{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:28:27Z","timestamp":1770478107059,"version":"3.49.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1995,1,1]]},"DOI":"10.1038\/ng0195-70","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T17:13:14Z","timestamp":1092849194000},"page":"70-74","source":"Crossref","is-referenced-by-count":229,"title":["A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer"],"prefix":"10.1038","volume":"9","author":[{"given":"Toshiyuki","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youko","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Okio","family":"Hino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFng019570_CR1","doi-asserted-by":"publisher","first-page":"10914","DOI":"10.1073\/pnas.90.23.10914","volume":"90","author":"AG Knudson","year":"1993","unstructured":"Knudson, A.G. Antloncogenes and human cancer. Proc. natn. Acad. Sci. U.S.A 90, 10914\u201310921 (1993).","journal-title":"Proc. natn. Acad. Sci. U.S.A"},{"key":"BFng019570_CR2","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/189858b0","volume":"189","author":"R Eker","year":"1961","unstructured":"Eker, R. & Mosslge, J.A. A dominant gene for renal adenomas in the rats. Nature 189, 858\u2013859 (1961).","journal-title":"Nature"},{"key":"BFng019570_CR3","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1016\/S0022-5347(17)37087-8","volume":"148","author":"JI Everitt","year":"1992","unstructured":"Everitt, J.I., Goldsworthy, T.L., Wolf, D.C. & Walker, C.L. Hereditary renal cell carcinoma In the Eker rat: a rodent familial cancer syndrome. J. Urol. 148, 1932\u20131936 (1992).","journal-title":"J. Urol."},{"key":"BFng019570_CR4","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1073\/pnas.90.1.327","volume":"90","author":"O Hino","year":"1993","unstructured":"Hino, O. et al. Spontaneous and radiation-induced renal tumours in the Eker rat model of dominantly inherited cancer. Proc. natl. Acad. Sci. U.S.A. 90, 327\u2013331 (1993).","journal-title":"Proc. natl. Acad. Sci. U.S.A."},{"key":"BFng019570_CR5","doi-asserted-by":"publisher","first-page":"8038","DOI":"10.1073\/pnas.90.17.8038","volume":"90","author":"RS Yeung","year":"1993","unstructured":"Yeung, R.S., Buetow, K.H., Testa, J.R. & Knudson, A.Q. Susceptibility to renal carcinoma In the Eker rat Involves a tumour suppressor gene on chromosome 10. Proc. natl. Acad. Sci. U.S.A 90, 8038\u20138042 (1993).","journal-title":"Proc. natl. Acad. Sci. U.S.A"},{"key":"BFng019570_CR6","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1111\/j.1349-7006.1993.tb02808.x","volume":"84","author":"O Hino","year":"1993","unstructured":"Hino, O., Mltani, H., Nishizawa, M., Katsuyama, H., Kobayashi, E. & Hlrayama, Y. A novel renal cell carcinoma susceptibility gene maps on chromosome 10 in the Eker rat.Jpn. J. Cancer Res. 84, 1106\u20131109 (1993).","journal-title":"Jpn. J. Cancer Res."},{"key":"BFng019570_CR7","first-page":"2633","volume":"54","author":"Y Kubo","year":"1994","unstructured":"Kubo, Y., Mitani, H. & Hino, O. Allelic loss at the predisposing gene locus in spontaneous and chemically induced renal cell carcinomas in the Eker rat. Cancer Res. 54, 2633\u20132635 (1994).","journal-title":"Cancer Res."},{"key":"BFng019570_CR8","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1073\/pnas.90.2.730","volume":"90","author":"O Hino","year":"1993","unstructured":"Hino, O. et al Universal mapping probes and origin of human chromosome 3. Proc. natl Acad. Sci. U.S.A 90, 730\u2013734 (1993).","journal-title":"Proc. natl Acad. Sci. U.S.A"},{"key":"BFng019570_CR9","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1126\/science.8493574","volume":"260","author":"FL Latif","year":"1993","unstructured":"Latif, F.L. et al. Identification of the von Hippel-Lindau disease tumour suppressor gene. Science 260, 1317\u20131320 (1993).","journal-title":"Science"},{"key":"BFng019570_CR10","first-page":"5856","volume":"53","author":"O Hino","year":"1993","unstructured":"Hino, O., Mitani, H. & Knudson, A.G. Genetic predisposition to transplacentally renal cell carcinomas in the Eker rat. Cancer Res. 53, 5856\u20136858 (1993).","journal-title":"Cancer Res."},{"key":"BFng019570_CR11","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0304-3835(94)90307-7","volume":"83","author":"O Hino","year":"1994","unstructured":"Hino, O., Mitani, H., Katsuyama, H. & Kubo, Y. A novel cancer predisposition syndrome in the Eker rat model. Cancer Lett. 83, 117\u2013121 (1994).","journal-title":"Cancer Lett."},{"key":"BFng019570_CR12","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1006\/bbrc.1994.2324","volume":"203","author":"O Hino","year":"1994","unstructured":"Hino, O. et al. The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene. Biochem. Biophys. Res. Commun. 203, 1302\u20131308 (1994).","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"BFng019570_CR13","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/0092-8674(94)90137-6","volume":"77","author":"The European Polycystic Kidney Dise","year":"1994","unstructured":"The polycytlc kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. Cell 77, 881\u2013894 (1994).","journal-title":"Cell"},{"key":"BFng019570_CR14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/ng0594-85","volume":"7","author":"JR Gnarra","year":"1994","unstructured":"Gnarra, J.R. et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nature Genet. 7, 85\u201390 (1994).","journal-title":"Nature Genet."},{"key":"BFng019570_CR15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/ng0294-193","volume":"6","author":"AJ Green","year":"1994","unstructured":"Green, A.J., Smith, M. & Yates, J.R.W. Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nature Genet. 6, 193\u2013196 (1994).","journal-title":"Nature Genet."},{"key":"BFng019570_CR16","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/ng0794-353","volume":"7","author":"T Jacks","year":"1994","unstructured":"Jacks, T., Shin, T.S., Schmitt, E.M., Bronson, R.T., Bernards, A. & Weinberg, R.A. Tumour predisposition in mice heterozygous for a trageted mutation in Nf1. Nature Genet. 7, 353\u2013361 (1994).","journal-title":"Nature Genet."},{"key":"BFng019570_CR17","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/ng0894-541","volume":"7","author":"J Wu","year":"1994","unstructured":"Wu, J., Forbes, J.R., Chen, H.S. & Cox, D.W. The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Nature Genet. 7, 541\u2013545 (1994).","journal-title":"Nature Gen"},{"key":"BFng019570_CR18","doi-asserted-by":"crossref","unstructured":"Chromosome 16 Tuberous Sclerosis Consortium. Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75, 1305\u20131315 (1993).","DOI":"10.1016\/0092-8674(93)90618-Z"},{"key":"BFng019570_CR19","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/ijc.2910350103","volume":"35","author":"O Hino","year":"1985","unstructured":"Hino, O., Kitagawa, T. & Sugano, H. Relationship between serum and hlstochemical markers for hepatitis B virus and rate of viral integration in hepatocellular carcinoma in Japan. Int. J. Cancer 35, 5\u201310 (1985).","journal-title":"Int. J. Cancer"}],"updated-by":[{"DOI":"10.1038\/ng0295-218a","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[1995,2,1]],"date-time":"1995-02-01T00:00:00Z","timestamp":791596800000}}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0195-70","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0195-70.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0195-70.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T16:17:50Z","timestamp":1684426670000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0195-70"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1,1]]}},"alternative-id":["BFng019570"],"URL":"https:\/\/doi.org\/10.1038\/ng0195-70","relation":{"correction":[{"id-type":"doi","id":"10.1038\/ng0295-218a","asserted-by":"object"}]},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1,1]]}}}