (2008)","journal-title":"Nature"},{"key":"BFnature23320_CR3","doi-asserted-by":"publisher","first-page":"16148","DOI":"10.1073\/pnas.0807576105","volume":"105","author":"I Andr\u00e9","year":"2008","unstructured":"Andr\u00e9, I., Strauss, C. E., Kaplan, D. B., Bradley, P. & Baker, D. Emergence of symmetry in homooligomeric biological assemblies. Proc. Natl Acad. Sci. USA 105, 16148\u201316152 (2008)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature23320_CR4","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.jmb.2009.10.044","volume":"395","author":"GE Schulz","year":"2010","unstructured":"Schulz, G. E. The dominance of symmetry in the evolution of homo-oligomeric proteins. J. Mol. Biol. 395, 834\u2013843 (2010)","journal-title":"J. Mol. Biol."},{"key":"BFnature23320_CR5","doi-asserted-by":"crossref","unstructured":"Ahnert, S. E ., Marsh, J. A ., Hern\u00e1ndez, H ., Robinson, C. V . & Teichmann, S. A. Principles of assembly reveal a periodic table of protein complexes. Science 350, aaa2245 (2015)","DOI":"10.1126\/science.aaa2245"},{"key":"BFnature23320_CR6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/B978-0-12-386931-9.00002-7","volume":"117","author":"ED Levy","year":"2013","unstructured":"Levy, E. D. & Teichmann, S. Structural, evolutionary, and assembly principles of protein oligomerization. Prog. Mol. Biol. Transl. Sci. 117, 25\u201351 (2013)","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"BFnature23320_CR7","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/0022-2836(79)90434-0","volume":"130","author":"GW Dykes","year":"1979","unstructured":"Dykes, G. W., Crepeau, R. H. & Edelstein, S. J. Three-dimensional reconstruction of the 14-filament fibers of hemoglobin S. J. Mol. Biol. 130, 451\u2013472 (1979)","journal-title":"J. Mol. Biol."},{"key":"BFnature23320_CR8","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1126\/science.1150421","volume":"319","author":"D Grueninger","year":"2008","unstructured":"Grueninger, D. et al. Designed protein-protein association. Science 319, 206\u2013209 (2008)","journal-title":"Science"},{"key":"BFnature23320_CR9","doi-asserted-by":"publisher","first-page":"10468","DOI":"10.1021\/jacs.5b05755","volume":"137","author":"JD Brodin","year":"2015","unstructured":"Brodin, J. D., Smith, S. J., Carr, J. R. & Tezcan, F. A. Designed, helical protein nanotubes with variable diameters from a single building block. J. Am. Chem. Soc. 137, 10468\u201310471 (2015)","journal-title":"J. Am. Chem. Soc."},{"key":"BFnature23320_CR10","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1073\/pnas.041614998","volume":"98","author":"JE Padilla","year":"2001","unstructured":"Padilla, J. E., Colovos, C. & Yeates, T. O. Nanohedra: using symmetry to design self assembling protein cages, layers, crystals, and filaments. Proc. Natl Acad. Sci. USA 98, 2217\u20132221 (2001)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature23320_CR11","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1126\/science.1219351","volume":"336","author":"YT Lai","year":"2012","unstructured":"Lai, Y. T., Cascio, D. & Yeates, T. O. Structure of a 16-nm cage designed by using protein oligomers. Science 336, 1129 (2012)","journal-title":"Science"},{"key":"BFnature23320_CR12","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1126\/science.1219364","volume":"336","author":"NP King","year":"2012","unstructured":"King, N. P. et al. Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science 336, 1171\u20131174 (2012)","journal-title":"Science"},{"key":"BFnature23320_CR13","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1126\/science.1233936","volume":"340","author":"JM Fletcher","year":"2013","unstructured":"Fletcher, J. M. et al. Self-assembling cages from coiled-coil peptide modules. Science 340, 595\u2013599 (2013)","journal-title":"Science"},{"key":"BFnature23320_CR14","doi-asserted-by":"publisher","first-page":"7304","DOI":"10.1073\/pnas.1112595109","volume":"109","author":"CJ Lanci","year":"2012","unstructured":"Lanci, C. J. et al. Computational design of a protein crystal. Proc. Natl Acad. Sci. USA 109, 7304\u20137309 (2012)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature23320_CR15","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nature17633","volume":"533","author":"Y Suzuki","year":"2016","unstructured":"Suzuki, Y. et al. Self-assembly of coherently dynamic, auxetic, two-dimensional protein crystals. Nature 533, 369\u2013373 (2016)","journal-title":"Nature"},{"key":"BFnature23320_CR16","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.jmb.2010.09.028","volume":"403","author":"ED Levy","year":"2010","unstructured":"Levy, E. D. A simple definition of structural regions in proteins and its use in analyzing interface evolution. J. Mol. Biol. 403, 660\u2013670 (2010)","journal-title":"J. Mol. Biol."},{"key":"BFnature23320_CR17","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.cell.2012.02.022","volume":"148","author":"D Eisenberg","year":"2012","unstructured":"Eisenberg, D. & Jucker, M. The amyloid state of proteins in human diseases. Cell 148, 1188\u20131203 (2012)","journal-title":"Cell"},{"key":"BFnature23320_CR18","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nrm3810","volume":"15","author":"TP Knowles","year":"2014","unstructured":"Knowles, T. P., Vendruscolo, M. & Dobson, C. M. The amyloid state and its association with protein misfolding diseases. Nat. Rev. Mol. Cell Biol. 15, 384\u2013396 (2014)","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFnature23320_CR19","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1126\/science.2392678","volume":"249","author":"MH Hecht","year":"1990","unstructured":"Hecht, M. H., Richardson, J. S., Richardson, D. C. & Ogden, R. C. De novo design, expression, and characterization of Felix: a four-helix bundle protein of native-like sequence. Science 249, 884\u2013891 (1990)","journal-title":"Science"},{"key":"BFnature23320_CR20","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1146\/annurev.biochem.68.1.779","volume":"68","author":"WF DeGrado","year":"1999","unstructured":"DeGrado, W. F., Summa, C. M., Pavone, V., Nastri, F. & Lombardi, A. De novo design and structural characterization of proteins and metalloproteins. Annu. Rev. Biochem. 68, 779\u2013819 (1999)","journal-title":"Annu. Rev. Biochem."},{"key":"BFnature23320_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1088\/1478-3967\/1\/1\/P02","volume":"1","author":"JP Doye","year":"2004","unstructured":"Doye, J. P., Louis, A. A. & Vendruscolo, M. Inhibition of protein crystallization by evolutionary negative design. Phys. Biol. 1, 9\u201313 (2004)","journal-title":"Phys. Biol."},{"key":"BFnature23320_CR22","doi-asserted-by":"publisher","first-page":"20461","DOI":"10.1073\/pnas.1209312109","volume":"109","author":"ED Levy","year":"2012","unstructured":"Levy, E. D., De, S. & Teichmann, S. A. Cellular crowding imposes global constraints on the chemistry and evolution of proteomes. Proc. Natl Acad. Sci. USA 109, 20461\u201320466 (2012)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature23320_CR23","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/256705a0","volume":"256","author":"C Chothia","year":"1975","unstructured":"Chothia, C. & Janin, J. Principles of protein\u2013protein recognition. Nature 256, 705\u2013708 (1975)","journal-title":"Nature"},{"key":"BFnature23320_CR24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1073\/pnas.93.1.13","volume":"93","author":"S Jones","year":"1996","unstructured":"Jones, S. & Thornton, J. M. Principles of protein-protein interactions. Proc. Natl Acad. Sci. USA 93, 13\u201320 (1996)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature23320_CR25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0065-3233(02)61001-0","volume":"61","author":"SJ Wodak","year":"2002","unstructured":"Wodak, S. J. & Janin, J. Structural basis of macromolecular recognition. Adv. Protein Chem. 61, 9\u201373 (2002)","journal-title":"Adv. Protein Chem."},{"key":"BFnature23320_CR26","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nature06524","volume":"450","author":"J Kuriyan","year":"2007","unstructured":"Kuriyan, J. & Eisenberg, D. The origin of protein interactions and allostery in colocalization. Nature 450, 983\u2013990 (2007)","journal-title":"Nature"},{"key":"BFnature23320_CR27","doi-asserted-by":"publisher","first-page":"10147","DOI":"10.1073\/pnas.0812771106","volume":"106","author":"R Narayanaswamy","year":"2009","unstructured":"Narayanaswamy, R. et al. Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation. Proc. Natl Acad. Sci. USA 106, 10147\u201310152 (2009)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature23320_CR28","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nature10879","volume":"483","author":"P Li","year":"2012","unstructured":"Li, P. et al. Phase transitions in the assembly of multivalent signalling proteins. Nature 483, 336\u2013340 (2012)","journal-title":"Nature"},{"key":"BFnature23320_CR29","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1083\/jcb.201003001","volume":"190","author":"C Noree","year":"2010","unstructured":"Noree, C., Sato, B. K., Broyer, R. M. & Wilhelm, J. E. Identification of novel filament-forming proteins in Saccharomyces cerevisiae and Drosophila melanogaster. J. Cell Biol. 190, 541\u2013551 (2010)","journal-title":"J. Cell Biol."},{"key":"BFnature23320_CR30","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/j.celrep.2012.09.036","volume":"2","author":"J Gsponer","year":"2012","unstructured":"Gsponer, J. & Babu, M. M. Cellular strategies for regulating functional and nonfunctional protein aggregation. Cell Reports 2, 1425\u20131437 (2012)","journal-title":"Cell Reports"},{"key":"BFnature23320_CR31","doi-asserted-by":"publisher","first-page":"e155","DOI":"10.1371\/journal.pcbi.0020155","volume":"2","author":"ED Levy","year":"2006","unstructured":"Levy, E. D., Pereira-Leal, J. B., Chothia, C. & Teichmann, S. A. 3D complex: a structural classification of protein complexes. PLoS Comput. Biol. 2, e155 (2006)","journal-title":"PLoS Comput. Biol."},{"key":"BFnature23320_CR32","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1016\/j.str.2007.09.019","volume":"15","author":"ED Levy","year":"2007","unstructured":"Levy, E. D. PiQSi: protein quaternary structure investigation. Structure 15, 1364\u20131367 (2007)","journal-title":"Structure"},{"key":"BFnature23320_CR33","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0378-1119(95)00037-7","volume":"156","author":"D Mumberg","year":"1995","unstructured":"Mumberg, D., M\u00fcller, R. & Funk, M. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 156, 119\u2013122 (1995)","journal-title":"Gene"},{"key":"BFnature23320_CR34","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1002\/prot.21786","volume":"71","author":"HE Klock","year":"2008","unstructured":"Klock, H. E., Koesema, E. J., Knuth, M. W. & Lesley, S. A. Combining the polymerase incomplete primer extension method for cloning and mutagenesis with microscreening to accelerate structural genomics efforts. Proteins 71, 982\u2013994 (2008)","journal-title":"Proteins"},{"key":"BFnature23320_CR35","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nbt0102-87","volume":"20","author":"T Nagai","year":"2002","unstructured":"Nagai, T. et al. A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat. Biotechnol. 20, 87\u201390 (2002)","journal-title":"Nat. Biotechnol."},{"key":"BFnature23320_CR36","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1002\/(SICI)1097-0061(199907)15:10B<963::AID-YEA399>3.0.CO;2-W","volume":"15","author":"M Knop","year":"1999","unstructured":"Knop, M. et al. Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines. Yeast 15 (10B), 963\u2013972 (1999)","journal-title":"Yeast"},{"key":"BFnature23320_CR37","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/978-1-61779-276-2_8","volume":"781","author":"Y Cohen","year":"2011","unstructured":"Cohen, Y. & Schuldiner, M. Advanced methods for high-throughput microscopy screening of genetically modified yeast libraries. Methods Mol. Biol. 781, 127\u2013159 (2011)","journal-title":"Methods Mol. Biol."},{"key":"BFnature23320_CR38","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"CA Schneider","year":"2012","unstructured":"Schneider, C. A., Rasband, W. S. & Eliceiri, K. W. NIH Image to ImageJ: 25 years of image analysis. Nat. Methods 9, 671\u2013675 (2012)","journal-title":"Nat. Methods"},{"key":"BFnature23320_CR39","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/S0021-9258(18)93499-X","volume":"243","author":"EA Boeker","year":"1968","unstructured":"Boeker, E. A. & Snell, E. E. Arginine decarboxylase from Escherichia coli. 2. Dissociation and reassociation of subunits. J. Biol. Chem. 243, 1678\u20131684 (1968)","journal-title":"J. Biol. Chem."},{"key":"BFnature23320_CR40","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jsb.2005.07.007","volume":"152","author":"DN Mastronarde","year":"2005","unstructured":"Mastronarde, D. N. Automated electron microscope tomography using robust prediction of specimen movements. J. Struct. Biol. 152, 36\u201351 (2005)","journal-title":"J. Struct. Biol."},{"key":"BFnature23320_CR41","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/nmeth.2472","volume":"10","author":"XM Li","year":"2013","unstructured":"Li, X. M. et al. Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nat. Methods 10, 584\u2013590 (2013)","journal-title":"Nat. Methods"},{"key":"BFnature23320_CR42","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/S1047-8477(03)00069-8","volume":"142","author":"JA Mindell","year":"2003","unstructured":"Mindell, J. A. & Grigorieff, N. Accurate determination of local defocus and specimen tilt in electron microscopy. J. Struct. Biol. 142, 334\u2013347 (2003)","journal-title":"J. Struct. Biol."},{"key":"BFnature23320_CR43","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jsb.2006.05.009","volume":"157","author":"G Tang","year":"2007","unstructured":"Tang, G. et al. EMAN2: an extensible image processing suite for electron microscopy. J. Struct. Biol. 157, 38\u201346 (2007)","journal-title":"J. Struct. Biol."},{"key":"BFnature23320_CR44","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jsb.2012.09.006","volume":"180","author":"SHW Scheres","year":"2012","unstructured":"Scheres, S. H. W. RELION: implementation of a Bayesian approach to cryo-EM structure determination. J. Struct. Biol. 180, 519\u2013530 (2012)","journal-title":"J. Struct. Biol."},{"key":"BFnature23320_CR45","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0022-2836(03)00845-3","volume":"332","author":"D Jozic","year":"2003","unstructured":"Jozic, D., Kaiser, J. T., Huber, R., Bode, W. & Maskos, K. X-ray structure of isoaspartyl dipeptidase from E. coli: a dinuclear zinc peptidase evolved from amidohydrolases. J. Mol. Biol. 332, 243\u2013256 (2003)","journal-title":"J. Mol. Biol."},{"key":"BFnature23320_CR46","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/nmeth.2727","volume":"11","author":"A Kucukelbir","year":"2014","unstructured":"Kucukelbir, A., Sigworth, F. J. & Tagare, H. D. Quantifying the local resolution of cryo-EM density maps. Nat. Methods 11, 63\u2013 (2014)","journal-title":"Nat. Methods"},{"key":"BFnature23320_CR47","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"EF Pettersen","year":"2004","unstructured":"Pettersen, E. F. et al. UCSF Chimera\u2014a visualization system for exploratory research and analysis. J. Comput. Chem. 25, 1605\u20131612 (2004)","journal-title":"J. Comput. Chem."},{"key":"BFnature23320_CR48","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nat. Methods 9, 676\u2013682 (2012)","journal-title":"Nat. Methods"},{"key":"BFnature23320_CR49","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.jmb.2005.07.042","volume":"352","author":"G Hible","year":"2005","unstructured":"Hible, G. et al. Calorimetric and crystallographic analysis of the oligomeric structure of Escherichia coli GMP kinase. J. Mol. Biol. 352, 1044\u20131059 (2005)","journal-title":"J. Mol. Biol."},{"key":"BFnature23320_CR50","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1110\/ps.062307706","volume":"15","author":"A Hindupur","year":"2006","unstructured":"Hindupur, A. et al. The crystal structure of the E. coli stress protein YciF. Protein Sci. 15, 2605\u20132611 (2006)","journal-title":"Protein Sci."},{"key":"BFnature23320_CR51","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1016\/S0969-2126(00)80029-5","volume":"7","author":"II Mathews","year":"1999","unstructured":"Mathews, I. I., Kappock, T. J., Stubbe, J. & Ealick, S. E. Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway. Structure 7, 1395\u20131406 (1999)","journal-title":"Structure"},{"key":"BFnature23320_CR52","doi-asserted-by":"publisher","first-page":"40211","DOI":"10.1074\/jbc.M007406200","volume":"275","author":"MW Lake","year":"2000","unstructured":"Lake, M. W., Temple, C. A., Rajagopalan, K. V. & Schindelin, H. The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis. J. Biol. Chem. 275, 40211\u201340217 (2000)","journal-title":"J. Biol. Chem."},{"key":"BFnature23320_CR53","doi-asserted-by":"publisher","first-page":"19792","DOI":"10.1074\/jbc.M201486200","volume":"277","author":"EK Jaffe","year":"2002","unstructured":"Jaffe, E. K. et al. Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid. J. Biol. Chem. 277, 19792\u201319799 (2002)","journal-title":"J. Biol. Chem."},{"key":"BFnature23320_CR54","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/S0969-2126(98)00132-4","volume":"6","author":"C Colovos","year":"1998","unstructured":"Colovos, C., Cascio, D. & Yeates, T. O. The 1.8 \u00c5 crystal structure of the ycaC gene product from Escherichia coli reveals an octameric hydrolase of unknown specificity. Structure 6, 1329\u20131337 (1998)","journal-title":"Structure"},{"key":"BFnature23320_CR55","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1093\/nar\/gkl009","volume":"34","author":"P Thaw","year":"2006","unstructured":"Thaw, P. et al. Structural insight into gene transcriptional regulation and effector binding by the Lrp\/AsnC family. Nucleic Acids Res. 34, 1439\u20131449 (2006)","journal-title":"Nucleic Acids Res."},{"key":"BFnature23320_CR56","doi-asserted-by":"publisher","first-page":"e32498","DOI":"10.1371\/journal.pone.0032498","volume":"7","author":"M Totir","year":"2012","unstructured":"Totir, M. et al. Macro-to-micro structural proteomics: native source proteins for high-throughput crystallization. PLoS ONE 7, e32498 (2012)","journal-title":"PLoS ONE"},{"key":"BFnature23320_CR57","doi-asserted-by":"publisher","first-page":"13567","DOI":"10.1073\/pnas.240463497","volume":"97","author":"G Auerbach","year":"2000","unstructured":"Auerbach, G. et al. Zinc plays a key role in human and bacterial GTP cyclohydrolase I. Proc. Natl Acad. Sci. USA 97, 13567\u201313572 (2000)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature23320_CR58","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0022-2836(02)00258-9","volume":"319","author":"S Thorell","year":"2002","unstructured":"Thorell, S., Sch\u00fcrmann, M., Sprenger, G. A. & Schneider, G. Crystal structure of decameric fructose-6-phosphate aldolase from Escherichia coli reveals inter-subunit helix swapping as a structural basis for assembly differences in the transaldolase family. J. Mol. Biol. 319, 161\u2013171 (2002)","journal-title":"J. Mol. Biol."},{"key":"BFnature23320_CR59","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/S0969-2126(03)00158-8","volume":"11","author":"F von Delft","year":"2003","unstructured":"von Delft, F. et al. Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites. Structure 11, 985\u2013996 (2003)","journal-title":"Structure"},{"key":"BFnature23320_CR60","doi-asserted-by":"publisher","first-page":"3915","DOI":"10.1021\/bi900075d","volume":"48","author":"J Andr\u00e9ll","year":"2009","unstructured":"Andr\u00e9ll, J. et al. Crystal structure of the acid-induced arginine decarboxylase from Escherichia coli: reversible decamer assembly controls enzyme activity. Biochemistry 48, 3915\u20133927 (2009)","journal-title":"Biochemistry"},{"key":"BFnature23320_CR61","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jmb.2009.06.022","volume":"391","author":"KH Lee","year":"2009","unstructured":"Lee, K. H. et al. Crystal structures and enzyme mechanisms of a dual fucose mutarotase\/ribose pyranase. J. Mol. Biol. 391, 178\u2013191 (2009)","journal-title":"J. Mol. Biol."},{"key":"BFnature23320_CR62","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/emboj.2011.5","volume":"30","author":"U Kanjee","year":"2011","unstructured":"Kanjee, U. et al. Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase. EMBO J. 30, 931\u2013944 (2011)","journal-title":"EMBO J."},{"key":"BFnature23320_CR63","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1074\/mcp.O111.014704","volume":"11","author":"M Wang","year":"2012","unstructured":"Wang, M. et al. PaxDb, a database of protein abundance averages across all three domains of life. Mol. Cell. Proteomics 11, 492\u2013500 (2012)","journal-title":"Mol. Cell. Proteomics"},{"key":"BFnature23320_CR64","doi-asserted-by":"crossref","unstructured":"Petrovska, I. et al. Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation. eLife (2014). Pages?","DOI":"10.7554\/eLife.02409"},{"key":"BFnature23320_CR65","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nmeth.1955","volume":"9","author":"D Landgraf","year":"2012","unstructured":"Landgraf, D., Okumus, B., Chien, P., Baker, T. A. & Paulsson, J. Segregation of molecules at cell division reveals native protein localization. Nat. Methods 9, 480\u2013482 (2012)","journal-title":"Nat. Methods"},{"key":"BFnature23320_CR66","unstructured":"DeLano, W. L. The PyMOL molecular graphics system (2002)"},{"key":"BFnature23320_CR67","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1126\/science.3892686","volume":"229","author":"SK Burley","year":"1985","unstructured":"Burley, S. K. & Petsko, G. A. Aromatic-aromatic interaction: a mechanism of protein structure stabilization. Science 229, 23\u201328 (1985)","journal-title":"Science"},{"key":"BFnature23320_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0014-5793(85)80982-0","volume":"191","author":"J Singh","year":"1985","unstructured":"Singh, J. & Thornton, J. The interaction between phenylalanine rings in proteins. FEBS Lett. 191, 1\u20136 (1985)","journal-title":"FEBS Lett."},{"key":"BFnature23320_CR69","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1126\/science.271.5246.163","volume":"271","author":"DA Dougherty","year":"1996","unstructured":"Dougherty, D. A. Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. Science 271, 163\u2013168 (1996)","journal-title":"Science"},{"key":"BFnature23320_CR70","doi-asserted-by":"publisher","first-page":"4843","DOI":"10.1073\/pnas.79.16.4843","volume":"79","author":"KA Thomas","year":"1982","unstructured":"Thomas, K. A., Smith, G. M., Thomas, T. B. & Feldmann, R. J. Electronic distributions within protein phenylalanine aromatic rings are reflected by the three-dimensional oxygen atom environments. Proc. Natl Acad. Sci. USA 79, 4843\u20134847 (1982)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature23320_CR71","first-page":"1616","volume":"266","author":"P Claverie","year":"1968","unstructured":"Claverie, P., Hofnung, M. & Monod, J. Sur certaines implications de l\u2019hypoth\u00e8se d\u2019\u00e9quivalence stricte entre les protom\u00e8res des prot\u00e9ines oligom\u00e9riques. C.R. Acad. Sci. III 266, 1616\u20131618 (1968)","journal-title":"C.R. Acad. Sci. III"},{"key":"BFnature23320_CR72","doi-asserted-by":"publisher","first-page":"178101","DOI":"10.1103\/PhysRevLett.97.178101","volume":"97","author":"DB Lukatsky","year":"2006","unstructured":"Lukatsky, D. B., Zeldovich, K. B. & Shakhnovich, E. I. Statistically enhanced self-attraction of random patterns. Phys. Rev. Lett. 97, 178101 (2006)","journal-title":"Phys. Rev. Lett."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature23320.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature23320","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nature23320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/nature23320.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:03:57Z","timestamp":1684418637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature23320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,2]]},"references-count":72,"journal-issue":{"issue":"7666","published-print":{"date-parts":[[2017,8,10]]}},"alternative-id":["BFnature23320"],"URL":"https:\/\/doi.org\/10.1038\/nature23320","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727868317.793535232","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.727868317.793537530","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,2]]},"assertion":[{"value":"28 July 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}