{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:24:02Z","timestamp":1779344642827,"version":"3.51.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2001,10,8]],"date-time":"2001-10-08T00:00:00Z","timestamp":1002499200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,10,8]],"date-time":"2001-10-08T00:00:00Z","timestamp":1002499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2001,11,1]]},"DOI":"10.1038\/ncb1101-973","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:34:56Z","timestamp":1027672496000},"page":"973-982","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":719,"title":["HER-2\/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation"],"prefix":"10.1038","volume":"3","author":[{"given":"Binhua P.","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiya","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bill","family":"Spohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mien-Chie","family":"Hung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2001,10,8]]},"reference":[{"key":"BFncb1101973_CR1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1126\/science.3798106","volume":"235","author":"DJ Slamon","year":"1987","unstructured":"Slamon, D. J. et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2\/neu oncogene. Science 235, 177\u2013182 (1987).","journal-title":"Science"},{"key":"BFncb1101973_CR2","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1126\/science.2470152","volume":"244","author":"DJ Slamon","year":"1989","unstructured":"Slamon, D. J. et al. Studies of the HER-2\/neu proto-oncogene in human breast and ovarian cancer. Science 244, 707\u2013712 (1989).","journal-title":"Science"},{"key":"BFncb1101973_CR3","volume-title":"DNA Alterations in Cancer","author":"D Yu","year":"2000","unstructured":"Yu, D. & Hung, M.-C. in DNA Alterations in Cancer (ed. Ehrlich, M.) Ch. 21 (Eaton, Natick, Massachusetts, 2000)."},{"key":"BFncb1101973_CR4","doi-asserted-by":"publisher","first-page":"8027","DOI":"10.1074\/jbc.275.11.8027","volume":"275","author":"BP Zhou","year":"2000","unstructured":"Zhou, B. P. et al. HER-2\/neu blocks tumor necrosis factor-induced apoptosis via the Akt\/NF-\u03baB pathways. J. Biol. Chem. 275, 8027\u20138031 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFncb1101973_CR5","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/35060032","volume":"3","author":"BP Zhou","year":"2001","unstructured":"Zhou, B. P. et al. Cytoplasmic localization of p21Cip1\/WAF1 by Akt-induced phosphorylation in HER-2\/neu-overexpressing cells. Nature Cell Biol. 3, 245\u2013252 (2001).","journal-title":"Nature Cell Biol."},{"key":"BFncb1101973_CR6","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/S0955-0674(98)80149-X","volume":"10","author":"J Downward","year":"1998","unstructured":"Downward, J. Mechanisms and consequences of activation of protein kinase B\/Akt. Curr. Opin. Cell Biol. 10, 262\u2013267 (1998).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFncb1101973_CR7","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1101\/gad.13.22.2905","volume":"13","author":"SR Datta","year":"1999","unstructured":"Datta, S. R., Brunet, A. & Greenberg, M. E. Cellular survival: a play in three Akts. Genes Dev. 13, 2905\u20132927 (1999).","journal-title":"Genes Dev."},{"key":"BFncb1101973_CR8","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1126\/science.278.5338.687","volume":"278","author":"LD Peso","year":"1997","unstructured":"Peso, L. D., Gonzalez-Garcia, M., Page, C., Herrera, R. & Nunez, G. Interleukin-3-induced phosphorylation of bad through the protein kinase Akt. Science 278, 687\u2013689 (1997).","journal-title":"Science"},{"key":"BFncb1101973_CR9","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.282.5392.1318","volume":"282","author":"MH Cardone","year":"1998","unstructured":"Cardone, M. H. et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 282, 1318\u20131321 (1998).","journal-title":"Science"},{"key":"BFncb1101973_CR10","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","volume":"96","author":"A Brunet","year":"1999","unstructured":"Brunet, A. et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96, 857\u2013868 (1999).","journal-title":"Cell"},{"key":"BFncb1101973_CR11","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/19328","volume":"398","author":"GJPL Kops","year":"1999","unstructured":"Kops, G. J. P. L. et al. Direct control of the forkhead transcription factor AFX by protein kinase B. Nature 398, 630\u2013634 (1999).","journal-title":"Nature"},{"key":"BFncb1101973_CR12","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/43466","volume":"401","author":"ON Ozes","year":"1999","unstructured":"Ozes, O. N. et al. NF-\u03baB activation by tumor necrosis factor requires the Akt serine\u2013threonine kinase. Nature 401, 82\u201385 (1999).","journal-title":"Nature"},{"key":"BFncb1101973_CR13","doi-asserted-by":"publisher","first-page":"24263","DOI":"10.1074\/jbc.274.34.24263","volume":"274","author":"P Sabbatini","year":"1999","unstructured":"Sabbatini, P. & McCormick, F. Phosphoinositide 3-OH kinase (PI3K) and PKB\/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis. J. Biol. Chem. 274, 24263\u201324269 (1999).","journal-title":"J. Biol. Chem."},{"key":"BFncb1101973_CR14","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1006\/excr.2000.5141","volume":"264","author":"DB Woods","year":"2001","unstructured":"Woods, D. B. & Vousden, K. H. Regulation of p53 function. Exp. Cell Res. 264, 56\u201366 (2001).","journal-title":"Exp. Cell Res."},{"key":"BFncb1101973_CR15","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S0959-437X(99)00038-6","volume":"10","author":"CJ Sherr","year":"2000","unstructured":"Sherr, C. J. & Weber, J. D. The ARF\/p53 pathway. Curr. Opin. Genet. Dev. 10, 94\u201399 (2000).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFncb1101973_CR16","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S0092-8674(00)00171-9","volume":"103","author":"KH Vousden","year":"2000","unstructured":"Vousden, K. H. p53: death star. Cell 103, 691\u2013694 (2000).","journal-title":"Cell"},{"key":"BFncb1101973_CR17","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/35042675","volume":"408","author":"B Vogelstein","year":"2000","unstructured":"Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307\u2013310 (2000).","journal-title":"Nature"},{"key":"BFncb1101973_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj3520001","volume":"352","author":"TR Hupp","year":"2000","unstructured":"Hupp, T. R., Lane, D. P. & Ball, K. L. Strategies for manipulating the p53 pathway in the treatment of human cancer. Biochem. J. 352, 1\u201317 (2000).","journal-title":"Biochem. J."},{"key":"BFncb1101973_CR19","doi-asserted-by":"publisher","first-page":"R315","DOI":"10.1016\/S0960-9822(00)00439-5","volume":"10","author":"T Caspari","year":"2000","unstructured":"Caspari, T. Checkpoints: how to activate p53. Curr. Biol. 10, R315\u2013R317 (2000).","journal-title":"Curr. Biol."},{"key":"BFncb1101973_CR20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0378-1119(99)00487-4","volume":"242","author":"J Momand","year":"2000","unstructured":"Momand, J., Wu, H.-H. & Dasgupta, G. MDM2\u2014master regulator of the p53 tumor suppressor protein. Gene 242, 15\u201329 (2000).","journal-title":"Gene"},{"key":"BFncb1101973_CR21","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S1383-5742(00)00035-1","volume":"462","author":"MS Colman","year":"2000","unstructured":"Colman, M. S., Afshari, C. A. & Barrett, J. C. Regulation of p53 stability and activity in response to genotoxic stress. Mut. Res. 462, 179\u2013188 (2000).","journal-title":"Mut. Res."},{"key":"BFncb1101973_CR22","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/42981","volume":"387","author":"NL Lill","year":"1997","unstructured":"Lill, N. L., Grossman, S. R., Ginsberg, D., DeCaprio, J. & Livingston, D. M. Binding and modulation of p53 by p300\/CBP coactivators. Nature 387, 823\u2013827 (1997).","journal-title":"Nature"},{"key":"BFncb1101973_CR23","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S1097-2765(00)80140-9","volume":"2","author":"SR Grossman","year":"1998","unstructured":"Grossman, S. R. et al. p300\/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol. Cell 2, 405\u2013415 (1998).","journal-title":"Mol. Cell"},{"key":"BFncb1101973_CR24","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/S0092-8674(00)81400-2","volume":"92","author":"J Pomerantz","year":"1998","unstructured":"Pomerantz, J. et al. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and nuetralizes MDM2's inhibition of p53. Cell 92, 713\u2013723 (1998).","journal-title":"Cell"},{"key":"BFncb1101973_CR25","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S0092-8674(00)81401-4","volume":"92","author":"Y Zhang","year":"1998","unstructured":"Zhang, Y., Xiong, Y. & Yarbrough, W. G. ARF promotes MDM2 degradation and stabilizes p53: ARF-Ink4a locus deletion impairs both Rb and p53 tumor suppressor pathways. Cell 92, 725\u2013734 (1998).","journal-title":"Cell"},{"key":"BFncb1101973_CR26","first-page":"3689","volume":"60","author":"CJ Sherr","year":"2000","unstructured":"Sherr, C. J. The Pezcoller Lecture: cancer cell cycles revisited. Cancer Res. 60, 3689\u20133695 (2000).","journal-title":"Cancer Res."},{"key":"BFncb1101973_CR27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1093\/emboj\/18.1.22","volume":"18","author":"R Honda","year":"1999","unstructured":"Honda, R. & Yasuda, H. Association of p19ARF with MDM2 inhibits ubiquitin ligase activity of MDM2 for tumor suppressor p53. EMBO J. 18, 22\u201327 (1999).","journal-title":"EMBO J."},{"key":"BFncb1101973_CR28","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/8991","volume":"1","author":"JD Weber","year":"1999","unstructured":"Weber, J. D., Taylor, L. J., Roussel, M. F., Sherr, C. J. & Bar-Sagi, D. Nucleolar Arf sequesters Mdm2 and activates p53. Nature Cell Biol. 1, 20\u201326 (1999).","journal-title":"Nature Cell Biol."},{"key":"BFncb1101973_CR29","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/S1097-2765(00)80351-2","volume":"3","author":"Y Zhang","year":"1999","unstructured":"Zhang, Y. & Xiong, Y. Mutation in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol. Cell 3, 579\u2013591 (1999).","journal-title":"Mol. Cell"},{"key":"BFncb1101973_CR30","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/1521-1878(200007)22:7<673::AID-BIES10>3.0.CO;2-A","volume":"22","author":"D Yu","year":"2000","unstructured":"Yu, D. & Hung, M.-C. Role of erbB2 in breast cancer chemosensitivity. BioEssays 22, 673\u2013680 (2000).","journal-title":"BioEssays"},{"key":"BFncb1101973_CR31","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1093\/jnci\/87.9.682","volume":"87","author":"CM Tsai","year":"1995","unstructured":"Tsai, C. M. et al. Enhanced chemoresistance by elevation of p185 levels in HER-2\/neu-transfected human lung cancer cells. J. Natl Cancer Inst. 87, 682\u2013684 (1995).","journal-title":"J. Natl Cancer Inst."},{"key":"BFncb1101973_CR32","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/35044005","volume":"408","author":"B-BS Zhou","year":"2000","unstructured":"Zhou, B.-B. S. & Elledge, S. J. The DNA damage response: putting checkings in perspective. Nature 408, 433\u2013439 (2000).","journal-title":"Nature"},{"key":"BFncb1101973_CR33","doi-asserted-by":"publisher","first-page":"7288","DOI":"10.1128\/MCB.18.12.7288","volume":"18","author":"DA Freedman","year":"1998","unstructured":"Freedman, D. A. & Levine, A. J. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol. Cell. Biol. 18, 7288\u20137293 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"BFncb1101973_CR34","doi-asserted-by":"publisher","first-page":"14973","DOI":"10.1073\/pnas.96.26.14973","volume":"96","author":"R Khosravi","year":"1999","unstructured":"Khosravi, R. et al. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc. Natl Acad. Sci. USA 96, 14973\u201314977 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb1101973_CR35","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/35074506","volume":"3","author":"S Lianos","year":"2001","unstructured":"Lianos, S., Clark, P. A., Rowe, J. & Peters, G. Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus. Nature Cell Biol. 3, 445\u2013452 (2001).","journal-title":"Nature Cell Biol."},{"key":"BFncb1101973_CR36","doi-asserted-by":"publisher","first-page":"11598","DOI":"10.1073\/pnas.181181198","volume":"98","author":"LD Mayo","year":"2001","unstructured":"Mayo, L. D. & Donner, D. B. A phosphatidylinositol 3-kinase\/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl Acad. Sci. USA 98, 11598\u201311603 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"}],"updated-by":[{"DOI":"10.1038\/ncb831","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000}}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb1101-973.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1101-973","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1101-973.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:22:58Z","timestamp":1684437778000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb1101-973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,8]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2001,11,1]]}},"alternative-id":["BFncb1101973"],"URL":"https:\/\/doi.org\/10.1038\/ncb1101-973","relation":{},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10,8]]},"assertion":[{"value":"2 May 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2001","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2001","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2001","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}