{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:39:47Z","timestamp":1779122387405,"version":"3.51.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,1,9]],"date-time":"2011-01-09T00:00:00Z","timestamp":1294531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1038\/nm.2279","type":"journal-article","created":{"date-parts":[[2011,1,9]],"date-time":"2011-01-09T14:03:36Z","timestamp":1294581816000},"page":"179-188","source":"Crossref","is-referenced-by-count":2315,"title":["The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance"],"prefix":"10.1038","volume":"17","author":[{"given":"Bolormaa","family":"Vandanmagsar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Hee","family":"Youm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Ravussin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose E","family":"Galgani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztian","family":"Stadler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall L","family":"Mynatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Ravussin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline M","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishwa Deep","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,1,9]]},"reference":[{"key":"BFnm2279_CR1","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1189\/jlb.0108028","volume":"84","author":"VD Dixit","year":"2008","unstructured":"Dixit, V.D. Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span. J. Leukoc. Biol. 84, 882\u2013892 (2008).","journal-title":"J. Leukoc. Biol."},{"key":"BFnm2279_CR2","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1038\/nri2449","volume":"8","author":"GS Hotamisligil","year":"2008","unstructured":"Hotamisligil, G.S. & Erbay, E. Nutrient sensing and inflammation in metabolic diseases. Nat. Rev. Immunol. 8, 923\u2013934 (2008).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm2279_CR3","doi-asserted-by":"publisher","first-page":"693","DOI":"10.3233\/JAD-2009-1022","volume":"16","author":"JA Luchsinger","year":"2009","unstructured":"Luchsinger, J.A. & Gustafson, D.R. Adiposity, type 2 diabetes and Alzheimer's disease. J. Alzheimers Dis. 16, 693\u2013704 (2009).","journal-title":"J. Alzheimers Dis."},{"key":"BFnm2279_CR4","doi-asserted-by":"publisher","first-page":"3803","DOI":"10.1182\/blood-2009-03-213595","volume":"114","author":"H Yang","year":"2009","unstructured":"Yang, H. et al. Obesity accelerates thymic aging. Blood 114, 3803\u20133812 (2009).","journal-title":"Blood"},{"key":"BFnm2279_CR5","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1172\/JCI200319246","volume":"112","author":"SP Weisberg","year":"2003","unstructured":"Weisberg, S.P. et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796\u20131808 (2003).","journal-title":"J. Clin. Invest."},{"key":"BFnm2279_CR6","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/ncpendmet0976","volume":"4","author":"JI Odegaard","year":"2008","unstructured":"Odegaard, J.I. & Chawla, A. Mechanisms of macrophage activation in obesity-induced insulin resistance. Nat. Clin. Pract. Endocrinol. Metab. 4, 619\u2013626 (2008).","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"BFnm2279_CR7","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1172\/JCI29881","volume":"117","author":"CN Lumeng","year":"2007","unstructured":"Lumeng, C.N., Bodzin, J.L. & Saltiel, A.R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117, 175\u2013184 (2007).","journal-title":"J. Clin. Invest."},{"key":"BFnm2279_CR8","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.cmet.2008.08.015","volume":"8","author":"D Patsouris","year":"2008","unstructured":"Patsouris, D. et al. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. 8, 301\u2013309 (2008).","journal-title":"Cell Metab."},{"key":"BFnm2279_CR9","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature05485","volume":"444","author":"GS Hotamisligil","year":"2006","unstructured":"Hotamisligil, G.S. Inflammation and metabolic disorders. Nature 444, 860\u2013867 (2006).","journal-title":"Nature"},{"key":"BFnm2279_CR10","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nm1185","volume":"11","author":"MC Arkan","year":"2005","unstructured":"Arkan, M.C. et al. IKK-\u03b2 links inflammation to obesity-induced insulin resistance. Nat. Med. 11, 191\u2013198 (2005).","journal-title":"Nat. Med."},{"key":"BFnm2279_CR11","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1210\/en.2006-0692","volume":"148","author":"J Jager","year":"2007","unstructured":"Jager, J., Gr\u00e9meaux, T., Cormont, M., Le Marchand-Brustel, Y. & Tanti, J.F. Interleukin-1\u03b2\u2013induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 148, 241\u2013251 (2007).","journal-title":"Endocrinology"},{"key":"BFnm2279_CR12","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1056\/NEJMoa065213","volume":"356","author":"CM Larsen","year":"2007","unstructured":"Larsen, C.M. et al. Interleukin-1\u2013receptor antagonist in type 2 diabetes mellitus. N. Engl. J. Med. 356, 1517\u20131526 (2007).","journal-title":"N. Engl. J. Med."},{"key":"BFnm2279_CR13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.cyto.2008.07.004","volume":"44","author":"O Osborn","year":"2008","unstructured":"Osborn, O. et al. Treatment with an Interleukin 1 \u03b2 antibody improves glycemic control in diet-induced obesity. Cytokine 44, 141\u2013148 (2008).","journal-title":"Cytokine"},{"key":"BFnm2279_CR14","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/nature06246","volume":"449","author":"R Medzhitov","year":"2007","unstructured":"Medzhitov, R. Recognition of microorganisms and activation of the immune response. Nature 449, 819\u2013826 (2007).","journal-title":"Nature"},{"key":"BFnm2279_CR15","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nri2587","volume":"9","author":"GM Barton","year":"2009","unstructured":"Barton, G.M. & Kagan, J.C. A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat. Rev. Immunol. 9, 535\u2013542 (2009).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm2279_CR16","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","volume":"20","author":"L Agostini","year":"2004","unstructured":"Agostini, L. et al. NLRP3 forms an IL-1\u03b2\u2013processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20, 319\u2013325 (2004).","journal-title":"Immunity"},{"key":"BFnm2279_CR17","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","volume":"454","author":"R Medzhitov","year":"2008","unstructured":"Medzhitov, R. Origin and physiological roles of inflammation. Nature 454, 428\u2013435 (2008).","journal-title":"Nature"},{"key":"BFnm2279_CR18","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1600-065X.2008.00730.x","volume":"227","author":"M Lamkanfi","year":"2009","unstructured":"Lamkanfi, M. & Dixit, V.M. Inflammasomes: guardians of cytosolic sanctity. Immunol. Rev. 227, 95\u2013105 (2009).","journal-title":"Immunol. Rev."},{"key":"BFnm2279_CR19","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ni.1703","volume":"10","author":"L Franchi","year":"2009","unstructured":"Franchi, L., Eigenbrod, T., Mu\u00f1oz-Planillo, R. & Nu\u00f1ez, G. The inflammasome: a caspase-1\u2013activation platform that regulates immune responses and disease pathogenesis. Nat. Immunol. 10, 241\u2013247 (2009).","journal-title":"Nat. Immunol."},{"key":"BFnm2279_CR20","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","volume":"27","author":"F Martinon","year":"2009","unstructured":"Martinon, F., Mayor, A. & Tschopp, J. The inflammasomes: guardians of the body. Annu. Rev. Immunol. 27, 229\u2013265 (2009).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnm2279_CR21","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","volume":"27","author":"CA Dinarello","year":"2009","unstructured":"Dinarello, C.A. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27, 519\u2013550 (2009).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnm2279_CR22","doi-asserted-by":"publisher","first-page":"5227","DOI":"10.1073\/pnas.86.14.5227","volume":"86","author":"MJ Kostura","year":"1989","unstructured":"Kostura, M.J. et al. Identification of a monocyte specific pre\u2013interleukin 1 \u03b2 convertase activity. Proc. Natl. Acad. Sci. USA 86, 5227\u20135231 (1989).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm2279_CR23","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1126\/science.7535475","volume":"267","author":"K Kuida","year":"1995","unstructured":"Kuida, K. et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267, 2000\u20132003 (1995).","journal-title":"Science"},{"key":"BFnm2279_CR24","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","volume":"10","author":"F Martinon","year":"2002","unstructured":"Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-\u03b2. Mol. Cell 10, 417\u2013426 (2002).","journal-title":"Mol. Cell"},{"key":"BFnm2279_CR25","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1126\/science.1156995","volume":"320","author":"C Dostert","year":"2008","unstructured":"Dostert, C. et al. Innate immune activation through Nlrp3 inflammasome sensing of asbestos and silica. Science 320, 674\u2013677 (2008).","journal-title":"Science"},{"key":"BFnm2279_CR26","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ni.1636","volume":"9","author":"A Halle","year":"2008","unstructured":"Halle, A. et al. The NLRP3 inflammasome is involved in the innate immune response to amyloid-\u03b2. Nat. Immunol. 9, 857\u2013865 (2008).","journal-title":"Nat. Immunol."},{"key":"BFnm2279_CR27","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nature04515","volume":"440","author":"S Mariathasan","year":"2006","unstructured":"Mariathasan, S. et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440, 228\u2013232 (2006).","journal-title":"Nature"},{"key":"BFnm2279_CR28","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature04516","volume":"440","author":"F Martinon","year":"2006","unstructured":"Martinon, F., P\u00e9trilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NLRP3 inflammasome. Nature 440, 237\u2013241 (2006).","journal-title":"Nature"},{"key":"BFnm2279_CR29","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nature02664","volume":"430","author":"S Mariathasan","year":"2004","unstructured":"Mariathasan, S. et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430, 213\u2013218 (2004).","journal-title":"Nature"},{"key":"BFnm2279_CR30","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1172\/JCI28898","volume":"116","author":"H Shi","year":"2006","unstructured":"Shi, H. et al. TLR4 links innate immunity and fatty acid\u2013induced insulin resistance. J. Clin. Invest. 116, 3015\u20133025 (2006).","journal-title":"J. Clin. Invest."},{"key":"BFnm2279_CR31","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.cmet.2009.09.006","volume":"10","author":"M Saberi","year":"2009","unstructured":"Saberi, M. et al. Hematopoietic cell-specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 10, 419\u2013429 (2009).","journal-title":"Cell Metab."},{"key":"BFnm2279_CR32","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.cmet.2010.11.011","volume":"12","author":"R Stienstra","year":"2009","unstructured":"Stienstra, R. et al. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell. Metab. 12, 593\u2013605 (2009).","journal-title":"Cell. Metab."},{"key":"BFnm2279_CR33","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/nrg2188","volume":"8","author":"NA Bishop","year":"2007","unstructured":"Bishop, N.A. & Guarente, L. Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat. Rev. Genet. 8, 835\u2013844 (2007).","journal-title":"Nat. Rev. Genet."},{"key":"BFnm2279_CR34","doi-asserted-by":"publisher","first-page":"841","DOI":"10.2337\/db08-0043","volume":"57","author":"JE Galgani","year":"2008","unstructured":"Galgani, J.E. et al. Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate. Diabetes 57, 841\u2013845 (2008).","journal-title":"Diabetes"},{"key":"BFnm2279_CR35","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1369\/jhc.6A7101.2006","volume":"55","author":"JA Kummer","year":"2007","unstructured":"Kummer, J.A. et al. Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site\u2013specific role in the inflammatory response. J. Histochem. Cytochem. 55, 443\u2013452 (2007).","journal-title":"J. Histochem. Cytochem."},{"key":"BFnm2279_CR36","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1002\/art.25006","volume":"60","author":"LA Joosten","year":"2009","unstructured":"Joosten, L.A. Inflammatory arthritis in caspase 1 gene\u2013deficient mice: contribution of proteinase 3 to caspase 1\u2013independent production of bioactive interleukin-1 \u03b2. Arthritis Rheum. 60, 3651\u20133662 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnm2279_CR37","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1172\/JCI6609","volume":"103","author":"A Virkam\u00e4ki","year":"1999","unstructured":"Virkam\u00e4ki, A., Ueki, K. & Kahn, C.R. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J. Clin. Invest. 103, 931\u2013943 (1999).","journal-title":"J. Clin. Invest."},{"key":"BFnm2279_CR38","first-page":"305","volume":"119","author":"AB Imaeda","year":"2009","unstructured":"Imaeda, A.B. et al. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nlrp3 inflammasome. J. Clin. Invest. 119, 305\u2013314 (2009).","journal-title":"J. Clin. Invest."},{"key":"BFnm2279_CR39","doi-asserted-by":"publisher","first-page":"G1248","DOI":"10.1152\/ajpgi.90223.2008","volume":"296","author":"A Watanabe","year":"2009","unstructured":"Watanabe, A. et al. Inflammasome-mediated regulation of hepatic stellate cells. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G1248\u2013G1257 (2009).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"BFnm2279_CR40","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1128\/MCB.01300-08","volume":"29","author":"T Khan","year":"2009","unstructured":"Khan, T. et al. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol. Cell. Biol. 29, 1575\u20131591 (2009).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm2279_CR41","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.atherosclerosis.2008.05.033","volume":"202","author":"L H\u00e5versen","year":"2009","unstructured":"H\u00e5versen, L., Danielsson, K.N., Fogelstrand, L. & Wiklund, O. Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. Atherosclerosis 202, 382\u2013393 (2009).","journal-title":"Atherosclerosis"},{"key":"BFnm2279_CR42","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1194\/jlr.M800147-JLR200","volume":"49","author":"TS Park","year":"2008","unstructured":"Park, T.S. et al. Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J. Lipid Res. 49, 2101\u20132112 (2008).","journal-title":"J. Lipid Res."},{"key":"BFnm2279_CR43","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.bbalip.2009.09.017","volume":"1801","author":"X Prieur","year":"2010","unstructured":"Prieur, X., Roszer, T. & Ricote, M. Lipotoxicity in macrophages: evidence from diseases associated with the metabolic syndrome. Biochim. Biophys. Acta 1801, 327\u2013337 (2010).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnm2279_CR44","doi-asserted-by":"publisher","first-page":"13538","DOI":"10.1074\/jbc.M709950200","volume":"283","author":"C Shah","year":"2008","unstructured":"Shah, C. et al. Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J. Biol. Chem. 283, 13538\u201313548 (2008).","journal-title":"J. Biol. Chem."},{"key":"BFnm2279_CR45","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/nm.2002","volume":"15","author":"M Feuerer","year":"2009","unstructured":"Feuerer, M. et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15, 930\u2013939 (2009).","journal-title":"Nat. Med."},{"key":"BFnm2279_CR46","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/nm.1964","volume":"15","author":"S Nishimura","year":"2009","unstructured":"Nishimura, S. et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15, 914\u2013920 (2009).","journal-title":"Nat. Med."},{"key":"BFnm2279_CR47","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/nm.2001","volume":"15","author":"S Winer","year":"2009","unstructured":"Winer, S. et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 15, 921\u2013929 (2009).","journal-title":"Nat. Med."},{"key":"BFnm2279_CR48","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.4049\/jimmunol.1000021","volume":"185","author":"H Yang","year":"2010","unstructured":"Yang, H. et al. Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J. Immunol. 185, 1836\u20131845 (2010).","journal-title":"J. Immunol."},{"key":"BFnm2279_CR49","doi-asserted-by":"publisher","first-page":"e297","DOI":"10.1371\/journal.pmed.0030297","volume":"3","author":"D McGonagle","year":"2006","unstructured":"McGonagle, D. & McDermott, M.F. A proposed classification of the immunological diseases. PLoS Med. 3, e297 (2006).","journal-title":"PLoS Med."},{"key":"BFnm2279_CR50","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1038\/nature08938","volume":"464","author":"P Duewell","year":"2010","unstructured":"Duewell, P. et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357\u20131361 (2010).","journal-title":"Nature"},{"key":"BFnm2279_CR51","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.4049\/jimmunol.0901080","volume":"183","author":"H Li","year":"2009","unstructured":"Li, H., Ambade, A. & Re, F. Cutting edge: Necrosis activates the NLRP3 inflammasome. J. Immunol. 183, 1528\u20131532 (2009).","journal-title":"J. Immunol."},{"key":"BFnm2279_CR52","doi-asserted-by":"publisher","first-page":"4467","DOI":"10.1128\/MCB.00192-09","volume":"29","author":"N Halberg","year":"2009","unstructured":"Halberg, N. et al. Hypoxia-inducible factor 1\u03b1 induces fibrosis and insulin resistance in white adipose tissue. Mol. Cell. Biol. 29, 4467\u20134483 (2009).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm2279_CR53","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.2337\/db07-0767","volume":"56","author":"KJ Strissel","year":"2007","unstructured":"Strissel, K.J. et al. Adipocyte death, adipose tissue remodeling and obesity complications. Diabetes 56, 2910\u20132918 (2007).","journal-title":"Diabetes"},{"key":"BFnm2279_CR54","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1172\/JCI42344","volume":"120","author":"A So","year":"2010","unstructured":"So, A. & Thorens, B. Uric acid transport and disease. J. Clin. Invest. 120, 1791\u20131799 (2010).","journal-title":"J. Clin. Invest."},{"key":"BFnm2279_CR55","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1056\/NEJMra0800885","volume":"359","author":"DI Feig","year":"2008","unstructured":"Feig, D.I., Kang, D.H. & Johnson, R.J. Uric acid and cardiovascular risk. N. Engl. J. Med. 359, 1811\u20131821 (2008).","journal-title":"N. Engl. J. Med."},{"key":"BFnm2279_CR56","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1038\/oby.2010.1","volume":"18","author":"KJ Strissel","year":"2010","unstructured":"Strissel, K.J. et al. T-cell recruitment and TH1 polarization in adipose tissue during diet-induced obesity in C57BL\/6 mice. Obesity 18, 1918\u20131925 (2010).","journal-title":"Obesity"},{"key":"BFnm2279_CR57","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1161\/ATVBAHA.109.192583","volume":"29","author":"C Duffaut","year":"2009","unstructured":"Duffaut, C. et al. Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulators. Arterioscler. Thromb. Vasc. Biol. 29, 1608\u20131614 (2009).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"BFnm2279_CR58","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/ni.1831","volume":"11","author":"R Zhou","year":"2010","unstructured":"Zhou, R., Tardivel, A., Thorens, B., Choi, I. & Tschopp, J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11, 136\u2013140 (2010).","journal-title":"Nat. Immunol."},{"key":"BFnm2279_CR59","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1159\/000088261","volume":"42","author":"H Dominguez","year":"2005","unstructured":"Dominguez, H. et al. Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes. J. Vasc. Res. 42, 517\u2013525 (2005).","journal-title":"J. Vasc. Res."},{"key":"BFnm2279_CR60","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1083\/jcb.200903124","volume":"187","author":"M Lamkanfi","year":"2009","unstructured":"Lamkanfi, M. et al. Glyburide inhibits the Cryopyrin\/Nlrp3 inflammasome. J. Cell Biol. 187, 61\u201370 (2009).","journal-title":"J. Cell Biol."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm.2279.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.2279","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.2279.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:26:31Z","timestamp":1684434391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.2279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,9]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["BFnm2279"],"URL":"https:\/\/doi.org\/10.1038\/nm.2279","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.8685960.9209056","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.8685960.10631054","asserted-by":"object"}]},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,9]]}}}