{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T21:37:03Z","timestamp":1784151423448,"version":"3.55.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1993,9,1]],"date-time":"1993-09-01T00:00:00Z","timestamp":746841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1993,9]]},"DOI":"10.1038\/ng0993-56","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T21:02:14Z","timestamp":1092862934000},"page":"56-61","source":"Crossref","is-referenced-by-count":230,"title":["Point mutations in the c\u2013Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas"],"prefix":"10.1038","volume":"5","author":[{"given":"K.","family":"Bhatia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Huppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Spangler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Siwarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Magrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng099356_CR1","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1146\/annurev.bi.61.070192.004113","volume":"61","author":"KB Marcu","year":"1992","unstructured":"Marcu, K.B., Bossone, S.A. & Patel, A.J. Myc function and regulation. Ann. Rev. Biochem. 61, 809\u2013860 (1992).","journal-title":"Ann. Rev. Biochem."},{"key":"BFng099356_CR2","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0168-9525(92)90196-B","volume":"8","author":"GC Prendergast","year":"1992","unstructured":"Prendergast, G.C. & Ziff, E.B. A new bind for myc. Trends Genet. 8, 91\u201396 (1992).","journal-title":"Trends Genet."},{"key":"BFng099356_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0065-230X(08)60994-X","volume":"57","author":"RA Depinho","year":"1991","unstructured":"Depinho, R.A., Schreiber-Agus, N. & Alt, F.W. Myc family oncogenes in the development of normal and neoplastic cells. Adv. cancer Res. 57, 1\u201346 (1991).","journal-title":"Adv. cancer Res."},{"key":"BFng099356_CR4","first-page":"361","volume":"20","author":"M Cole","year":"1986","unstructured":"Cole, M. The myc oncogene: its role in transformation and differentiation. Adv. cancer Res. 20, 361\u2013384 (1986).","journal-title":"Adv. cancer Res."},{"key":"BFng099356_CR5","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1093\/carcin\/13.10.1681","volume":"13","author":"M Potter","year":"1992","unstructured":"Potter, M. & Wiener, F. Plasmacytomagenesis in mice: model; model of neoplastic development dependent upon chromosomal translocations. Carcinogenesis 13, 1681\u20131697 (1992).","journal-title":"Carcinogenesis"},{"key":"BFng099356_CR6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0065-230X(08)60470-4","volume":"55","author":"I Magrath","year":"1990","unstructured":"Magrath, I. The pathogenesis of Burkitt's lymphoma. Adv. cancer Res. 55, 133\u2013270 (1990).","journal-title":"Adv. cancer Res."},{"key":"BFng099356_CR7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0092-8674(92)90123-T","volume":"69","author":"GI Evan","year":"1992","unstructured":"Evan, G.I. et al. Induction of apoptosis in fibroblasts by c\u2013Myc protein. Cell 69, 119\u2013128 (1992).","journal-title":"Cell"},{"key":"BFng099356_CR8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/bjc.1987.186","volume":"56","author":"AH Wyllie","year":"1987","unstructured":"Wyllie, A.H. et al. Rodent fibroblast tumours expressing human myc and ras genes: growth, metastasis and endogenous oncogene expression. Br. J. Cancer 56, 251\u2013259 (1987).","journal-title":"Br. J. Cancer"},{"key":"BFng099356_CR9","first-page":"1915","volume":"6","author":"D Askew","year":"1991","unstructured":"Askew, D., Ashmun, R., Simmons, B. & Cleveland, J. Constitutive c\u2013myc expression in IL\u20133 dependent myeloid cell line suppresses cycle arrest and accelerates apoptosis. Oncogene 6, 1915\u20131922 (1991).","journal-title":"Oncogene"},{"key":"BFng099356_CR10","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1126\/science.1378649","volume":"257","author":"Y Shi","year":"1992","unstructured":"Shi, Y. et al. Role for c\u2013myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257, 212\u2013214 (1992).","journal-title":"Science"},{"key":"BFng099356_CR11","first-page":"285","volume":"3","author":"I Magrath","year":"1992","unstructured":"Magrath, I., Jain, V. & Bhatia, K. Epstein-Barr virus and Burkitt's lymphoma. Sem. Cancer Biol. 3, 285\u2013295 (1992).","journal-title":"Sem. Cancer Biol."},{"key":"BFng099356_CR12","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/306760a0","volume":"306","author":"TH Rabbitts","year":"1983","unstructured":"Rabbitts, T.H., Hamlyn, R.H. & Baer, R. Altered nucleotide sequences of a translocated c\u2013myc gene in Burkitt lymphoma. Nature 306, 760\u2013765 (1983).","journal-title":"Nature"},{"key":"BFng099356_CR13","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/309592a0","volume":"309","author":"TH Rabbitts","year":"1984","unstructured":"Rabbitts, T.H., Forster, A., Hamlyn, P. & Baer, R. Effect of somatic mutations within translocated c\u2013myc genes in Burkitt lymphoma. Nature 309, 592\u2013597 (1984).","journal-title":"Nature"},{"key":"BFng099356_CR14","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1002\/j.1460-2075.1987.tb02657.x","volume":"6","author":"E Legouy","year":"1987","unstructured":"Legouy, E. et al. Structure and expression of the murine L\u2013myc gene. The EMBO J. 6, 3359\u20133366 (1987).","journal-title":"The EMBO J."},{"key":"BFng099356_CR15","doi-asserted-by":"publisher","first-page":"3216","DOI":"10.1073\/pnas.90.8.3216","volume":"90","author":"S Gupta","year":"1993","unstructured":"Gupta, S., Seth, A. & Davis, R.J. Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr\u201358 and Ser\u201362. Proc. natn. Acad. Sci. U.S.A. 90, 3216\u20133220 (1993).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng099356_CR16","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1073\/pnas.90.7.2935","volume":"90","author":"W Gu","year":"1993","unstructured":"Gu, W., Cechova, K., Tassi, V. & Dalla-Favera, R. Opposite regulation of gene transcription and cell proliferation by c\u2013Myc and Max. Proc. natn. Acad. Sci. U.S.A. 90, 2935\u20132939 (1993).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng099356_CR17","doi-asserted-by":"crossref","first-page":"23521","DOI":"10.1016\/S0021-9258(18)54312-X","volume":"266","author":"A Seth","year":"1991","unstructured":"Seth, A., Alvarez, E., Gupta, S. & Davis, R.J. A phosphorylation site located in the NH2-terminal domain of c\u2013Myc increases transactivation of gene expression. J. biol. Chem. 266, 23521\u201323524 (1991).","journal-title":"J. biol. Chem."},{"key":"BFng099356_CR18","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1126\/science.3810165","volume":"235","author":"M Potter","year":"1987","unstructured":"Potter, M. et al. Avian v\u2013myc replaces chromosomal translocation in murine plasmacytomagenesis. Science 235, 787\u2013789 (1987).","journal-title":"Science"},{"key":"BFng099356_CR19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0065-230X(08)60200-6","volume":"47","author":"S Cory","year":"1986","unstructured":"Cory, S. Activation of cellular oncogenes in hemopoietic cells by chromosome translocation. Adv. cancer Res. 47, 189\u2013234 (1986).","journal-title":"Adv. cancer Res."},{"key":"BFng099356_CR20","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1128\/MCB.11.1.354","volume":"11","author":"T-C Suen","year":"1991","unstructured":"Suen, T.-C. & Hung, M.-C. & Hung, M.-C. c\u2013myc reverses neu-induced transformed morphology by transcriptional repression. Molec. cell. Biol. 11, 354\u2013362 (1991).","journal-title":"Molec. cell. Biol."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0993-56","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0993-56.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0993-56.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:57:38Z","timestamp":1684443458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0993-56"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["BFng099356"],"URL":"https:\/\/doi.org\/10.1038\/ng0993-56","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]}}}