{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:37:06Z","timestamp":1772134626969,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2005,4,24]],"date-time":"2005-04-24T00:00:00Z","timestamp":1114300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1038\/ng1554","type":"journal-article","created":{"date-parts":[[2005,4,25]],"date-time":"2005-04-25T08:40:02Z","timestamp":1114418402000},"page":"544-548","source":"Crossref","is-referenced-by-count":228,"title":["The transcriptional consequences of mutation and natural selection in Caenorhabditis elegans"],"prefix":"10.1038","volume":"37","author":[{"given":"Dee R","family":"Denver","sequence":"first","affiliation":[]},{"given":"Krystalynne","family":"Morris","sequence":"additional","affiliation":[]},{"given":"J Todd","family":"Streelman","sequence":"additional","affiliation":[]},{"given":"Stuart K","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Lynch","sequence":"additional","affiliation":[]},{"given":"W Kelley","family":"Thomas","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2005,4,24]]},"reference":[{"key":"BFng1554_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1126\/science.1090005","volume":"188","author":"M-C King","year":"1975","unstructured":"King, M.-C. & Wilson, A.C. Evolution at two levels in humans and chimpanzees. Science 188, 107\u2013116 (1975).","journal-title":"Science"},{"key":"BFng1554_CR2","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/ng983","volume":"32","author":"MF Oleksiak","year":"2002","unstructured":"Oleksiak, M.F., Churchill, G.A. & Crawford, D.L. Variation in gene expression within and among natural populations. Nat. Genet. 32, 261\u2013266 (2002).","journal-title":"Nat. Genet."},{"key":"BFng1554_CR3","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1371\/journal.pbio.0020132","volume":"2","author":"P Khaitovich","year":"2004","unstructured":"Khaitovich, P. et al. A neutral model of transcriptome evolution. PLoS Biol. 2, 682\u2013689 (2004).","journal-title":"PLoS Biol."},{"key":"BFng1554_CR4","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1111\/j.0014-3820.2000.tb00557.x","volume":"54","author":"LL Vassilieva","year":"2000","unstructured":"Vassilieva, L.L., Hook, A.M. & Lynch, M. The fitness effects of spontaneous mutations in Caenorhabditis elegans. Evolution 54, 1234\u20131246 (2000).","journal-title":"Evolution"},{"key":"BFng1554_CR5","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1126\/science.1089370","volume":"302","author":"M Lynch","year":"2003","unstructured":"Lynch, M. & Conery, J.S. The origins of genome complexity. Science 302, 1401\u20131404 (2003).","journal-title":"Science"},{"key":"BFng1554_CR6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/genetics\/161.1.99","volume":"161","author":"A Graustein","year":"2002","unstructured":"Graustein, A., Gaspar, J.M., Walters, J.R. & Palopoli, M.F. Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis. Genetics 161, 99\u2013107 (2002).","journal-title":"Genetics"},{"key":"BFng1554_CR7","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nature02697","volume":"430","author":"DR Denver","year":"2004","unstructured":"Denver, D.R., Morris, K., Lynch, M. & Thomas, W.K. High mutation rate and predominace of insertions in the Caenorhabditis elegans nuclear genome. Nature 430, 679\u2013682 (2004).","journal-title":"Nature"},{"key":"BFng1554_CR8","doi-asserted-by":"publisher","first-page":"R716","DOI":"10.1016\/S0960-9822(02)01244-7","volume":"12","author":"B Charlesworth","year":"2002","unstructured":"Charlesworth, B. Effective population size. Curr. Biol. 12, R716\u2013R717 (2002).","journal-title":"Curr. Biol."},{"key":"BFng1554_CR9","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1093\/biostatistics\/2.2.183","volume":"2","author":"MK Kerr","year":"2001","unstructured":"Kerr, M.K. & Churchill, G.A. Experimental design for gene expression microarrays. Biostatistics 2, 183\u2013201 (2001).","journal-title":"Biostatistics"},{"key":"BFng1554_CR10","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1093\/molbev\/msg044","volume":"20","author":"DR Denver","year":"2003","unstructured":"Denver, D.R., Morris, K. & Thomas, W.K. Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing. Mol. Biol. Evol. 20, 393\u2013400 (2003).","journal-title":"Mol. Biol. Evol."},{"key":"BFng1554_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/gb-2003-4-4-210","volume":"4","author":"X Cui","year":"2003","unstructured":"Cui, X. & Churchill, G.A. Statistical tests for differential expression in cDNA microarray experiments. Genome Biol. 4, 210 (2003).","journal-title":"Genome Biol."},{"key":"BFng1554_CR12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nature02698","volume":"430","author":"PJ Wittkopp","year":"2004","unstructured":"Wittkopp, P.J., Haerum, B.K. & Clark, A.G. Evolutionary changes in cis and trans gene regulation. Nature 430, 85\u201388 (2004).","journal-title":"Nature"},{"key":"BFng1554_CR13","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1093\/molbev\/msg140","volume":"20","author":"GA Wray","year":"2003","unstructured":"Wray, G.A. et al. The evolution of transcriptional regulation in eukaryotes. Mol. Biol. Evol. 20, 1377\u20131419 (2003).","journal-title":"Mol. Biol. Evol."},{"key":"BFng1554_CR14","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1126\/science.1061603","volume":"293","author":"SK Kim","year":"2001","unstructured":"Kim, S.K. et al. A gene expression map for Caenorhabditis elegans. Science 293, 2087\u20132092 (2001).","journal-title":"Science"},{"key":"BFng1554_CR15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/genetics\/141.1.159","volume":"141","author":"TM Barnes","year":"1995","unstructured":"Barnes, T.M., Kohara, Y., Coulson, A. & Hekimi, S. Meiotic recombination, noncoding DNA and genomic organization in Caenorhabditis elegans. Genetics 141, 159\u2013179 (1995).","journal-title":"Genetics"},{"key":"BFng1554_CR16","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1101\/gr.GR-1471R","volume":"10","author":"R Koch","year":"2000","unstructured":"Koch, R., van Luenen, H.G., van der Horst, M., Thijssen, K.L. & Plasterk, R.H. Single nucleotide polymorphisms in wild isolates of Caenorhabditis elegans. Genome Res. 10, 1690\u20131696 (2000).","journal-title":"Genome Res."},{"key":"BFng1554_CR17","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1017\/S0016672300010156","volume":"8","author":"WG Hill","year":"1966","unstructured":"Hill, W.G. & Robertson, A. The effects of linkage on limits to artificial selection. Genet. Res. 8, 269\u2013294 (1966).","journal-title":"Genet. Res."},{"key":"BFng1554_CR18","doi-asserted-by":"crossref","unstructured":"The C. elegans Sequencing Consortium. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282, 2012\u20132018 (1998).","DOI":"10.1126\/science.282.5396.2012"},{"key":"BFng1554_CR19","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/nature01012","volume":"418","author":"PJ Roy","year":"2002","unstructured":"Roy, P.J., Stuart, J.M., Lund, J. & Kim, S.K. Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans. Nature 418, 975\u2013979 (2002).","journal-title":"Nature"},{"key":"BFng1554_CR20","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1101\/gr.553803","volume":"13","author":"ML Lercher","year":"2003","unstructured":"Lercher, M.L., Blumenthal, T. & Hurst, L.D. Coexpression of neighboring genes in Caenorhabditis elegans is mostly due to operons and duplicate genes. Genome Res. 13, 238\u2013243 (2003).","journal-title":"Genome Res."},{"key":"BFng1554_CR21","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1111\/j.1558-5646.1986.tb00561.x","volume":"40","author":"M Lynch","year":"1986","unstructured":"Lynch, M. & Hill, W.G. Phenotypic evolution by neutral mutation. Evolution 40, 915\u2013935 (1986).","journal-title":"Evolution"},{"key":"BFng1554_CR22","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/genetics\/165.2.747","volume":"165","author":"W Hsieh","year":"2003","unstructured":"Hsieh, W., Chu, T., Wolfinger, R.D. & Gibson, G. Mixed-model reanalysis of primate data suggests tissue and species biases in oligonucleotide-based gene expression profiles. Genetics 165, 747\u2013757 (2003).","journal-title":"Genetics"},{"key":"BFng1554_CR23","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1126\/science.1068996","volume":"296","author":"W Enard","year":"2002","unstructured":"Enard, W. et al. Intra- and interspecific variation in primate gene expression patterns. Science 296, 340\u2013343 (2002).","journal-title":"Science"},{"key":"BFng1554_CR24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner, M. et al. Gene ontology: tool for the unification of biology. Gene Ontology Consortium. Nat. Genet. 25, 25\u201329 (2000).","journal-title":"Nat. Genet."},{"key":"BFng1554_CR25","doi-asserted-by":"publisher","first-page":"D411","DOI":"10.1093\/nar\/gkh066","volume":"32","author":"TW Harris","year":"2004","unstructured":"Harris, T.W. et al. WormBase: a multi-species resource for nematode biology and genomics. Nucleic Acids Res. 32, D411\u2013D417 (2004).","journal-title":"Nucleic Acids Res."},{"key":"BFng1554_CR26","doi-asserted-by":"publisher","first-page":"B145","DOI":"10.1093\/geronj\/49.4.B145","volume":"49","author":"TJ Fabian","year":"1994","unstructured":"Fabian, T.J. & Johnson, T.E. Production of age-synchronous mass cultures of Caenorhabditis elegans. J. Gerontol. 49, B145\u2013B156 (1994).","journal-title":"J. Gerontol."},{"key":"BFng1554_CR27","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1073\/pnas.98.1.218","volume":"98","author":"M Jiang","year":"2001","unstructured":"Jiang, M. et al. Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 98, 218\u2013223 (2001).","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1554.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1554","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1554.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:09:02Z","timestamp":1684433342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,24]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["BFng1554"],"URL":"https:\/\/doi.org\/10.1038\/ng1554","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1026117.347632","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1026117.324900","asserted-by":"object"}]},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,24]]}}}