{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:21:22Z","timestamp":1774282882778,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2008,4,27]],"date-time":"2008-04-27T00:00:00Z","timestamp":1209254400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Biotechnol"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1038\/nbt1399","type":"journal-article","created":{"date-parts":[[2008,4,27]],"date-time":"2008-04-27T13:24:46Z","timestamp":1209302686000},"page":"549-551","source":"Crossref","is-referenced-by-count":258,"title":["CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression"],"prefix":"10.1038","volume":"26","author":[{"given":"Stephen C","family":"Hyde","sequence":"first","affiliation":[]},{"given":"Ian A","family":"Pringle","sequence":"additional","affiliation":[]},{"given":"Syahril","family":"Abdullah","sequence":"additional","affiliation":[]},{"given":"Anna E","family":"Lawton","sequence":"additional","affiliation":[]},{"given":"Lee A","family":"Davies","sequence":"additional","affiliation":[]},{"given":"Anusha","family":"Varathalingam","sequence":"additional","affiliation":[]},{"given":"Graciela","family":"Nunez-Alonso","sequence":"additional","affiliation":[]},{"given":"Anne-Marie","family":"Green","sequence":"additional","affiliation":[]},{"given":"Reto P","family":"Bazzani","sequence":"additional","affiliation":[]},{"given":"Stephanie G","family":"Sumner-Jones","sequence":"additional","affiliation":[]},{"given":"Mario","family":"Chan","sequence":"additional","affiliation":[]},{"given":"Hongyu","family":"Li","sequence":"additional","affiliation":[]},{"given":"Nelson S","family":"Yew","sequence":"additional","affiliation":[]},{"given":"Seng H","family":"Cheng","sequence":"additional","affiliation":[]},{"given":"A","family":"Christopher Boyd","sequence":"additional","affiliation":[]},{"given":"Jane C","family":"Davies","sequence":"additional","affiliation":[]},{"given":"Uta","family":"Griesenbach","sequence":"additional","affiliation":[]},{"given":"David J","family":"Porteous","sequence":"additional","affiliation":[]},{"given":"David N","family":"Sheppard","sequence":"additional","affiliation":[]},{"given":"Felix M","family":"Munkonge","sequence":"additional","affiliation":[]},{"given":"Eric W F W","family":"Alton","sequence":"additional","affiliation":[]},{"given":"Deborah R","family":"Gill","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,4,27]]},"reference":[{"key":"BFnbt1399_CR1","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1038\/sj.gt.3301212","volume":"7","author":"SC Hyde","year":"2000","unstructured":"Hyde, S.C. et al. Gene Ther. 7, 1156\u20131165 (2000).","journal-title":"Gene Ther."},{"key":"BFnbt1399_CR2","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/S0140-6736(98)06532-5","volume":"353","author":"EW Alton","year":"1999","unstructured":"Alton, E.W. et al. Lancet 353, 947\u2013954 (1999).","journal-title":"Lancet"},{"key":"BFnbt1399_CR3","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1089\/hum.1997.8.6-765","volume":"8","author":"SJ Eastman","year":"1997","unstructured":"Eastman, S.J. et al. Hum. Gene Ther. 8, 765\u2013773 (1997).","journal-title":"Hum. Gene Ther."},{"key":"BFnbt1399_CR4","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1038\/sj.gt.3301561","volume":"8","author":"DR Gill","year":"2001","unstructured":"Gill, D.R. et al. Gene Ther. 8, 1539\u20131546 (2001).","journal-title":"Gene Ther."},{"key":"BFnbt1399_CR5","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1038\/sj.gt.3302518","volume":"12","author":"IA Pringle","year":"2005","unstructured":"Pringle, I.A. et al. Gene Ther. 12, 1206\u20131214 (2005).","journal-title":"Gene Ther."},{"key":"BFnbt1399_CR6","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1089\/104303401750148667","volume":"12","author":"FE Ruiz","year":"2001","unstructured":"Ruiz, F.E. et al. Hum. Gene Ther. 12, 751\u2013761 (2001).","journal-title":"Hum. Gene Ther."},{"key":"BFnbt1399_CR7","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/35047123","volume":"408","author":"H Hemmi","year":"2000","unstructured":"Hemmi, H. et al. Nature 408, 740\u2013745 (2000).","journal-title":"Nature"},{"key":"BFnbt1399_CR8","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/374546a0","volume":"374","author":"AM Krieg","year":"1995","unstructured":"Krieg, A.M. et al. Nature 374, 546\u2013549 (1995).","journal-title":"Nature"},{"key":"BFnbt1399_CR9","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/sj.gt.3301097","volume":"7","author":"G McLachlan","year":"2000","unstructured":"McLachlan, G. et al. Gene Ther. 7, 384\u2013392 (2000).","journal-title":"Gene Ther."},{"key":"BFnbt1399_CR10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1006\/mthe.2000.0036","volume":"1","author":"NS Yew","year":"2000","unstructured":"Yew, N.S. et al. Mol. Ther. 1, 255\u2013262 (2000).","journal-title":"Mol. Ther."},{"key":"BFnbt1399_CR11","doi-asserted-by":"publisher","first-page":"6338","DOI":"10.1128\/jb.177.22.6338-6345.1995","volume":"177","author":"F Wu","year":"1995","unstructured":"Wu, F. et al. J. Bacteriol. 177, 6338\u20136345 (1995).","journal-title":"J. Bacteriol."},{"key":"BFnbt1399_CR12","unstructured":"Fed. Regist. 72, 61172 (2007)."},{"key":"BFnbt1399_CR13","doi-asserted-by":"crossref","unstructured":"European Pharmacopoeia 6.0, 5.14 667\u2013676 (2007).","DOI":"10.1111\/j.1468-1331.2007.01814.x"},{"key":"BFnbt1399_CR14","first-page":"797","volume":"3","author":"JR Dorin","year":"1996","unstructured":"Dorin, J.R. et al. Gene Ther. 3, 797\u2013801 (1996).","journal-title":"Gene Ther."},{"key":"BFnbt1399_CR15","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1172\/JCI7935","volume":"104","author":"BG Harvey","year":"1999","unstructured":"Harvey, B.G. et al. J. Clin. Invest. 104, 1245\u20131255 (1999).","journal-title":"J. Clin. Invest."}],"container-title":["Nature Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nbt1399.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt1399","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt1399.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T15:54:58Z","timestamp":1684425298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nbt1399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,27]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["BFnbt1399"],"URL":"https:\/\/doi.org\/10.1038\/nbt1399","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1116283.572287","asserted-by":"object"}]},"ISSN":["1087-0156","1546-1696"],"issn-type":[{"value":"1087-0156","type":"print"},{"value":"1546-1696","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,27]]}}}