{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:12:31Z","timestamp":1776946351135,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,1,13]],"date-time":"2008-01-13T00:00:00Z","timestamp":1200182400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1038\/ncb1684","type":"journal-article","created":{"date-parts":[[2008,1,13]],"date-time":"2008-01-13T13:42:16Z","timestamp":1200231736000},"page":"160-169","source":"Crossref","is-referenced-by-count":176,"title":["TBL1\u2013TBLR1 and \u03b2-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis"],"prefix":"10.1038","volume":"10","author":[{"given":"Jiong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cun-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,1,13]]},"reference":[{"key":"BFncb1684_CR1","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0092-8674(00)00122-7","volume":"103","author":"M Bienz","year":"2000","unstructured":"Bienz, M. & Clevers, H. Linking colorectal cancer to Wnt signalling. Cell 103, 311\u2013320 (2000).","journal-title":"Cell"},{"key":"BFncb1684_CR2","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1101\/gad.1424006","volume":"20","author":"K Willert","year":"2006","unstructured":"Willert, K. & Jones, K. A. Wnt signalling is the party in the nucleus? Genes Dev. 20, 1394\u20131404 (2006).","journal-title":"Genes Dev."},{"key":"BFncb1684_CR3","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1126\/science.1094291","volume":"303","author":"WJ Nelson","year":"2004","unstructured":"Nelson, W. J. & Nusse, R. Convergence of Wnt, \u03b2-Catenin and cadherin pathways. Science 303, 1483\u20131487 (2004).","journal-title":"Science"},{"key":"BFncb1684_CR4","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nrg1427","volume":"5","author":"RT Moon","year":"2004","unstructured":"Moon, R. T., Kohn, A. D., De Ferrari, G. V. & Kaykas, A. WNT and \u03b2-catenin signalling: diseases and therapies. Nature Rev. Genet. 5, 691\u2013701 (2004).","journal-title":"Nature Rev. Genet."},{"key":"BFncb1684_CR5","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","volume":"275","author":"PJ Morin","year":"1997","unstructured":"Morin, P. J. et al. Activation of \u03b2-catenin\u2013Tcf signalling in colon cancer by mutations in \u03b2-catenin or APC. Science 275, 1787\u20131790 (1997).","journal-title":"Science"},{"key":"BFncb1684_CR6","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1126\/science.275.5307.1790","volume":"275","author":"B Rubinfeld","year":"1997","unstructured":"Rubinfeld, B. et al. Stabilization of \u03b2-catenin by genetic defects in melanoma cell lines. Science 275, 1790\u20131792 (1997).","journal-title":"Science"},{"key":"BFncb1684_CR7","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1126\/science.275.5307.1784","volume":"275","author":"V Korinek","year":"1997","unstructured":"Korinek, V. et al. Constitutive transcriptional activation by a \u03b2-catenin\u2013Tcf complex in APC\u2212\/\u2212 colon carcinoma. Science 275, 1784\u20131787 (1997).","journal-title":"Science"},{"key":"BFncb1684_CR8","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1126\/science.281.5382.1509","volume":"281","author":"T He","year":"1998","unstructured":"He, T. et al. Identification of c-MYC as a target of the APC pathway. Science 281, 1509\u20131512 (1998).","journal-title":"Science"},{"key":"BFncb1684_CR9","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/26989","volume":"395","author":"J Roose","year":"1998","unstructured":"Roose, J. et al. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature 395, 608\u2013612 (1998).","journal-title":"Nature"},{"key":"BFncb1684_CR10","first-page":"364","volume":"12","author":"DL Daniels","year":"2005","unstructured":"Daniels, D. L. & Weis W. I. \u03b2-catenin directly displaces Groucho\/TLE repressors from Tcf\/Lef in Wnt-mediated transcription activation. Nature Cell Biol. 12, 364\u2013371 (2005).","journal-title":"Nature Cell Biol."},{"key":"BFncb1684_CR11","doi-asserted-by":"publisher","first-page":"6882","DOI":"10.1128\/MCB.20.18.6882-6890.2000","volume":"20","author":"AN Billin","year":"2000","unstructured":"Billin, A. N. Thirlwell, H. & Ayer, D. E. \u03b2-catenin\u2013histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressors to an activator. Mol. Cell. Biol. 20, 6882\u20136890 (2000).","journal-title":"Mol. Cell. Biol."},{"key":"BFncb1684_CR12","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S0092-8674(00)00192-6","volume":"103","author":"TA Graham","year":"2000","unstructured":"Graham, T. A., Weaver, C., Mao, F., Kimelman, D. & Xu, W. Crystal structure of a \u03b2-catenin\/Tcf complex. Cell 103, 885\u2013896 (2000).","journal-title":"Cell"},{"key":"BFncb1684_CR13","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nature01611","volume":"423","author":"K Willert","year":"2004","unstructured":"Willert, K. et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423, 448\u2013452 (2004).","journal-title":"Nature"},{"key":"BFncb1684_CR14","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1242\/dev.01117","volume":"131","author":"X He","year":"2004","unstructured":"He, X., Semenov, M., Tamai, K. & Zeng, X. LDL receptor-related proteins 5 and 6 in Wnt\/\u03b2-catenin signalling: arrows point the way. Development 131, 1663\u20131677 (2004).","journal-title":"Development"},{"key":"BFncb1684_CR15","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1101\/gad.1385806","volume":"20","author":"J Sierra","year":"2006","unstructured":"Sierra, J., Yoshida, T., Joazeiro, C. & Jones, K. A. The APC tumor suppressor counteracts \u03b2-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev. 20, 586\u2013600 (2006).","journal-title":"Genes Dev."},{"key":"BFncb1684_CR16","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.cell.2006.01.053","volume":"125","author":"C Mosimann","year":"2006","unstructured":"Mosimann, C., Hausmann, G. & Basler, K. Parafibromin\/hyrax Activates Wnt\/Wg target gene transcription by direct association with \u03b2-catenin\/armadillo. Cell 125, 327\u2013341 (2006).","journal-title":"Cell"},{"key":"BFncb1684_CR17","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0092-8674(02)00679-7","volume":"109","author":"T Kramps","year":"2002","unstructured":"Kramps, T. et al. Wnt\/Wingless signalling requires BCL9\/Legless-mediated recruitment of pygopus to the nuclear \u03b2-catenin\u2013TCF complex. Cell 109, 47\u201360 (2002).","journal-title":"Cell"},{"key":"BFncb1684_CR18","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/S1097-2765(01)00242-8","volume":"7","author":"SI Matsuzawa","year":"2001","unstructured":"Matsuzawa, S. I. & Reed, J. C. Siah-1, SIP, and Ebi collaborate in a novel pathway for \u03b2-catenin degradation linked to p53 responses. Mol. Cell 7, 915\u2013926 (2001).","journal-title":"Mol. Cell"},{"key":"BFncb1684_CR19","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1101\/gad.1424806","volume":"20","author":"MG Rosenfeld","year":"2006","unstructured":"Rosenfeld, M. G., Lunyak, V. V. & Glass, C. K. Sensors and signals: a coactivator\/corepressor\/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev. 20, 1405\u20131428 (2006).","journal-title":"Genes Dev."},{"key":"BFncb1684_CR20","doi-asserted-by":"publisher","first-page":"4935","DOI":"10.1093\/emboj\/20.17.4935","volume":"20","author":"N Barker","year":"2001","unstructured":"Barker, N. et al. The chromatin remodelling factor Brg-1 interacts with \u03b2-catenin to promote target gene activation. EMBO J. 20, 4935\u20134943 (2001).","journal-title":"EMBO J."},{"key":"BFncb1684_CR21","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S0092-8674(02)00875-9","volume":"110","author":"L Tsuda","year":"2002","unstructured":"Tsuda, L., Nagaraj, R., Zipursky, S. L. & Banerjee, U. An EGFR\/Ebi\/Sno pathway promotes delta expression by inactivating Su(H)\/SMRTER repression during inductive notch signalling. Cell 110, 625\u2013637 (2002).","journal-title":"Cell"},{"key":"BFncb1684_CR22","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1093\/emboj\/cdg120","volume":"22","author":"HG Yoon","year":"2003","unstructured":"Yoon, H. G. et al. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J. 22, 1336\u20131346 (2003).","journal-title":"EMBO J."},{"key":"BFncb1684_CR23","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1128\/MCB.25.1.324-335.2005","volume":"25","author":"HG Yoon","year":"2005","unstructured":"Yoon, H. G., Choi, Y., Cole, P. A. & Wong, J. Reading and function of a histone code involved in targeting corepressor complexes for repression. Mol. Cell. Biol. 25, 324\u2013335 (2005).","journal-title":"Mol. Cell. Biol."},{"key":"BFncb1684_CR24","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S0092-8674(04)00133-3","volume":"116","author":"V Perissi","year":"2004","unstructured":"Perissi, V., Aggarwal, A., Glass, C. K., Rose, D. W. & Rosenfeld, M. G. A corepressor\/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell 116, 511\u2013526 (2004).","journal-title":"Cell"},{"key":"BFncb1684_CR25","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/S1097-2765(01)00224-6","volume":"7","author":"J Mao","year":"2001","unstructured":"Mao, J. Low-density lipoprotein receptor-related protein-5 binds to axin and regulates the canonical Wnt signalling pathway. Mol. Cell 7, 801\u2013809 (2001).","journal-title":"Mol. Cell"},{"key":"BFncb1684_CR26","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/35001615","volume":"403","author":"W Zeng","year":"1998","unstructured":"Zeng, W. et al. naked cuticle encodes an inducible antagonist of Wnt signalling Nature 403, 789\u2013795 (1998).","journal-title":"Nature"},{"key":"BFncb1684_CR27","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1038\/sj.emboj.7601153","volume":"25","author":"M Fang","year":"2006","unstructured":"Fang, M., Li, J., Blauwkamp, T., Bhambhani, C., Campbell, N. & Cadigan, K. M. C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila. EMBO J. 25, 2735\u20132745 (2006).","journal-title":"EMBO J."},{"key":"BFncb1684_CR28","doi-asserted-by":"publisher","first-page":"21657","DOI":"10.1074\/jbc.M200139200","volume":"277","author":"JY Leung","year":"2002","unstructured":"Leung, J. Y. et al. Activation of AXIN2 expression by \u03b2-catenin-T cell factor. A feedback repressor pathway regulating Wnt signalling. J. Biol. Chem. 277, 21657\u201321665 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFncb1684_CR29","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1128\/MCB.22.4.1184-1193.2002","volume":"22","author":"B Lustig","year":"2002","unstructured":"Lustig, B. et al. Negative feedback loop of Wnt signalling through upregulation of conductin\/axin2 in colorectal and liver tumors. Mol. Cell. Biol. 22, 1184\u20131193 (2002).","journal-title":"Mol. Cell. Biol."},{"key":"BFncb1684_CR30","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1128\/MCB.22.4.1172-1183.2002","volume":"22","author":"EH Jho","year":"2002","unstructured":"Jho, E. H. et al. Wnt\/\u03b2-catenin\/Tcf signalling induces the transcription of Axin2, a negative regulator of the signalling pathway. Mol. Cell. Biol. 22, 1172\u20131183 (2002).","journal-title":"Mol. Cell. Biol."},{"key":"BFncb1684_CR31","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1093\/emboj\/cdg105","volume":"22","author":"R Rosin-Arbesfeld","year":"2003","unstructured":"Rosin-Arbesfeld, R., Cliffe, A., Brabletz, T. & Bienz, M. Nuclear export of the APC tumour suppressor controls \u03b2-catenin function in transcription. EMBO J. 22, 1101\u20131113 (2003).","journal-title":"EMBO J."},{"key":"BFncb1684_CR32","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/ncb1141","volume":"6","author":"FM Townsley","year":"2004","unstructured":"Townsley, F. M., Cliffem A. & Bienz, M. Pygopus and Legless target Armadillo\/\u03b2-catenin to the nucleus to enable its transcriptional co-activator function. Nature Cell Biol. 6, 626\u2013633 (2004).","journal-title":"Nature Cell Biol."},{"key":"BFncb1684_CR33","doi-asserted-by":"publisher","first-page":"7950","DOI":"10.1073\/pnas.93.15.7950","volume":"93","author":"PJ Morin","year":"1996","unstructured":"Morin, P. J., Vogelstein, B. & Kinzler, K. W. Apoptosis and APC in colorectal tumorigenesis. Proc. Natl Acad. Sci. USA 93, 7950\u20137954 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb1684_CR34","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S1535-6108(02)00035-1","volume":"1","author":"FT Kolligs","year":"2002","unstructured":"Kolligs, F. T. et al. ITF-2, a downstream target of the Wnt\/TCF pathway, is activated in human cancers with \u03b2-catenin defects and promotes neoplastic transformation. Cancer Cell 1, 145\u2013155 (2002).","journal-title":"Cancer Cell"},{"key":"BFncb1684_CR35","first-page":"53","volume":"28","author":"K Hovanes","year":"2001","unstructured":"Hovanes, K. et al. \u03b2-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Nature Genet. 28, 53\u201357 (2001).","journal-title":"Nature Genet."},{"key":"BFncb1684_CR36","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1083\/jcb.200201110","volume":"157","author":"Z You","year":"2002","unstructured":"You, Z. et al. Wnt signalling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J. Cell Biol. 157, 429\u2013440 (2002).","journal-title":"J. Cell Biol."},{"key":"BFncb1684_CR37","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1083\/jcb.152.1.87","volume":"152","author":"S Chen","year":"2001","unstructured":"Chen, S. et al. Wnt-1 signalling inhibits apoptosis by activating \u03b2-catenin\/T cell factor-mediated transcription. J. Cell Biol. 152, 87\u201396 (2001).","journal-title":"J. Cell Biol."},{"key":"BFncb1684_CR38","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.cellsig.2005.06.015","volume":"18","author":"F Yang","year":"2006","unstructured":"Yang, F., Zeng, Q., Yu, G., Li, S. & Wang, C. Y. Wnt\/\u03b2-catenin signalling inhibits death receptor-mediated apoptosis and promotes invasive growth of HNSCC. Cell Signal. 18, 679\u2013687 (2006).","journal-title":"Cell Signal."},{"key":"BFncb1684_CR39","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1126\/science.1109374","volume":"308","author":"R DasGupta","year":"2005","unstructured":"DasGupta, R., Kaykas, A., Moon, R. T. & Perrimon, N. Functional genomic analysis of the Wnt\u2013wingless signalling pathway. Science 308, 826\u2013833 (2005).","journal-title":"Science"},{"key":"BFncb1684_CR40","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/nature04185","volume":"438","author":"X Zeng","year":"2005","unstructured":"Zeng, X. et al. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 438, 873\u2013877 (2005).","journal-title":"Nature"},{"key":"BFncb1684_CR41","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/nature04170","volume":"438","author":"G Davidson","year":"2005","unstructured":"Davidson, G. et al. Casein kinase 1 \u03b3 couples Wnt receptor activation to cytoplasmic signal transduction. Nature 438, 867\u2013872 (2005).","journal-title":"Nature"}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb1684.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1684","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1684.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T15:30:51Z","timestamp":1684423851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb1684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,13]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["BFncb1684"],"URL":"https:\/\/doi.org\/10.1038\/ncb1684","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1104187.560181","asserted-by":"object"}]},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,13]]}}}