{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:11:35Z","timestamp":1775787095560,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2002,11,11]],"date-time":"2002-11-11T00:00:00Z","timestamp":1036972800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,11,11]],"date-time":"2002-11-11T00:00:00Z","timestamp":1036972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2002,12]]},"DOI":"10.1038\/ng1047","type":"journal-article","created":{"date-parts":[[2002,11,27]],"date-time":"2002-11-27T21:00:06Z","timestamp":1038430806000},"page":"650-654","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":799,"title":["Functional SNPs in the lymphotoxin-\u03b1 gene that are associated with susceptibility to myocardial infarction"],"prefix":"10.1038","volume":"32","author":[{"given":"Kouichi","family":"Ozaki","sequence":"first","affiliation":[]},{"given":"Yozo","family":"Ohnishi","sequence":"additional","affiliation":[]},{"given":"Aritoshi","family":"Iida","sequence":"additional","affiliation":[]},{"given":"Akihiko","family":"Sekine","sequence":"additional","affiliation":[]},{"given":"Ryo","family":"Yamada","sequence":"additional","affiliation":[]},{"given":"Tatsuhiko","family":"Tsunoda","sequence":"additional","affiliation":[]},{"given":"Hiroshi","family":"Sato","sequence":"additional","affiliation":[]},{"given":"Hideyuki","family":"Sato","sequence":"additional","affiliation":[]},{"given":"Masatsugu","family":"Hori","sequence":"additional","affiliation":[]},{"given":"Yusuke","family":"Nakamura","sequence":"additional","affiliation":[]},{"given":"Toshihiro","family":"Tanaka","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2002,11,11]]},"reference":[{"key":"BFng1047z_CR1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s100380170047","volume":"46","author":"Y Ohnishi","year":"2001","unstructured":"Ohnishi, Y. et al. A high-throughput SNP typing system for genome-wide association studies. J. Hum. Genet. 46, 471\u2013477 (2001).","journal-title":"J. Hum. Genet."},{"key":"BFng1047z_CR2","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s100380200092","volume":"47","author":"H Haga","year":"2002","unstructured":"Haga, H., Yamada, R., Ohnishi, Y., Nakamura, Y. & Tanaka, T. Gene-based SNP discovery as part of the Japanese Millennium Genome project: identification of 190,562 genetic variations in the human genome. J. Hum. Genet. 47, 605\u2013610 (2002).","journal-title":"J. Hum. Genet."},{"key":"BFng1047z_CR3","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1126\/science.274.5287.536","volume":"274","author":"ES Lander","year":"1996","unstructured":"Lander, E.S. The new genomics: global views of biology. Science 274, 536\u2013539 (1996).","journal-title":"Science"},{"key":"BFng1047z_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJM199901143400207","volume":"340","author":"R Ross","year":"1999","unstructured":"Ross, R. Atherosclerosis\u2014an inflammatory disease. N. Engl. J. Med. 340, 115\u2013126 (1999).","journal-title":"N. Engl. J. Med."},{"key":"BFng1047z_CR5","first-page":"175","volume":"198","author":"CF Ware","year":"1995","unstructured":"Ware, C.F., VanArsdale, T.L., Crowe, P.D. & Browning, J.L. The ligands and receptors of the lymphotoxin system. Curr. Top. Microbiol. Immunol. 198, 175\u2013218 (1995).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"BFng1047z_CR6","first-page":"2469","volume":"51","author":"B Vanhaesebroeck","year":"1991","unstructured":"Vanhaesebroeck, B. et al. Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line. Cancer Res. 51, 2469\u20132477 (1991).","journal-title":"Cancer Res."},{"key":"BFng1047z_CR7","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1161\/01.CIR.91.11.2844","volume":"21","author":"P Libby","year":"1995","unstructured":"Libby, P. Molecular bases of the acute coronary syndrome. Circulation 21, 2844\u20132850 (1995).","journal-title":"Circulation"},{"key":"BFng1047z_CR8","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1136\/hrt.53.4.363","volume":"53","author":"MJ Davies","year":"1985","unstructured":"Davies, M.J. & Thomas, A.C. Plaque fissuring\u2014the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br. Heart J. 53, 363\u2013373 (1985).","journal-title":"Br. Heart J."},{"key":"BFng1047z_CR9","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/362801a0","volume":"362","author":"R Ross","year":"1993","unstructured":"Ross, R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801\u2013809 (1993).","journal-title":"Nature"},{"key":"BFng1047z_CR10","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1161\/01.CIR.89.1.36","volume":"89","author":"AC van der Wal","year":"1994","unstructured":"van der Wal, A.C., Becker, A.E., van der Loos, C.M. & Das, P.K. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 89, 36\u201344 (1994).","journal-title":"Circulation"},{"key":"BFng1047z_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1161\/01.ATV.6.2.131","volume":"6","author":"L Jonasson","year":"1986","unstructured":"Jonasson, L., Holm, J., Skalli, O., Bondjers, G. & Hansson, G.K. Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis 6, 131\u2013138 (1986).","journal-title":"Arteriosclerosis"},{"key":"BFng1047z_CR12","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1161\/01.CIR.90.4.1669","volume":"90","author":"M Kaartinen","year":"1994","unstructured":"Kaartinen, M., Penttila, A. & Kovanen, P.T. Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture. Circulation 90, 1669\u20131678 (1994).","journal-title":"Circulation"},{"key":"BFng1047z_CR13","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1161\/01.RES.75.1.181","volume":"75","author":"ZS Galis","year":"1994","unstructured":"Galis, Z.S. et al. Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circ. Res. 75, 181\u2013189 (1994).","journal-title":"Circ. Res."},{"key":"BFng1047z_CR14","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1161\/01.CIR.94.11.2787","volume":"94","author":"M Kaartinen","year":"1996","unstructured":"Kaartinen, M., Penttila, A. & Kovanen, P.T. Mast cells in rupture-prone areas of human coronary atheromas produce and store TNF-\u03b1. Circulation 94, 2787\u20132792 (1996).","journal-title":"Circulation"},{"key":"BFng1047z_CR15","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1161\/01.CIR.93.4.672","volume":"93","author":"KD O'Brien","year":"1996","unstructured":"O'Brien, K.D., McDonald, T.O., Chait, A., Allen, M.D. & Alpers, C.E. Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content. Circulation 93, 672\u2013682 (1996).","journal-title":"Circulation"},{"key":"BFng1047z_CR16","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1161\/01.CIR.96.12.4219","volume":"96","author":"SJ Hwang","year":"1997","unstructured":"Hwang, S.J. et al. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. Circulation 96, 4219\u20134225 (1997).","journal-title":"Circulation"},{"key":"BFng1047z_CR17","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0021-9150(97)06083-8","volume":"131","author":"N Morisaki","year":"1997","unstructured":"Morisaki, N. et al. New indices of ischemic heart disease and aging: studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease. Atherosclerosis 131, 43\u201348 (1997).","journal-title":"Atherosclerosis"},{"key":"BFng1047z_CR18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/BF02263499","volume":"45","author":"F Squadrito","year":"1996","unstructured":"Squadrito, F. et al. Thrombolytic therapy with urokinase reduces increased circulating endothelial adhesion molecules in acute myocardial infarction. Inflamm. Res. 45, 14\u201319 (1996).","journal-title":"Inflamm. Res."},{"key":"BFng1047z_CR19","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1161\/01.CIR.95.8.2027","volume":"95","author":"JJ Belch","year":"1997","unstructured":"Belch, J.J. et al. The white blood cell adhesion molecule E-selectin predicts restenosis in patients with intermittent claudication undergoing percutaneous transluminal angioplasty. Circulation 95, 2027\u20132031 (1997).","journal-title":"Circulation"},{"key":"BFng1047z_CR20","doi-asserted-by":"publisher","first-page":"12364","DOI":"10.1074\/jbc.M111727200","volume":"277","author":"SA Schreyer","year":"2002","unstructured":"Schreyer, S.A, Vick, C.M. & LeBoeuf, R.C. Loss of lymphotoxin-\u03b1 but not tumor necrosis factor-\u03b1 reduces atherosclerosis in mice. J. Biol. Chem. 277, 12364\u201312368 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFng1047z_CR21","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/nm0697-600","volume":"3","author":"JL Breslow","year":"1997","unstructured":"Breslow, J.L. Cardiovascular disease burden increases, NIH funding decreases. Nature Med. 3, 600\u2013601 (1997).","journal-title":"Nature Med."},{"key":"BFng1047z_CR22","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1056\/NEJM199711063371906","volume":"337","author":"E Braunwald","year":"1997","unstructured":"Braunwald, E. Shattuck lecture\u2014cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N. Engl. J. Med. 337, 1360\u20131369 (1997).","journal-title":"N. Engl. J. Med."},{"key":"BFng1047z_CR23","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1007\/s100380170019","volume":"46","author":"A Iida","year":"2001","unstructured":"Iida, A. et al. Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins. J. Hum. Genet. 46, 668\u2013683 (2001).","journal-title":"J. Hum. Genet."},{"key":"BFng1047z_CR24","first-page":"921","volume":"12","author":"L Excoffier","year":"1995","unstructured":"Excoffier, L. & Slatkin, M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol. Biol. Evol. 12, 921\u2013927 (1995).","journal-title":"Mol. Biol. Evol."},{"key":"BFng1047z_CR25","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/ng1001-229","volume":"29","author":"MJ Daly","year":"2001","unstructured":"Daly, M.J., Rioux, J.D., Schaffner, S.F., Hudson, T.J. & Lander, E.S. High-resolution haplotype structure in the human genome. Nature Genet. 29, 229\u2013232 (2001).","journal-title":"Nature Genet."},{"key":"BFng1047z_CR26","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1086\/318789","volume":"68","author":"R Yamada","year":"2001","unstructured":"Yamada, R. et al. Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to the disease. Am. J. Hum. Genet. 68, 674\u2013685 (2001).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng1047z_CR27","unstructured":"Andrews, N.C. & Faller, D.V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 11, 2499 (1991)."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1047z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1047z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1047z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:04:00Z","timestamp":1684429440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1047z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,11]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["BFng1047z"],"URL":"https:\/\/doi.org\/10.1038\/ng1047","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1010810.166757","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1010810.184822","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1010810.176510","asserted-by":"object"}]},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,11]]},"assertion":[{"value":"7 May 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2002","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}