{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:18:45Z","timestamp":1770704325113,"version":"3.49.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1998,8]]},"DOI":"10.1038\/nm0898-939","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T02:21:51Z","timestamp":1092882111000},"page":"939-944","source":"Crossref","is-referenced-by-count":121,"title":["A minimal glycine-alanine repeat prevents the interaction of ubiquitinated I\u03baB\u03b1 with the proteasome: a new mechanism for selective inhibition of proteolysis"],"prefix":"10.1038","volume":"4","author":[{"given":"Anatoly","family":"Sharipo","sequence":"first","affiliation":[]},{"given":"Marta","family":"Imreh","sequence":"additional","affiliation":[]},{"given":"Ainars","family":"Leonchiks","sequence":"additional","affiliation":[]},{"given":"Stefan","family":"Imreh","sequence":"additional","affiliation":[]},{"given":"Maria G.","family":"Masucci","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFnm0898939_CR1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/viro.1997.8674","volume":"234","author":"MB Oldstone","year":"1997","unstructured":"Oldstone, M.B. How viruses escape from cytotoxic T lymphocytes: molecular parameters and players. Virology 234, 179\u2013185 (1997).","journal-title":"Virology"},{"key":"BFnm0898939_CR2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0966-842X(94)90599-1","volume":"2","author":"MG Masucci","year":"1994","unstructured":"Masucci, M.G. & Ernberg, I. Epstein-Barr virus: Adaptation to a life within the immune sytem. Trends Mkrobiol. 2, 125\u2013130 (1994).","journal-title":"Trends Mkrobiol."},{"key":"BFnm0898939_CR3","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1146\/annurev.immunol.15.1.405","volume":"15","author":"AB Rickinson","year":"1997","unstructured":"Rickinson, A.B. & Moss, D.J. Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection. Annu. Rev. Immunol. 15, 405\u2013431 (1997).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnm0898939_CR4","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S1074-7613(00)80397-0","volume":"7","author":"N Blake","year":"1997","unstructured":"Blake, N. et al. Human CD8(+) T Cell responses to EBV EBNA1-HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing. Immunity 7, 791\u2013802 (1997).","journal-title":"Immunity"},{"key":"BFnm0898939_CR5","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1099\/0022-1317-76-4-779","volume":"76","author":"K Falk","year":"1995","unstructured":"Falk, K. et al. The role of repetitive DNA sequences in the size variation of Epstein-Barr virus (EBV) nuclear antigens, and the identification of different EBV isolates using RFLP and PCR analysis. J. Gen. Virol. 76, 779\u2013790 (1995).","journal-title":"J. Gen. Virol."},{"key":"BFnm0898939_CR6","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/375685a0","volume":"375","author":"J Levitskaya","year":"1995","unstructured":"Levitskaya, J. et al. Inhibition of antigen processing by the internal repeat region of the Epstein-Barr Virus nuclear antigen-1. Nature 375, 685\u2013688 (1995).","journal-title":"Nature"},{"key":"BFnm0898939_CR7","doi-asserted-by":"publisher","first-page":"12616","DOI":"10.1073\/pnas.94.23.12616","volume":"94","author":"J Levitskaya","year":"1997","unstructured":"Levitskaya, J., Sharipo, A., Leonchiks, A., Ciechanover, A. & Masucci, M. Inhibition of ubiquitin\/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epsein-Barr-virus nuclear antigen 1. Proc. Natl. Acad. Sci USA 94, 12616\u201312621 (1997).","journal-title":"Proc. Natl. Acad. Sci USA"},{"key":"BFnm0898939_CR8","first-page":"131","volume":"378","author":"AL Goldberg","year":"1997","unstructured":"Goldberg, A.L., Akopian, T.N., Kisselev, A.F., Lee, D.H. & Rohrwild, M. New insights into the mechanisms and importance of the proteasome in intracellular protein degradation. Biol. Chem. 378, 131\u2013140 (1997).","journal-title":"Biol. Chem."},{"key":"BFnm0898939_CR9","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1101\/gad.7.11.2064","volume":"7","author":"AA Berg","year":"1993","unstructured":"Berg, A.A. & Baldwin, A.S.J. The I\u03baB proteins: multifunctional regulators of rel\/NF-\u03baB transcription factors. Genet Dev. 7, 2064\u20132070 (1993).","journal-title":"Genet Dev."},{"key":"BFnm0898939_CR10","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1073\/pnas.90.6.2532","volume":"90","author":"K Brown","year":"1993","unstructured":"Brown, K., Park, S., Kanno, T., Franzoso, G. & Siebenlist, U. Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha. Proc. Notl. Acad. Sci USA 90, 2532\u20132536 (1993).","journal-title":"Proc. Notl. Acad. Sci USA"},{"key":"BFnm0898939_CR11","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/365182a0","volume":"365","author":"T Henkel","year":"1993","unstructured":"Henkel, T. et al. Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B. Nature 365, 182\u2013185 (1993).","journal-title":"Nature"},{"key":"BFnm0898939_CR12","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1128\/MCB.15.3.1302","volume":"15","author":"JA DiDonato","year":"1995","unstructured":"DiDonato, J.A., Mercurio, F. & Karin, M. Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B. Mol. Cell. Biol. 15, 1302\u20131311 (1995).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm0898939_CR13","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1128\/MCB.15.4.2166","volume":"15","author":"E Jaffray","year":"1995","unstructured":"Jaffray, E., Wood, K.M. & Hay, R.T. Domain organization of I kappa B alpha and sites of interaction with NF-kappa B p65. Mol. Cell. Biol. 15, 2166\u20132172 (1995).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm0898939_CR14","doi-asserted-by":"publisher","first-page":"4685","DOI":"10.1002\/j.1460-2075.1993.tb06157.x","volume":"12","author":"NR Rise","year":"1993","unstructured":"Rise, N.R. & Ernst, M.K. In vivo control of NF-kappaB activation by IkappaBalpha. EMBO J. 12, 4685\u20134695 (1993).","journal-title":"EMBO J."},{"key":"BFnm0898939_CR15","doi-asserted-by":"publisher","first-page":"6716","DOI":"10.1002\/j.1460-2075.1996.tb01061.x","volume":"15","author":"D Krappmann","year":"1996","unstructured":"Krappmann, D., Wulczyn, F.G. & Scheidereit, C. Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo. EMBO J. 15, 6716\u20136726 (1996).","journal-title":"EMBO J."},{"key":"BFnm0898939_CR16","first-page":"784","volume":"27A","author":"CY Wang","year":"1997","unstructured":"Wang, C.Y., Mayo, M.W. & Baldwin, A.S.J. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 27A, 784\u2013787 (1997).","journal-title":"Science"},{"key":"BFnm0898939_CR17","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1126\/science.274.5288.782","volume":"274","author":"AA Beg","year":"1996","unstructured":"Beg, A.A. & Baltimore, D. An essential role for NF-kappaB in preventing TNF-alpha-in-duced cell death. Science 274, 782\u2013784 (1996).","journal-title":"Science"},{"key":"BFnm0898939_CR18","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1126\/science.274.5288.787","volume":"27A","author":"DJ Van Antwerp","year":"1996","unstructured":"Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R. & Verma, I.M. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 27A, 787\u2013789 (1996).","journal-title":"Science"},{"key":"BFnm0898939_CR19","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1101\/gad.9.13.1586","volume":"9","author":"Z Chen","year":"1995","unstructured":"Chen, Z. et al. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev. 9, 1586\u20131597 (1995).","journal-title":"Genes Dev."},{"issue":"5203","key":"BFnm0898939_CR20","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1126\/science.7878466","volume":"267","author":"K. Brown","year":"1995","unstructured":"Brown, K., Gerstberger, S., Carlson, L., Franzoso, G. & Siebenlist, U. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation. Science 267, 1485\u20131488(1995).","journal-title":"Science"},{"key":"BFnm0898939_CR21","doi-asserted-by":"publisher","first-page":"2876","DOI":"10.1002\/j.1460-2075.1995.tb07287.x","volume":"14","author":"EB Traenckner","year":"1995","unstructured":"Traenckner, E.B. et al. Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli. EMBOJ. 14, 2876\u20132883 (1995).","journal-title":"EMBOJ."},{"key":"BFnm0898939_CR22","first-page":"2425","volume":"12","author":"MS Rodriguez","year":"1996","unstructured":"Rodriguez, M.S. et al. Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivo. Oncogene 12, 2425\u20132435 (1996).","journal-title":"Oncogene"},{"key":"BFnm0898939_CR23","doi-asserted-by":"publisher","first-page":"12740","DOI":"10.1073\/pnas.91.26.12740","volume":"91","author":"S Miyamoto","year":"1994","unstructured":"Miyamoto, S., Maki, M., Schmitt, M.J., Hatanaka, M. & Verma, I.M. Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B. Proc. Natl. Acad. Sci USA 91, 12740\u201312744 (1994).","journal-title":"Proc. Natl. Acad. Sci USA"},{"key":"BFnm0898939_CR24","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1073\/pnas.92.2.552","volume":"92","author":"YC Lin","year":"1995","unstructured":"Lin, Y.C., Brown, K. & Siebenlist, U. Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B. Proc. Natl. Acad. Sci USA 92, 552\u2013556 (1995).","journal-title":"Proc. Natl. Acad. Sci USA"},{"key":"BFnm0898939_CR25","doi-asserted-by":"publisher","first-page":"11884","DOI":"10.1073\/pnas.91.25.11884","volume":"91","author":"TS Finco","year":"1994","unstructured":"Finco, T.S., Beg, A.A. & Baldwin, A.S.J. Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors. Proc. Natl. Acad. Sci USA 91, 11884\u201311888 (1994).","journal-title":"Proc. Natl. Acad. Sci USA"},{"key":"BFnm0898939_CR26","doi-asserted-by":"publisher","first-page":"10599","DOI":"10.1073\/pnas.92.23.10599","volume":"92","author":"I Alkalay","year":"1995","unstructured":"Alkalay, I. et al. Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci USA 92, 10599\u201310603 (1995).","journal-title":"Proc. Natl. Acad. Sci USA"},{"key":"BFnm0898939_CR27","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/0092-8674(94)90396-4","volume":"79","author":"A Ciechanover","year":"1994","unstructured":"Ciechanover, A. The ubiquitin-proteasome proteolytic pathway. Cell 79, 13\u201321 (1994).","journal-title":"Cell"},{"key":"BFnm0898939_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/viro.1996.0392","volume":"222","author":"JL Yates","year":"1996","unstructured":"Yates, J.L., Camiolo, S.M., Ali, S. & Ying, A. Comparison of the EBNA1 proteins of Epstein-Barr virus and herpesvirus papio in sequence and function. Virology 222, 1\u201313 (1996).","journal-title":"Virology"},{"key":"BFnm0898939_CR29","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1002\/(SICI)1097-0282(199706)41:7<703::AID-BIP1>3.0.CO;2-T","volume":"41","author":"BL Thiel","year":"1997","unstructured":"Thiel, B.L., Guess, K.B. & Viney, C. Non-periodic lattice crystals in the hierarchical microstructure of spider (major ampullate) silk. Biopolymers 41, 703\u2013719 (1997).","journal-title":"Biopolymers"},{"key":"BFnm0898939_CR30","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1126\/science.271.5245.84","volume":"271","author":"AH Simmons","year":"1996","unstructured":"Simmons, A.H., Michal, C.A. & Jelinski, L.W. Molecular orientation and two-component nature of the crystalline fraction of spider dragline silk. Science 271, 84\u201387 (1996).","journal-title":"Science"},{"key":"BFnm0898939_CR31","first-page":"149","volume":"199","author":"J Williams","year":"1995","unstructured":"Williams, J., Williams, M., Liu, C. & Telling, G. Assessing the role of El A in the differential oncogenicity of group A and group C human adenoviruses. Curr. Top. Microbiol. Immunol. 199, 149\u2013175 (1995).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"BFnm0898939_CR32","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1128\/MCB.16.5.2248","volume":"16","author":"L Lin","year":"1996","unstructured":"Lin, L. & Ghosh, S. A glycin-rich region of NF-\u03baB p105 functions as a processing signal for the generation of the p50 subunit. Mol. Cell. Biol. 16, 2248\u20132254 (1996).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm0898939_CR33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0959-440X(97)80007-3","volume":"7","author":"PM Harrison","year":"1997","unstructured":"Harrison, P.M., Bamborough, P., Daggett, V., Prusiner, S.B. & Cohen, F.E. The prion folding problem. Curr. Opin. Struct. Biol. 7, 53\u201359 (1997).","journal-title":"Curr. Opin. Struct. Biol."},{"key":"BFnm0898939_CR34","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0959-440X(97)80036-X","volume":"7","author":"W Baumeister","year":"1997","unstructured":"Baumeister, W. & Lupas, A. The proteasome. Curr. Opin. Struct. Biol. 7, 273\u2013278 (1997).","journal-title":"Curr. Opin. Struct. Biol."},{"key":"BFnm0898939_CR35","doi-asserted-by":"publisher","first-page":"20427","DOI":"10.1074\/jbc.272.33.20427","volume":"272","author":"EA Fisher","year":"1997","unstructured":"Fisher, E.A. et al. The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J. Biol. Chem. 272, 20427\u201320434 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFnm0898939_CR36","doi-asserted-by":"publisher","first-page":"4773","DOI":"10.1128\/MCB.16.9.4773","volume":"16","author":"DH Lee","year":"1996","unstructured":"Lee, D.H., Sherman, M.Y. & Goldberg, A.L. Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 4773\u20134781 (1996).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm0898939_CR37","doi-asserted-by":"publisher","first-page":"9002","DOI":"10.1074\/jbc.272.14.9002","volume":"272","author":"B Bercovich","year":"1997","unstructured":"Bercovich, B. et al. Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70. J. Biol. Chem. 272, 9002\u20139010 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFnm0898939_CR38","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1128\/MCB.16.4.1295","volume":"16","author":"J DiDonato","year":"1996","unstructured":"DiDonato, J. et al. Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16, 1295\u20131304 (1996).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm0898939_CR39","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1042\/bj3050245","volume":"305","author":"KB Hendil","year":"1995","unstructured":"Hendil, K.B., Kristensen, P. & Uerkvitz, W. Human proteasomes analysed with monoclonal antibodies. Biochem. J. 305, 245\u2013252 (1995).","journal-title":"Biochem. J."},{"key":"BFnm0898939_CR40","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1126\/science.8367725","volume":"261","author":"Y Devary","year":"1993","unstructured":"Devary, Y., Rosette, C., DiDonato, J.A. & Karin, M. NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. Science 261, 1442\u20131445 (1993).","journal-title":"Science"},{"key":"BFnm0898939_CR41","doi-asserted-by":"publisher","first-page":"4652","DOI":"10.1073\/pnas.81.15.4652","volume":"81","author":"J Dillner","year":"1984","unstructured":"Dillner, J. et al. Antibodies against a synthetic peptide identify the Epstein-Barr virus-determined nuclear antigen. Proc. Natl. Acad. Sci USA 81, 4652\u20134656 (1984).","journal-title":"Proc. Natl. Acad. Sci USA"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm0898-939","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0898-939.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0898-939.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:31:30Z","timestamp":1684452690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm0898-939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1998,8]]}},"alternative-id":["BFnm0898939"],"URL":"https:\/\/doi.org\/10.1038\/nm0898-939","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8]]}}}