{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:47:18Z","timestamp":1779349638799,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2005,2,20]],"date-time":"2005-02-20T00:00:00Z","timestamp":1108857600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1038\/ncb1223","type":"journal-article","created":{"date-parts":[[2005,2,20]],"date-time":"2005-02-20T23:48:30Z","timestamp":1108943310000},"page":"295-302","source":"Crossref","is-referenced-by-count":345,"title":["Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development"],"prefix":"10.1038","volume":"7","author":[{"given":"Savraj S.","family":"Grewal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Orian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert N.","family":"Eisenman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A.","family":"Edgar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,2,20]]},"reference":[{"key":"BFncb1223_CR1","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1101\/gad.1256704","volume":"18","author":"D Rudra","year":"2004","unstructured":"Rudra, D. & Warner, J.R. What better measure than ribosome synthesis? Genes Dev. 18, 2431\u20132436 (2004).","journal-title":"Genes Dev."},{"key":"BFncb1223_CR2","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1101\/gad.1098503R","volume":"17","author":"I Grummt","year":"2003","unstructured":"Grummt, I. Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus. Genes Dev. 17, 1691\u20131702 (2003).","journal-title":"Genes Dev."},{"key":"BFncb1223_CR3","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0092-8674(02)00761-4","volume":"109","author":"T Moss","year":"2002","unstructured":"Moss, T. & Stefanovsky, V.Y. At the center of eukaryotic life. Cell 109, 545\u2013548 (2002).","journal-title":"Cell"},{"key":"BFncb1223_CR4","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0968-0004(99)01460-7","volume":"24","author":"JR Warner","year":"1999","unstructured":"Warner, J.R. The economics of ribosome biosynthesis in yeast. Trends Biochem. Sci. 24, 437\u2013440 (1999).","journal-title":"Trends Biochem. Sci."},{"key":"BFncb1223_CR5","doi-asserted-by":"crossref","first-page":"6857","DOI":"10.1128\/JB.181.22.6857-6864.1999","volume":"181","author":"M Nomura","year":"1999","unstructured":"Nomura, M. Regulation of ribosome biosynthesis in Escherichia coli and Saccharomyces cerevisiae: diversity and common principles. J. Bacteriol. 181, 6857\u20136864 (1999).","journal-title":"J. Bacteriol."},{"key":"BFncb1223_CR6","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0959-437X(02)00341-6","volume":"12","author":"LJ Saucedo","year":"2002","unstructured":"Saucedo, L.J. & Edgar, B.A. Why size matters: altering cell size. Curr. Opin. Genet. Dev. 12, 565\u2013571 (2002).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFncb1223_CR7","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/BF00260636","volume":"228","author":"W Seifarth","year":"1991","unstructured":"Seifarth, W. et al. Identification of the genes coding for the second-largest subunits of RNA polymerases I and III of Drosophila melanogaster. Mol. Gen. Genet. 228, 424\u2013432 (1991).","journal-title":"Mol. Gen. Genet."},{"key":"BFncb1223_CR8","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1242\/dev.125.22.4483","volume":"125","author":"G Campbell","year":"1998","unstructured":"Campbell, G. & Tomlinson, A. The roles of the homeobox genes aristaless and Distal-less in patterning the legs and wings of Drosophila. Development 125, 4483\u20134493 (1998).","journal-title":"Development"},{"key":"BFncb1223_CR9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0065-2660(08)60142-X","volume":"38","author":"A Lambertsson","year":"1998","unstructured":"Lambertsson, A. The minute genes in Drosophila and their molecular functions. Adv. Genet. 38, 69\u2013134 (1998).","journal-title":"Adv. Genet."},{"key":"BFncb1223_CR10","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1146\/annurev.cellbio.16.1.653","volume":"16","author":"C Grandori","year":"2000","unstructured":"Grandori, C., Cowley, S.M. James, L.P. Eisenman, R.N. The Myc\/Max\/Mad network and the transcriptional control of cell behavior. Annu. Rev. Cell. Dev. Biol. 16, 653\u2013699 (2000).","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"key":"BFncb1223_CR11","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1126\/science.274.5292.1523","volume":"274","author":"P Gallant","year":"1996","unstructured":"Gallant, P., Shiio, Y., Cheng, P.F., Parkhurst, S. M. & Eisenman, R. N. Myc and Max homologs in Drosophila. Science 274, 1523\u20131527 (1996).","journal-title":"Science"},{"key":"BFncb1223_CR12","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/S0092-8674(00)81512-3","volume":"98","author":"LA Johnston","year":"1999","unstructured":"Johnston, L.A., Prober, D. A., Edgar, B. A., Eisenman, R. N. & Gallant, P. Drosophila myc regulates cellular growth during development. Cell 98, 779\u2013790 (1999).","journal-title":"Cell"},{"key":"BFncb1223_CR13","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1242\/dev.00932","volume":"131","author":"JZ Maines","year":"2004","unstructured":"Maines, J.Z., Stevens, L.M., Tong, X. & Stein, D. Drosophila dMyc is required for ovary cell growth and endoreplication. Development 131, 775\u2013786 (2004).","journal-title":"Development"},{"key":"BFncb1223_CR14","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1073\/pnas.94.4.1235","volume":"94","author":"N Schreiber-Agus","year":"1997","unstructured":"Schreiber-Agus, N. et al. Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype. Proc. Natl Acad. Sci. USA 94, 1235\u20131240 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb1223_CR15","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1242\/dev.01108","volume":"131","author":"SB Pierce","year":"2004","unstructured":"Pierce, S.B. et al. dMyc is required for larval growth and endoreplication in Drosophila. Development 131, 2317\u20132327 (2004).","journal-title":"Development"},{"key":"BFncb1223_CR16","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.cub.2004.04.040","volume":"14","author":"KH Moberg","year":"2004","unstructured":"Moberg, K.H. Mukherjee, A., Veraska, A., Artavanis-Tsakonas, S. & Hariharan, I.K. The Drosophila F Box protein Archipelago regulates dMyc protein levels in vivo. Curr. Biol. 14, 965\u2013974 (2004).","journal-title":"Curr. Biol."},{"key":"BFncb1223_CR17","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0092-8674(04)00262-4","volume":"117","author":"E Moreno","year":"2004","unstructured":"Moreno, E. & Basler, K. dMyc transforms cells into super-competitors. Cell 117, 117\u2013129 (2004).","journal-title":"Cell"},{"key":"BFncb1223_CR18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0092-8674(04)00214-4","volume":"117","author":"C de la Cova","year":"2004","unstructured":"de la Cova, C., Abril, M., Bellosta, P., Gallant, P. & Johnston, L.A. Drosophila myc regulates organ size by inducing cell competition. Cell 117, 107\u2013116 (2004).","journal-title":"Cell"},{"key":"BFncb1223_CR19","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1101\/gad.1066903","volume":"17","author":"A Orian","year":"2003","unstructured":"Orian, A. et al. Genomic binding by the Drosophila Myc, Max, Mad\/Mnt transcription factor network. Genes Dev. 17, 1101\u20131114 (2003).","journal-title":"Genes Dev."},{"key":"BFncb1223_CR20","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1242\/dev.125.18.3571","volume":"125","author":"S Zaffran","year":"1998","unstructured":"Zaffran, S. et al. A Drosophila RNA helicase gene, pitchoune, is required for cell growth and proliferation and is a potential target of d-Myc. Development 125, 3571\u20133584 (1998).","journal-title":"Development"},{"key":"BFncb1223_CR21","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0925-4773(03)00049-2","volume":"120","author":"L Perrin","year":"2003","unstructured":"Perrin, L., Benassayag, C., Morello, D., Pradel, J. & Montagne, J. Modulo is a target of Myc selectively required for growth of proliferative cells in Drosophila. Mech. Dev. 120, 645\u2013655 (2003).","journal-title":"Mech. Dev."},{"key":"BFncb1223_CR22","doi-asserted-by":"publisher","first-page":"11198","DOI":"10.1073\/pnas.200372597","volume":"97","author":"S Kim","year":"2000","unstructured":"Kim, S., Li, Q., Dang, C.V. & Lee, L.A. Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo. Proc. Natl Acad. Sci. USA 97, 11198\u201311202 (2000).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb1223_CR23","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1093\/emboj\/20.6.1383","volume":"20","author":"K Boon","year":"2001","unstructured":"Boon, K. et al. N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis. EMBO J. 20, 1383\u20131393 (2001).","journal-title":"EMBO J."},{"key":"BFncb1223_CR24","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.1073\/pnas.97.7.3260","volume":"97","author":"HA Coller","year":"2000","unstructured":"Coller, H.A. et al. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc. Natl Acad. Sci. USA 97, 3260\u20133265 (2000).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb1223_CR25","first-page":"5922","volume":"60","author":"QM Guo","year":"2000","unstructured":"Guo, Q.M. et al. Identification of c-myc responsive genes using rat cDNA microarray. Cancer Res. 60, 5922\u20135928 (2000).","journal-title":"Cancer Res."},{"key":"BFncb1223_CR26","doi-asserted-by":"publisher","first-page":"6148","DOI":"10.1093\/nar\/gkg794","volume":"31","author":"I Schlosser","year":"2003","unstructured":"Schlosser, I. et al. A role for c-Myc in the regulation of ribosomal RNA processing. Nucleic Acids Res. 31, 6148\u20136156 (2003).","journal-title":"Nucleic Acids Res."},{"key":"BFncb1223_CR27","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/ng569","volume":"28","author":"JD Lieb","year":"2001","unstructured":"Lieb, J.D., Liu, X. Botstein, D. & Brown, P. O. Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nature Genet. 28, 327\u2013334 (2001).","journal-title":"Nature Genet."},{"key":"BFncb1223_CR28","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1126\/science.1070850","volume":"297","author":"P Jorgensen","year":"2002","unstructured":"Jorgensen, P., Nishikawa, J.L., Breitkreutz, B.J. & Tyers, M. Systematic identification of pathways that couple cell growth and division in yeast. Science 297, 395\u2013400 (2002).","journal-title":"Science"},{"key":"BFncb1223_CR29","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nature01327","volume":"421","author":"N Gomez-Roman","year":"2003","unstructured":"Gomez-Roman, N., Grandori, C., Eisenman, R.N. & White, R.J. Direct activation of RNA polymerase III transcription by c-Myc. Nature 421, 290\u2013294 (2003).","journal-title":"Nature"},{"key":"BFncb1223_CR30","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/74487","volume":"18","author":"B van Steensel","year":"2000","unstructured":"van Steensel, B. & Henikoff, S. Identification of in vivo DNA targets of chromatin proteins using tethered dam methyltransferase. Nature Biotechnol. 18, 424\u2013428 (2000).","journal-title":"Nature Biotechnol."},{"key":"BFncb1223_CR31","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0166-2236(00)01791-4","volume":"24","author":"T Lee","year":"2001","unstructured":"Lee, T. & Luo, L. Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci. 24, 251\u2013254 (2001).","journal-title":"Trends Neurosci."},{"key":"BFncb1223_CR32","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0092-8674(00)80679-0","volume":"100","author":"DA Prober","year":"2000","unstructured":"Prober, D.A. & Edgar, B.A. Ras1 promotes cellular growth in the Drosophila wing. Cell 100, 435\u2013446 (2000).","journal-title":"Cell"},{"key":"BFncb1223_CR33","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.1101\/gad.11.19.2522","volume":"11","author":"M Polymenis","year":"1997","unstructured":"Polymenis, M. & Schmidt, E.V. Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast. Genes Dev. 11, 2522\u20132531 (1997).","journal-title":"Genes Dev."},{"key":"BFncb1223_CR34","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1242\/jcs.112.18.3137","volume":"112","author":"RR Daga","year":"1999","unstructured":"Daga, R.R. & Jimenez, J. Translational control of the cdc25 cell cycle phosphatase: a molecular mechanism coupling mitosis to cell growth. J. Cell Sci. 112, 3137\u20133146 (1999).","journal-title":"J. Cell Sci."},{"key":"BFncb1223_CR35","first-page":"1291","volume":"152","author":"M Derenzini","year":"1998","unstructured":"Derenzini, M. et al. Nucleolar function and size in cancer cells. Am. J. Pathol. 152, 1291\u20131297 (1998).","journal-title":"Am. J. Pathol."},{"key":"BFncb1223_CR36","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nrc1015","volume":"3","author":"D Ruggero","year":"2003","unstructured":"Ruggero, D. & Pandolfi, P.P. Does the ribosome translate cancer? Nature Rev. Cancer 3, 179\u2013192 (2003).","journal-title":"Nature Rev. Cancer"},{"key":"BFncb1223_CR37","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1083\/jcb.107.1.17","volume":"107","author":"JP Aris","year":"1988","unstructured":"Aris, J.P. & Blobel, G. Identification and characterization of a yeast nucleolar protein that is similar to a rat liver nucleolar protein. J. Cell Biol. 107, 17\u201331 (1988).","journal-title":"J. Cell Biol."}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb1223","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1223.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1223.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T15:26:22Z","timestamp":1684423582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb1223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,20]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["BFncb1223"],"URL":"https:\/\/doi.org\/10.1038\/ncb1223","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1024764.293740","asserted-by":"object"}]},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,20]]}}}