{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:25:34Z","timestamp":1777353934527,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2004,1,11]],"date-time":"2004-01-11T00:00:00Z","timestamp":1073779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1038\/ni1031","type":"journal-article","created":{"date-parts":[[2004,1,11]],"date-time":"2004-01-11T18:36:55Z","timestamp":1073846215000},"page":"224-229","source":"Crossref","is-referenced-by-count":203,"title":["Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1\u2013mutant mice"],"prefix":"10.1038","volume":"5","author":[{"given":"Philip D","family":"Bardwell","sequence":"first","affiliation":[]},{"given":"Caroline J","family":"Woo","sequence":"additional","affiliation":[]},{"given":"Kaichun","family":"Wei","sequence":"additional","affiliation":[]},{"given":"Ziqiang","family":"Li","sequence":"additional","affiliation":[]},{"given":"Alberto","family":"Martin","sequence":"additional","affiliation":[]},{"given":"Stephen Z","family":"Sack","sequence":"additional","affiliation":[]},{"given":"Tchaiko","family":"Parris","sequence":"additional","affiliation":[]},{"given":"Winfried","family":"Edelmann","sequence":"additional","affiliation":[]},{"given":"Matthew D","family":"Scharff","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2004,1,11]]},"reference":[{"key":"BFni1031_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1146\/annurev.iy.12.040194.001001","volume":"12","author":"IC MacLennan","year":"1994","unstructured":"MacLennan, I.C. Germinal centers. Annu. Rev. Immunol. 12, 117\u2013139 (1994).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni1031_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0167-4781(92)90134-L","volume":"1171","author":"IB Rogozin","year":"1992","unstructured":"Rogozin, I.B. & Kolchanov, N.A. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim. Biophys. Acta 1171, 11\u201318 (1992).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFni1031_CR3","first-page":"127","volume":"245","author":"J Stavnezer","year":"2000","unstructured":"Stavnezer, J. Molecular processes that regulate class switching. Curr. Top. Microbiol. Immunol. 245, 127\u2013168 (2000).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"BFni1031_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1600-065X.1998.tb01424.x","volume":"162","author":"U Storb","year":"1998","unstructured":"Storb, U. Progress in understanding the mechanism and consequences of somatic hypermutation. Immunol. Rev. 162, 5\u201311 (1998).","journal-title":"Immunol. Rev."},{"key":"BFni1031_CR5","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/35080033","volume":"2","author":"K Kinoshita","year":"2001","unstructured":"Kinoshita, K. & Honjo, T. Linking class-switch recombination with somatic hypermutation. Nat. Rev. Mol. Cell Biol. 2, 493\u2013503 (2001).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFni1031_CR6","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nri858","volume":"2","author":"A Martin","year":"2002","unstructured":"Martin, A. & Scharff, M.D. AID and mismatch repair in antibody diversification. Nat. Rev. Immunol. 2, 605\u2013614 (2002).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni1031_CR7","doi-asserted-by":"publisher","first-page":"4102","DOI":"10.1073\/pnas.0730835100","volume":"100","author":"R Bransteitter","year":"2003","unstructured":"Bransteitter, R., Pham, P., Scharff, M.D. & Goodman, M.F. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. USA 100, 4102\u20134107 (2003).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1031_CR8","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nature01574","volume":"422","author":"J Chaudhuri","year":"2003","unstructured":"Chaudhuri, J. et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422, 726\u2013730 (2003).","journal-title":"Nature"},{"key":"BFni1031_CR9","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1084\/jem.20030481","volume":"197","author":"SK Dickerson","year":"2003","unstructured":"Dickerson, S.K., Market, E., Besmer, E. & Papavasiliou, F.N. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 197, 1291\u20131296 (2003).","journal-title":"J. Exp. Med."},{"key":"BFni1031_CR10","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1093\/nar\/gkg464","volume":"31","author":"A Sohail","year":"2003","unstructured":"Sohail, A., Klapacz, J., Samaranayake, M., Ullah, A. & Bhagwat, A.S. Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nucleic Acids Res. 31, 2990\u20132994 (2003).","journal-title":"Nucleic Acids Res."},{"key":"BFni1031_CR11","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/ni918","volume":"4","author":"R Shinkura","year":"2003","unstructured":"Shinkura, R. et al. The influence of transcriptional orientation on endogenous switch region function. Nat. Immunol. 4, 435\u2013441 (2003).","journal-title":"Nat. Immunol."},{"key":"BFni1031_CR12","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/ni919","volume":"4","author":"K Yu","year":"2003","unstructured":"Yu, K., Chedin, F., Hsieh, C.L., Wilson, T.E. & Lieber, M.R. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat. Immunol. 4, 442\u2013451 (2003).","journal-title":"Nat. Immunol."},{"key":"BFni1031_CR13","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S1074-7613(00)80595-6","volume":"9","author":"C Rada","year":"1998","unstructured":"Rada, C., Ehrenstein, M.R., Neuberger, M.S. & Milstein, C. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 9, 135\u2013141 (1998).","journal-title":"Immunity"},{"key":"BFni1031_CR14","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/88740","volume":"2","author":"X Zeng","year":"2001","unstructured":"Zeng, X. et al. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat. Immunol. 2, 537\u2013541 (2001).","journal-title":"Nat. Immunol."},{"key":"BFni1031_CR15","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1084\/jem.191.3.579","volume":"191","author":"M Wiesendanger","year":"2000","unstructured":"Wiesendanger, M., Kneitz, B., Edelmann, W. & Scharff, M.D. Somatic mutation in MSH3, MSH6, and MSH3\/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. J. Exp. Med. 191, 579\u2013584 (2000).","journal-title":"J. Exp. Med."},{"key":"BFni1031_CR16","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1146\/annurev.genet.33.1.533","volume":"33","author":"AB Buermeyer","year":"1999","unstructured":"Buermeyer, A.B., Deschenes, S.M., Baker, S.M. & Liskay, R.M. Mammalian DNA mismatch repair. Annu. Rev. Genet. 33, 533\u2013564 (1999).","journal-title":"Annu. Rev. Genet."},{"key":"BFni1031_CR17","doi-asserted-by":"publisher","first-page":"7839","DOI":"10.1128\/MCB.20.21.7839-7844.2000","volume":"20","author":"E Evans","year":"2000","unstructured":"Evans, E. & Alani, E. Roles for mismatch repair factors in regulating genetic recombination. Mol. Cell Biol. 20, 7839\u20137844 (2000).","journal-title":"Mol. Cell Biol."},{"key":"BFni1031_CR18","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1101\/gad.10.4.407","volume":"10","author":"GT Marsischky","year":"1996","unstructured":"Marsischky, G.T., Filosi, N., Kane, M.F. & Kolodner, R. Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes Dev. 10, 407\u2013420 (1996).","journal-title":"Genes Dev."},{"key":"BFni1031_CR19","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1126\/science.7604265","volume":"268","author":"F Palombo","year":"1995","unstructured":"Palombo, F. et al. GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science 268, 1912\u20131914 (1995).","journal-title":"Science"},{"key":"BFni1031_CR20","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1101\/gad.10.12.1433","volume":"10","author":"R Kolodner","year":"1996","unstructured":"Kolodner, R. Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev. 10, 1433\u20131442 (1996).","journal-title":"Genes Dev."},{"key":"BFni1031_CR21","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1126\/science.7855597","volume":"267","author":"P Szankasi","year":"1995","unstructured":"Szankasi, P. & Smith, G.R. A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction. Science 267, 1166\u20131169 (1995).","journal-title":"Science"},{"key":"BFni1031_CR22","doi-asserted-by":"publisher","first-page":"13302","DOI":"10.1074\/jbc.M111854200","volume":"277","author":"J Genschel","year":"2002","unstructured":"Genschel, J., Bazemore, L.R. & Modrich, P. Human exonuclease I is required for 5\u2032 and 3\u2032 mismatch repair. J. Biol. Chem. 277, 13302\u201313311 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFni1031_CR23","doi-asserted-by":"publisher","first-page":"7487","DOI":"10.1073\/pnas.94.14.7487","volume":"94","author":"DX Tishkoff","year":"1997","unstructured":"Tishkoff, D.X. et al. Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2. Proc. Natl. Acad. Sci. USA 94, 7487\u20137492 (1997).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1031_CR24","doi-asserted-by":"publisher","first-page":"9760","DOI":"10.1073\/pnas.161175998","volume":"98","author":"PT Tran","year":"2001","unstructured":"Tran, P.T., Simon, J.A. & Liskay, R.M. Interactions of Exo1p with components of MutL\u03b1 in Saccharomyces cerevisiae . Proc. Natl. Acad. Sci. USA 98, 9760\u20139765 (2001).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1031_CR25","doi-asserted-by":"publisher","first-page":"33011","DOI":"10.1074\/jbc.M102670200","volume":"276","author":"C Schmutte","year":"2001","unstructured":"Schmutte, C., Sadoff, M.M., Shim, K.S., Acharya, S. & Fishel, R. The interaction of DNA mismatch repair proteins with human exonuclease I. J. Biol. Chem. 276, 33011\u201333018 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFni1031_CR26","doi-asserted-by":"publisher","first-page":"5142","DOI":"10.1128\/MCB.21.15.5142-5155.2001","volume":"21","author":"NS Amin","year":"2001","unstructured":"Amin, N.S., Nguyen, M.N., Oh, S. & Kolodner, R.D. exo1-dependent mutator mutations: model system for studying functional interactions in mismatch repair. Mol. Cell Biol. 21, 5142\u20135155 (2001).","journal-title":"Mol. Cell Biol."},{"key":"BFni1031_CR27","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1101\/gad.1060603","volume":"17","author":"K Wei","year":"2003","unstructured":"Wei, K. et al. Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility and male and female sterility. Genes Dev. 17, 603\u2013614 (2003).","journal-title":"Genes Dev."},{"key":"BFni1031_CR28","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1084\/jem.190.3.323","volume":"190","author":"CE Schrader","year":"1999","unstructured":"Schrader, C.E., Edelmann, W., Kucherlapati, R. & Stavnezer, J. Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J. Exp. Med. 190, 323\u2013330 (1999).","journal-title":"J. Exp. Med."},{"key":"BFni1031_CR29","doi-asserted-by":"publisher","first-page":"14553","DOI":"10.1073\/pnas.241525998","volume":"98","author":"MR Ehrenstein","year":"2001","unstructured":"Ehrenstein, M.R., Rada, C., Jones, A.M., Milstein, C. & Neuberger, M.S. Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination. Proc. Natl. Acad. Sci. USA 98, 14553\u201314558 (2001).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1031_CR30","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1084\/jem.20011877","volume":"195","author":"CE Schrader","year":"2002","unstructured":"Schrader, C.E., Vardo, J. & Stavnezer, J. Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. J. Exp. Med. 195, 367\u2013373 (2002).","journal-title":"J. Exp. Med."},{"key":"BFni1031_CR31","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1084\/jem.187.6.885","volume":"187","author":"Y Takahashi","year":"1998","unstructured":"Takahashi, Y., Dutta, P.R., Cerasoli, D.M. & Kelsoe, G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J. Exp. Med. 187, 885\u2013895 (1998).","journal-title":"J. Exp. Med."},{"key":"BFni1031_CR32","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S1074-7613(00)80594-4","volume":"9","author":"S Frey","year":"1998","unstructured":"Frey, S. et al. Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. Immunity 9, 127\u2013134 (1998).","journal-title":"Immunity"},{"key":"BFni1031_CR33","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S1074-7613(00)80240-X","volume":"6","author":"S Denepoux","year":"1997","unstructured":"Denepoux, S. et al. Induction of somatic mutation in a human B cell line in vitro . Immunity 6, 35\u201346 (1997).","journal-title":"Immunity"},{"key":"BFni1031_CR34","doi-asserted-by":"publisher","first-page":"7976","DOI":"10.1073\/pnas.141222198","volume":"98","author":"V Poltoratsky","year":"2001","unstructured":"Poltoratsky, V. et al. Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation. Proc. Natl. Acad. Sci. USA 98, 7976\u20137981 (2001).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1031_CR35","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S1074-7613(03)00261-9","volume":"19","author":"CJ Woo","year":"2003","unstructured":"Woo, C.J., Martin, A. & Scharff, M.D. Induction of hypermutation is associated with modifications of variable region chromatin in BL2 cells. Immunity 19, 479\u2013489 (2003).","journal-title":"Immunity"},{"key":"BFni1031_CR36","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1084\/jem.192.10.1509","volume":"192","author":"M Bemark","year":"2000","unstructured":"Bemark, M. et al. Somatic hypermutation in the absence of DNA-PK or Rag1 activity. J. Exp. Med. 192, 1509\u20131514 (2000).","journal-title":"J. Exp. Med."},{"key":"BFni1031_CR37","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1084\/jem.187.12.2081","volume":"187","author":"JP Manis","year":"1998","unstructured":"Manis, J.P. et al. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J. Exp. Med. 187, 2081\u20132089 (1998).","journal-title":"J. Exp. Med."},{"key":"BFni1031_CR38","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1084\/jem.20030569","volume":"197","author":"B Reina-San-Martin","year":"2003","unstructured":"Reina-San-Martin, B. et al. H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J. Exp. Med. 197, 1767\u20131778 (2003).","journal-title":"J. Exp. Med."},{"key":"BFni1031_CR39","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1084\/jem.189.3.471","volume":"189","author":"KA Vora","year":"1999","unstructured":"Vora, K.A. et al. Severe attenuation of the B cell immune response in Msh2-deficient mice. J. Exp. Med. 189, 471\u2013481 (1999).","journal-title":"J. Exp. Med."},{"key":"BFni1031_CR40","doi-asserted-by":"publisher","first-page":"3819","DOI":"10.4049\/jimmunol.169.7.3819","volume":"169","author":"B Alabyev","year":"2002","unstructured":"Alabyev, B. & Manser, T. Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice. J. Immunol. 169, 3819\u20133824 (2002).","journal-title":"J. Immunol."},{"key":"BFni1031_CR41","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1084\/jem.190.1.21","volume":"190","author":"N Kim","year":"1999","unstructured":"Kim, N., Bozek, G., Lo, J.C. & Storb, U. Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications. J. Exp. Med. 190, 21\u201330 (1999).","journal-title":"J. Exp. Med."},{"key":"BFni1031_CR42","doi-asserted-by":"publisher","first-page":"6953","DOI":"10.1073\/pnas.95.12.6953","volume":"95","author":"DB Winter","year":"1998","unstructured":"Winter, D.B. et al. Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2. Proc. Natl. Acad. Sci. USA 95, 6953\u20136958 (1998).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1031_CR43","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1084\/jem.20022190","volume":"197","author":"CE Schrader","year":"2003","unstructured":"Schrader, C.E., Vardo, J. & Stavnezer, J. Mlh1 can function in antibody class switch recombination independently of Msh2. J. Exp. Med. 197, 1377\u20131383 (2003).","journal-title":"J. Exp. Med."},{"key":"BFni1031_CR44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/genetics\/158.1.369","volume":"158","author":"Q Kong","year":"2001","unstructured":"Kong, Q. & Maizels, N. DNA breaks in hypermutating immunoglobulin genes: evidence for a break and repair pathway of somatic mutation. Genetics 158, 369\u2013378 (2001).","journal-title":"Genetics"},{"issue":"Suppl.","key":"BFni1031_CR45","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1016\/S0092-8674(02)00706-7","volume":"109","author":"FN Papavasiliou","year":"2002","unstructured":"Papavasiliou, F.N. & Schatz, D.G. Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Cell 109 (Suppl.), S35\u2013S44 (2002).","journal-title":"Cell"},{"key":"BFni1031_CR46","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1084\/jem.187.11.1745","volume":"187","author":"QH Phung","year":"1998","unstructured":"Phung, Q.H. et al. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J. Exp. Med. 187, 1745\u20131751 (1998).","journal-title":"J. Exp. Med."},{"key":"BFni1031_CR47","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1093\/emboj\/18.12.3484","volume":"18","author":"MR Ehrenstein","year":"1999","unstructured":"Ehrenstein, M.R. & Neuberger, M.S. Deficiency in msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. EMBO J. 18, 3484\u20133490 (1999).","journal-title":"EMBO J."},{"key":"BFni1031_CR48","doi-asserted-by":"publisher","first-page":"13914","DOI":"10.1073\/pnas.96.24.13914","volume":"96","author":"TF Wang","year":"1999","unstructured":"Wang, T.F., Kleckner, N. & Hunter, N. Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction. Proc. Natl. Acad. Sci. USA 96, 13914\u201313919 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1031_CR49","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1091\/mbc.11.7.2221","volume":"11","author":"H Tsubouchi","year":"2000","unstructured":"Tsubouchi, H. & Ogawa, H. Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae . Mol. Biol. Cell 11, 2221\u20132233 (2000).","journal-title":"Mol. Biol. Cell"},{"key":"BFni1031_CR50","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0161-5890(01)00058-X","volume":"38","author":"SZ Sack","year":"2001","unstructured":"Sack, S.Z., Bardwell, P.D. & Scharff, M.D. Testing the reverse transcriptase model of somatic mutation. Mol. Immunol. 38, 303\u2013311 (2001).","journal-title":"Mol. Immunol."}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ni1031","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni1031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni1031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:37:08Z","timestamp":1684449428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni1031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,11]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["BFni1031"],"URL":"https:\/\/doi.org\/10.1038\/ni1031","relation":{},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,11]]}}}