{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:41:05Z","timestamp":1773268865774,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2002,9,9]],"date-time":"2002-09-09T00:00:00Z","timestamp":1031529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2002,11]]},"DOI":"10.1038\/ng988","type":"journal-article","created":{"date-parts":[[2002,10,30]],"date-time":"2002-10-30T12:44:39Z","timestamp":1035981879000},"page":"426-431","source":"Crossref","is-referenced-by-count":370,"title":["Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1"],"prefix":"10.1038","volume":"32","author":[{"given":"Galina V.","family":"Fitzpatrick","sequence":"first","affiliation":[]},{"given":"Paul D.","family":"Soloway","sequence":"additional","affiliation":[]},{"given":"Michael J.","family":"Higgins","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2002,9,9]]},"reference":[{"key":"BFng988z_CR1","doi-asserted-by":"publisher","first-page":"5203","DOI":"10.1073\/pnas.96.9.5203","volume":"96","author":"MP Lee","year":"1999","unstructured":"Lee, M.P. et al. Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith\u2013Wiedemann syndrome and is independent of insulin-like growth factor II imprinting. Proc. Natl Acad. Sci. USA 96, 5203\u20135208 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng988z_CR2","doi-asserted-by":"publisher","first-page":"8064","DOI":"10.1073\/pnas.96.14.8064","volume":"96","author":"NJ Smilinich","year":"1999","unstructured":"Smilinich, N.J. et al. A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith\u2013Wiedemann syndrome. Proc. Natl Acad. Sci. USA 96, 8064\u20138069 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng988z_CR3","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1136\/jmg.37.12.921","volume":"37","author":"JR Engel","year":"2000","unstructured":"Engel, J.R. et al. Epigenotype-phenotype correlations in Beckwith\u2013Wiedemann syndrome. J. Med. Genet. 37, 921\u2013926 (2000).","journal-title":"J. Med. Genet."},{"key":"BFng988z_CR4","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1172\/JCI9340","volume":"105","author":"ER Maher","year":"2000","unstructured":"Maher, E.R. & Reik, W. Beckwith\u2013Wiedemann syndrome: imprinting in clusters revisited. J. Clin. Invest. 105, 247\u2013252 (2000).","journal-title":"J. Clin. Invest."},{"key":"BFng988z_CR5","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/375034a0","volume":"375","author":"PA Leighton","year":"1995","unstructured":"Leighton, P.A., Ingram, R.S., Eggenschwiler, J., Efstratiadis, A. & Tilghman, S.M. Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature 375, 34\u201339 (1995).","journal-title":"Nature"},{"key":"BFng988z_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/387151a0","volume":"387","author":"P Zhang","year":"1997","unstructured":"Zhang, P. et al. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith\u2013Wiedemann syndrome. Nature 387, 151\u2013158 (1997).","journal-title":"Nature"},{"key":"BFng988z_CR7","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1101\/gad.13.23.3115","volume":"13","author":"T Caspary","year":"1999","unstructured":"Caspary, T. et al. Oppositely imprinted genes p57 (Kip2) and Igf2 interact in a mouse model for Beckwith\u2013Wiedemann syndrome. Genes Dev. 13, 3115\u20133124 (1999).","journal-title":"Genes Dev."},{"key":"BFng988z_CR8","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1038\/35013178","volume":"405","author":"W Reik","year":"2000","unstructured":"Reik, W. & Murrell, A. Genomic imprinting. Silence across the border. Nature 405, 408\u2013409 (2000).","journal-title":"Nature"},{"key":"BFng988z_CR9","doi-asserted-by":"publisher","first-page":"3466","DOI":"10.1128\/MCB.18.6.3466","volume":"18","author":"T Caspary","year":"1998","unstructured":"Caspary, T., Cleary, M.A., Baker, C.C., Guan, X.J. & Tilghman, S.M. Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster. Mol. Cell. Biol. 18, 3466\u20133474 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"BFng988z_CR10","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/ng715","volume":"29","author":"MA Cleary","year":"2001","unstructured":"Cleary, M.A. et al. Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice. Nature Genet. 29, 78\u201382 (2001).","journal-title":"Nature Genet."},{"key":"BFng988z_CR11","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1093\/hmg\/9.18.2691","volume":"9","author":"S Engemann","year":"2000","unstructured":"Engemann, S. et al. Sequence and functional comparison in the Beckwith\u2013Wiedemann region: implications for a novel imprinting center and extended imprinting. Hum. Mol. Genet. 9, 2691\u20132706 (2000).","journal-title":"Hum. Mol. Genet."},{"key":"BFng988z_CR12","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1093\/hmg\/6.12.2021","volume":"6","author":"N Qian","year":"1997","unstructured":"Qian, N. et al. The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis. Hum. Mol. Genet. 6, 2021\u20132029 (1997).","journal-title":"Hum. Mol. Genet."},{"key":"BFng988z_CR13","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.1101\/gr.3.4.S48","volume":"3","author":"J Singer-Sam","year":"1994","unstructured":"Singer-Sam, J. Quantitation of specific transcripts by RT\u2013PCR SNuPE assay. PCR Methods Appl. 3, S48\u2013S50 (1994).","journal-title":"PCR Methods Appl."},{"key":"BFng988z_CR14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1006\/geno.1998.5221","volume":"49","author":"PR Cooper","year":"1998","unstructured":"Cooper, P.R. et al. Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. Genomics 49, 38\u201351 (1998).","journal-title":"Genomics"},{"key":"BFng988z_CR15","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/ng1095-204","volume":"11","author":"I Hatada","year":"1995","unstructured":"Hatada, I. & Mukai, T. Genomic imprinting of p57-KIP2, a cyclin-dependent kinase inhibitor, in mouse. Nature Genet. 11, 204\u2013206 (1995).","journal-title":"Nature Genet."},{"key":"BFng988z_CR16","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1101\/gad.14.10.1186","volume":"14","author":"M Srivastava","year":"2000","unstructured":"Srivastava, M. et al. H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis-acting regulatory region upstream of H19. Genes Dev. 14, 1186\u20131195 (2000).","journal-title":"Genes Dev."},{"key":"BFng988z_CR17","doi-asserted-by":"publisher","first-page":"3693","DOI":"10.1101\/gad.12.23.3693","volume":"12","author":"JL Thorvaldsen","year":"1998","unstructured":"Thorvaldsen, J.L., Duran, K.L. & Bartolomei, M.S. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2. Genes Dev. 12, 3693\u20133702 (1998).","journal-title":"Genes Dev."},{"key":"BFng988z_CR18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/ng0598-25","volume":"19","author":"T Yang","year":"1998","unstructured":"Yang, T. et al. A mouse model for Prader\u2013Willi syndrome imprinting-center mutations. Nature Genet. 19, 25\u201331 (1998).","journal-title":"Nature Genet."},{"key":"BFng988z_CR19","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1101\/gad.206201","volume":"15","author":"R Zwart","year":"2001","unstructured":"Zwart, R., Sleutels, F., Wutz, A., Schinkel, A.H. & Barlow, D.P. Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes. Genes Dev. 15, 2361\u20132366 (2001).","journal-title":"Genes Dev."},{"key":"BFng988z_CR20","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1093\/hmg\/9.14.2075","volume":"9","author":"S Horike","year":"2000","unstructured":"Horike, S. et al. Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith\u2013Wiedemann syndrome. Hum. Mol. Genet. 9, 2075\u20132083 (2000).","journal-title":"Hum. Mol. Genet."},{"key":"BFng988z_CR21","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1093\/hmg\/8.4.683","volume":"8","author":"MP Lee","year":"1999","unstructured":"Lee, M.P. et al. Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. Hum. Mol. Genet. 8, 683\u2013690 (1999).","journal-title":"Hum. Mol. Genet."},{"key":"BFng988z_CR22","doi-asserted-by":"publisher","first-page":"5279","DOI":"10.1073\/pnas.080409297","volume":"97","author":"V Grandjean","year":"2000","unstructured":"Grandjean, V., Smith, J., Schofield, P.N. & Ferguson-Smith, A.C. Increased IGF-II protein affects p57kip2 expression in vivo and in vitro: implications for Beckwith\u2013Wiedemann syndrome. Proc. Natl Acad. Sci. USA 97, 5279\u20135284 (2000).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng988z_CR23","doi-asserted-by":"publisher","first-page":"18106","DOI":"10.1074\/jbc.M200031200","volume":"277","author":"C Kanduri","year":"2002","unstructured":"Kanduri, C. et al. A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator. J. Biol. Chem. 277, 18106\u201318110 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFng988z_CR24","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/415810a","volume":"415","author":"F Sleutels","year":"2002","unstructured":"Sleutels, F., Zwart, R. & Barlow, D.P. The non-coding Air RNA is required for silencing autosomal imprinted genes. Nature 415, 810\u2013813 (2002).","journal-title":"Nature"},{"key":"BFng988z_CR25","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","volume":"69","author":"E Li","year":"1992","unstructured":"Li, E., Bestor, T.H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915\u2013926 (1992).","journal-title":"Cell"},{"key":"BFng988z_CR26","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1126\/science.1065848","volume":"294","author":"D Bourc'his","year":"2001","unstructured":"Bourc'his, D., Xu, G.L., Lin, C.S., Bollman, B. & Bestor, T.H. Dnmt3L and the establishment of maternal genomic imprints. Science 294, 2536\u20132539 (2001).","journal-title":"Science"},{"key":"BFng988z_CR27","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1242\/dev.129.8.1983","volume":"129","author":"K Hata","year":"2002","unstructured":"Hata, K., Okano, M., Lei, H. & Li, E. Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 129, 1983\u20131993 (2002).","journal-title":"Development"},{"key":"BFng988z_CR28","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S0960-9822(06)00059-5","volume":"7","author":"M Lewandoski","year":"1997","unstructured":"Lewandoski, M., Wassarman, K.M. & Martin, G.R. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr. Biol. 7, 148\u2013151 (1997).","journal-title":"Curr. Biol."},{"key":"BFng988z_CR29","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1093\/hmg\/9.12.1829","volume":"9","author":"M Paulsen","year":"2000","unstructured":"Paulsen, M. et al. Sequence conservation and variability of imprinting in the Beckwith\u2013Wiedemann syndrome gene cluster in human and mouse. Hum. Mol. Genet. 9, 1829\u20131841 (2000).","journal-title":"Hum. Mol. Genet."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng988z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng988z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng988z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:19:02Z","timestamp":1684433942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng988z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9,9]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["BFng988z"],"URL":"https:\/\/doi.org\/10.1038\/ng988","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718836627.135757","asserted-by":"object"}]},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9,9]]}}}