{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T21:25:10Z","timestamp":1777152310782,"version":"3.51.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2003,1,13]],"date-time":"2003-01-13T00:00:00Z","timestamp":1042416000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Biotechnol"],"published-print":{"date-parts":[[2003,2]]},"DOI":"10.1038\/nbt780","type":"journal-article","created":{"date-parts":[[2003,1,30]],"date-time":"2003-01-30T21:35:23Z","timestamp":1043962523000},"page":"183-186","source":"Crossref","is-referenced-by-count":1308,"title":["Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture"],"prefix":"10.1038","volume":"21","author":[{"given":"Qi-Long","family":"Ying","sequence":"first","affiliation":[]},{"given":"Marios","family":"Stavridis","sequence":"additional","affiliation":[]},{"given":"Dean","family":"Griffiths","sequence":"additional","affiliation":[]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[]},{"given":"Austin","family":"Smith","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2003,1,13]]},"reference":[{"key":"BFnbt780_CR1","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/0955-0674(95)80071-9","volume":"7","author":"GM Keller","year":"1995","unstructured":"Keller, G.M. In vitro differentiation of embryonic stem cells. Curr. Opin. Cell. Biol. 7, 862\u2013869 (1995).","journal-title":"Curr. Opin. Cell. Biol."},{"key":"BFnbt780_CR2","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1146\/annurev.cellbio.17.1.435","volume":"17","author":"AG Smith","year":"2001","unstructured":"Smith, A.G. Embryo-derived stem cells: of mice and men. Ann. Rev. Cell Dev. Biol. 17, 435\u2013462 (2001).","journal-title":"Ann. Rev. Cell Dev. Biol."},{"key":"BFnbt780_CR3","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1006\/dbio.1995.1085","volume":"168","author":"G Bain","year":"1995","unstructured":"Bain, G., Kitchens, D., Yao, M., Huettner, J.E. & Gottlieb, D.I. Embryonic stem cells express neuronal properties in vitro. Dev. Biol. 168, 342\u2013357 (1995).","journal-title":"Dev. Biol."},{"key":"BFnbt780_CR4","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1006\/excr.1998.4353","volume":"247","author":"MV Wiles","year":"1999","unstructured":"Wiles, M.V. & Johansson, B.M. Embryonic stem cell development in a chemically defined medium. Exp. Cell Res. 247, 241\u2013248 (1999).","journal-title":"Exp. Cell Res."},{"key":"BFnbt780_CR5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0896-6273(00)00083-0","volume":"28","author":"H Kawasaki","year":"2000","unstructured":"Kawasaki, H. et al. Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 28, 31\u201340 (2000).","journal-title":"Neuron"},{"key":"BFnbt780_CR6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nrn786","volume":"3","author":"I Munoz-Sanjuan","year":"2002","unstructured":"Munoz-Sanjuan, I. & Brivanlou, A.H. Neural induction, the default model and embryonic stem cells. Nat. Rev. Neurosci. 3, 271\u2013280 (2002).","journal-title":"Nat. Rev. Neurosci."},{"issue":"Suppl.","key":"BFnbt780_CR7","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/nn747","volume":"4","author":"SI Wilson","year":"2001","unstructured":"Wilson, S.I. & Edlund, T. Neural induction: toward a unifying mechanism. Nat. Neurosci. 4 (Suppl.), 1161\u20131168 (2001).","journal-title":"Nat. Neurosci."},{"key":"BFnbt780_CR8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0896-6273(01)00263-X","volume":"30","author":"V Tropepe","year":"2001","unstructured":"Tropepe, V. et al. Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron 30, 65\u201378 (2001).","journal-title":"Neuron"},{"key":"BFnbt780_CR9","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0925-4773(99)00116-1","volume":"86","author":"HB Wood","year":"1999","unstructured":"Wood, H.B. & Episkopou, V. Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mech. Dev. 86, 197\u2013201 (1999).","journal-title":"Mech. Dev."},{"key":"BFnbt780_CR10","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1038\/nbt763","volume":"20","author":"J Aubert","year":"2002","unstructured":"Aubert, J., Dunstan, H., Chambers, I. & Smith, A. Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat. Biotechnol. 20, 1240\u20131245 (2002).","journal-title":"Nat. Biotechnol."},{"key":"BFnbt780_CR11","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/82868","volume":"4","author":"KL Tucker","year":"2001","unstructured":"Tucker, K.L., Meyer, M. & Barde, Y.A. Neurotrophins are required for nerve growth during development. Nat. Neurosci. 4, 29\u201337 (2001).","journal-title":"Nat. Neurosci."},{"key":"BFnbt780_CR12","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/76536","volume":"18","author":"SH Lee","year":"2000","unstructured":"Lee, S.H., Lumelsky, N., Studer, L., Auerbach, J.M. & McKay, R.D. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat. Biotechnol. 18, 675\u2013679 (2000).","journal-title":"Nat. Biotechnol."},{"key":"BFnbt780_CR13","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/74199","volume":"24","author":"H Niwa","year":"2000","unstructured":"Niwa, H., Miyazaki, J. & Smith, A.G. Quantitative expression of Oct-3\/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24, 372\u2013376 (2000).","journal-title":"Nat. Genet."},{"key":"BFnbt780_CR14","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nature729","volume":"416","author":"QL Ying","year":"2002","unstructured":"Ying, Q.L., Nichols, J., Evans, E.P. & Smith, A.G. Changing potency by spontaneous fusion. Nature 416, 545\u2013548 (2002).","journal-title":"Nature"},{"key":"BFnbt780_CR15","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/nature01042","volume":"419","author":"F Cebria","year":"2002","unstructured":"Cebria, F. et al. FGFR-related gene nou-darake restricts brain tissues to the head region of planarians. Nature 419, 620\u2013624 (2002).","journal-title":"Nature"},{"key":"BFnbt780_CR16","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1242\/dev.122.3.869","volume":"122","author":"C Launay","year":"1996","unstructured":"Launay, C., Fromentoux, V., Shi, D.L. & Boucaut, J.C. A truncated FGF receptor blocks neural induction by endogenous Xenopus inducers. Development 122, 869\u2013880 (1996).","journal-title":"Development"},{"key":"BFnbt780_CR17","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/35017617","volume":"406","author":"A Streit","year":"2000","unstructured":"Streit, A., Berliner, A.J., Papanayotou, C., Sirulnik, A. & Stern, C.D. Initiation of neural induction by FGF signalling before gastrulation. Nature 406, 74\u201378 (2000).","journal-title":"Nature"},{"key":"BFnbt780_CR18","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S0960-9822(00)00431-0","volume":"10","author":"SI Wilson","year":"2000","unstructured":"Wilson, S.I., Graziano, E., Harland, R., Jessell, T.M. & Edlund, T. An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo. Curr. Biol. 10, 421\u2013429 (2000).","journal-title":"Curr. Biol."},{"key":"BFnbt780_CR19","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1126\/science.276.5314.955","volume":"276","author":"M Mohammadi","year":"1997","unstructured":"Mohammadi, M. et al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science 276, 955\u2013960 (1997).","journal-title":"Science"},{"key":"BFnbt780_CR20","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1083\/jcb.153.4.811","volume":"153","author":"X Li","year":"2001","unstructured":"Li, X. et al. Fibroblast growth factor signaling and basement membrane assembly are connected during epithelial morphogenesis of the embryoid body. J. Cell Biol. 153, 811\u2013822 (2001).","journal-title":"J. Cell Biol."},{"key":"BFnbt780_CR21","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1126\/science.7809630","volume":"267","author":"B Feldman","year":"1995","unstructured":"Feldman, B., Poueymirou, W., Papaioannou, V.E., DeChiara, T.M. & Goldfarb, M. Requirement of FGF-4 for postimplantation mouse development. Science 267, 246\u2013249 (1995).","journal-title":"Science"},{"key":"BFnbt780_CR22","doi-asserted-by":"publisher","first-page":"5082","DOI":"10.1073\/pnas.95.9.5082","volume":"95","author":"E Arman","year":"1998","unstructured":"Arman, E., Krausz-Haffner, R., Chen, Y., Heath, J.K. & Lonai, P. Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc. Natl. Acad. Sci. USA 95, 5082\u20135087 (1998).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt780_CR23","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1242\/dev.128.12.2333","volume":"128","author":"J Nichols","year":"2001","unstructured":"Nichols, J., Chambers, I., Taga, T. & Smith, A.G. Physiological rationale for responsiveness of mouse epiblast and embryonic stem cells to gp130 cytokines. Development 128, 2333\u20132339 (2001).","journal-title":"Development"}],"container-title":["Nature Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nbt780.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt780","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt780.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:55:57Z","timestamp":1684439757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nbt780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,13]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["BFnbt780"],"URL":"https:\/\/doi.org\/10.1038\/nbt780","relation":{},"ISSN":["1087-0156","1546-1696"],"issn-type":[{"value":"1087-0156","type":"print"},{"value":"1546-1696","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1,13]]}}}