{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:03:03Z","timestamp":1773864183157,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1996,12,1]],"date-time":"1996-12-01T00:00:00Z","timestamp":849398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1996,12]]},"DOI":"10.1038\/ng1296-371","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T20:13:21Z","timestamp":1092860001000},"page":"371-373","source":"Crossref","is-referenced-by-count":249,"title":["Who's afraid of epistasis?"],"prefix":"10.1038","volume":"14","author":[{"given":"Wayne N.","family":"Frankel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Schork","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFng1296371_CR1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/ng1296-465","volume":"14","author":"RJA Fijneman","year":"1996","unstructured":"Fijneman, R.J.A. . S.S., de Vries, R. C., Jansen, & P., Demant . Nature Genet. 14, 465\u2013467 (1996).","journal-title":"Nature Genet."},{"key":"BFng1296371_CR2","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/ng1296-468","volume":"14","author":"T van Wezel","year":"1996","unstructured":"van Wezel, T., A.P.M. Stassen, C.J.A., Moen, A.A.M., Hart, M.A. van der Valk & P. Demant . Nature Genet. 14, 468\u2013470 (1996).","journal-title":"Nature Genet."},{"key":"BFng1296371_CR3","first-page":"368","volume":"1","author":"W Bateson","year":"1907","unstructured":"Bateson, W. Prog. Res. Bot. 1, 368 (1907).","journal-title":"Prog. Res. Bot."},{"key":"BFng1296371_CR4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0022-5193(68)90186-0","volume":"20","author":"DL Hartl","year":"1968","unstructured":"Hartl, D.L. & Maruyama, T . J. Theor. Biol. 20, 129\u2013163 (1968).","journal-title":"J. Theor. Biol."},{"key":"BFng1296371_CR5","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1126\/science.8202715","volume":"264","author":"K Kajiwara","year":"1994","unstructured":"Kajiwara, K., Berson, E.L. & Dryja, T.P. Science 264, 1604\u20131608 (1994).","journal-title":"Science"},{"key":"BFng1296371_CR6","first-page":"1127","volume":"53","author":"NJ Schork","year":"1993","unstructured":"Schork, N.J., Boehnke, M., Terwilliger, J.T. & Ott, J. Am. J. Hum. Genet. 53, 1127\u20131136 (1993).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng1296371_CR7","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/genetics\/139.3.1455","volume":"139","author":"JM Cheverud","year":"1995","unstructured":"Cheverud, J.M. & Routman, E.J. Genetics 139, 1455\u20131461 (1995).","journal-title":"Genetics"},{"key":"BFng1296371_CR8","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1006\/geno.1994.1064","volume":"19","author":"PJ Tienari","year":"1994","unstructured":"Tienari, P.J., Terwilliger, J.D., Ott, J., Palo, J. & Peltonen, L. Genomics 19, 320\u2013325 (1994).","journal-title":"Genomics"},{"key":"BFng1296371_CR9","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/ng1095-150","volume":"11","author":"GT De Sanctis","year":"1995","unstructured":"De Sanctis, G.T. et al. Nature Genet. 11, 150\u2013154 (1995).","journal-title":"Nature Genet."},{"key":"BFng1296371_CR10","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1007\/BF00292431","volume":"6","author":"WN Frankel","year":"1995","unstructured":"Frankel, W.N. et al. Mamm. Genome 6, 830\u2013838 (1995).","journal-title":"Mamm. Genome"},{"key":"BFng1296371_CR11","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.2527\/jas1978.4651192x","volume":"46","author":"S Wright","year":"1978","unstructured":"Wright, S. J. Anim. Sci. 46, 1192\u20131200 (1978).","journal-title":"J. Anim. Sci."},{"key":"BFng1296371_CR12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/genetics\/16.2.97","volume":"16","author":"S Wright","year":"1931","unstructured":"Wright, S., Genetics 16, 97\u2013159 (1931).","journal-title":"Genetics"},{"key":"BFng1296371_CR13","unstructured":"Schork, N.J. Hypertension (in the press)."},{"key":"BFng1296371_CR14","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1126\/science.272.5262.741","volume":"272","author":"LH Rieseberg","year":"1996","unstructured":"Rieseberg, L.H., B., Sinervo, C., Randal-Linder, M.C., Ungerer & Arias, D. M. Science 272, 741\u2013745 (1996).","journal-title":"Science"},{"key":"BFng1296371_CR15","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1006\/geno.1995.9946","volume":"29","author":"VA Letts","year":"1995","unstructured":"Letts, V.A., Schork, N.J., Copp, A.J., Bernfield, M. & Frankel, W.N. Genomics 29, 719\u2013724 (1995).","journal-title":"Genomics"},{"key":"BFng1296371_CR16","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1097\/00004872-199404000-00004","volume":"12","author":"JP Rapp","year":"1994","unstructured":"Rapp, J.P., Dene, H. & Deng, A.Y. J. Hypertension 12, 349\u2013355 (1994).","journal-title":"J. Hypertension"},{"key":"BFng1296371_CR17","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1126\/science.8091226","volume":"265","author":"ES Lander","year":"1994","unstructured":"Lander, E.S. & Schork, N.J. Science 265, 2037\u20132048 (1994).","journal-title":"Science"},{"key":"BFng1296371_CR18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/genetics\/121.1.185","volume":"121","author":"ES Lander","year":"1989","unstructured":"Lander, E.S. & Botstein, D. Genetics 121, 185\u2013199 (1989).","journal-title":"Genetics"},{"key":"BFng1296371_CR19","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ng1195-241","volume":"11","author":"E Lander","year":"1995","unstructured":"Lander, E. & Kruglyak, L. Nature Genet. 11, 241\u2013247 (1995).","journal-title":"Nature Genet."},{"key":"BFng1296371_CR20","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.1096\/fasebj.6.10.1634045","volume":"6","author":"PC Groot","year":"1992","unstructured":"Groot, P.C. et al. FASEB J. 6, 2826\u20132835 (1992).","journal-title":"FASEB J."},{"key":"BFng1296371_CR21","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/genetics\/136.4.1447","volume":"136","author":"RC Jansen","year":"1994","unstructured":"Jansen, R.C. & Stam, P. Genetics 136, 1447\u20131455 (1994).","journal-title":"Genetics"},{"key":"BFng1296371_CR22","first-page":"11","volume":"56","author":"LB Jorde","year":"1995","unstructured":"Jorde, L.B. Am. J. Hum. Genet. 56, 11\u201314 (1995).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng1296371_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.ge.16.120182.000245","volume":"16","author":"S Wright","year":"1982","unstructured":"Wright, S. Ann. Rev. Genet. 16, 1\u201319 (1982).","journal-title":"Ann. Rev. Genet."},{"key":"BFng1296371_CR24","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/BF00292432","volume":"6","author":"WN Frankel","year":"1995","unstructured":"Frankel, W.N., Johnson, E.W. & Lutz, C.M. Mamm. Genome 6, 839\u2013843 (1995).","journal-title":"Mamm. Genome"},{"key":"BFng1296371_CR25","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s003359900098","volume":"7","author":"L Morel","year":"1996","unstructured":"Morel, L., Yu, Y., Blenman, K.R., Caldwell, R. A. & Wakeland, E.K. Mamm. Genome 7, 335\u2013339 (1996).","journal-title":"Mamm. Genome"},{"key":"BFng1296371_CR26","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/S0168-9525(00)89155-6","volume":"11","author":"WN Frankel","year":"1995","unstructured":"Frankel, W.N., Trends Genet. 11, 471\u2013477 (1995).","journal-title":"Trends Genet."},{"key":"BFng1296371_CR27","unstructured":"Johnson, K.R., Lane, P.W., Ward-Bailey, P. & Davisson, M.T., 29, 457\u2013464 (1995)."},{"key":"BFng1296371_CR28","unstructured":"Falconer, D.S. Introduction to Quantitative Genetics. 3rd edn. (Essex: Longman Scientific and Technical, 1989)."},{"key":"BFng1296371_CR29","first-page":"427","volume":"7","author":"NJ Schork","year":"1990","unstructured":"Schork, N.J., Weder, A. & Schork, M., Epidemiol. 7, 427\u2013446 (1990).","journal-title":"Epidemiol."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1296-371","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1296-371.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1296-371.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:02:54Z","timestamp":1684447374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1296-371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,12]]}},"alternative-id":["BFng1296371"],"URL":"https:\/\/doi.org\/10.1038\/ng1296-371","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,12]]}}}