{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:41:23Z","timestamp":1783633283445,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1038\/ng1901","type":"journal-article","created":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T18:16:14Z","timestamp":1159726574000},"page":"1289-1297","source":"Crossref","is-referenced-by-count":1148,"title":["Genome-wide analysis of estrogen receptor binding sites"],"prefix":"10.1038","volume":"38","author":[{"given":"Jason S","family":"Carroll","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford A","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R","family":"Geistlinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Eeckhoute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander S","family":"Brodsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Krasnickas","family":"Keeton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten C","family":"Fertuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles F","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianben","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bekiranov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Sementchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela A","family":"Silver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R","family":"Gingeras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X Shirley","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,10,1]]},"reference":[{"key":"BFng1901_CR1","doi-asserted-by":"publisher","first-page":"10869","DOI":"10.1073\/pnas.191367098","volume":"98","author":"T Sorlie","year":"2001","unstructured":"Sorlie, T. et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. USA 98, 10869\u201310874 (2001).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng1901_CR2","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/415530a","volume":"415","author":"LJ van 't Veer","year":"2002","unstructured":"van 't Veer, L.J. et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530\u2013536 (2002).","journal-title":"Nature"},{"key":"BFng1901_CR3","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1056\/NEJMoa021967","volume":"347","author":"MJ van de Vijver","year":"2002","unstructured":"van de Vijver, M.J. et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347, 1999\u20132009 (2002).","journal-title":"N. Engl. J. Med."},{"key":"BFng1901_CR4","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S0140-6736(05)70933-8","volume":"365","author":"Y Wang","year":"2005","unstructured":"Wang, Y. et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 365, 671\u2013679 (2005).","journal-title":"Lancet"},{"key":"BFng1901_CR5","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/35021093","volume":"406","author":"CM Perou","year":"2000","unstructured":"Perou, C.M. et al. Molecular portraits of human breast tumours. Nature 406, 747\u2013752 (2000).","journal-title":"Nature"},{"key":"BFng1901_CR6","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/S0092-8674(00)00188-4","volume":"103","author":"Y Shang","year":"2000","unstructured":"Shang, Y., Hu, X., DiRenzo, J., Lazar, M.A. & Brown, M. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103, 843\u2013852 (2000).","journal-title":"Cell"},{"key":"BFng1901_CR7","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1126\/science.1068537","volume":"295","author":"Y Shang","year":"2002","unstructured":"Shang, Y. & Brown, M. Molecular determinants for the tissue specificity of SERMs. Science 295, 2465\u20132468 (2002).","journal-title":"Science"},{"key":"BFng1901_CR8","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S0092-8674(03)00934-6","volume":"115","author":"R Metivier","year":"2003","unstructured":"Metivier, R. et al. Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115, 751\u2013763 (2003).","journal-title":"Cell"},{"key":"BFng1901_CR9","doi-asserted-by":"publisher","first-page":"11651","DOI":"10.1073\/pnas.0505575102","volume":"102","author":"J Laganiere","year":"2005","unstructured":"Laganiere, J. et al. Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc. Natl. Acad. Sci. USA 102, 11651\u201311656 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng1901_CR10","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.molcel.2005.12.016","volume":"21","author":"AS Cheng","year":"2006","unstructured":"Cheng, A.S. et al. Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters. Mol. Cell 21, 393\u2013404 (2006).","journal-title":"Mol. Cell"},{"key":"BFng1901_CR11","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cell.2005.05.008","volume":"122","author":"JS Carroll","year":"2005","unstructured":"Carroll, J.S. et al. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell 122, 33\u201343 (2005).","journal-title":"Cell"},{"key":"BFng1901_CR12","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1126\/science.1108625","volume":"308","author":"J Cheng","year":"2005","unstructured":"Cheng, J. et al. Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. Science 308, 1149\u20131154 (2005).","journal-title":"Science"},{"key":"BFng1901_CR13","doi-asserted-by":"publisher","first-page":"R64","DOI":"10.1186\/gb-2005-6-8-r64","volume":"6","author":"AS Brodsky","year":"2005","unstructured":"Brodsky, A.S. et al. Genomic mapping of RNA polymerase II reveals sites of co-transcriptional regulation in human cells. Genome Biol. 6, R64 (2005).","journal-title":"Genome Biol."},{"key":"BFng1901_CR14","doi-asserted-by":"crossref","unstructured":"Johnson, W.E. et al. MAT: Model-based analysis of tiling-arrays for ChIP-chip. Proc. Natl. Acad. Sci. USA (in the press) (2006).","DOI":"10.1073\/pnas.0601180103"},{"key":"BFng1901_CR15","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1101\/gr.229202","volume":"12","author":"WJ Kent","year":"2002","unstructured":"Kent, W.J. BLAT\u2013the BLAST-like alignment tool. Genome Res. 12, 656\u2013664 (2002).","journal-title":"Genome Res."},{"key":"BFng1901_CR16","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/nature03877","volume":"436","author":"TH Kim","year":"2005","unstructured":"Kim, T.H. et al. A high-resolution map of active promoters in the human genome. Nature 436, 876\u2013880 (2005).","journal-title":"Nature"},{"key":"BFng1901_CR17","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1093\/nar\/29.14.2905","volume":"29","author":"CM Klinge","year":"2001","unstructured":"Klinge, C.M. Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res. 29, 2905\u20132919 (2001).","journal-title":"Nucleic Acids Res."},{"key":"BFng1901_CR18","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1210\/me.2003-0044","volume":"18","author":"R O'Lone","year":"2004","unstructured":"O'Lone, R., Frith, M.C., Karlsson, E.K. & Hansen, U. Genomic targets of nuclear estrogen receptors. Mol. Endocrinol. 18, 1859\u20131875 (2004).","journal-title":"Mol. Endocrinol."},{"key":"BFng1901_CR19","doi-asserted-by":"publisher","first-page":"4562","DOI":"10.1210\/en.2003-0567","volume":"144","author":"J Frasor","year":"2003","unstructured":"Frasor, J. et al. Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 144, 4562\u20134574 (2003).","journal-title":"Endocrinology"},{"key":"BFng1901_CR20","first-page":"797","volume":"25","author":"T Nishidate","year":"2004","unstructured":"Nishidate, T. et al. Genome-wide gene-expression profiles of breast-cancer cells purified with laser microbeam microdissection: identification of genes associated with progression and metastasis. Int. J. Oncol. 25, 797\u2013819 (2004).","journal-title":"Int. J. Oncol."},{"key":"BFng1901_CR21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.tem.2005.01.004","volume":"16","author":"D Kalaitzidis","year":"2005","unstructured":"Kalaitzidis, D. & Gilmore, T.D. Transcription factor cross-talk: the estrogen receptor and NF-kappaB. Trends Endocrinol. Metab. 16, 46\u201352 (2005).","journal-title":"Trends Endocrinol. Metab."},{"key":"BFng1901_CR22","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/0378-1119(95)00601-X","volume":"166","author":"G Lazennec","year":"1995","unstructured":"Lazennec, G., Huignard, H., Valotaire, Y. & Kern, L. Characterization of the transcription start point of the trout estrogen receptor-encoding gene: evidence for alternative splicing in the 5\u2032 untranslated region. Gene 166, 243\u2013247 (1995).","journal-title":"Gene"},{"key":"BFng1901_CR23","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1101\/gad.9.18.2266","volume":"9","author":"JP Lydon","year":"1995","unstructured":"Lydon, J.P. et al. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 9, 2266\u20132278 (1995).","journal-title":"Genes Dev."},{"key":"BFng1901_CR24","first-page":"6367","volume":"60","author":"MG Ghosh","year":"2000","unstructured":"Ghosh, M.G., Thompson, D.A. & Weigel, R.J. PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer. Cancer Res. 60, 6367\u20136375 (2000).","journal-title":"Cancer Res."},{"key":"BFng1901_CR25","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/(SICI)1097-0215(19990420)84:2<122::AID-IJC5>3.0.CO;2-S","volume":"84","author":"RV Hoch","year":"1999","unstructured":"Hoch, R.V., Thompson, D.A., Baker, R.J. & Weigel, R.J. GATA-3 is expressed in association with estrogen receptor in breast cancer. Int. J. Cancer 84, 122\u2013128 (1999).","journal-title":"Int. J. Cancer"},{"key":"BFng1901_CR26","first-page":"1587","volume":"7","author":"D Dubik","year":"1992","unstructured":"Dubik, D. & Shiu, R.P. Mechanism of estrogen activation of c-myc oncogene expression. Oncogene 7, 1587\u20131594 (1992).","journal-title":"Oncogene"},{"key":"BFng1901_CR27","doi-asserted-by":"publisher","first-page":"26713","DOI":"10.1074\/jbc.274.38.26713","volume":"274","author":"GG Prefontaine","year":"1999","unstructured":"Prefontaine, G.G. et al. Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. J. Biol. Chem. 274, 26713\u201326719 (1999).","journal-title":"J. Biol. Chem."},{"key":"BFng1901_CR28","doi-asserted-by":"publisher","first-page":"7260","DOI":"10.1128\/MCB.24.16.7260-7274.2004","volume":"24","author":"L Cicatiello","year":"2004","unstructured":"Cicatiello, L. et al. Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun\/c-Fos\/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter. Mol. Cell. Biol. 24, 7260\u20137274 (2004).","journal-title":"Mol. Cell. Biol."},{"key":"BFng1901_CR29","first-page":"1749","volume":"12","author":"M Boruk","year":"1998","unstructured":"Boruk, M., Savory, J.G. & Hache, R.J. AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor. Mol. Endocrinol. 12, 1749\u20131763 (1998).","journal-title":"Mol. Endocrinol."},{"key":"BFng1901_CR30","doi-asserted-by":"crossref","first-page":"16433","DOI":"10.1016\/S0021-9258(17)34025-5","volume":"269","author":"Y Umayahara","year":"1994","unstructured":"Umayahara, Y. et al. Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer. J. Biol. Chem. 269, 16433\u201316442 (1994).","journal-title":"J. Biol. Chem."},{"key":"BFng1901_CR31","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0960-0760(00)00108-4","volume":"74","author":"PJ Kushner","year":"2000","unstructured":"Kushner, P.J. et al. Estrogen receptor pathways to AP-1. J. Steroid Biochem. Mol. Biol. 74, 311\u2013317 (2000).","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"BFng1901_CR32","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1093\/emboj\/17.1.244","volume":"17","author":"LA Cirillo","year":"1998","unstructured":"Cirillo, L.A. et al. Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome. EMBO J. 17, 244\u2013254 (1998).","journal-title":"EMBO J."},{"key":"BFng1901_CR33","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S1097-2765(02)00459-8","volume":"9","author":"LA Cirillo","year":"2002","unstructured":"Cirillo, L.A. et al. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol. Cell 9, 279\u2013289 (2002).","journal-title":"Mol. Cell"},{"key":"BFng1901_CR34","doi-asserted-by":"publisher","first-page":"6745","DOI":"10.1128\/MCB.18.11.6745","volume":"18","author":"CH Lee","year":"1998","unstructured":"Lee, C.H., Chinpaisal, C. & Wei, L.N. Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2. Mol. Cell. Biol. 18, 6745\u20136755 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"BFng1901_CR35","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1210\/me.2002-0324","volume":"17","author":"C Teyssier","year":"2003","unstructured":"Teyssier, C., Belguise, K., Galtier, F., Cavailles, V. & Chalbos, D. Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. Mol. Endocrinol. 17, 287\u2013299 (2003).","journal-title":"Mol. Endocrinol."},{"key":"BFng1901_CR36","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0092-8674(04)00127-8","volume":"116","author":"S Cawley","year":"2004","unstructured":"Cawley, S. et al. Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell 116, 499\u2013509 (2004).","journal-title":"Cell"},{"key":"BFng1901_CR37","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nature03574","volume":"435","author":"CG Spilianakis","year":"2005","unstructured":"Spilianakis, C.G., Lalioti, M.D., Town, T., Lee, G.R. & Flavell, R.A. Interchromosomal associations between alternatively expressed loci. Nature 435, 637\u2013645 (2005).","journal-title":"Nature"},{"issue":"Suppl.","key":"BFng1901_CR38","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1038\/ng1559","volume":"37","author":"B van Steensel","year":"2005","unstructured":"van Steensel, B. Mapping of genetic and epigenetic regulatory networks using microarrays. Nat. Genet. 37 (Suppl.), S18\u2013S24 (2005).","journal-title":"Nat. Genet."},{"key":"BFng1901_CR39","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1210\/mend.13.10.0357","volume":"13","author":"P Webb","year":"1999","unstructured":"Webb, P. et al. The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions. Mol. Endocrinol. 13, 1672\u20131685 (1999).","journal-title":"Mol. Endocrinol."},{"key":"BFng1901_CR40","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1101\/gad.949802","volume":"16","author":"B Ren","year":"2002","unstructured":"Ren, B. et al. E2F integrates cell cycle progression with DNA repair, replication, and G(2)\/M checkpoints. Genes Dev. 16, 245\u2013256 (2002).","journal-title":"Genes Dev."},{"key":"BFng1901_CR41","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1126\/science.1068597","volume":"296","author":"P Kapranov","year":"2002","unstructured":"Kapranov, P. et al. Large-scale transcriptional activity in chromosomes 21 and 22. Science 296, 916\u2013919 (2002).","journal-title":"Science"},{"key":"BFng1901_CR42","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1093\/nar\/gng015","volume":"31","author":"RA Irizarry","year":"2003","unstructured":"Irizarry, R.A. et al. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 31, e15 (2003).","journal-title":"Nucleic Acids Res."},{"key":"BFng1901_CR43","doi-asserted-by":"publisher","first-page":"e175","DOI":"10.1093\/nar\/gni179","volume":"33","author":"M Dai","year":"2005","unstructured":"Dai, M. et al. Evolving gene\/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res. 33, e175 (2005).","journal-title":"Nucleic Acids Res."},{"key":"BFng1901_CR44","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1101\/gr.3715005","volume":"15","author":"A Siepel","year":"2005","unstructured":"Siepel, A. et al. Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res. 15, 1034\u20131050 (2005).","journal-title":"Genome Res."},{"key":"BFng1901_CR45","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1093\/nar\/gkg108","volume":"31","author":"V Matys","year":"2003","unstructured":"Matys, V. et al. TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res. 31, 374\u2013378 (2003).","journal-title":"Nucleic Acids Res."},{"key":"BFng1901_CR46","doi-asserted-by":"publisher","first-page":"D91","DOI":"10.1093\/nar\/gkh012","volume":"32","author":"A Sandelin","year":"2004","unstructured":"Sandelin, A., Alkema, W., Engstrom, P., Wasserman, W.W. & Lenhard, B. JASPAR: an open-access database for eukaryotic transcription factor binding profiles. Nucleic Acids Res. 32, D91\u2013D94 (2004).","journal-title":"Nucleic Acids Res."},{"key":"BFng1901_CR47","unstructured":"Song, J.S. & Liu, X.S. LeitMotif: de novo motif discovery for ChIP-Chip in mammalian genomes. In Preparation."},{"key":"BFng1901_CR48","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/nbt717","volume":"20","author":"XS Liu","year":"2002","unstructured":"Liu, X.S., Brutlag, D.L. & Liu, J.S. An algorithm for finding protein-DNA binding sites with applications to chromatin-immunoprecipitation microarray experiments. Nat. Biotechnol. 20, 835\u2013839 (2002).","journal-title":"Nat. Biotechnol."},{"key":"BFng1901_CR49","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1214\/aos\/1176345006","volume":"8","author":"J Darroch","year":"1980","unstructured":"Darroch, J., Lauritzen, S. & Speed, T. Markov fields and log-linear interaction models for contingency tables. Ann. Statist. 8, 522\u2013539 (1980).","journal-title":"Ann. Statist."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1901.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1901","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1901.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:12:53Z","timestamp":1684447973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,1]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["BFng1901"],"URL":"https:\/\/doi.org\/10.1038\/ng1901","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,1]]}}}