{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T05:26:46Z","timestamp":1772256406234,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"7676","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1038\/nature23885","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T12:13:48Z","timestamp":1508242428000},"page":"388-392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":230,"title":["Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex"],"prefix":"10.1038","volume":"550","author":[{"given":"Ryan","family":"Remedios","sequence":"first","affiliation":[]},{"given":"Ann","family":"Kennedy","sequence":"additional","affiliation":[]},{"given":"Moriel","family":"Zelikowsky","sequence":"additional","affiliation":[]},{"given":"Benjamin F.","family":"Grewe","sequence":"additional","affiliation":[]},{"given":"Mark J.","family":"Schnitzer","sequence":"additional","affiliation":[]},{"given":"David J.","family":"Anderson","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"key":"BFnature23885_CR1","unstructured":"Tinbergen, N. The Study of Instinct (Clarendon Press, 1951)"},{"key":"BFnature23885_CR2","unstructured":"Lorenz, K. On Aggression (Harcourt, Brace & World, 1966)"},{"key":"BFnature23885_CR3","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nature13897","volume":"515","author":"CM Root","year":"2014","unstructured":"Root, C. M., Denny, C. A., Hen, R. & Axel, R. The participation of cortical amygdala in innate, odour-driven behaviour. Nature 515, 269\u2013273 (2014)","journal-title":"Nature"},{"key":"BFnature23885_CR4","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/j.1749-6632.1999.tb09271.x","volume":"877","author":"SW Newman","year":"1999","unstructured":"Newman, S. W. The medial extended amygdala in male reproductive behavior. A node in the mammalian social behavior network. Ann. NY Acad. Sci. 877, 242\u2013257 (1999)","journal-title":"Ann. NY Acad. Sci."},{"key":"BFnature23885_CR5","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ejphar.2005.09.041","volume":"526","author":"JG Veening","year":"2005","unstructured":"Veening, J. G. et al. Do similar neural systems subserve aggressive and sexual behaviour in male rats? Insights from c-Fos and pharmacological studies. Eur. J. Pharmacol. 526, 226\u2013239 (2005)","journal-title":"Eur. J. Pharmacol."},{"key":"BFnature23885_CR6","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.cell.2013.04.017","volume":"153","author":"CF Yang","year":"2013","unstructured":"Yang, C. F. et al. Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males. Cell 153, 896\u2013909 (2013)","journal-title":"Cell"},{"key":"BFnature23885_CR7","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nature13169","volume":"509","author":"H Lee","year":"2014","unstructured":"Lee, H. et al. Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus. Nature 509, 627\u2013632 (2014)","journal-title":"Nature"},{"key":"BFnature23885_CR8","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1111\/ejn.12131","volume":"37","author":"K Sano","year":"2013","unstructured":"Sano, K., Tsuda, M. C., Musatov, S., Sakamoto, T. & Ogawa, S. Differential effects of site-specific knockdown of estrogen receptor \u03b1 in the medial amygdala, medial pre-optic area, and ventromedial nucleus of the hypothalamus on sexual and aggressive behavior of male mice. Eur. J. Neurosci. 37, 1308\u20131319 (2013)","journal-title":"Eur. J. Neurosci."},{"key":"BFnature23885_CR9","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nmeth.1694","volume":"8","author":"KK Ghosh","year":"2011","unstructured":"Ghosh, K. K. et al. Miniaturized integration of a fluorescence microscope. Nat. Methods 8, 871\u2013878 (2011)","journal-title":"Nat. Methods"},{"key":"BFnature23885_CR10","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nn.3329","volume":"16","author":"Y Ziv","year":"2013","unstructured":"Ziv, Y. et al. Long-term dynamics of CA1 hippocampal place codes. Nat. Neurosci. 16, 264\u2013266 (2013)","journal-title":"Nat. Neurosci."},{"key":"BFnature23885_CR11","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nature12354","volume":"499","author":"TW Chen","year":"2013","unstructured":"Chen, T. W. et al. Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature 499, 295\u2013300 (2013)","journal-title":"Nature"},{"key":"BFnature23885_CR12","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/0031-9384(75)90086-4","volume":"14","author":"JB Thurmond","year":"1975","unstructured":"Thurmond, J. B. Technique for producing and measuring territorial aggression using laboratory mice. Physiol. Behav. 14, 879\u2013881 (1975)","journal-title":"Physiol. Behav."},{"key":"BFnature23885_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0003-2670(86)80028-9","volume":"185","author":"P Geladi","year":"1986","unstructured":"Geladi, P. & Kowalski, B. R. Partial least-squares regression: a tutorial. Anal. Chim. Acta 185, 1\u201317 (1986)","journal-title":"Anal. Chim. Acta"},{"key":"BFnature23885_CR14","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09736","volume":"470","author":"D Lin","year":"2011","unstructured":"Lin, D. et al. Functional identification of an aggression locus in the mouse hypothalamus. Nature 470, 221\u2013226 (2011)","journal-title":"Nature"},{"key":"BFnature23885_CR15","doi-asserted-by":"publisher","first-page":"5971","DOI":"10.1523\/JNEUROSCI.5109-13.2014","volume":"34","author":"AL Falkner","year":"2014","unstructured":"Falkner, A. L., Dollar, P., Perona, P., Anderson, D. J. & Lin, D. Decoding ventromedial hypothalamic neural activity during male mouse aggression. J. Neurosci. 34, 5971\u20135984 (2014)","journal-title":"J. Neurosci."},{"key":"BFnature23885_CR16","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/nn.4264","volume":"19","author":"AL Falkner","year":"2016","unstructured":"Falkner, A. L., Grosenick, L., Davidson, T. J., Deisseroth, K. & Lin, D. Hypothalamic control of male aggression-seeking behavior. Nat. Neurosci. 19, 596\u2013604 (2016)","journal-title":"Nat. Neurosci."},{"key":"BFnature23885_CR17","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1523\/JNEUROSCI.16-04-01486.1996","volume":"16","author":"MN Shadlen","year":"1996","unstructured":"Shadlen, M. N., Britten, K. H., Newsome, W. T. & Movshon, J. A. A computational analysis of the relationship between neuronal and behavioral responses to visual motion. J. Neurosci. 16, 1486\u20131510 (1996)","journal-title":"J. Neurosci."},{"key":"BFnature23885_CR18","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.cell.2014.12.026","volume":"160","author":"JH Jennings","year":"2015","unstructured":"Jennings, J. H. et al. Visualizing hypothalamic network dynamics for appetitive and consummatory behaviors. Cell 160, 516\u2013527 (2015)","journal-title":"Cell"},{"key":"BFnature23885_CR19","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/nature21682","volume":"543","author":"BF Grewe","year":"2017","unstructured":"Grewe, B. F. et al. Neural ensemble dynamics underlying a long-term associative memory. Nature 543, 670\u2013675 (2017)","journal-title":"Nature"},{"key":"BFnature23885_CR20","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1214\/009053604000000067","volume":"32","author":"B Efron","year":"2004","unstructured":"Efron, B., Hastie, T., Johnstone, I. & Tibshirani, R. Least angle regression. Ann. Statist. 32, 407\u2013499 (2004)","journal-title":"Ann. Statist."},{"key":"BFnature23885_CR21","doi-asserted-by":"publisher","first-page":"12887","DOI":"10.1073\/pnas.96.22.12887","volume":"96","author":"S Ogawa","year":"1999","unstructured":"Ogawa, S. et al. Survival of reproductive behaviors in estrogen receptor \u03b2 gene-deficient (\u03b2ERKO) male and female mice. Proc. Natl Acad. Sci. USA 96, 12887\u201312892 (1999)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature23885_CR22","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1002\/cne.21364","volume":"502","author":"KL Gobrogge","year":"2007","unstructured":"Gobrogge, K. L., Liu, Y., Jia, X. & Wang, Z. Anterior hypothalamic neural activation and neurochemical associations with aggression in pair-bonded male prairie voles. J. Comp. Neurol. 502, 1109\u20131122 (2007)","journal-title":"J. Comp. Neurol."},{"key":"BFnature23885_CR23","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nature13725","volume":"513","author":"RL Redondo","year":"2014","unstructured":"Redondo, R. L. et al. Bidirectional switch of the valence associated with a hippocampal contextual memory engram. Nature 513, 426\u2013430 (2014)","journal-title":"Nature"},{"key":"BFnature23885_CR24","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.neuron.2016.07.034","volume":"91","author":"PS Xu","year":"2016","unstructured":"Xu, P. S., Lee, D. & Holy, T. E. Experience-dependent plasticity drives individual differences in pheromone-sensing neurons. Neuron 91, 878\u2013892 (2016)","journal-title":"Neuron"},{"key":"BFnature23885_CR25","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.conb.2016.04.001","volume":"38","author":"L Stowers","year":"2016","unstructured":"Stowers, L. & Liberles, S. D. State-dependent responses to sex pheromones in mouse. Curr. Opin. Neurobiol. 38, 74\u201379 (2016)","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnature23885_CR26","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.biopsych.2014.03.022","volume":"76","author":"R Gur","year":"2014","unstructured":"Gur, R., Tendler, A. & Wagner, S. Long-term social recognition memory is mediated by oxytocin-dependent synaptic plasticity in the medial amygdala. Biol. Psychiatry 76, 377\u2013386 (2014)","journal-title":"Biol. Psychiatry"},{"key":"BFnature23885_CR27","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.neuroscience.2005.06.018","volume":"138","author":"BM Cooke","year":"2006","unstructured":"Cooke, B. M. Steroid-dependent plasticity in the medial amygdala. Neuroscience 138, 997\u20131005 (2006)","journal-title":"Neuroscience"},{"key":"BFnature23885_CR28","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev-neuro-062111-150351","volume":"35","author":"JJ Knierim","year":"2012","unstructured":"Knierim, J. J. & Zhang, K. Attractor dynamics of spatially correlated neural activity in the limbic system. Annu. Rev. Neurosci. 35, 267\u2013285 (2012)","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnature23885_CR29","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.conb.2014.01.013","volume":"25","author":"Y Burak","year":"2014","unstructured":"Burak, Y. Spatial coding and attractor dynamics of grid cells in the entorhinal cortex. Curr. Opin. Neurobiol. 25, 169\u2013175 (2014)","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnature23885_CR30","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1146\/annurev.neuro.31.061307.090723","volume":"31","author":"EI Moser","year":"2008","unstructured":"Moser, E. I., Kropff, E. & Moser, M.-B. Place cells, grid cells, and the brain\u2019s spatial representation system. Annu. Rev. Neurosci. 31, 69\u201389 (2008)","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnature23885_CR31","doi-asserted-by":"publisher","first-page":"14737","DOI":"10.1073\/pnas.250473597","volume":"97","author":"S Ogawa","year":"2000","unstructured":"Ogawa, S. et al. Abolition of male sexual behaviors in mice lacking estrogen receptors \u03b1 and \u03b2 (\u03b1\u03b2ERKO). Proc. Natl Acad. Sci. USA 97, 14737\u201314741 (2000)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature23885_CR32","doi-asserted-by":"publisher","first-page":"e108697","DOI":"10.1371\/journal.pone.0108697","volume":"9","author":"H Dana","year":"2014","unstructured":"Dana, H. et al. Thy1\u2013GCaMP6 transgenic mice for neuronal population imaging in vivo. PLoS ONE 9, e108697 (2014)","journal-title":"PLoS ONE"},{"key":"BFnature23885_CR33","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nprot.2016.021","volume":"11","author":"SL Resendez","year":"2016","unstructured":"Resendez, S. L. et al. Visualization of cortical, subcortical and deep brain neural circuit dynamics during naturalistic mammalian behavior with head-mounted microscopes and chronically implanted lenses. Nat. Protocols 11, 566\u2013597 (2016)","journal-title":"Nat. Protocols"},{"key":"BFnature23885_CR34","doi-asserted-by":"crossref","unstructured":"Doll\u00e1r, P., Welinder, P . & Perona, P. Cascaded pose regression. In IEEE Conference on Computer Vision and Pattern Recognition 1078\u20131085 (CVPR, 2010)","DOI":"10.1109\/CVPR.2010.5540094"},{"key":"BFnature23885_CR35","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.neuron.2009.08.009","volume":"63","author":"EA Mukamel","year":"2009","unstructured":"Mukamel, E. A., Nimmerjahn, A. & Schnitzer, M. J. Automated analysis of cellular signals from large-scale calcium imaging data. Neuron 63, 747\u2013760 (2009)","journal-title":"Neuron"},{"key":"BFnature23885_CR36","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1523\/JNEUROSCI.3276-09.2010","volume":"30","author":"CK Machens","year":"2010","unstructured":"Machens, C. K., Romo, R. & Brody, C. D. Functional, but not anatomical, separation of \u201cwhat\u201d and \u201cwhen\u201d in prefrontal cortex. J. Neurosci. 30, 350\u2013360 (2010)","journal-title":"J. Neurosci."},{"key":"BFnature23885_CR37","unstructured":"Jolliffe, I. Principal Component Analysis (Wiley Online Library, 2002)"},{"key":"BFnature23885_CR38","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0169-7439(93)85002-X","volume":"18","author":"S De Jong","year":"1993","unstructured":"De Jong, S. SIMPLS: an alternative approach to partial least squares regression. Chemom. Intell. Lab. Syst. 18, 251\u2013263 (1993)","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"BFnature23885_CR39","doi-asserted-by":"crossref","unstructured":"Cristianini, N & Shawe-Taylor, J. An Introduction to Support Vector Machines and Other Kernel-based Learning Methods (Cambridge Univ. Press, 2000)","DOI":"10.1017\/CBO9780511801389"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature23885.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature23885","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nature23885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/nature23885.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:05:06Z","timestamp":1684418706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature23885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":39,"journal-issue":{"issue":"7676","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["BFnature23885"],"URL":"https:\/\/doi.org\/10.1038\/nature23885","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732015011.793538695","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.732015011.793541942","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.732015011.793541072","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.732015011.793561597","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"3 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M.J.S. is a scientific co-founder of Inscopix Inc., which produced the miniature fluorescence microscope used in this study. R.R., A.K., M.Z., B.F.G. and D.J.A. declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}