{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:25:19Z","timestamp":1776749119404,"version":"3.51.2"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,12,19]],"date-time":"2004-12-19T00:00:00Z","timestamp":1103414400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,12,19]],"date-time":"2004-12-19T00:00:00Z","timestamp":1103414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2005,1,1]]},"DOI":"10.1038\/nm1163","type":"journal-article","created":{"date-parts":[[2004,12,19]],"date-time":"2004-12-19T13:49:01Z","timestamp":1103464141000},"page":"35-42","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":496,"title":["The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption"],"prefix":"10.1038","volume":"11","author":[{"given":"Rainer","family":"Spanagel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurudutt","family":"Pendyala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Abarca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Zghoul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carles","family":"Sanchis-Segura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Chiara","family":"Magnone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Lascorz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Depner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Holzberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Soyka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Lathrop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunter","family":"Schumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,12,19]]},"reference":[{"key":"BFnm1163_CR1","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/35088576","volume":"2","author":"MW Young","year":"2001","unstructured":"Young, M.W. & Kay, S.A. Time zones: a comparative genetics of circadian clocks. Nat. Rev. Genet. 2, 702\u2013715 (2001).","journal-title":"Nat. Rev. Genet."},{"key":"BFnm1163_CR2","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nrn1177","volume":"4","author":"MH Hastings","year":"2003","unstructured":"Hastings, M.H., Reddy, A.B. & Maywood, E.S. A clockwork web: timing in brain and periphery, in health and disease. Nat. Rev. Neurosci. 4, 649\u2013661 (2003).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnm1163_CR3","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1146\/annurev.neuro.23.1.713","volume":"23","author":"DP King","year":"2000","unstructured":"King, D.P. & Takahashi, J.S. Molecular genetics of circadian rhythms in mammals. Annu. Rev. Neurosci. 23, 713\u2013742 (2000).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnm1163_CR4","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1038\/nature00965","volume":"418","author":"SM Reppert","year":"2002","unstructured":"Reppert, S.M. & Weaver, D.R. Coordination of circadian timing in mammals. Nature 418, 935\u2013941 (2002).","journal-title":"Nature"},{"key":"BFnm1163_CR5","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1152\/japplphysiol.00759.2001","volume":"92","author":"U Albrecht","year":"2002","unstructured":"Albrecht, U. Invited review: regulation of mammalian circadian clock genes. J. Appl. Physiol. 92, 1348\u20131355 (2002).","journal-title":"J. Appl. Physiol."},{"key":"BFnm1163_CR6","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/35081582","volume":"2","author":"RM Buijs","year":"2001","unstructured":"Buijs, R.M. & Kalsbeek, A. Hypothalamic integration of central and peripheral clocks. Nat. Rev. Neurosci. 2, 521\u2013526 (2001).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnm1163_CR7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0301-0082(96)00032-9","volume":"50","author":"FJ Ebling","year":"1996","unstructured":"Ebling, F.J. The role of glutamate in the photic regulation of the suprachiasmatic nucleus. Prog. Neurobiol. 50, 109\u2013132 (1996).","journal-title":"Prog. Neurobiol."},{"key":"BFnm1163_CR8","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1046\/j.1460-9568.2002.02224.x","volume":"16","author":"L Yan","year":"2002","unstructured":"Yan, L. & Silver, R. Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts. Eur. J. Neurosci. 16, 1531\u20131540 (2002).","journal-title":"Eur. J. Neurosci."},{"key":"BFnm1163_CR9","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1177\/074873001129001791","volume":"16","author":"U Albrecht","year":"2001","unstructured":"Albrecht, U. et al. mPer1 and mPer2 are essential for normal resetting of the circadian clock. J. Biol. Rhythms. 16, 100\u2013104 (2001).","journal-title":"J. Biol. Rhythms."},{"key":"BFnm1163_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","volume":"65","author":"NC Danbolt","year":"2001","unstructured":"Danbolt, N.C. Glutamate uptake. Prog. Neurobiol. 65, 1\u2013105 (2001).","journal-title":"Prog. Neurobiol."},{"key":"BFnm1163_CR11","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/S0896-6273(00)80086-0","volume":"16","author":"JD Rothstein","year":"1996","unstructured":"Rothstein, J.D. et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16, 675\u2013686 (1996).","journal-title":"Neuron"},{"key":"BFnm1163_CR12","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/annurev.med.49.1.173","volume":"49","author":"G Tsai","year":"1998","unstructured":"Tsai, G. Coyle, JT. The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu. Rev. Med. 49, 173\u2013184 (1998).","journal-title":"Annu. Rev. Med."},{"key":"BFnm1163_CR13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1515\/REVNEURO.2001.12.2.141","volume":"12","author":"L Pulvirenti","year":"2001","unstructured":"Pulvirenti, L. & Diana, M. Drug dependence as a disorder of neural plasticity: focus on dopamine and glutamate. Rev. Neurosci. 12, 141\u2013158 (2001).","journal-title":"Rev. Neurosci."},{"key":"BFnm1163_CR14","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1196\/annals.1300.012","volume":"1003","author":"GR Siggins","year":"2003","unstructured":"Siggins, G.R. et al. Glutamatergic transmission in opiate and alcohol dependence. Ann. NY Acad. Sci. 1003, 196\u2013211 (2003).","journal-title":"Ann. NY Acad. Sci."},{"key":"BFnm1163_CR15","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1111\/j.1360-0443.1995.tb01088.x","volume":"90","author":"J Littleton","year":"1995","unstructured":"Littleton, J. Acamprosate in alcohol dependence: how does it work? Addiction 90, 1179\u20131188 (1995).","journal-title":"Addiction"},{"key":"BFnm1163_CR16","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S0165-6147(97)89800-8","volume":"18","author":"R Spanagel","year":"1997","unstructured":"Spanagel, R, Zieglgansberger, W. Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends Pharmacol. Sci. 18, 54\u201359 (1997).","journal-title":"Trends Pharmacol. Sci."},{"key":"BFnm1163_CR17","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1111\/j.1530-0277.2002.tb02578.x","volume":"26","author":"GF Koob","year":"2002","unstructured":"Koob, G.F. et al. Potential neuroprotective effects of acamprosate. Alcohol. Clin. Exp. Res. 26, 586\u2013592 (2002).","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"BFnm1163_CR18","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1055\/s-2003-45139","volume":"36","author":"A Heinz","year":"2003","unstructured":"Heinz, A., Schafer, M, Higley, J.D., Krystal, J.H. & Goldman, D. Neurobiological correlates of the disposition and maintenance of alcoholism. Pharmacopsychiatry 36, 255\u2013258 (2003).","journal-title":"Pharmacopsychiatry"},{"key":"BFnm1163_CR19","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0163-7258(03)00054-8","volume":"99","author":"JH Krystal","year":"2003","unstructured":"Krystal, J.H. et al. N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacol. Ther. 99, 79\u201394 (2003).","journal-title":"Pharmacol. Ther."},{"key":"BFnm1163_CR20","first-page":"1","volume-title":"Alcohol dependence and addiction, in Ionotropic glutamate receptors as therapeutic targets","author":"R Spanagel","year":"2002","unstructured":"Spanagel, R. & Bienkowski, P. Alcohol dependence and addiction, in Ionotropic glutamate receptors as therapeutic targets (eds Lodge, D., Danysz, W. & Parsons, C.G.) pp 1\u201327 (FP Graham Publishing Co., Johnson City, Tennessee, 2002)."},{"key":"BFnm1163_CR21","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1046\/j.1460-9568.2003.02657.x","volume":"17","author":"E Aronica","year":"2003","unstructured":"Aronica, E. et al. Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins. Eur. J. Neurosci. 17, 2106\u20132118 (2003).","journal-title":"Eur. J. Neurosci."},{"key":"BFnm1163_CR22","doi-asserted-by":"publisher","first-page":"8676","DOI":"10.1523\/JNEUROSCI.22-19-08676.2002","volume":"22","author":"R Spanagel","year":"2002","unstructured":"Spanagel, R. et al. The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol. J. Neurosci. 22, 8676\u20138683 (2002).","journal-title":"J. Neurosci."},{"key":"BFnm1163_CR23","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/13556210310001602202","volume":"8","author":"JA McQuade","year":"2003","unstructured":"McQuade, J.A., Xu, M., Woods, S.C., Seeley, R.J. & Benoit, S.C. Ethanol consumption in mice with a targeted disruption of the dopamine-3 receptor gene. Addict. Biol. 8, 295\u2013303 (2003).","journal-title":"Addict. Biol."},{"key":"BFnm1163_CR24","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/135562101200100553","volume":"7","author":"H Matsumoto","year":"2002","unstructured":"Matsumoto, H & Fukui, Y. Pharmacokinetics of ethanol: a review of the methodology. Addict. Biol. 7, 5\u201314 (2002).","journal-title":"Addict. Biol."},{"key":"BFnm1163_CR25","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s002130050656","volume":"138","author":"P Jelic","year":"1997","unstructured":"Jelic, P., Shih, M.F. & Taberner, P.V. Diurnal variation in plasma ethanol levels of TO and CBA mice on chronic ethanol drinking or ethanol liquid diet schedules. Psychopharmacology 138, 143\u2013150 (1997).","journal-title":"Psychopharmacology"},{"key":"BFnm1163_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/jpet.102.035063","volume":"305","author":"JD Salamone","year":"2003","unstructured":"Salamone, J.D., Correa, M., Mingote, S. & Weber, S.M. Nucleus accumbens dopamine and the regulation of effort in food-seeking behavior: implications for studies of natural motivation, psychiatry, and drug abuse. J. Pharmacol. Exp.Ther. 305, 1\u20138 (2003).","journal-title":"J. Pharmacol. Exp.Ther."},{"key":"BFnm1163_CR27","first-page":"649","volume":"6","author":"R Schreiber","year":"2000","unstructured":"Schreiber, R. & Freund, W.D. Glutamate transport is downregulated in the cerebral cortex of alcohol-preferring rats. Med. Sci. Monit. 6, 649\u2013652 (2000).","journal-title":"Med. Sci. Monit."},{"key":"BFnm1163_CR28","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1001\/archpsyc.1996.01830080023006","volume":"53","author":"H Sass","year":"1996","unstructured":"Sass, H., Soyka, M., Mann, K., & Zieglg\u00e4nsberger, W. Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence. Arch. Gen. Psychiatry 53, 673\u2013680 (1996).","journal-title":"Arch. Gen. Psychiatry"},{"key":"BFnm1163_CR29","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/01.ALC.0000108656.81563.05","volume":"28","author":"K Mann","year":"2004","unstructured":"Mann, K., Lehert, P. & Morgan, M.Y. The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis. Alcohol. Clin. Exp. Res. 28, 51\u201363 (2004).","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"BFnm1163_CR30","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0163-7258(02)00200-0","volume":"94","author":"AD L\u00ea","year":"2002","unstructured":"L\u00ea, A.D. & Shaham, Y. Neurobiology of relapse to alcohol in rats. Pharmacol. & Ther. 94, 137\u2013156 (2002).","journal-title":"Pharmacol. & Ther."},{"key":"BFnm1163_CR31","doi-asserted-by":"publisher","first-page":"3332","DOI":"10.1523\/JNEUROSCI.22-09-03332.2002","volume":"22","author":"F Weiss","year":"2002","unstructured":"Weiss, F. & Porrino, L.J. Behavioral neurobiology of alcohol addiction: recent advances and challenges. J. Neurosci. 22: 3332\u20133337 (2002).","journal-title":"J. Neurosci."},{"key":"BFnm1163_CR32","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0301-0082(99)00031-3","volume":"60","author":"A Dahchour","year":"2000","unstructured":"Dahchour, A. & De Witte, P. Ethanol and amino acids in the central nervous system: assessment of the pharmacological actions of acamprosate. Prog. Neurobiol. 60, 343\u2013362 (2000).","journal-title":"Prog. Neurobiol."},{"key":"BFnm1163_CR33","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/01.ALC.0000056617.68874.18","volume":"27","author":"A Dahchour","year":"2003","unstructured":"Dahchour, A. & De Witte, P. Effects of acamprosate on excitatory amino acids during multiple ethanol withdrawal periods. Alcohol. Clin. Exp. Res. 27, 465\u2013470 (2003).","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"BFnm1163_CR34","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1007\/s00210-003-0795-3","volume":"368","author":"MJ Cano-Cebrian","year":"2003","unstructured":"Cano-Cebrian, M.J. et al. Acamprosate blocks the increase in dopamine extracellular levels in nucleus accumbens evoked by chemical stimulation of the ventral hippocampus. Naunyn-Schmiedebergs Arch. Pharmacol. 368, 324\u2013327 (2003).","journal-title":"Naunyn-Schmiedebergs Arch. Pharmacol."},{"key":"BFnm1163_CR35","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0166-2236(99)01447-2","volume":"22","author":"R Spanagel","year":"1999","unstructured":"Spanagel, R. & Weiss, F. The dopamine hypothesis of reward: past and current status. Trends Neurosci. 22, 521\u2013527 (1999).","journal-title":"Trends Neurosci."},{"key":"BFnm1163_CR36","doi-asserted-by":"publisher","first-page":"149","DOI":"10.15288\/jsa.1994.55.149","volume":"55","author":"KK Bucholz","year":"1994","unstructured":"Bucholz, K.K. et al. A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J. Stud. Alcohol. 55 149\u2013158. (1994).","journal-title":"J. Stud. Alcohol."},{"key":"BFnm1163_CR37","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1016\/S0006-3223(03)00635-8","volume":"54","author":"G Schumann","year":"2003","unstructured":"Schumann, G. et al. Analysis of genetic variations of Protein Tyrosine Kinase fyn and their association with alcohol dependence in two independent cohorts. Biol. Psychiatry 54, 1422\u20131426 (2003).","journal-title":"Biol. Psychiatry"},{"key":"BFnm1163_CR38","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1126\/science.285.5430.1066","volume":"285","author":"R Andretic","year":"1999","unstructured":"Andretic, R., Chaney, S. & Hirsh J. Requirement of circadian genes for cocaine sensitization in drosophila. Science 285, 1066\u20131068 (1999).","journal-title":"Science"},{"key":"BFnm1163_CR39","doi-asserted-by":"publisher","first-page":"9026","DOI":"10.1073\/pnas.142039099","volume":"99","author":"C Abarca","year":"2002","unstructured":"Abarca, C., Albrecht, U. & Spanagel, R. Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Proc. Natl. Acad. Sci. USA 99, 9026\u20139030 (2002).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1163_CR40","unstructured":"Liu, Y. et al. The role of mPer1 on morphine dependence in mice. Neuropsychopharmacology (in press)."},{"key":"BFnm1163_CR41","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/syn.10198","volume":"48","author":"V Yuferov","year":"2003","unstructured":"Yuferov, V. et al. Differential gene expression in the rat caudate putamen after \u201cbinge\u201d cocaine administration: advantage of triplicate microarray analysis. Synapse 48, 157\u2013169 (2003).","journal-title":"Synapse"},{"key":"BFnm1163_CR42","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1124\/mol.59.4.894","volume":"59","author":"T Nikaido","year":"2001","unstructured":"Nikaido, T., Akyiama, M., Moriya, T. & Shibata, S. Sensitized increase of Period gene expression in the mouse caudate\/putamen caused by repeated injection of methamphetamine. Mol. Pharmacol. 59, 894\u2013900 (2001).","journal-title":"Mol. Pharmacol."},{"key":"BFnm1163_CR43","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1111\/j.1460-9568.2000.01313.x","volume":"12","author":"S Masubuchi","year":"2000","unstructured":"Masubuchi, S. et al. Clock genes outside the suprachiasmatic nucleus involved in manifestation of locomotor activity rhythm in rats. Eur. J. Neurosci. 12, 4206\u20134214 (2000).","journal-title":"Eur. J. Neurosci."},{"key":"BFnm1163_CR44","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1002\/(SICI)1097-0274(199809)34:3<266::AID-AJIM9>3.0.CO;2-T","volume":"34","author":"AM Trinkoff","year":"1998","unstructured":"Trinkoff, A.M. & Storr, C.L. Work schedule characteristics and substance use. Am. J. Ind. Med. 34, 266\u2013271 (1998).","journal-title":"Am. J. Ind. Med."},{"key":"BFnm1163_CR45","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1177\/216507990205001006","volume":"50","author":"HL Rogers","year":"2002","unstructured":"Rogers, H.L. and Reilly, S.M. A survey of the health experiences of international business travellers. AAOHN J. 50, 449\u2013459 (2002).","journal-title":"AAOHN J."},{"key":"BFnm1163_CR46","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/22118","volume":"400","author":"B Zhang","year":"1999","unstructured":"Zhang, B. et al. The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 400, 169\u2013173 (1999).","journal-title":"Nature"},{"key":"BFnm1163_CR47","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0165-0270(94)00124-Y","volume":"57","author":"I Smolders","year":"1995","unstructured":"Smolders, I., Sarre, S., Michotte, Y. & Ebinger, G. The analysis of excitatory, inhibitory and other amino acids in rat brain microdialysates using microbore liquid chromatography. J. Neurosci. Meth. 57, 47\u201353 (1995).","journal-title":"J. Neurosci. Meth."},{"key":"BFnm1163_CR48","doi-asserted-by":"publisher","first-page":"375","DOI":"10.2307\/3001775","volume":"11","author":"P Armitage","year":"1955","unstructured":"Armitage, P. Tests for linear trends in proportions and frequencies. Biometrics 11, 375\u2013386 (1955).","journal-title":"Biometrics"}],"updated-by":[{"DOI":"10.1038\/nm0205-233c","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000}}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm1163.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1163","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1163.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T21:38:16Z","timestamp":1705441096000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm1163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,19]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1,1]]}},"alternative-id":["BFnm1163"],"URL":"https:\/\/doi.org\/10.1038\/nm1163","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1032401.374377","asserted-by":"object"}]},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,19]]},"assertion":[{"value":"14 June 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}