{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:13:24Z","timestamp":1764688404198},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1994,1]]},"DOI":"10.1038\/ng0194-41","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T21:05:35Z","timestamp":1092863135000},"page":"41-46","source":"Crossref","is-referenced-by-count":133,"title":["Allele specificity of DNA replication timing in the Angelman\/Prader\u2013Willi syndrome imprinted chromosomal region"],"prefix":"10.1038","volume":"6","author":[{"given":"Joan H.M.","family":"Knoll","sequence":"first","affiliation":[]},{"given":"Sou-De","family":"Cheng","sequence":"additional","affiliation":[]},{"given":"Marc","family":"Lalande","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFng019441_CR1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0014-4827(86)90583-5","volume":"165","author":"H Nakamura","year":"1986","unstructured":"Nakamura, H., Morita, T. & Sato, C. Structural Organization of Replicon Domains during DMA Synthetic Phase in the Mammalian Nucleus. Exp. Cell Res. 165, 291\u2013297 (1986).","journal-title":"Exp. Cell Res."},{"key":"BFng019441_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1083\/jcb.108.1.1","volume":"108","author":"H Nakayasu","year":"1989","unstructured":"Nakayasu, H. & Berezney, R. Mapping Replicational Sites in the Eucaryotic cell Nucleus. J. Cell Biol. 108, 1\u201311 (1989).","journal-title":"J. Cell Biol."},{"key":"BFng019441_CR3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1242\/jcs.99.2.247","volume":"99","author":"MH Fox","year":"1991","unstructured":"Fox, M.H., Arndt-Jovin, D.J., Jovin, T., Baumann, P.H. & Robert-Nicoud, M. Spatial and temporal distribution of DNA replication sites localized by immunofluorescence and confocal microscopy in mouse fibroblasts. J. Cell Sci. 99, 247\u2013253 (1991).","journal-title":"J. Cell Sci."},{"key":"BFng019441_CR4","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1083\/jcb.116.5.1095","volume":"116","author":"RT O'Keefe","year":"1992","unstructured":"O'Keefe, R.T., Henderson, S.C. & Spector, D.L. Dynamic Organization of DNA replication in Mammalian Cell Nuclei: Spatially and Temporally Defined Replication of Chromosome-specific-\u03b1-Satellite DNA sequences. J. Cell Biol. 116, 1095\u20131110 (1992).","journal-title":"J. Cell Biol."},{"key":"BFng019441_CR5","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/BF01731703","volume":"99","author":"R Drouin","year":"1990","unstructured":"Drouin, R., Lemieux, N. & Richer, C.-L. Analysis of DNA replication during S-phase by means of dynamic chromosome banding at high resolution. Chromosoma 99, 273\u2013280 (1990).","journal-title":"Chromosoma"},{"key":"BFng019441_CR6","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.1073\/pnas.70.12.3395","volume":"70","author":"SA Latt","year":"1973","unstructured":"Latt, S.A. Miorofluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes. Proc. natn. Acad. Sci. U.S.A. 70, 3395\u20133399 (1973).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng019441_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/BF00293440","volume":"58","author":"B Dutrillaux","year":"1976","unstructured":"Dutrillaux, B., Couturier, J., Richer, C.-L. & Viegas-P\u00e9quignot, E. Sequence of DNA replication in 227 R-and Q-bands of human chromosomes using a BrdU treatment. Chmmosoma 58, 51\u201361 (1976).","journal-title":"Chmmosoma"},{"key":"BFng019441_CR8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1146\/annurev.ge.09.120175.001333","volume":"9","author":"HJ Edenberg","year":"1975","unstructured":"Edenberg, H.J. & Huberman, J.A. Eucaryotic chromosome replication. Ann. Rev. Genet. 9, 245\u2013284 (1975).","journal-title":"Ann. Rev. Genet."},{"key":"BFng019441_CR9","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0092-8674(78)90001-6","volume":"15","author":"R Hand","year":"1978","unstructured":"Hand, R. Eucaryotic DNA: Organization of the genome for replication. Cell 15, 317\u2013325 (1978).","journal-title":"Cell"},{"key":"BFng019441_CR10","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1083\/jcb.35.2.483","volume":"35","author":"JH Priest","year":"1967","unstructured":"Priest, J.H., Heady, J.E. & Priest, R.E. Delayed onset of replication of human X chromosomes. J. Cell Biol. 35, 483\u2013487 (1967).","journal-title":"J. Cell Biol."},{"key":"BFng019441_CR11","first-page":"213","volume":"28","author":"HF Willard","year":"1976","unstructured":"Willard, H.F. & Latt, S.A. Analysis of deoxyribonucleic acid replication in human X chromosomes by fluorescence microscopy. Am. J. hum. Genet. 28, 213\u2013227 (1976).","journal-title":"Am. J. hum. Genet."},{"key":"BFng019441_CR12","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1126\/science.6719109","volume":"224","author":"MA Goldman","year":"1984","unstructured":"Goldman, M.A., Holmquist, G.P., Gray, M.C., Caston, L.A. & Nag, A. Replication timing of mammalian genes and middle repetitive sequences. Science 224, 686\u2013692 (1984).","journal-title":"Science"},{"key":"BFng019441_CR13","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1128\/MCB.8.5.2149","volume":"8","author":"KS Hatton","year":"1988","unstructured":"Hatton, K.S. et al. Replication program of active and inactive multigene families in mammalian cells. Molec. Cell. Biol. 8, 2149\u20132158 (1988).","journal-title":"Molec. Cell. Biol."},{"key":"BFng019441_CR14","doi-asserted-by":"publisher","first-page":"3524","DOI":"10.1128\/MCB.9.8.3524","volume":"9","author":"V Dhar","year":"1989","unstructured":"Dhar, V., Skoultchi, A.I. & Schildkraut, C.L. Activation and repression of a \u03b2-globin gene in cell hybrids is accompanied by a shift in its temporal replication. Molec. Cell. Biol. 9, 3524\u20133532 (1989).","journal-title":"Molec. Cell. Biol."},{"key":"BFng019441_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF01213082","volume":"87","author":"Y Izumikawa","year":"1991","unstructured":"Izumikawa, Y., Naritomi, K. & Hirayama, K. Replication asynchrony between homologs 15q11.2: oytogenetic evidence for genomic imprinting. Hum. Genet. 87, 1\u20135 (1991).","journal-title":"Hum. Genet."},{"key":"BFng019441_CR16","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/364459a0","volume":"364","author":"D Kitsberg","year":"1993","unstructured":"Kitsberg, D. et al. Allele-specific replication timing of imprinted gene regions. Nature 364, 459\u2013463 (1993).","journal-title":"Nature"},{"key":"BFng019441_CR17","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1056\/NEJM198102053040604","volume":"304","author":"DH Ledbetter","year":"1981","unstructured":"Ledbetter, D.H. et al. Deletions of chromosome 15 as a cause of the Prader-Willi syndrome. New Engl. J. Med. 304, 325\u2013329 (1981).","journal-title":"New Engl. J. Med."},{"key":"BFng019441_CR18","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/S0140-6736(83)92745-9","volume":"1","author":"MG Butler","year":"1983","unstructured":"Butler, M.G. & Palmer, C.G. Parental origin of chromosome 15 deletion in Prader-Willi syndrome. Lancet 1, 1285\u20131286 (1983).","journal-title":"Lancet"},{"key":"BFng019441_CR19","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/342281a0","volume":"342","author":"RD Nicholls","year":"1989","unstructured":"Nicholls, R.D., Knoll, J.H.M., Butler, M.G., Karam, S. & Lalande, M. Genetic imprinting suggested by maternal heterodisomy in non-deletion Prader-Willi syndrome. Nature 342, 281\u2013285 (1989).","journal-title":"Nature"},{"key":"BFng019441_CR20","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/ajmg.1320320235","volume":"32","author":"JHM Knoll","year":"1989","unstructured":"Knoll, J.H.M. et al. Angelman and Prader-Willi syndromes share a common chromosome 15 deletion but differ in parental origin of the deletion. Am. J. med. Genet. 32, 285\u2013290 (1989).","journal-title":"Am. J. med. Genet."},{"key":"BFng019441_CR21","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/0140-6736(91)90278-W","volume":"337","author":"S Malcolm","year":"1991","unstructured":"Malcolm, S. et al. Uniparental paternal disomy in Angelman's syndrome. Lancet 337, 694\u2013697 (1991).","journal-title":"Lancet"},{"key":"BFng019441_CR22","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ng0792-291","volume":"1","author":"J Wagstaff","year":"1992","unstructured":"Wagstaff, J. et al. Maternal but not paternal transmission of 15q11\u201313-linked nondeletion Angelman syndrome leads to phenotypic expression. Nature Genet. 1, 291\u2013294 (1992).","journal-title":"Nature Genet."},{"key":"BFng019441_CR23","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/ng1292-265","volume":"2","author":"T Ozcelik","year":"1992","unstructured":"Ozcelik, T. et al. Small nuclear ribonucleoprotein polypeptide N (SNRPN), an expressed gene in the Prader-Willi syndrome critical region. Nature Genet. 2, 265\u2013269 (1992).","journal-title":"Nature Genet."},{"key":"BFng019441_CR24","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1002\/j.1460-2075.1992.tb05162.x","volume":"11","author":"S Selig","year":"1992","unstructured":"Selig, S., Okumura, K., Ward, D.C. & Cedar, H. Delineation of DNA replication time zones by fluorescence in situ hybridization. EMBO J. 11, 1217\u20131225 (1992).","journal-title":"EMBO J."},{"key":"BFng019441_CR25","first-page":"330","volume":"49","author":"J Wagstaff","year":"1991","unstructured":"Wagstaff, J. et al. Localization of the gene encoding the GABAA receptor \u03b23 subunit to the Angelman\/Prader-Willi region of human chromosome 15. Am. J. hum. Genet. 49, 330\u2013337 (1991).","journal-title":"Am. J. hum."},{"key":"BFng019441_CR26","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1093\/hmg\/2.2.183","volume":"2","author":"JHM Knoll","year":"1993","unstructured":"Knoll, J.H.M. et al. FISH ordering of reference markers and of the gene for the \u03b15 subunit of the \u03b3-aminobutyric acid receptor (GABRA5) within the Angelman and Prader-Willi syndrome chromosomal regions. Hum. molec. Genet. 2, 183\u2013189 (1993).","journal-title":"Hum. molec. Genet."},{"key":"BFng019441_CR27","first-page":"1216","volume":"52","author":"D Sinnett","year":"1993","unstructured":"Sinnett, D. et al. High-resolution mapping of the gamma-aminobutyric acid receptor subunit \u03b23 and \u03b15 gene cluster on chromosome 15q11\u2013q13 and localization of breakpoints in two Angelman syndrome patients. Am. J. hum. Genet. 52, 1216\u20131229 (1993).","journal-title":"Am. J. hum. Genet."},{"key":"BFng019441_CR28","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1126\/science.257.5073.1121","volume":"257","author":"JM Gardner","year":"1992","unstructured":"Gardner, J.M. et al. The mouse pink-eyed dilution gene: Association with human Prader-Willi and Angelman syndromes. Science 257, 1121\u20131124 (1992).","journal-title":"Science"},{"key":"BFng019441_CR29","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/ng1292-259","volume":"2","author":"SE Left","year":"1992","unstructured":"Left, S.E. et al. Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Wilii syndrome region. Nature Genet. 2, 259\u2013264 (1992).","journal-title":"Nature Genet."},{"key":"BFng019441_CR30","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/ng1292-270","volume":"2","author":"BM Cattanach","year":"1992","unstructured":"Cattanach, B.M. et al. A candidate mouse model for Prader-Willi syndrome which shows an absence of Snrpn expression. Nature Genet. 2, 270\u2013274 (1992).","journal-title":"Nature Genet."},{"key":"BFng019441_CR31","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1128\/MCB.9.2.586","volume":"9","author":"M Leffak","year":"1989","unstructured":"Leffak, M. & James, C.D. Opposite replication polarity of the germ line c-myc gene in HeLa Cells compared with that of two Burkitt lymphoma cell lines. Molec. Cell. Biol. 9, 586\u2013593 (1989).","journal-title":"Molec. Cell. Biol."},{"key":"BFng019441_CR32","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/0092-8674(92)90505-7","volume":"71","author":"WL Fangman","year":"1992","unstructured":"Fangman, W.L. & Brewer, B.J. A Question of Time: Replication Origins of Eukaryotic Chromosomes. Cell 71, 363\u2013366 (1992).","journal-title":"Cell"},{"key":"BFng019441_CR33","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/ajmg.1320410117","volume":"41","author":"J Hamabe","year":"1991","unstructured":"Hamabe, J. et al. DNA deletion and its parental origin in Angelman syndrome patients. Am. J. med. Genet. 41, 64\u201368 (1991).","journal-title":"Am. J. med. Genet."},{"key":"BFng019441_CR34","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/0140-6736(92)91686-3","volume":"339","author":"S Saitoh","year":"1992","unstructured":"Saitoh, S. et al. Familial Angelman syndrome caused by imprinted submicroscopic deletion encompassing GABAA receptor \u03b23-subunit gene. Lancet 339, 366\u2013367 (1992).","journal-title":"Lancet"},{"key":"BFng019441_CR35","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1073\/pnas.88.2.603","volume":"88","author":"LE Schanberg","year":"1991","unstructured":"Schanberg, L.E., Fleenor, D.E., Kurtzberg, J., Haynes, B.F. & Kaufman, R.E. Isolation and characterization of the genomic human CD7 gene: Structural similarity with the murine Thy\u22121 gene. Proc. natn. Acad. Sci. U.S.A. 88, 603\u2013607 (1991).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng019441_CR36","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1126\/science.1257746","volume":"191","author":"JJ Yunis","year":"1976","unstructured":"Yunis, J.J. High resolution of human chromosomes. Science 191, 1268\u20131270 (1976).","journal-title":"Science"},{"key":"BFng019441_CR37","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1126\/science.2203143","volume":"249","author":"JB Lawrence","year":"1990","unstructured":"Lawrence, J.B., Singer, R.H. & McNeil, J.A. Interphase and metaphase resolution of different distances within the human dystrophin gene. Science 249, 928\u2013932 (1990).","journal-title":"Science"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0194-41","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0194-41.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0194-41.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:17:38Z","timestamp":1684441058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0194-41"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["BFng019441"],"URL":"https:\/\/doi.org\/10.1038\/ng0194-41","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}