{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:17:09Z","timestamp":1779340629644,"version":"3.51.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[1996,11,1]],"date-time":"1996-11-01T00:00:00Z","timestamp":846806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Biotechnol"],"published-print":{"date-parts":[[1996,11]]},"DOI":"10.1038\/nbt1196-1562","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T22:23:58Z","timestamp":1092867838000},"page":"1562-1565","source":"Crossref","is-referenced-by-count":113,"title":["Sustained somatic gene inactivation by viral transfer of Cre recombinase"],"prefix":"10.1038","volume":"14","author":[{"given":"Astrid","family":"Rohlmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gotthardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Willnow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Herz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFnbt11961562_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1101\/SQB.1981.045.01.042","volume":"45","author":"N Sternberg","year":"1981","unstructured":"Sternberg, N., Hamilton, D., Austin, S., Yarmolinsky, M. and Hoess, R. 1981. Site-specific recombination and its role in the life cylce of bacteriophage P1. Cold Spring Harbor. Symp. 45: 297\u2013309.","journal-title":"Cold Spring Harbor. Symp."},{"key":"BFnbt11961562_CR2","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/0076-6879(93)25056-8","volume":"225","author":"B Sauer","year":"1993","unstructured":"Sauer, B. 1993. Manipulation of transgenes by site-specific recombination: use of Cre recombinase. Methods Enzymol. 225: 890\u2013900.","journal-title":"Methods Enzymol."},{"key":"BFnbt11961562_CR3","doi-asserted-by":"publisher","first-page":"6861","DOI":"10.1073\/pnas.89.15.6861","volume":"89","author":"PC Orban","year":"1992","unstructured":"Orban, P.C., Chui, D. and Marth, J.D. 1992. Tissue- and site-specific DNA recombination in transgenic mice. Proc. Natl. Acad. Sci. USA 89: 6861\u20136865.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt11961562_CR4","doi-asserted-by":"publisher","first-page":"6232","DOI":"10.1073\/pnas.89.14.6232","volume":"89","author":"M Lakso","year":"1992","unstructured":"Lakso, M., Sauer, B., Mosinger, B. Jr., Lee, E.J., Manning, R.W., Yu, S.-H. et al. 1992. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl. Acad. Sci. USA 89: 6232\u20136236.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt11961562_CR5","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1126\/science.8016642","volume":"265","author":"H Gu","year":"1994","unstructured":"Gu, H., Marth, J.D., Orban, P.C., Mossmann, H. and Rajewski, K. 1994. Deletion of the DNA polymerase \u00df gene in T cells using tissue-specific gene targeting. Science 265: 103\u2013106.","journal-title":"Science"},{"key":"BFnbt11961562_CR6","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1126\/science.7660125","volume":"269","author":"R K\u00fchn","year":"1995","unstructured":"K\u00fchn, R., Schwenk, F., Aguet, M. and Rajewsky, K. 1995. Inducitale gene targeting in mice. Science 269: 1427\u20131429.","journal-title":"Science"},{"key":"BFnbt11961562_CR7","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/378720a0","volume":"378","author":"R Ramirez-Solis","year":"1995","unstructured":"Ramirez-Solis, R., Liu, P. and Bradley, A. 1995. Chromosome engineering in mice. Nature 378: 720\u2013724.","journal-title":"Nature"},{"key":"BFnbt11961562_CR8","doi-asserted-by":"publisher","first-page":"7376","DOI":"10.1073\/pnas.92.16.7376","volume":"92","author":"J Van Deursen","year":"1995","unstructured":"Van Deursen, J., Fornerod, M., Van Rees, B. and Grosveld, G. 1995. Cre-mediated site-specific translocation between nonhomologous mouse chromosomes. Proc. Natl. Acad. Sci. USA 92: 7376\u20137380.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt11961562_CR9","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0168-9525(00)89008-3","volume":"11","author":"AJ Copp","year":"1995","unstructured":"Copp, A.J. 1995. Death before birth: clues from gene knockouts and mutations. TIG 11: 87\u201393.","journal-title":"TIG"},{"key":"BFnbt11961562_CR10","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1146\/annurev.bi.63.070194.003125","volume":"63","author":"M Krieger","year":"1994","unstructured":"Krieger, M. and Herz, J. 1994. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Ann. Rev. Biochem. 63: 601\u2013637.","journal-title":"Ann. Rev. Biochem."},{"key":"BFnbt11961562_CR11","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/0092-8674(92)90511-A","volume":"71","author":"J Herz","year":"1992","unstructured":"Herz, J., Clouthier, D.E. and Hammer, R.E. 1992. LDL receptor-related protein internalizes and degrades uPA\/PAI-1 complexes and is essential for embryo implantation. Cell 71: 411\u2013421.","journal-title":"Cell"},{"key":"BFnbt11961562_CR12","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1128\/JVI.69.8.4600-4606.1995","volume":"69","author":"M Anton","year":"1995","unstructured":"Anton, M. and Graham, F.L. 1995. Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression. J. Virol. 69: 4600\u20134606.","journal-title":"J. Virol."},{"key":"BFnbt11961562_CR13","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1006\/viro.1995.1400","volume":"211","author":"DS Pereira","year":"1995","unstructured":"Pereira, D.S., Rosenthal, K.L. and Graham, F.L. 1995. Identification of adenovirus E1A regions which affect MHC class I expression and susceptibility to cytotoxic T lymphocytes. Virol. 211: 268\u2013277.","journal-title":"Virol."},{"key":"BFnbt11961562_CR14","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.4049\/jimmunol.155.5.2564","volume":"155","author":"Y Yang","year":"1995","unstructured":"Yang, Y. and Wilson, J.M. 1995. Clearance of adenovirus-infected hepatocytes by MHC class l-restricted CD4+ CTLs in vivo. J. Immunol. 155: 2564\u20132570.","journal-title":"J. Immunol."},{"key":"BFnbt11961562_CR15","doi-asserted-by":"publisher","first-page":"4407","DOI":"10.1073\/pnas.91.10.4407","volume":"91","author":"Y Yang","year":"1994","unstructured":"Yang, Y., Nunes, F.A., Berencsi, K., Furth, E.E., Gonczol, E., and Wilson, J.M. 1994. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91: 4407\u20134411.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt11961562_CR16","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1172\/JCI115902","volume":"90","author":"LD Stratford-Perricaudet","year":"1992","unstructured":"Stratford-Perricaudet, L.D., Makeh, I., Perricaudet, M. and Briand, P. 1992. Widespread long-term gene transfer to mouse skeletal muscle and heart. J. Clin. Invest. 90: 626\u2013630.","journal-title":"J. Clin. Invest."},{"key":"BFnbt11961562_CR17","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1073\/pnas.90.7.2812","volume":"90","author":"J Herz","year":"1993","unstructured":"Herz, J. and Gerard, R.D. 1993. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc. Natl. Acad. Sci. USA 90: 2812\u20132816.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt11961562_CR18","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/0092-8674(91)90499-O","volume":"64","author":"P Soriano","year":"1991","unstructured":"Soriano, P., Montgomery, C., Geske, R. and Bradley, A. 1991. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64: 693\u2013702.","journal-title":"Cell"},{"key":"BFnbt11961562_CR19","doi-asserted-by":"crossref","first-page":"17401","DOI":"10.1016\/S0021-9258(18)38172-9","volume":"265","author":"DK Strickland","year":"1990","unstructured":"Strickland, D.K., Ashcom, J.D., Williams, S., Burgess, W.H., Migliorini, M. and Argraves, W.S. 1990. Sequence identity between the \u03b12-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J. Biol. Chem. 265: 17401\u201317404.","journal-title":"J. Biol. Chem."},{"key":"BFnbt11961562_CR20","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0014-5793(90)80530-V","volume":"276","author":"T Kristensen","year":"1990","unstructured":"Kristensen, T., Moestrup, S.K., Gliemann, J., Bendtsen, L., Sand, O. and Sottrup-Jensen, L. 1990. Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the \u03b12-macroglobulin receptor. FEBS Lett. 276: 151\u2013155.","journal-title":"FEBS Lett."},{"key":"BFnbt11961562_CR21","doi-asserted-by":"publisher","first-page":"3932","DOI":"10.1073\/pnas.93.9.3932","volume":"93","author":"Y Wang","year":"1996","unstructured":"Wang, Y., Krushel, L.A. and Edelman, G.M. 1996. Targeted DNA recombination in vivo using an adenovirus carrying the ere recombinase. Proc. Natl. Acad. Sci. USA 93: 3932\u20133936.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt11961562_CR22","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0167-4781(89)90107-3","volume":"1009","author":"H K\u00fctt","year":"1989","unstructured":"K\u00fctt, H., Herz, J. and Stanley, K.K. 1989. Structure of the low-density lipoprotein receptor-related protein (LRP) promoter. Biochim. Biophys. Acta 1009: 229\u2013236.","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnbt11961562_CR23","first-page":"305","volume-title":"Methods in cell biology 43","author":"TE Willnow","year":"1994","unstructured":"Willnow, T.E. and Herz, J. 1994. Homologous recombination for gene replacement in mouse cell lines, pp. 305\u2013334 in Methods in cell biology 43. Roth, M. (ed.). Academic Press, San Diego."},{"key":"BFnbt11961562_CR24","doi-asserted-by":"publisher","first-page":"4537","DOI":"10.1073\/pnas.92.10.4537","volume":"92","author":"TE Willnow","year":"1995","unstructured":"Willnow, T.E., Armstrong, S.A., Hammer, R.E. and Herz, J. 1995. Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. Proc. Natl. Acad. Sci. USA 92: 4537\u20134541.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt11961562_CR25","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1126\/science.7515194","volume":"264","author":"TE Willnow","year":"1994","unstructured":"Willnow, T.E., Sheng, Z., Ishibashi, S. and Herz, J. 1994. Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science 264: 1471\u20131474","journal-title":"Science"}],"container-title":["Nature Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nbt1196-1562","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt1196-1562.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt1196-1562.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:43:49Z","timestamp":1684439029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nbt1196-1562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1996,11]]}},"alternative-id":["BFnbt11961562"],"URL":"https:\/\/doi.org\/10.1038\/nbt1196-1562","relation":{},"ISSN":["1087-0156","1546-1696"],"issn-type":[{"value":"1087-0156","type":"print"},{"value":"1546-1696","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,11]]}}}