{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:20:30Z","timestamp":1776108030854,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T00:00:00Z","timestamp":1212105600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1038\/ncb1745","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T08:07:56Z","timestamp":1212134876000},"page":"849-857","source":"Crossref","is-referenced-by-count":96,"title":["WAVE and Arp2\/3 jointly inhibit filopodium formation by entering into a complex with mDia2"],"prefix":"10.1038","volume":"10","author":[{"given":"Petra","family":"Beli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Mascheroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Metello","family":"Innocenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,5,30]]},"reference":[{"key":"BFncb1745_CR1","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1126\/science.280.5372.2074","volume":"280","author":"A Hall","year":"1998","unstructured":"Hall, A. G proteins and small GTPases: distant relatives keep in touch. Science 280, 2074\u20132075 (1998).","journal-title":"Science"},{"key":"BFncb1745_CR2","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/S0092-8674(03)00120-X","volume":"112","author":"TD Pollard","year":"2003","unstructured":"Pollard, T. D. & Borisy, G. G. Cellular motility driven by assembly and disassembly of actin filaments. Cell 112, 453\u2013465 (2003).","journal-title":"Cell"},{"key":"BFncb1745_CR3","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1083\/jcb.200210174","volume":"160","author":"TM Svitkina","year":"2003","unstructured":"Svitkina, T. M. et al. Mechanism of filopodia initiation by reorganization of a dendritic network. J. Cell Biol. 160, 409\u2013421 (2003).","journal-title":"J. Cell Biol."},{"key":"BFncb1745_CR4","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1146\/annurev.biophys.35.040405.101936","volume":"36","author":"TD Pollard","year":"2007","unstructured":"Pollard, T. D. Regulation of actin filament assembly by Arp2\/3 complex and formins. Annu. Rev. Biophys. Biomol. Struct. 36, 451\u2013477 (2007).","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"BFncb1745_CR5","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/S0959-440X(02)00396-2","volume":"12","author":"TD Pollard","year":"2002","unstructured":"Pollard, T. D. & Beltzner, C. C. Structure and function of the Arp2\/3 complex. Curr. Opin. Struct. Biol. 12, 768\u2013774 (2002).","journal-title":"Curr. Opin. Struct. Biol."},{"key":"BFncb1745_CR6","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1146\/annurev.biochem.70.1.649","volume":"70","author":"HN Higgs","year":"2001","unstructured":"Higgs, H. N. & Pollard, T. D. Regulation of actin filament network formation through ARP2\/3 complex: activation by a diverse array of proteins. Annu. Rev. Biochem. 70, 649\u2013676 (2001).","journal-title":"Annu. Rev. Biochem."},{"key":"BFncb1745_CR7","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S1631-0691(03)00067-2","volume":"326","author":"MF Carlier","year":"2003","unstructured":"Carlier, M. F., Wiesner, S., Le Clainche, C. & Pantaloni, D. Actin-based motility as a self-organized system: mechanism and reconstitution in vitro. C. R. Biol. 326, 161\u2013170 (2003).","journal-title":"C. R. Biol."},{"key":"BFncb1745_CR8","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1074\/jbc.M006205200","volume":"276","author":"AS Alberts","year":"2001","unstructured":"Alberts, A. S. Identification of a carboxyl-terminal diaphanous-related formin homology protein autoregulatory domain. J. Biol. Chem. 276, 2824\u20132830 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFncb1745_CR9","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/nature03251","volume":"433","author":"T Otomo","year":"2005","unstructured":"Otomo, T. et al. Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain. Nature 433, 488\u2013494 (2005).","journal-title":"Nature"},{"key":"BFncb1745_CR10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ceb.2003.10.019","volume":"16","author":"SH Zigmond","year":"2004","unstructured":"Zigmond, S. H. Formin-induced nucleation of actin filaments. Curr. Opin. Cell Biol. 16, 99\u2013105 (2004).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFncb1745_CR11","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.cell.2004.09.039","volume":"119","author":"S Romero","year":"2004","unstructured":"Romero, S. et al. Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis. Cell 119, 419\u2013429 (2004).","journal-title":"Cell"},{"key":"BFncb1745_CR12","doi-asserted-by":"publisher","first-page":"R520","DOI":"10.1016\/j.cub.2004.06.043","volume":"14","author":"ES Harris","year":"2004","unstructured":"Harris, E. S. & Higgs, H. N. Actin cytoskeleton: formins lead the way. Curr. Biol. 14, R520\u2013R522 (2004).","journal-title":"Curr. Biol."},{"key":"BFncb1745_CR13","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/S0960-9822(03)00170-2","volume":"13","author":"J Peng","year":"2003","unstructured":"Peng, J., Wallar, B. J., Flanders, A., Swiatek, P. J. & Alberts, A. S. Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42. Curr. Biol. 13, 534\u2013545 (2003).","journal-title":"Curr. Biol."},{"key":"BFncb1745_CR14","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/ncb1105","volume":"6","author":"M Innocenti","year":"2004","unstructured":"Innocenti, M. et al. Abi1 is essential for the formation and activation of a WAVE2 signalling complex. Nature Cell Biol. 6, 319\u2013327 (2004).","journal-title":"Nature Cell Biol."},{"key":"BFncb1745_CR15","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1091\/mbc.e05-10-0955","volume":"17","author":"L Vidali","year":"2006","unstructured":"Vidali, L., Chen, F., Cicchetti, G., Ohta, Y. & Kwiatkowski, D. J. Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol. Biol. Cell 17, 2377\u20132390 (2006).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb1745_CR16","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/ncb1304","volume":"7","author":"M Innocenti","year":"2005","unstructured":"Innocenti, M. et al. Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes. Nature Cell Biol. 7, 969\u2013976 (2005).","journal-title":"Nature Cell Biol."},{"key":"BFncb1745_CR17","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/sj.emboj.7600084","volume":"23","author":"A Steffen","year":"2004","unstructured":"Steffen, A. et al. Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. EMBO J. 23, 749\u2013759 (2004).","journal-title":"EMBO J."},{"key":"BFncb1745_CR18","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.cub.2005.01.011","volume":"15","author":"S Pellegrin","year":"2005","unstructured":"Pellegrin, S. & Mellor, H. The Rho family GTPase Rif induces filopodia through mDia2. Curr. Biol. 15, 129\u2013133 (2005).","journal-title":"Curr. Biol."},{"key":"BFncb1745_CR19","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/nature01770","volume":"424","author":"D Yamazaki","year":"2003","unstructured":"Yamazaki, D. et al. WAVE2 is required for directed cell migration and cardiovascular development. Nature 424, 452\u2013456 (2003).","journal-title":"Nature"},{"key":"BFncb1745_CR20","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nature00859","volume":"418","author":"S Eden","year":"2002","unstructured":"Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M. & Kirschner, M. W. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 418, 790\u2013793 (2002).","journal-title":"Nature"},{"key":"BFncb1745_CR21","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/ncb1001-897","volume":"3","author":"SB Snapper","year":"2001","unstructured":"Snapper, S. B. et al. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nature Cell Biol. 3, 897\u2013904 (2001).","journal-title":"Nature Cell Biol."},{"key":"BFncb1745_CR22","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/35020106","volume":"406","author":"EA Clark","year":"2000","unstructured":"Clark, E. A., Golub, T. R., Lander, E. S. & Hynes, R. O. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406, 532\u2013535 (2000).","journal-title":"Nature"},{"key":"BFncb1745_CR23","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1091\/mbc.e05-11-1088","volume":"17","author":"A Steffen","year":"2006","unstructured":"Steffen, A. et al. Filopodia formation in the absence of functional WAVE- and Arp2\/3-complexes. Mol. Biol. Cell 17, 2581\u20132591 (2006).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb1745_CR24","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1083\/jcb.200603013","volume":"174","author":"D Vignjevic","year":"2006","unstructured":"Vignjevic, D. et al. Role of fascin in filopodial protrusion. J. Cell Biol. 174, 863\u2013875 (2006).","journal-title":"J. Cell Biol."},{"key":"BFncb1745_CR25","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1006\/bbrc.1999.0894","volume":"260","author":"S Suetsugu","year":"1999","unstructured":"Suetsugu, S., Miki, H. & Takenawa, T. Identification of two human WAVE\/SCAR homologues as general actin regulatory molecules which associate with the Arp2\/3 complex. Biochem. Biophys. Res. Commun. 260, 296\u2013302 (1999).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFncb1745_CR26","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.cub.2007.03.024","volume":"17","author":"KM Eisenmann","year":"2007","unstructured":"Eisenmann, K. M. et al. Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex. Curr. Biol. 17, 579\u2013591 (2007).","journal-title":"Curr. Biol."},{"key":"BFncb1745_CR27","doi-asserted-by":"publisher","first-page":"e317","DOI":"10.1371\/journal.pbio.0050317","volume":"5","author":"C Yang","year":"2007","unstructured":"Yang, C. et al. Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells. PLoS Biol. 5, e317 (2007).","journal-title":"PLoS Biol."},{"key":"BFncb1745_CR28","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ceb.2005.11.002","volume":"18","author":"J Faix","year":"2006","unstructured":"Faix, J. & Rottner, K. The making of filopodia. Curr. Opin. Cell Biol. 18, 18\u201325 (2006).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFncb1745_CR29","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1242\/jcs.02285","volume":"118","author":"H Bierne","year":"2005","unstructured":"Bierne, H. et al. WASP-related proteins, Abi1 and Ena\/VASP are required for Listeria invasion induced by the Met receptor. J. Cell Sci. 118, 1537\u20131547 (2005).","journal-title":"J. Cell Sci."}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb1745.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1745","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1745.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T15:31:28Z","timestamp":1684423888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb1745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,30]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["BFncb1745"],"URL":"https:\/\/doi.org\/10.1038\/ncb1745","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1115282.571288","asserted-by":"object"}]},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,30]]}}}