{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:48:59Z","timestamp":1778050139557,"version":"3.51.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2006,7,16]],"date-time":"2006-07-16T00:00:00Z","timestamp":1153008000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1038\/ng1844","type":"journal-article","created":{"date-parts":[[2006,7,16]],"date-time":"2006-07-16T13:55:21Z","timestamp":1153058121000},"page":"896-903","source":"Crossref","is-referenced-by-count":445,"title":["Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways"],"prefix":"10.1038","volume":"38","author":[{"given":"Ben","family":"Lehner","sequence":"first","affiliation":[]},{"given":"Catriona","family":"Crombie","sequence":"additional","affiliation":[]},{"given":"Julia","family":"Tischler","sequence":"additional","affiliation":[]},{"given":"Angelo","family":"Fortunato","sequence":"additional","affiliation":[]},{"given":"Andrew G","family":"Fraser","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2006,7,16]]},"reference":[{"key":"BFng1844_CR1","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/nrg910","volume":"3","author":"JL Badano","year":"2002","unstructured":"Badano, J.L. & Katsanis, N. Beyond Mendel: an evolving view of human genetic disease transmission. Nat. Rev. Genet. 3, 779\u2013789 (2002).","journal-title":"Nat. Rev. Genet."},{"key":"BFng1844_CR2","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","volume":"61","author":"ER Fearon","year":"1990","unstructured":"Fearon, E.R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759\u2013767 (1990).","journal-title":"Cell"},{"key":"BFng1844_CR3","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1126\/science.291.5506.1001","volume":"291","author":"JLt Hartman","year":"2001","unstructured":"Hartman, J.L.t., Garvik, B. & Hartwell, L. Principles for the buffering of genetic variation. Science 291, 1001\u20131004 (2001).","journal-title":"Science"},{"key":"BFng1844_CR4","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1126\/science.1065810","volume":"294","author":"AH Tong","year":"2001","unstructured":"Tong, A.H. et al. Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294, 2364\u20132368 (2001).","journal-title":"Science"},{"key":"BFng1844_CR5","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1126\/science.1091317","volume":"303","author":"AH Tong","year":"2004","unstructured":"Tong, A.H. et al. Global mapping of the yeast genetic interaction network. Science 303, 808\u2013813 (2004).","journal-title":"Science"},{"key":"BFng1844_CR6","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1038\/ng1640","volume":"37","author":"AP Davierwala","year":"2005","unstructured":"Davierwala, A.P. et al. The synthetic genetic interaction spectrum of essential genes. Nat. Genet. 37, 1147\u20131152 (2005).","journal-title":"Nat. Genet."},{"key":"BFng1844_CR7","doi-asserted-by":"publisher","first-page":"12992","DOI":"10.1073\/pnas.0403131101","volume":"101","author":"G van Haaften","year":"2004","unstructured":"van Haaften, G., Vastenhouw, N.L., Nollen, E.A., Plasterk, R.H. & Tijsterman, M. Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proc. Natl. Acad. Sci. USA 101, 12992\u201312996 (2004).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng1844_CR8","doi-asserted-by":"publisher","first-page":"R45","DOI":"10.1186\/gb-2005-6-5-r45","volume":"6","author":"LR Baugh","year":"2005","unstructured":"Baugh, L.R. et al. Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions. Genome Biol. 6, R45 (2005).","journal-title":"Genome Biol."},{"key":"BFng1844_CR9","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1038\/27579","volume":"395","author":"L Timmons","year":"1998","unstructured":"Timmons, L. & Fire, A. Specific interference by ingested dsRNA. Nature 395, 854 (1998).","journal-title":"Nature"},{"key":"BFng1844_CR10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature01278","volume":"421","author":"RS Kamath","year":"2003","unstructured":"Kamath, R.S. et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421, 231\u2013237 (2003).","journal-title":"Nature"},{"key":"BFng1844_CR11","doi-asserted-by":"crossref","unstructured":"Sundaram, M.V. RTK\/Ras\/MAP kinase signaling. WormBook [online] &lt; http:\/\/www.wormbook.org &gt;, published online 11 February 2006 (doi\/10.1895\/wormbook.1.80.1).","DOI":"10.1895\/wormbook.1.80.1"},{"key":"BFng1844_CR12","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/nature04010","volume":"436","author":"D Wang","year":"2005","unstructured":"Wang, D. et al. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature 436, 593\u2013597 (2005).","journal-title":"Nature"},{"key":"BFng1844_CR13","doi-asserted-by":"publisher","first-page":"R4","DOI":"10.1186\/gb-2006-7-1-r4","volume":"7","author":"B Lehner","year":"2006","unstructured":"Lehner, B. et al. Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference. Genome Biol. 7, R4 (2006).","journal-title":"Genome Biol."},{"key":"BFng1844_CR14","first-page":"1","volume":"65","author":"JM Kinchen","year":"2005","unstructured":"Kinchen, J.M. & Hengartner, M.O. Tales of cannibalism, suicide, and murder: programmed cell death in C. elegans. Curr. Top. Dev. Biol. 65, 1\u201345 (2005).","journal-title":"Curr. Top. Dev. Biol."},{"key":"BFng1844_CR15","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1101\/gad.998402","volume":"16","author":"RM Howard","year":"2002","unstructured":"Howard, R.M. & Sundaram, M.V. C. elegans EOR-1\/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component. Genes Dev. 16, 1815\u20131827 (2002).","journal-title":"Genes Dev."},{"key":"BFng1844_CR16","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1101\/gad.12.10.1425","volume":"12","author":"M Kokel","year":"1998","unstructured":"Kokel, M., Borland, C.Z., DeLong, L., Horvitz, H.R. & Stern, M.J. clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes Dev. 12, 1425\u20131437 (1998).","journal-title":"Genes Dev."},{"key":"BFng1844_CR17","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/nature01765","volume":"424","author":"A Bergman","year":"2003","unstructured":"Bergman, A. & Siegal, M.L. Evolutionary capacitance as a general feature of complex gene networks. Nature 424, 549\u2013552 (2003).","journal-title":"Nature"},{"key":"BFng1844_CR18","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/24550","volume":"396","author":"SL Rutherford","year":"1998","unstructured":"Rutherford, S.L. & Lindquist, S. Hsp90 as a capacitor for morphological evolution. Nature 396, 336\u2013342 (1998).","journal-title":"Nature"},{"key":"BFng1844_CR19","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/nature749","volume":"417","author":"C Queitsch","year":"2002","unstructured":"Queitsch, C., Sangster, T.A. & Lindquist, S. Hsp90 as a capacitor of phenotypic variation. Nature 417, 618\u2013624 (2002).","journal-title":"Nature"},{"key":"BFng1844_CR20","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S1534-5807(04)00065-6","volume":"6","author":"CJ Ceol","year":"2004","unstructured":"Ceol, C.J. & Horvitz, H.R. A new class of C. elegans synMuv genes implicates a Tip60\/NuA4-like HAT complex as a negative regulator of Ras signaling. Dev. Cell 6, 563\u2013576 (2004).","journal-title":"Dev. Cell"},{"key":"BFng1844_CR21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1242\/dev.00189","volume":"130","author":"N Moghal","year":"2003","unstructured":"Moghal, N. & Sternberg, P.W. A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans. Development 130, 57\u201369 (2003).","journal-title":"Development"},{"key":"BFng1844_CR22","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1101\/gad.13.7.877","volume":"13","author":"LI Jiang","year":"1999","unstructured":"Jiang, L.I. & Sternberg, P.W. An HMG1-like protein facilitates Wnt signaling in Caenorhabditis elegans. Genes Dev. 13, 877\u2013889 (1999).","journal-title":"Genes Dev."},{"key":"BFng1844_CR23","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1101\/gad.312604","volume":"18","author":"AH Ludewig","year":"2004","unstructured":"Ludewig, A.H. et al. A novel nuclear receptor\/coregulator complex controls C. elegans lipid metabolism, larval development, and aging. Genes Dev. 18, 2120\u20132133 (2004).","journal-title":"Genes Dev."},{"key":"BFng1844_CR24","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1242\/dev.126.5.1055","volume":"126","author":"MA Herman","year":"1999","unstructured":"Herman, M.A. et al. EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans. Development 126, 1055\u20131064 (1999).","journal-title":"Development"},{"key":"BFng1844_CR25","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/ng1067","volume":"33","author":"V Sollars","year":"2003","unstructured":"Sollars, V. et al. Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution. Nat. Genet. 33, 70\u201374 (2003).","journal-title":"Nat. Genet."},{"key":"BFng1844_CR26","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S0092-8674(00)81131-9","volume":"92","author":"SE George","year":"1998","unstructured":"George, S.E., Simokat, K., Hardin, J. & Chisholm, A.D. The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans. Cell 92, 633\u2013643 (1998).","journal-title":"Cell"},{"key":"BFng1844_CR27","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF00293205","volume":"247","author":"DV Clark","year":"1995","unstructured":"Clark, D.V., Suleman, D.S., Beckenbach, K.A., Gilchrist, E.J. & Baillie, D.L. Molecular cloning and characterization of the dpy-20 gene of Caenorhabditis elegans. Mol. Gen. Genet. 247, 367\u2013378 (1995).","journal-title":"Mol. Gen. Genet."},{"key":"BFng1844_CR28","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1242\/dev.128.5.767","volume":"128","author":"H Zhang","year":"2001","unstructured":"Zhang, H. & Emmons, S.W. The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression. Development 128, 767\u2013777 (2001).","journal-title":"Development"},{"key":"BFng1844_CR29","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0960-9822(00)00343-2","volume":"10","author":"F Solari","year":"2000","unstructured":"Solari, F. & Ahringer, J. NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans. Curr. Biol. 10, 223\u2013226 (2000).","journal-title":"Curr. Biol."},{"key":"BFng1844_CR30","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1242\/dev.126.15.3303","volume":"126","author":"Q Ch'ng","year":"1999","unstructured":"Ch'ng, Q. & Kenyon, C. egl-27 generates anteroposterior patterns of cell fusion in C. elegans by regulating Hox gene expression and Hox protein function. Development 126, 3303\u20133312 (1999).","journal-title":"Development"},{"key":"BFng1844_CR31","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/genetics\/154.2.695","volume":"154","author":"I Rebay","year":"2000","unstructured":"Rebay, I. et al. A genetic screen for novel components of the Ras\/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein. Genetics 154, 695\u2013712 (2000).","journal-title":"Genetics"},{"key":"BFng1844_CR32","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/S0960-9822(00)00625-4","volume":"10","author":"F Chen","year":"2000","unstructured":"Chen, F. & Rebay, I. split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells. Curr. Biol. 10, 943\u2013946 (2000).","journal-title":"Curr. Biol."},{"key":"BFng1844_CR33","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1242\/dev.00527","volume":"130","author":"HV Lin","year":"2003","unstructured":"Lin, H.V. et al. Splits ends is a tissue\/promoter specific regulator of Wingless signaling. Development 130, 3125\u20133135 (2003).","journal-title":"Development"},{"key":"BFng1844_CR34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/genetics\/153.1.275","volume":"153","author":"K Staehling-Hampton","year":"1999","unstructured":"Staehling-Hampton, K., Ciampa, P.J., Brook, A. & Dyson, N. A genetic screen for modifiers of E2F in Drosophila melanogaster. Genetics 153, 275\u2013287 (1999).","journal-title":"Genetics"},{"key":"BFng1844_CR35","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1242\/dev.126.23.5373","volume":"126","author":"EL Wiellette","year":"1999","unstructured":"Wiellette, E.L. et al. spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk. Development 126, 5373\u20135385 (1999).","journal-title":"Development"},{"key":"BFng1844_CR36","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1242\/dev.127.7.1517","volume":"127","author":"B Kuang","year":"2000","unstructured":"Kuang, B., Wu, S.C., Shin, Y., Luo, L. & Kolodziej, P. split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo. Development 127, 1517\u20131529 (2000).","journal-title":"Development"},{"key":"BFng1844_CR37","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S1074-7613(03)00029-3","volume":"18","author":"K Kuroda","year":"2003","unstructured":"Kuroda, K. et al. Regulation of marginal zone B cell development by MINT, a suppressor of Notch\/RBP-J signaling pathway. Immunity 18, 301\u2013312 (2003).","journal-title":"Immunity"},{"key":"BFng1844_CR38","doi-asserted-by":"publisher","first-page":"5417","DOI":"10.1093\/emboj\/cdf549","volume":"21","author":"F Oswald","year":"2002","unstructured":"Oswald, F. et al. SHARP is a novel component of the Notch\/RBP-Jkappa signalling pathway. EMBO J. 21, 5417\u20135426 (2002).","journal-title":"EMBO J."},{"key":"BFng1844_CR39","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1101\/gad.871201","volume":"15","author":"Y Shi","year":"2001","unstructured":"Shi, Y. et al. Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. Genes Dev. 15, 1140\u20131151 (2001).","journal-title":"Genes Dev."},{"key":"BFng1844_CR40","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/genetics\/165.3.1149","volume":"165","author":"EA Bach","year":"2003","unstructured":"Bach, E.A., Vincent, S., Zeidler, M.P. & Perrimon, N. A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase\/signal transducer and activator of transcription pathway. Genetics 165, 1149\u20131166 (2003).","journal-title":"Genetics"},{"key":"BFng1844_CR41","first-page":"90","volume":"43","author":"F Janody","year":"2002","unstructured":"Janody, F., Benlali, A., Martirosyan, Z. & Treisman, J. Blind spot and Kohtalo, two components of the Drosophila mediator complex, act together to control a subset of Hedgehog and Wingless target genes. A. Dros. Res. Conf. 43, 90 (2002).","journal-title":"A. Dros. Res. Conf."},{"key":"BFng1844_CR42","first-page":"346A","volume":"44","author":"I Carrera","year":"2003","unstructured":"Carrera, I., Janody, F., Martirosyan, Z. & Treisman, J. Two subunits of the mediator complex act as adaptors for Notch and Wingless signaling. A. Dros. Res. Conf. 44, 346A (2003).","journal-title":"A. Dros. Res. Conf."},{"key":"BFng1844_CR43","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1128\/MCB.26.6.2347-2359.2006","volume":"26","author":"M Gause","year":"2006","unstructured":"Gause, M. et al. Nipped-A, the Tra1\/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development. Mol. Cell. Biol. 26, 2347\u20132359 (2006).","journal-title":"Mol. Cell. Biol."},{"key":"BFng1844_CR44","doi-asserted-by":"publisher","first-page":"11197","DOI":"10.1074\/jbc.M210816200","volume":"278","author":"H Xiao","year":"2003","unstructured":"Xiao, H., Chung, J., Kao, H.Y. & Yang, Y.C. Tip60 is a co-repressor for STAT3. J. Biol. Chem. 278, 11197\u201311204 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFng1844_CR45","first-page":"8726","volume":"63","author":"Y Feng","year":"2003","unstructured":"Feng, Y., Lee, N. & Fearon, E.R. TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling. Cancer Res. 63, 8726\u20138734 (2003).","journal-title":"Cancer Res."},{"key":"BFng1844_CR46","doi-asserted-by":"publisher","first-page":"4546","DOI":"10.1128\/MCB.24.10.4546-4556.2004","volume":"24","author":"S Taubert","year":"2004","unstructured":"Taubert, S. et al. E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1. Mol. Cell. Biol. 24, 4546\u20134556 (2004).","journal-title":"Mol. Cell. Biol."},{"key":"BFng1844_CR47","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature02371","volume":"428","author":"K Berns","year":"2004","unstructured":"Berns, K. et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428, 431\u2013437 (2004).","journal-title":"Nature"},{"issue":"Suppl.","key":"BFng1844_CR48","doi-asserted-by":"publisher","first-page":"S203","DOI":"10.1016\/S0925-4773(03)00117-5","volume":"119","author":"T Inoue","year":"2002","unstructured":"Inoue, T. et al. Gene expression markers for Caenorhabditis elegans vulval cells. Mech. Dev. 119 (Suppl.), S203\u2013S209 (2002).","journal-title":"Mech. Dev."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1844.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1844","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1844.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:12:12Z","timestamp":1684433532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,16]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["BFng1844"],"URL":"https:\/\/doi.org\/10.1038\/ng1844","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1015745.389044","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1015745.502410","asserted-by":"object"}]},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,16]]}}}