{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:39:11Z","timestamp":1787002751204,"version":"3.56.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2005,2,13]],"date-time":"2005-02-13T00:00:00Z","timestamp":1108252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1038\/nm1196","type":"journal-article","created":{"date-parts":[[2005,2,13]],"date-time":"2005-02-13T13:29:13Z","timestamp":1108301353000},"page":"312-319","source":"Crossref","is-referenced-by-count":933,"title":["Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy"],"prefix":"10.1038","volume":"11","author":[{"given":"Alexander J","family":"Muller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B","family":"DuHadaway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Scott","family":"Donover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Sutanto-Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C","family":"Prendergast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,2,13]]},"reference":[{"key":"BFnm1196_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrc1252","volume":"4","author":"G Dranoff","year":"2004","unstructured":"Dranoff, G. Cytokines in cancer pathogenesis and cancer therapy. Nat. Rev. Cancer 4, 11\u201322 (2004).","journal-title":"Nat. Rev. Cancer"},{"key":"BFnm1196_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0065-2776(08)60911-6","volume":"74","author":"FM Marincola","year":"2000","unstructured":"Marincola, F.M., Jaffee, E.M., Hicklin, D.J. & Ferrone, S. Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv. Immunol. 74, 181\u2013273 (2000).","journal-title":"Adv. Immunol."},{"key":"BFnm1196_CR3","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/ng0996-69","volume":"14","author":"D Sakamuro","year":"1996","unstructured":"Sakamuro, D., Elliott, K., Wechsler-Reya, R. & Prendergast, G.C. BIN1 is a novel MYC-interacting protein with features of a tumor suppressor. Nat. Genet. 14, 69\u201377 (1996).","journal-title":"Nat. Genet."},{"key":"BFnm1196_CR4","doi-asserted-by":"publisher","first-page":"3564","DOI":"10.1038\/sj.onc.1202670","volume":"18","author":"K Elliott","year":"1999","unstructured":"Elliott, K. et al. Bin1 functionally interacts with Myc in cells and inhibits cell proliferation by multiple mechanisms. Oncogene 18, 3564\u20133573 (1999).","journal-title":"Oncogene"},{"key":"BFnm1196_CR5","doi-asserted-by":"publisher","first-page":"9689","DOI":"10.1073\/pnas.96.17.9689","volume":"96","author":"K Ge","year":"1999","unstructured":"Ge, K. et al. Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma. Proc. Natl. Acad. Sci. USA 96, 9689\u20139694 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1196_CR6","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1002\/(SICI)1097-0215(20000201)85:3<376::AID-IJC14>3.0.CO;2-1","volume":"85","author":"K Ge","year":"2000","unstructured":"Ge, K. et al. Losses of the tumor suppressor Bin1 in breast carcinoma are frequent and reflect deficits in a programmed cell death capacity. Int. J. Cancer 85, 376\u2013383 (2000).","journal-title":"Int. J. Cancer"},{"key":"BFnm1196_CR7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/(SICI)1097-0215(20000415)86:2<155::AID-IJC2>3.0.CO;2-M","volume":"86","author":"K Ge","year":"2000","unstructured":"Ge, K. et al. Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma. Int. J. Cancer 86, 155\u2013161 (2000).","journal-title":"Int. J. Cancer"},{"key":"BFnm1196_CR8","first-page":"3345","volume":"9","author":"T Tajiri","year":"2003","unstructured":"Tajiri, T. et al. Expression of a MYCN-interacting isoform of the tumor suppressor BIN1 is reduced in neuroblastomas with unfavorable biological features. Clin. Cancer Res. 9, 3345\u20133355 (2003).","journal-title":"Clin. Cancer Res."},{"key":"BFnm1196_CR9","doi-asserted-by":"crossref","unstructured":"Muller, A.J., DuHadaway, J.B., Donover, P.S., Sutanto-Ward, E. & Prendergast, G.C. Targeted deletion of the suppressor gene Bin1\/Amphiphysin2 enhances the malignant character of transformed cells. Cancer Biol. Ther. 3, published online 14 December 2004.","DOI":"10.4161\/cbt.3.12.1232"},{"key":"BFnm1196_CR10","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0166-2236(98)01264-8","volume":"21","author":"P Wigge","year":"1998","unstructured":"Wigge, P. & McMahon, H.T. The amphiphysin family of proteins and their role in endocytosis at the synapse. Trends Neurosci. 21, 339\u2013344 (1998).","journal-title":"Trends Neurosci."},{"key":"BFnm1196_CR11","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1242\/dev.128.24.5005","volume":"128","author":"AC Zelhof","year":"2001","unstructured":"Zelhof, A.C. et al. Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in synaptic vesicle endocytosis. Development 128, 5005\u20135015 (2001).","journal-title":"Development"},{"key":"BFnm1196_CR12","doi-asserted-by":"publisher","first-page":"4295","DOI":"10.1128\/MCB.23.12.4295-4306.2003","volume":"23","author":"AJ Muller","year":"2003","unstructured":"Muller, A.J. et al. Targeted disruption of the murine Bin1\/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation. Mol. Cell. Biol. 23, 4295\u20134306 (2003).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm1196_CR13","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/sj.onc.1206162","volume":"22","author":"EL Routhier","year":"2003","unstructured":"Routhier, E.L., Donover, P.S. & Prendergast, G.C. hob1+, the homolog of Bin1 in fission yeast, is dispensable for endocytosis but required for the response to starvation or genotoxic stress. Oncogene 22, 637\u2013648 (2003).","journal-title":"Oncogene"},{"key":"BFnm1196_CR14","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1242\/jcs.00403","volume":"116","author":"C Leprince","year":"2003","unstructured":"Leprince, C. et al. Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J. Cell Sci. 116, 1937\u20131948 (2003).","journal-title":"J. Cell Sci."},{"key":"BFnm1196_CR15","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1126\/science.1092586","volume":"303","author":"BJ Peter","year":"2003","unstructured":"Peter, B.J. et al. BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. Science 303, 495\u2013499 (2003).","journal-title":"Science"},{"key":"BFnm1196_CR16","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S0092-8674(04)00117-5","volume":"116","author":"M Miaczynska","year":"2004","unstructured":"Miaczynska, M. et al. APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell 116, 445\u2013456 (2004).","journal-title":"Cell"},{"key":"BFnm1196_CR17","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1084\/jem.189.9.1363","volume":"189","author":"DH Munn","year":"1999","unstructured":"Munn, D.H. et al. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J. Exp. Med. 189, 1363\u20131372 (1999).","journal-title":"J. Exp. Med."},{"key":"BFnm1196_CR18","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/S1471-4906(03)00072-3","volume":"24","author":"U Grohmann","year":"2003","unstructured":"Grohmann, U., Fallarino, F. & Puccetti, P. Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol. 24, 242\u2013248 (2003).","journal-title":"Trends Immunol."},{"key":"BFnm1196_CR19","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1126\/science.281.5380.1191","volume":"281","author":"DH Munn","year":"1998","unstructured":"Munn, D.H. et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281, 1191\u20131193 (1998).","journal-title":"Science"},{"key":"BFnm1196_CR20","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/ijc.10645","volume":"101","author":"M Friberg","year":"2002","unstructured":"Friberg, M. et al. Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection. Int. J. Cancer 101, 151\u2013155 (2002).","journal-title":"Int. J. Cancer"},{"key":"BFnm1196_CR21","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/nm934","volume":"9","author":"C Uyttenhove","year":"2003","unstructured":"Uyttenhove, C. et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat. Med. 9, 1269\u20131274 (2003).","journal-title":"Nat. Med."},{"key":"BFnm1196_CR22","first-page":"3151","volume":"16","author":"JB DuHadaway","year":"2001","unstructured":"DuHadaway, J.B., Sakamuro, D., Ewert, D.L. & Prendergast, G.C. Bin1 mediates apoptosis by c-Myc in transformed primary cells. Cancer Res. 16, 3151\u20133156 (2001).","journal-title":"Cancer Res."},{"key":"BFnm1196_CR23","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.4049\/jimmunol.147.9.2846","volume":"147","author":"JE Debrick","year":"1991","unstructured":"Debrick, J.E., Campbell, P.A. & Staerz, U.D. Macrophages as accessory cells for class I MHC-restricted immune responses. J. Immunol. 147, 2846\u20132851 (1991).","journal-title":"J. Immunol."},{"key":"BFnm1196_CR24","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1093\/emboj\/cdf351","volume":"21","author":"AH Bild","year":"2002","unstructured":"Bild, A.H., Turkson, J. & Jove, R. Cytoplasmic transport of Stat3 by receptor-mediated endocytosis. EMBO J. 21, 3255\u20133263 (2002).","journal-title":"EMBO J."},{"key":"BFnm1196_CR25","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1128\/IAI.22.3.752-757.1978","volume":"22","author":"F Shimizu","year":"1978","unstructured":"Shimizu, F., Satoh, J., Tada, M. & Kumagai, K. Suppression of in vitro growth of virulent and avirulent herpes simplex viruses by cell-mediated immune mechanisms, antibody, and interferon. Infect. Immun. 22, 752\u2013577 (1978).","journal-title":"Infect. Immun."},{"key":"BFnm1196_CR26","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1089\/107999000312531","volume":"20","author":"MX Du","year":"2000","unstructured":"Du, M.X., Sotero-Esteva, W.D. & Taylor, M.W. Analysis of transcription factors regulating induction of indoleamine 2,3-dioxygenase by IFN-gamma. J. Interferon Cytokine Res. 20, 133\u2013142 (2000).","journal-title":"J. Interferon Cytokine Res."},{"key":"BFnm1196_CR27","first-page":"599","volume":"18","author":"K Mason","year":"2001","unstructured":"Mason, K. et al. Enhancement of tumor radioresponse by docetaxel: involvement of immune system. Int. J. Oncol. 18, 599\u2013606 (2001).","journal-title":"Int. J. Oncol."},{"key":"BFnm1196_CR28","doi-asserted-by":"publisher","first-page":"5459","DOI":"10.1038\/sj.onc.1204709","volume":"20","author":"R Brandt","year":"2001","unstructured":"Brandt, R., Wong, A.M. & Hynes, N.E. Mammary glands reconstituted with Neu\/ErbB2 transformed HC11 cells provide a novel orthotopic tumor model for testing anti-cancer agents. Oncogene 20, 5459\u20135465 (2001).","journal-title":"Oncogene"},{"key":"BFnm1196_CR29","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/nm0895-792","volume":"1","author":"NE Kohl","year":"1005","unstructured":"Kohl, N.E. et al. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat. Med. 1, 792\u2013797 (1005).","journal-title":"Nat. Med."},{"key":"BFnm1196_CR30","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1006\/prep.2000.1214","volume":"19","author":"TK Littlejohn","year":"2000","unstructured":"Littlejohn, T.K. et al. Expression and purification of recombinant human indoleamine 2,3-dioxygenase. Prot. Exp. Purif. 19, 22\u201329 (2000).","journal-title":"Prot. Exp. Purif."},{"key":"BFnm1196_CR31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan, D. & Weinberg, R.A. The hallmarks of cancer. Cell 100, 57\u201370 (2000).","journal-title":"Cell"},{"key":"BFnm1196_CR32","first-page":"6868","volume":"60","author":"H Huang","year":"2000","unstructured":"Huang, H. et al. Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays. Cancer Res. 60, 6868\u20136874 (2000).","journal-title":"Cancer Res."},{"key":"BFnm1196_CR33","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1002\/jcb.10380","volume":"88","author":"JB DuHadaway","year":"2003","unstructured":"DuHadaway, J.B. et al. Immunohistochemical analysis of Bin1\/Amphiphysin II in human tissues: Diverse sites of nuclear expression and losses in prostate cancer. J. Cell. Biochem. 88, 635\u2013642 (2003).","journal-title":"J. Cell. Biochem."},{"key":"BFnm1196_CR34","first-page":"4490","volume":"63","author":"AK Nowak","year":"2003","unstructured":"Nowak, A.K., Robinson, B.W. & Lake, R.A. Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors. Cancer Res. 63, 4490\u20134496 (2003).","journal-title":"Cancer Res."},{"key":"BFnm1196_CR35","first-page":"3689","volume":"61","author":"JP Machiels","year":"2001","unstructured":"Machiels, J.P. et al. Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte\/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2\/neu tolerized mice. Cancer Res. 61, 3689\u20133697 (2001).","journal-title":"Cancer Res."},{"key":"BFnm1196_CR36","first-page":"3258","volume":"57","author":"R Wechsler-Reya","year":"1997","unstructured":"Wechsler-Reya, R., Elliott, K., Herlyn, M. & Prendergast, G.C. The putative tumor suppressor BIN1 is a short-lived nuclear phosphoprotein whose localization is altered in malignant cells. Cancer Res. 57, 3258\u20133263 (1997).","journal-title":"Cancer Res."},{"key":"BFnm1196_CR37","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1128\/MCB.18.1.566","volume":"18","author":"R Wechsler-Reya","year":"1998","unstructured":"Wechsler-Reya, R., Elliott, K. & Prendergast, G.C. A role for the putative tumor suppressor Bin1 in muscle cell differentiation. Mol. Cell. Biol. 18, 566\u2013575 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm1196_CR38","doi-asserted-by":"publisher","first-page":"9574","DOI":"10.1073\/pnas.96.17.9574","volume":"96","author":"AR Meloni","year":"1999","unstructured":"Meloni, A.R., Smith, E.J. & Nevins, J.R. A mechanism for Rb\/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc. Natl. Acad. Sci. USA 96, 9574\u20139579 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1196_CR39","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/46587","volume":"402","author":"R Weigert","year":"1999","unstructured":"Weigert, R. et al. CtBP\/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid. Nature 402, 429\u2013433 (1999).","journal-title":"Nature"},{"key":"BFnm1196_CR40","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1083\/jcb.153.7.1511","volume":"153","author":"M Vecchi","year":"2001","unstructured":"Vecchi, M. et al. Nucleocytoplasmic shuttling of endocytic proteins. J. Cell Biol. 153, 1511\u20131517 (2001).","journal-title":"J. Cell Biol."},{"key":"BFnm1196_CR41","doi-asserted-by":"publisher","first-page":"3578","DOI":"10.1038\/sj.onc.1206481","volume":"22","author":"JB DuHadaway","year":"2003","unstructured":"DuHadaway, J.B. et al. Transformation selective apoptosis by farnesyltransferase inhibitors requires Bin1. Oncogene 22, 3578\u20133588 (2003).","journal-title":"Oncogene"},{"key":"BFnm1196_CR42","doi-asserted-by":"publisher","first-page":"4669","DOI":"10.1038\/sj.onc.1203681","volume":"19","author":"K Elliott","year":"2000","unstructured":"Elliott, K., Ge, K., Du, W. & Prendergast, G.C. The c-Myc-interacting adapter protein Bin1 activates a caspase-independent cell death program. Oncogene 19, 4669\u20134684 (2000).","journal-title":"Oncogene"},{"key":"BFnm1196_CR43","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/0092-8674(86)90509-X","volume":"47","author":"R Bernards","year":"1986","unstructured":"Bernards, R., Dessain, S.K. & Weinberg, R.A. N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma. Cell 47, 667\u2013674 (1986).","journal-title":"Cell"},{"key":"BFnm1196_CR44","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1002\/j.1460-2075.1988.tb02909.x","volume":"7","author":"R Versteeg","year":"1988","unstructured":"Versteeg, R., Noordermeer, I.A., Kruse-Wolters, M., Ruiter, D.J. & Schrier, P.I. c-myc down-regulates class I HLA expression in human melanomas. EMBO J. 7, 1023\u20131029 (1988).","journal-title":"EMBO J."},{"key":"BFnm1196_CR45","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1042\/bj0640578","volume":"64","author":"E Boyland","year":"1956","unstructured":"Boyland, E. & Willliams, D.C. The metabolism of tryptophan. 2. The metabolism of tryptophan in patients suffering from cancer of the bladder. Biochem. J. 64, 578\u2013582 (1956).","journal-title":"Biochem. J."},{"key":"BFnm1196_CR46","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0140-6736(67)91301-3","volume":"1","author":"D Rose","year":"1967","unstructured":"Rose, D. Tryptophan metabolism in carcinoma of the breast. Lancet 1, 239\u2013241 (1967).","journal-title":"Lancet"},{"key":"BFnm1196_CR47","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1126\/science.1073514","volume":"297","author":"DH Munn","year":"2002","unstructured":"Munn, D.H. et al. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 297, 1867\u20131870 (2002).","journal-title":"Science"},{"key":"BFnm1196_CR48","first-page":"739","volume":"10","author":"SK Gilmour","year":"1999","unstructured":"Gilmour, S.K., Birchler, M., Smith, M.K., Rayca, K. & Mostochuk, J. Effect of elevated levels of ornithine decarboxylase on cell cycle progression in skin. Cell Growth Differ. 10, 739\u2013748 (1999).","journal-title":"Cell Growth Differ."},{"key":"BFnm1196_CR49","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/BF01542654","volume":"5","author":"H Koprowski","year":"1979","unstructured":"Koprowski, H. et al. Colorectal carcinoma antigens detected by hybridoma antibodies. Som. Cell Genet. 5, 957\u2013972 (1979).","journal-title":"Som. Cell Genet."},{"key":"BFnm1196_CR50","first-page":"4.1.1","volume-title":"Current Protocols in Immunology","author":"A Kruisbeek","year":"1991","unstructured":"Kruisbeek, A. In vivo depletion of CD4- and CD8-specific T cells. in Current Protocols in Immunology (eds. Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. & Strober, W.) p. 4.1.1\u20134.1.5 (John Wiley & Sons, Inc., New York, 1991)."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm1196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1196","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:13:09Z","timestamp":1684433589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm1196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,13]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["BFnm1196"],"URL":"https:\/\/doi.org\/10.1038\/nm1196","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1024616.292750","asserted-by":"object"}]},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,13]]}}}