{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:02:39Z","timestamp":1776286959996,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1995,4,1]],"date-time":"1995-04-01T00:00:00Z","timestamp":796694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1995,4]]},"DOI":"10.1038\/ng0495-401","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T21:16:58Z","timestamp":1092863818000},"page":"401-406","source":"Crossref","is-referenced-by-count":1175,"title":["In vivo amplification of the androgen receptor gene and progression of human prostate cancer"],"prefix":"10.1038","volume":"9","author":[{"given":"Tapio","family":"Visakorpi","sequence":"first","affiliation":[]},{"given":"Eija","family":"Hyytinen","sequence":"additional","affiliation":[]},{"given":"Pasi","family":"Koivisto","sequence":"additional","affiliation":[]},{"given":"Minna","family":"Tanner","sequence":"additional","affiliation":[]},{"given":"Riitta","family":"Kein\u00e4nen","sequence":"additional","affiliation":[]},{"given":"Christian","family":"Palmberg","sequence":"additional","affiliation":[]},{"given":"Aarno","family":"Palotie","sequence":"additional","affiliation":[]},{"given":"Teuvo","family":"Tammela","sequence":"additional","affiliation":[]},{"given":"Jorma","family":"Isola","sequence":"additional","affiliation":[]},{"given":"Olli-P.","family":"Kallioniemi","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFng0495401_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/canjclin.43.1.7","volume":"43","author":"CC Boring","year":"1993","unstructured":"Boring, C.C., Squires, T.S. & Tong, T. Cancer Statistics, 1993 CA. Cancer J. Clin. 43, 7\u201326 (1993).","journal-title":"CA. Cancer J. Clin."},{"key":"BFng0495401_CR2","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1056\/NEJM199101243240406","volume":"324","author":"RF Gittes","year":"1991","unstructured":"Gittes, R.F. Carcinoma of the prostate. New Engl. J. Med. 324, 236\u2013245 (1991).","journal-title":"New Engl. J. Med."},{"key":"BFng0495401_CR3","first-page":"540","volume":"67","author":"ME Stearn","year":"1992","unstructured":"Stearn, M.E. & McGarvey, T. Biology of disease. Prostate cancer: therapeutics, diagnostic, and basic studies. Lab. Invest. 67, 540\u2013552 (1992).","journal-title":"Lab. Invest."},{"key":"BFng0495401_CR4","doi-asserted-by":"publisher","first-page":"8910","DOI":"10.1073\/pnas.90.19.8910","volume":"90","author":"RR Berges","year":"1993","unstructured":"Berges, R.R., Furuya, Y., Remington, L., English, H.F., Jacks, T. .& Isaacs, J.T. Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation. Proc. natn. Acad. Sci. U.S.A. 90, 8910\u20138914 (1993).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng0495401_CR5","first-page":"475","volume":"16","author":"F Labrie","year":"1993","unstructured":"Labrie, F., Belanger, A., Dupont, A., Luu-The, V., Simard, J. & Labrie, C. Science behind total androgen blockade: from gene to combination therapy. Clin. Invest. Med. 16, 475\u2013492 (1993).","journal-title":"Clin. Invest. Med."},{"key":"BFng0495401_CR6","first-page":"1541","volume":"7","author":"Z Culig","year":"1993","unstructured":"Culig, Z. et al. Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. Molec. Endocrinol. 7, 1541\u20131550 (1993).","journal-title":"Molec. Endocrinol."},{"key":"BFng0495401_CR7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1006\/bbrc.1994.1011","volume":"198","author":"MP Schoenberg","year":"1994","unstructured":"Schoenberg, M.P. et al. Microsatelllte mutation (CAG24\u201318) in the androgen receptor gene In human prostate cancer. Biochem. Biophys. Res. Comm. 198, 74\u201380 (1994).","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"BFng0495401_CR8","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/S0006-291X(05)80067-1","volume":"173","author":"J Veldscholte","year":"1990","unstructured":"Veldscholte, J. et al. A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens. Biochem. Biophys. Res. Commun. 173, 534\u2013540 (1990).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFng0495401_CR9","first-page":"345","volume":"2","author":"TC Thompson","year":"1990","unstructured":"Thompson, T.C. Growth factors and oncogenes in prostate cancer. Cancer Cells 2, 345\u2013354 (1990).","journal-title":"Cancer Cells"},{"key":"BFng0495401_CR10","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1126\/science.1359641","volume":"258","author":"A Kallioniemi","year":"1992","unstructured":"Kallioniemi, A. et al. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumours. Science 258, 818\u2013821 (1992).","journal-title":"Science"},{"key":"BFng0495401_CR11","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/gcc.2870100403","volume":"10","author":"O-P Kallioniemi","year":"1994","unstructured":"Kallioniemi, O.-P. et al. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumours. Genes Chrom. Cancer 10, 231\u2013243 (1994).","journal-title":"Genes Chrom. Cancer"},{"key":"BFng0495401_CR12","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/0888-7543(91)90143-3","volume":"11","author":"RG Lafreniere","year":"1991","unstructured":"Lafreniere, R.G. et al. Physical mapping of 60 DNA markers in the p21.1\u201321.3 region of the human X chromosome. Genomics 11, 352\u2013363 (1991).","journal-title":"Genomics"},{"key":"BFng0495401_CR13","first-page":"2861","volume":"54","author":"JP Gaddipati","year":"1994","unstructured":"Gaddipati, J.P., McLeod, D.G. & Heidenberg, H.B. Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. Cancer Res. 54, 2861\u20132864 (1994).","journal-title":"Cancer Res."},{"key":"BFng0495401_CR14","volume-title":"Gene amplificatlon in mammalian cells. A comprehensive guide","author":"RE Kellens","year":"1993","unstructured":"Kellens, R.E. Gene amplificatlon in mammalian cells. A comprehensive guide. (Marcel Dekker, Inc., New York, 1993)."},{"key":"BFng0495401_CR15","first-page":"2203","volume":"46","author":"PC Nowell","year":"1986","unstructured":"Nowell, P.C. Mechanisms of tumour progression. Cancer Res. 46, 2203\u20132207 (1986).","journal-title":"Cancer Res."},{"key":"BFng0495401_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/pros.2990250707","volume":"5","author":"L Dennis","year":"1994","unstructured":"Dennis, L. Role of maximal androgen blockade in advanced prostate cancer. Prostate (suppl) 5, 17\u201322 (1994).","journal-title":"Prostate"},{"key":"BFng0495401_CR17","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1056\/NEJM198908173210702","volume":"321","author":"ED Crawford","year":"1989","unstructured":"Crawford, E.D. et al. A controlled trial of leuprolide with and without flutamlde in prostatic carcinoma. New Engl. J. Med. 321, 419\u2013424 (1989).","journal-title":"New Engl. J. Med."},{"key":"BFng0495401_CR18","doi-asserted-by":"publisher","first-page":"5523","DOI":"10.1073\/pnas.91.12.5523","volume":"91","author":"R Corvi","year":"1994","unstructured":"Corvi, R., Amler, L.C., Savelyeva, L., Gehring, M. & Schwab, M. MYCN is retained in single copy at chromosome 2 band p23\u2013p24 during amplification in human neuroblastoma cells. Proc. natn. Acad. Sci. U.S.A. 91, 5523\u20135527 (1994).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng0495401_CR19","first-page":"342","volume":"55","author":"T Visakorpi","year":"1995","unstructured":"Visakorpi, T. et al. Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization. Cancer Res. 55, 342\u2013347 (1995).","journal-title":"Cancer Res."},{"key":"BFng0495401_CR20","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/gcc.2870110304","volume":"11","author":"ML Cher","year":"1994","unstructured":"Cher, M.L., MacGrogan, D., Bookstein, R., Brown, J.A., Jenkins, R.B. & Jensen, R. Comparative genomic hybridization, allelic imbalance, and fluorescence in situ hybridization on chromosome 8 in prostate cancer. Genes Chrom. Cancer 11, 153\u2013162 (1994).","journal-title":"Genes Chrom. Cancer"},{"key":"BFng0495401_CR21","first-page":"2457","volume":"54","author":"M Tanner","year":"1994","unstructured":"Tanner, M. et al. Increased copy number at 20q13 in breast cancer: defining the minimal region and exclusion of candidate genes. Cancer Res. 54, 2457\u20132460 (1994).","journal-title":"Cancer Res."},{"key":"BFng0495401_CR22","volume-title":"Molecular Cloning: A Laboratory Manual","author":"J Sambrook","year":"1989","unstructured":"Sambrook, J., Fritsch, E.F. & Maniatis, T. Molecular Cloning: A Laboratory Manual (Cold Spring Habor Laboratory Press, Cold Spring Harbor, (1989)."},{"key":"BFng0495401_CR23","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/cyto.990160202","volume":"16","author":"E Hyytinen","year":"1994","unstructured":"Hyytinen, E., Visakorpi, T., Kallioniemi, A., Kallioniemi, O.-P. & Isola, J. Improved technique for analysis of formalin-fixed paraffin-embedded tumours by fluorescence in situ hybridization. Cytometry 16, 93\u201399 (1994).","journal-title":"Cytometry"},{"key":"BFng0495401_CR24","doi-asserted-by":"publisher","first-page":"5321","DOI":"10.1073\/pnas.89.12.5321","volume":"88","author":"OP Kallioniemi","year":"1992","unstructured":"Kallioniemi, O.P. et al. ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Proc. natn. Acad. Sci. U.S.A. 88, 5321\u20135325 (1992).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng0495401_CR25","first-page":"938","volume":"16","author":"J Ihalainen","year":"1994","unstructured":"Ihalainen, J., Siitari, H., Laine, S., Syv\u00e4nen, A.C. & Palotie, A. Towards automatic detection of point mutations: use of scintillating microplates in solid-phase minisequencing. Biotechniques 16, 938\u2013943 (1994).","journal-title":"Biotechniques"},{"key":"BFng0495401_CR26","volume-title":"BMDP Statistical Software","author":"WJ Dixon","year":"1981","unstructured":"Dixon, W.J. BMDP Statistical Software (University of California Press, Los Angeles, 1981)."},{"key":"BFng0495401_CR27","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/0046-8177(92)90083-F","volume":"23","author":"AA Sandberg","year":"1992","unstructured":"Sandberg, A.A. Chromosomal abnormalities and related events in prostate cancer. Hum. Pathol. 23, 368\u2013380 (1992).","journal-title":"Hum. Pathol."},{"key":"BFng0495401_CR28","first-page":"6249","volume":"54","author":"CW Rinker-Schaeffer","year":"1994","unstructured":"Rinker-Schaeffer, C.W. et al. Differential suppression of mammary and prostate cancer metastasis by human chromosomes 17 and 11. Cancer Res. 54, 6249\u20136256 (1994).","journal-title":"Cancer Res."},{"key":"BFng0495401_CR29","first-page":"514","volume":"21","author":"WB Isaacs","year":"1994","unstructured":"Isaacs, W.B., Bova, G.S., Morton, R.A., Bussemakers, M.J.G., Brooks, J.D. & Ewing, C.M. Molecular biology of prostate cancer. Semin. Oncol. 21, 514\u2013521 (1994).","journal-title":"Semin. Oncol."},{"key":"BFng0495401_CR30","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/gcc.2870080205","volume":"8","author":"JA Macoska","year":"1993","unstructured":"Macoska, J.A., Micale, M.A., Sakr, W.A., Benson, P.D. & Wolman, S.R. Extensive genetic alterations in prostate cancer revealed by dual PCR and FISH analysis. Genes Chrom. Cancer 8, 88\u201397 (1993).","journal-title":"Genes Chrom. Cancer"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0495-401","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0495-401.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0495-401.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:31:52Z","timestamp":1684441912000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0495-401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,4]]}},"alternative-id":["BFng0495401"],"URL":"https:\/\/doi.org\/10.1038\/ng0495-401","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,4]]}}}