{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:36:19Z","timestamp":1772134579919,"version":"3.50.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2002,4,22]],"date-time":"2002-04-22T00:00:00Z","timestamp":1019433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1038\/ncb786","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:54:57Z","timestamp":1027659297000},"page":"367-373","source":"Crossref","is-referenced-by-count":249,"title":["A new nuclear component of the Wnt signalling pathway"],"prefix":"10.1038","volume":"4","author":[{"given":"Barry","family":"Thompson","sequence":"first","affiliation":[]},{"given":"Fiona","family":"Townsley","sequence":"additional","affiliation":[]},{"given":"Rina","family":"Rosin-Arbesfeld","sequence":"additional","affiliation":[]},{"given":"Hannah","family":"Musisi","sequence":"additional","affiliation":[]},{"given":"Mariann","family":"Bienz","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2002,4,22]]},"reference":[{"key":"BFncb786_CR1","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.1101\/gad.11.24.3286","volume":"11","author":"KM Cadigan","year":"1997","unstructured":"Cadigan, K. M. & Nusse, R. Wnt signaling: a common theme in animal development. Genes Dev. 11, 3286\u20133305 (1997).","journal-title":"Genes Dev."},{"key":"BFncb786_CR2","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/0092-8674(94)90351-4","volume":"76","author":"N Perrimon","year":"1994","unstructured":"Perrimon, N. The genetic basis of patterned baldness in Drosophila. Cell 76, 781\u2013784 (1994).","journal-title":"Cell"},{"key":"BFncb786_CR3","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1101\/gad.10.20.2527","volume":"10","author":"JR Miller","year":"1996","unstructured":"Miller, J. R. & Moon, R. T. Signal transduction through \u03b2-catenin and specification of cell fate during embryogenesis. Genes Dev. 10, 2527\u20132539 (1996).","journal-title":"Genes Dev."},{"key":"BFncb786_CR4","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1101\/gad.14.15.1837","volume":"14","author":"P Polakis","year":"2000","unstructured":"Polakis, P. Wnt signaling and cancer. Genes Dev. 14, 1837\u20131851 (2000).","journal-title":"Genes Dev."},{"key":"BFncb786_CR5","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0092-8674(00)00122-7","volume":"103","author":"M Bienz","year":"2000","unstructured":"Bienz, M. & Clevers, H. Linking colorectal cancer to Wnt signaling. Cell 103, 311\u2013320 (2000).","journal-title":"Cell"},{"key":"BFncb786_CR6","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","volume":"275","author":"PJ Morin","year":"1997","unstructured":"Morin, P. J. et al. Activation of \u03b2-catenin-Tcf signaling in colon cancer by mutations in \u03b2-catenin or APC. Science 275, 1787\u20131790 (1997).","journal-title":"Science"},{"key":"BFncb786_CR7","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/embo-reports\/kve019","volume":"2","author":"M Freeman","year":"2001","unstructured":"Freeman, M. & Bienz, M. EGF receptor\/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye. EMBO Rep. 2, 157\u2013162 (2001).","journal-title":"EMBO Rep."},{"key":"BFncb786_CR8","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/0012-1606(88)90062-0","volume":"125","author":"NE Baker","year":"1988","unstructured":"Baker, N. E. Embryonic and imaginal requirements for wingless, a segment-polarity gene in Drosophila. Dev. Biol. 125, 96\u2013108 (1988).","journal-title":"Dev. Biol."},{"key":"BFncb786_CR9","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1242\/dev.111.4.1029","volume":"111","author":"M Peifer","year":"1991","unstructured":"Peifer, M., Rauskolb, C., Williams, M., Riggleman, B. & Wieschaus, E. The segment polarity gene armadillo interacts with the Wingless signaling pathway in both embryonic and adult pattern formation. Development 111, 1029\u20131043 (1991).","journal-title":"Development"},{"key":"BFncb786_CR10","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/S0092-8674(00)81925-X","volume":"88","author":"M van de Wetering","year":"1997","unstructured":"van de Wetering, M. et al. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88, 789\u2013799 (1997).","journal-title":"Cell"},{"key":"BFncb786_CR11","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/385829a0","volume":"385","author":"E Brunner","year":"1997","unstructured":"Brunner, E., Peter, O., Schweizer, L. & Basler, K. Pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila. Nature 385, 829\u2013833 (1997).","journal-title":"Nature"},{"key":"BFncb786_CR12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1242\/dev.118.2.427","volume":"118","author":"RG Phillips","year":"1993","unstructured":"Phillips, R. G. & Whittle, J. R. Wingless expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development. Development 118, 427\u2013438 (1993).","journal-title":"Development"},{"key":"BFncb786_CR13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1242\/dev.120.3.621","volume":"120","author":"JP Couso","year":"1994","unstructured":"Couso, J. P., Bishop, S. A. & Martinez Arias, A. The Wingless signalling pathway and the patterning of the wing margin in Drosophila. Development 120, 621\u2013636 (1994).","journal-title":"Development"},{"key":"BFncb786_CR14","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1002\/bies.950190813","volume":"19","author":"C Neumann","year":"1997","unstructured":"Neumann, C. & Cohen, S. Morphogens and pattern formation. Bioessays 19, 721\u2013729 (1997).","journal-title":"Bioessays"},{"key":"BFncb786_CR15","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1242\/dev.124.20.4053","volume":"124","author":"SS Blair","year":"1997","unstructured":"Blair, S. S. & Ralston, A. Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila. Development 124, 4053\u20134063 (1997).","journal-title":"Development"},{"key":"BFncb786_CR16","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/39343","volume":"389","author":"I Rodriguez","year":"1997","unstructured":"Rodriguez, I. & Basler, K. Control of compartmental affinity boundaries by Hedgehog. Nature 389, 614\u2013618 (1997).","journal-title":"Nature"},{"key":"BFncb786_CR17","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1242\/dev.121.3.785","volume":"121","author":"MA Sturtevant","year":"1995","unstructured":"Sturtevant, M. A. & Bier, E. Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development 121, 785\u2013801 (1995).","journal-title":"Development"},{"key":"BFncb786_CR18","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0092-8674(00)81385-9","volume":"87","author":"M Freeman","year":"1996","unstructured":"Freeman, M. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87, 651\u2013660 (1996).","journal-title":"Cell"},{"key":"BFncb786_CR19","doi-asserted-by":"publisher","first-page":"3254","DOI":"10.1101\/gad.11.23.3254","volume":"11","author":"M Dominguez","year":"1997","unstructured":"Dominguez, M. & Hafen, E. Hedgehog directly controls initiation and propagation of retinal differentiation in the Drosophila eye. Genes Dev. 11, 3254\u20133264 (1997).","journal-title":"Genes Dev."},{"key":"BFncb786_CR20","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1242\/dev.124.11.2255","volume":"124","author":"LM Pai","year":"1997","unstructured":"Pai, L. M., Orsulic, S., Bejsovec, A. & Peifer, M. Negative regulation of Armadillo, a Wingless effector in Drosophila. Development 124, 2255\u20132266 (1997).","journal-title":"Development"},{"key":"BFncb786_CR21","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1006\/dbio.1995.1243","volume":"170","author":"KB Yoffe","year":"1995","unstructured":"Yoffe, K. B., Manoukian, A. S., Wilder, E. L., Brand, A. H. & Perrimon, N. Evidence for engrailed-independent wingless autoregulation in Drosophila. Dev. Biol. 170, 636\u2013650 (1995).","journal-title":"Dev. Biol."},{"key":"BFncb786_CR22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1242\/dev.113.2.471","volume":"113","author":"A Bejsovec","year":"1991","unstructured":"Bejsovec, A. & Martinez Arias, A. Roles of wingless in patterning the larval epidermis of Drosophila. Development 113, 471\u2013485 (1991).","journal-title":"Development"},{"key":"BFncb786_CR23","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1002\/j.1460-2075.1993.tb05896.x","volume":"12","author":"F Th\u00fcringer","year":"1993","unstructured":"Th\u00fcringer, F., Cohen, S. M. & Bienz, M. Dissection of an indiret autoregulatory response of a homeotic Drosophila gene. EMBO J. 12, 2419\u20132430 (1993).","journal-title":"EMBO J."},{"key":"BFncb786_CR24","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0092-8674(00)81924-8","volume":"88","author":"J Riese","year":"1997","unstructured":"Riese, J. et al. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic. Cell 88, 777\u2013787 (1997).","journal-title":"Cell"},{"key":"BFncb786_CR25","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1242\/dev.122.3.849","volume":"122","author":"X Yu","year":"1996","unstructured":"Yu, X., Hoppler, S., Eresh, S. & Bienz, M. Decapentaplegic, a target gene of the wingless signalling pathway in the Drosophila midgut. Development 122, 849\u2013858 (1996).","journal-title":"Development"},{"key":"BFncb786_CR26","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/S0092-8674(00)81991-1","volume":"87","author":"M Zecca","year":"1996","unstructured":"Zecca, M., Basler, K. & Struhl, G. Direct and long-range action of a wingless morphogen gradient. Cell 87, 833\u2013844 (1996).","journal-title":"Cell"},{"key":"BFncb786_CR27","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1242\/dev.120.2.369","volume":"120","author":"M Peifer","year":"1994","unstructured":"Peifer, M., Sweeton, D., Casey, M. & Wieschaus, E. Wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development 120, 369\u2013380 (1994).","journal-title":"Development"},{"key":"BFncb786_CR28","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/384072a0","volume":"384","author":"EJ Rulifson","year":"1996","unstructured":"Rulifson, E. J., Micchelli, C. A., Axelrod, J. D., Perrimon, N. & Blair, S. S. Wingless refines its own expression domain on the Drosophila wing margin. Nature 384, 72\u201374 (1996).","journal-title":"Nature"},{"key":"BFncb786_CR29","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S0968-0004(00)88957-4","volume":"20","author":"R Aasland","year":"1995","unstructured":"Aasland, R., Gibson, T. J. & Stewart, A. F. The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem. Sci. 20, 56\u201359 (1995).","journal-title":"Trends Biochem. Sci."},{"key":"BFncb786_CR30","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1006\/jmbi.2000.4308","volume":"304","author":"J Pascual","year":"2000","unstructured":"Pascual, J., Martinez-Yamout, M., Dyson, H. J. & Wright, P. E. Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor. J. Mol. Biol. 304, 723\u2013729 (2000).","journal-title":"J. Mol. Biol."},{"key":"BFncb786_CR31","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/emboj\/20.1.165","volume":"20","author":"AD Capili","year":"2001","unstructured":"Capili, A. D., Schultz, D. C., Rauscher, I. F. & Borden, K. L. Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains. EMBO J. 20, 165\u2013177 (2001).","journal-title":"EMBO J."},{"key":"BFncb786_CR32","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0959-437X(99)80027-6","volume":"9","author":"S Jacobson","year":"1999","unstructured":"Jacobson, S. & Pillus, L. Modifying chromatin and concepts of cancer. Curr. Opin. Genet. Dev. 9, 175\u2013184 (1999).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFncb786_CR33","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/26989","volume":"395","author":"J Roose","year":"1998","unstructured":"Roose, J. et al. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature 395, 608\u2013612 (1998).","journal-title":"Nature"},{"key":"BFncb786_CR34","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/26785","volume":"395","author":"L Waltzer","year":"1998","unstructured":"Waltzer, L. & Bienz, M. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. Nature 395, 521\u2013525 (1998).","journal-title":"Nature"},{"key":"BFncb786_CR35","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/35078107","volume":"411","author":"SM Elbashir","year":"2001","unstructured":"Elbashir, S. M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494\u2013498 (2001).","journal-title":"Nature"},{"key":"BFncb786_CR36","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1126\/science.275.5307.1784","volume":"275","author":"V Korinek","year":"1997","unstructured":"Korinek, V. et al. Constitutive transcriptional activation by a \u03b2-catenin-Tcf complex in APC-\/- colon carcinoma. Science 275, 1784\u20131787 (1997).","journal-title":"Science"},{"key":"BFncb786_CR37","doi-asserted-by":"crossref","unstructured":"Roose, J. & Clevers, H. TCF transcription factors: molecular switches in carcinogenesis. Biochim. Biophys. Acta 1424, M23\u2013M37 (1999).","DOI":"10.1016\/S0304-419X(99)00026-8"},{"key":"BFncb786_CR38","doi-asserted-by":"publisher","first-page":"11590","DOI":"10.1073\/pnas.95.20.11590","volume":"95","author":"D Levanon","year":"1998","unstructured":"Levanon, D. et al. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE\/Groucho corepressors. Proc. Natl Acad. Sci. USA 95, 11590\u201311595 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb786_CR39","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1242\/dev.126.14.3159","volume":"126","author":"M Brannon","year":"1999","unstructured":"Brannon, M., Brown, J. D., Bates, R., Kimelman, D. & Moon, R. T. XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. Development 126, 3159\u20133170 (1999).","journal-title":"Development"},{"key":"BFncb786_CR40","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1093\/emboj\/19.8.1839","volume":"19","author":"A Hecht","year":"2000","unstructured":"Hecht, A., Vleminckx, K., Stemmler, M. P., van Roy, F. & Kemler, R. The p300\/CBP acetyltransferases function as transcriptional coactivators of \u03b2-catenin in vertebrates. EMBO J. 19, 1839\u20131850 (2000).","journal-title":"EMBO J."},{"key":"BFncb786_CR41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1083\/jcb.149.2.249","volume":"149","author":"KI Takemaru","year":"2000","unstructured":"Takemaru, K. I. & Moon, R. T. The transcriptional coactivator CBP interacts with \u03b2-catenin to activate gene expression. J. Cell Biol. 149, 249\u2013254 (2000).","journal-title":"J. Cell Biol."},{"key":"BFncb786_CR42","doi-asserted-by":"publisher","first-page":"4935","DOI":"10.1093\/emboj\/20.17.4935","volume":"20","author":"N Barker","year":"2001","unstructured":"Barker, N. et al. The chromatin remodelling factor Brg-1 interacts with \u03b2-catenin to promote target gene activation. EMBO J. 20, 4935\u20134943 (2001).","journal-title":"EMBO J."},{"key":"BFncb786_CR43","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1101\/gad.946501","volume":"15","author":"AV Tutter","year":"2001","unstructured":"Tutter, A. V., Fryer, C. J. & Jones, K. A. Chromatin-specific regulation of LEF-1-\u03b2-catenin transcription activation and inhibition in vitro. Genes Dev. 15, 3342\u20133354 (2001).","journal-title":"Genes Dev."},{"key":"BFncb786_CR44","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/S0968-0004(01)01952-1","volume":"26","author":"DL Daniels","year":"2001","unstructured":"Daniels, D. L., Eklof Spink, K. & Weis, W. I. \u03b2-catenin: molecular plasticity and drug design. Trends Biochem. Sci. 26, 672\u2013678 (2001).","journal-title":"Trends Biochem. Sci."},{"key":"BFncb786_CR45","doi-asserted-by":"publisher","first-page":"4807","DOI":"10.1128\/MCB.18.8.4807","volume":"18","author":"SC Hsu","year":"1998","unstructured":"Hsu, S. C., Galceran, J. & Grosschedl, R. Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with \u03b2-catenin. Mol. Cell. Biol. 18, 4807\u20134818 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"BFncb786_CR46","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1038\/79039","volume":"7","author":"JP von Kries","year":"2000","unstructured":"von Kries, J. P. et al. Hot spots in \u03b2-catenin for interactions with LEF-1, conductin and APC. Nature Struct. Biol. 7, 800\u2013807 (2000).","journal-title":"Nature Struct. Biol."},{"key":"BFncb786_CR47","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1091\/mbc.10.4.1119","volume":"10","author":"F Yokoya","year":"1999","unstructured":"Yokoya, F., Imamoto, N., Tachibana, T. & Yoneda, Y. \u03b2-catenin can be transported into the nucleus in a Ran-unassisted manner. Mol. Biol. Cell 10, 1119\u20131131 (1999).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb786_CR48","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/S0960-9822(00)00045-2","volume":"11","author":"N Wiechens","year":"2001","unstructured":"Wiechens, N. & Fagotto, F. CRM1- and Ran-independent nuclear export of \u03b2-catenin. Curr. Biol. 11, 18\u201327 (2001).","journal-title":"Curr. Biol."},{"key":"BFncb786_CR49","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1242\/dev.128.11.2107","volume":"128","author":"NS Tolwinski","year":"2001","unstructured":"Tolwinski, N. S. & Wieschaus, E. Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF\/Pan. Development 128, 2107\u20132117 (2001).","journal-title":"Development"},{"key":"BFncb786_CR50","doi-asserted-by":"publisher","first-page":"6203","DOI":"10.1093\/emboj\/20.22.6203","volume":"20","author":"K Eklof Spink","year":"2001","unstructured":"Eklof Spink, K., Fridman, S. G. & Weis, W. I. Molecular mechanisms of \u03b2-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC\u2013\u03b2-catenin complex. EMBO J. 20, 6203\u20136212 (2001).","journal-title":"EMBO J."},{"key":"BFncb786_CR51","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/383627a0","volume":"383","author":"B Sanson","year":"1996","unstructured":"Sanson, B., White, P. & Vincent, J. P. Uncoupling cadherin-based adhesion from wingless signalling in Drosophila. Nature 383, 627\u2013630 (1996).","journal-title":"Nature"},{"key":"BFncb786_CR52","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1242\/dev.124.4.871","volume":"124","author":"CJ Neumann","year":"1997","unstructured":"Neumann, C. J. & Cohen, S. M. Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing. Development 124, 871\u2013880 (1997).","journal-title":"Development"},{"key":"BFncb786_CR53","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1128\/MCB.16.3.745","volume":"16","author":"M Van de Wetering","year":"1996","unstructured":"Van de Wetering, M., Castrop, J., Korinek, V. & Clevers, H. Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol. Cell. Biol. 16, 745\u2013752 (1996).","journal-title":"Mol. Cell. Biol."},{"key":"BFncb786_CR54","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/ncb1001-933","volume":"3","author":"BM McCartney","year":"2001","unstructured":"McCartney, B. M. et al. Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. Nature Cell Biol. 3, 933\u2013938 (2001).","journal-title":"Nature Cell Biol."},{"key":"BFncb786_CR55","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/35023016","volume":"406","author":"R Rosin-Arbesfeld","year":"2000","unstructured":"Rosin-Arbesfeld, R., Townsley, F. & Bienz, M. The APC tumour suppressor has a nuclear export function. Nature 406, 1009\u20131012 (2000).","journal-title":"Nature"}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb786","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T15:50:58Z","timestamp":1684425058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,22]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["BFncb786"],"URL":"https:\/\/doi.org\/10.1038\/ncb786","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1007225.90562","asserted-by":"object"}]},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,22]]}}}