{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:33:16Z","timestamp":1779345196281,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2001,12,21]],"date-time":"2001-12-21T00:00:00Z","timestamp":1008892800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2002,2]]},"DOI":"10.1038\/ncb740","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:30:32Z","timestamp":1027657832000},"page":"106-110","source":"Crossref","is-referenced-by-count":130,"title":["Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus"],"prefix":"10.1038","volume":"4","author":[{"given":"Masafumi","family":"Muratani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gerlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Janicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Gebhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Eils","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Spector","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2001,12,21]]},"reference":[{"key":"BFncb740_CR1","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1242\/jcs.114.16.2891","volume":"114","author":"DL Spector","year":"2001","unstructured":"Spector, D. L. Nuclear bodies. J. Cell Sci. 114, 2891\u20132893 (2001).","journal-title":"J. Cell Sci."},{"key":"BFncb740_CR2","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/0092-8674(94)90340-9","volume":"76","author":"JA Dyck","year":"1994","unstructured":"Dyck, J. A. et al. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell 76, 333\u2013343 (1994).","journal-title":"Cell"},{"key":"BFncb740_CR3","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1002\/j.1460-2075.1994.tb06356.x","volume":"13","author":"MH Koken","year":"1994","unstructured":"Koken, M. H. et al. The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. EMBO J. 13, 1073\u20131083 (1994).","journal-title":"EMBO J."},{"key":"BFncb740_CR4","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1242\/jcs.101.4.773","volume":"101","author":"N Stuurman","year":"1992","unstructured":"Stuurman, N. et al. A monoclonal antibody recognizing nuclear matrix-associated nuclear bodies. J. Cell Sci. 101, 773\u2013784 (1992).","journal-title":"J. Cell Sci."},{"key":"BFncb740_CR5","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/0092-8674(94)90341-7","volume":"76","author":"K Weis","year":"1994","unstructured":"Weis, K. et al. Retinoic acid regulates aberrant nuclear localization of PML-RAR\u03b1 in acute promyelocytic leukemia cells. Cell 76, 345\u2013356 (1994).","journal-title":"Cell"},{"key":"BFncb740_CR6","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1002\/(SICI)1521-1878(199808)20:8<660::AID-BIES9>3.0.CO;2-M","volume":"20","author":"GG Maul","year":"1998","unstructured":"Maul, G. G. Nuclear domain 10, the site of DNA virus transcription and replication. Bioessays 20, 660\u2013667 (1998).","journal-title":"Bioessays"},{"key":"BFncb740_CR7","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1002\/jcb.240590410","volume":"59","author":"GG Maul","year":"1995","unstructured":"Maul, G. G., Yu, E., Ishov, A. M. & Epstein, A. L. Nuclear domain 10 (ND10) associated proteins are also present in nuclear bodies and redistribute to hundreds of nuclear sites after stress. J. Cell. Biochem. 59, 498\u2013513 (1995).","journal-title":"J. Cell. Biochem."},{"key":"BFncb740_CR8","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.4049\/jimmunol.149.12.4067","volume":"149","author":"HH Guldner","year":"1992","unstructured":"Guldner, H. H., Szostecki, C., Grotzinger, T. & Will, H. IFN enhance expression of Sp100, an autoantigen in primary biliary cirrhosis. J. Immunol. 149, 4067\u20134073 (1992).","journal-title":"J. Immunol."},{"key":"BFncb740_CR9","first-page":"2565","volume":"11","author":"M Stadler","year":"1995","unstructured":"Stadler, M. et al. Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene 11, 2565\u20132573 (1995).","journal-title":"Oncogene"},{"key":"BFncb740_CR10","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1099\/0022-1317-74-12-2679","volume":"74","author":"GG Maul","year":"1993","unstructured":"Maul, G. G., Guldner, H. H. & Spivack, J. G. Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0). J. Gen. Virol. 74, 2679\u20132690 (1993).","journal-title":"J. Gen. Virol."},{"key":"BFncb740_CR11","doi-asserted-by":"publisher","first-page":"E85","DOI":"10.1038\/35010583","volume":"2","author":"S Zhong","year":"2000","unstructured":"Zhong, S., Salomoni, P. & Pandolfi, P. P. The transcriptional role of PML and the nuclear body. Nature Cell Biol. 2, E85\u2013E90 (2000).","journal-title":"Nature Cell Biol."},{"key":"BFncb740_CR12","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1242\/jcs.112.20.3443","volume":"112","author":"RD Everett","year":"1999","unstructured":"Everett, R. D. et al. A dynamic connection between centromeres and ND10 proteins. J. Cell Sci. 112, 3443\u20133454 (1999).","journal-title":"J. Cell Sci."},{"key":"BFncb740_CR13","first-page":"2027","volume":"9","author":"MK Chelbi-Alix","year":"1995","unstructured":"Chelbi-Alix, M. K. et al. Induction of the PML protein by interferons in normal and APL cells. Leukemia 9, 2027\u20132033 (1995).","journal-title":"Leukemia"},{"key":"BFncb740_CR14","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/35046510","volume":"2","author":"T Tsukamoto","year":"2000","unstructured":"Tsukamoto, T. et al. Visualization of gene activity in living cells. Nature Cell Biol. 2, 871\u2013878 (2000).","journal-title":"Nature Cell Biol."},{"key":"BFncb740_CR15","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/387523a0","volume":"387","author":"T Misteli","year":"1997","unstructured":"Misteli, T., C\u00e1ceres, J. F. & Spector, D. L. The dynamics of a pre-mRNA splicing factor in living cells. Nature 387, 523\u2013527 (1997).","journal-title":"Nature"},{"key":"BFncb740_CR16","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1083\/jcb.151.7.1561","volume":"151","author":"M Platani","year":"2000","unstructured":"Platani, M., Goldberg, I., Swedlow, J. R. & Lamond, A. I. In vivo analysis of Cajal body movement, separation, and joining in live human cells. J. Cell Biol. 151, 1561\u20131574 (2000).","journal-title":"J. Cell Biol."},{"key":"BFncb740_CR17","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1007\/s004120000073","volume":"109","author":"D Plehn-Dujowich","year":"2000","unstructured":"Plehn-Dujowich, D., Bell, P., Ishov, A. M., Baumann, C. & Maul, G. G. Non-apoptotic chromosome condensation induced by stress: delineation of interchromosomal spaces. Chromosoma 109, 266\u2013279 (2000).","journal-title":"Chromosoma"},{"key":"BFncb740_CR18","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1083\/jcb.112.5.785","volume":"112","author":"CA Ascoli","year":"1991","unstructured":"Ascoli, C. A. & Maul, G. G. Identification of a novel nuclear domain. J. Cell Biol. 112, 785\u2013795 (1991).","journal-title":"J. Cell Biol."},{"key":"BFncb740_CR19","doi-asserted-by":"publisher","first-page":"7950","DOI":"10.1073\/pnas.96.14.7950","volume":"96","author":"W Tvarusko","year":"1999","unstructured":"Tvarusko, W. et al. Time-resolved analysis and visualization of dynamic processes in living cells. Proc. Natl Acad. Sci. USA 96, 7950\u20137955 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb740_CR20","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/0092-8674(88)90403-5","volume":"52","author":"WD Richardson","year":"1988","unstructured":"Richardson, W. D., Mills, A. D., Dilworth, S. M., Laskey, R. A. & Dingwall, C. Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores. Cell 52, 655\u2013664 (1988).","journal-title":"Cell"},{"key":"BFncb740_CR21","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.1002\/j.1460-2075.1991.tb04954.x","volume":"10","author":"A Guiochon-Mantel","year":"1991","unstructured":"Guiochon-Mantel, A. et al. Nucleocytoplasmic shuttling of the progesterone receptor. EMBO J. 10, 3851\u20133859 (1991).","journal-title":"EMBO J."},{"key":"BFncb740_CR22","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/35007077","volume":"404","author":"RD Phair","year":"2000","unstructured":"Phair, R. D. & Misteli, T. High mobility of proteins in the mammalian cell nucleus. Nature 404, 604\u2013609 (2000).","journal-title":"Nature"},{"key":"BFncb740_CR23","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S0092-8674(00)81633-5","volume":"95","author":"K Zhao","year":"1998","unstructured":"Zhao, K. et al. Rapid and phosphoinositol-dependent binding of the SWI\/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell 95, 625\u2013636 (1998).","journal-title":"Cell"},{"key":"BFncb740_CR24","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/S0962-8924(99)01713-4","volume":"10","author":"OJ Rando","year":"2000","unstructured":"Rando, O. J., Zhao, K. & Crabtree, G. R. Searching for a function for nuclear actin. Trends Cell Biol. 10, 92\u201397 (2000).","journal-title":"Trends Cell Biol."},{"key":"BFncb740_CR25","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1091\/mbc.11.3.799","volume":"11","author":"T Pederson","year":"2000","unstructured":"Pederson, T. Half a century of \u201cthe nuclear matrix\u201d. Mol. Biol. Cell 11, 799\u2013805 (2000).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb740_CR26","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1126\/science.290.5490.337","volume":"290","author":"L Pestic-Dragovich","year":"2000","unstructured":"Pestic-Dragovich, L. et al. A myosin I isoform in the nucleus. Science 290, 337\u2013341 (2000).","journal-title":"Science"},{"key":"BFncb740_CR27","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1083\/jcb.131.1.179","volume":"131","author":"LP Cramer","year":"1995","unstructured":"Cramer, L. P. & Mitchison, T. J. Myosin is involved in postmitotic cell spreading. J. Cell Biol. 131, 179\u2013189 (1995).","journal-title":"J. Cell Biol."},{"key":"BFncb740_CR28","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S0171-9335(98)80087-3","volume":"77","author":"G Steinberg","year":"1998","unstructured":"Steinberg, G. & McIntosh, J. R. Effects of the myosin inhibitor 2,3-butanedione monoxime on the physiology of fission yeast. Eur. J. Cell Biol. 77, 284\u2013293 (1998).","journal-title":"Eur. J. Cell Biol."},{"key":"BFncb740_CR29","doi-asserted-by":"publisher","first-page":"7316","DOI":"10.1073\/pnas.95.13.7316","volume":"95","author":"JS Seeler","year":"1998","unstructured":"Seeler, J. S., Marchio, A., Sitterlin, D., Transy, C. & Dejean, A. Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. Proc. Natl Acad. Sci. USA 95, 7316\u20137321 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb740_CR30","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1002\/(SICI)1097-4644(19961201)63:3<280::AID-JCB3>3.0.CO;2-T","volume":"63","author":"MA Grande","year":"1996","unstructured":"Grande, M. A. et al. PML-containing nuclear bodies: their spatial distribution in relation to other nuclear components. J. Cell Biochem. 63, 280\u2013291 (1996).","journal-title":"J. Cell Biochem."},{"key":"BFncb740_CR31","first-page":"871","volume":"11","author":"C Lavau","year":"1995","unstructured":"Lavau, C. et al. The acute promyelocytic leukaemia-associated PML gene is induced by interferon. Oncogene 11, 871\u2013876 (1995).","journal-title":"Oncogene"},{"key":"BFncb740_CR32","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1083\/jcb.139.7.1621","volume":"139","author":"T Sternsdorf","year":"1997","unstructured":"Sternsdorf, T., Jensen, K. & Will, H. Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1\/SUMO-1. J. Cell Biol. 139, 1621\u20131634 (1997).","journal-title":"J. Cell Biol."},{"key":"BFncb740_CR33","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1093\/emboj\/16.7.1519","volume":"16","author":"RD Everett","year":"1997","unstructured":"Everett, R. D. et al. A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein. EMBO J. 16, 1519\u20131530 (1997).","journal-title":"EMBO J."},{"key":"BFncb740_CR34","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1242\/jcs.111.10.1319","volume":"111","author":"T Cao","year":"1998","unstructured":"Cao, T., Duprez, E., Borden, K. L., Freemont, P. S. & Etkin, L. D. Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. J. Cell Sci. 111, 1319\u20131329 (1998).","journal-title":"J. Cell Sci."},{"key":"BFncb740_CR35","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1126\/science.291.5505.843","volume":"291","author":"T Misteli","year":"2001","unstructured":"Misteli, T. Protein dynamics: implications for nuclear architecture and gene expression. Science 291, 843\u2013847 (2001).","journal-title":"Science"},{"key":"BFncb740_CR36","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0092-8674(01)00258-6","volume":"104","author":"T Pederson","year":"2001","unstructured":"Pederson, T. Protein mobility within the nucleus\u2014what are the right moves? Cell 104, 635\u2013638 (2001).","journal-title":"Cell"},{"key":"BFncb740_CR37","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/S0960-9822(06)00412-X","volume":"7","author":"WF Marshall","year":"1997","unstructured":"Marshall, W. F. et al. Interphase chromosomes undergo constrained diffusional motion in living cells. Curr. Biol. 7, 930\u2013939 (1997).","journal-title":"Curr. Biol."},{"key":"BFncb740_CR38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/35050515","volume":"3","author":"DL Stenoien","year":"2001","unstructured":"Stenoien, D. L. et al. FRAP reveals that mobility of oestrogen receptor-\u03b1 is ligand- and proteasome-dependent. Nature Cell Biol. 3, 15\u201323 (2001).","journal-title":"Nature Cell Biol."},{"key":"BFncb740_CR39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1242\/jcs.114.1.59","volume":"114","author":"D Negorev","year":"2001","unstructured":"Negorev, D., Ishov, A. M. & Maul, G. G. Evidence for separate ND10-binding and homo-oligomerization domains of Sp100. J. Cell Sci. 114, 59\u201368 (2001).","journal-title":"J. Cell Sci."},{"key":"BFncb740_CR40","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1091\/mbc.11.2.413","volume":"11","author":"R Eils","year":"2000","unstructured":"Eils, R., Gerlich, D., Tvarusko, W., Spector, D. L. & Misteli, T. Quantitative imaging of pre-mRNA splicing factors in living cells. Mol. Biol. Cell 11, 413\u2013418 (2000).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb740_CR41","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1126\/science.1065366","volume":"294","author":"P Heun","year":"2001","unstructured":"Heun, P., Laroche, T., Shimada, K., Furrer, P. & Gasser, S.M. Chromosome dynamics in the yeast interphase nucleus. Science 294, 2181\u20132186 (2001).","journal-title":"Science"}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb740.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb740","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb740.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T15:50:36Z","timestamp":1684425036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,21]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["BFncb740"],"URL":"https:\/\/doi.org\/10.1038\/ncb740","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1003594.38954","asserted-by":"object"}]},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,21]]}}}