{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:04:08Z","timestamp":1773288248002,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[1996,12,1]],"date-time":"1996-12-01T00:00:00Z","timestamp":849398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1996,12]]},"DOI":"10.1038\/nm1296-1386","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T01:22:41Z","timestamp":1092878561000},"page":"1386-1389","source":"Crossref","is-referenced-by-count":60,"title":["Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function"],"prefix":"10.1038","volume":"2","author":[{"given":"Jun","family":"Ishizaki","sequence":"first","affiliation":[]},{"given":"Joseph R.","family":"Nevins","sequence":"additional","affiliation":[]},{"given":"Bruce A.","family":"Sullenger","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFnm12961386_CR1","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/0092-8674(93)90636-5","volume":"73","author":"CJ Sherr","year":"1993","unstructured":"Sherr, C.J. Mammalian G1 cyclins. Cell 73, 1059\u20131065 (1993).","journal-title":"Cell"},{"key":"BFnm12961386_CR2","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/0092-8674(93)90528-X","volume":"75","author":"T Hunter","year":"1993","unstructured":"Hunter, T. Braking the cycle. Cell 75, 839\u2013841 (1993).","journal-title":"Cell"},{"key":"BFnm12961386_CR3","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1126\/science.1411535","volume":"258","author":"JR Nevins","year":"1992","unstructured":"Nevins, J.R. E2F: A link between the Rb tumor suppressor protein and viral onco-proteins. Science 258, 424\u2013429 (1992).","journal-title":"Science"},{"key":"BFnm12961386_CR4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0962-8924(93)90150-Y","volume":"3","author":"K Helin","year":"1993","unstructured":"Helin, K. & Harlow, E. The retinoblastoma protein as a transcriptional repressor. Trends Cell Biol. 3, 43\u201346 (1993).","journal-title":"Trends Cell Biol."},{"key":"BFnm12961386_CR5","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/0968-0004(94)90202-X","volume":"19","author":"NB La Thangue","year":"1994","unstructured":"La Thangue, N.B. DRTF1\/E2F: An expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19, 108\u2013114 (1994).","journal-title":"Trends Biochem. Sci."},{"key":"BFnm12961386_CR6","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1101\/gad.9.10.1149","volume":"9","author":"CJ Sherr","year":"1995","unstructured":"Sherr, C.J. & Roberts, J.M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9, 1149\u20131163 (1995).","journal-title":"Genes Dev."},{"key":"BFnm12961386_CR7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/0092-8674(95)90385-2","volume":"81","author":"RA Weinberg","year":"1995","unstructured":"Weinberg, R.A. The retinoblastoma protein and cell cycle control. Cell 81, 323\u2013330 (1995).","journal-title":"Cell"},{"key":"BFnm12961386_CR8","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1146\/annurev.bi.64.070195.003555","volume":"64","author":"L Gold","year":"1995","unstructured":"Gold, L., Polisky, B., Uhlenbeck, O. & Yarus, M. Diversity of oligonucleotide functions. Annu. Rev. Biochem. 64, 763\u2013797 (1995).","journal-title":"Annu. Rev. Biochem."},{"key":"BFnm12961386_CR9","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0968-0004(92)90242-2","volume":"17","author":"JW Szostak","year":"1992","unstructured":"Szostak, J.W. In vitro genetics. Trends Biochem. Sci. 17, 89\u201393 (1992).","journal-title":"Trends Biochem. Sci."},{"key":"BFnm12961386_CR10","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1126\/science.2200121","volume":"249","author":"C Tuerk","year":"1990","unstructured":"Tuerk, C. & Gold, L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249, 505\u2013510 (1990).","journal-title":"Science"},{"key":"BFnm12961386_CR11","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0378-1119(93)90248-2","volume":"137","author":"C Tuerk","year":"1993","unstructured":"Tuerk, C. & MacDougal-Waugh, S. In vitro evolution of functional nucleic acids: High-affinity RNA ligands of HIV-1 proteins. Gene 137, 33\u201339 (1993).","journal-title":"Gene"},{"key":"BFnm12961386_CR12","doi-asserted-by":"publisher","first-page":"6314","DOI":"10.1128\/MCB.13.10.6314","volume":"13","author":"WD Cress","year":"1993","unstructured":"Cress, W.D., Johnson, D.G. & Nevins, J.R. A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4. Mol. Cell. Biol. 13, 6314\u20136325 (1993).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm12961386_CR13","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1126\/science.2468181","volume":"244","author":"M Zuker","year":"1989","unstructured":"Zuker, M. On finding all suboptimal foldings of an RNA molecule. Science 244, 48\u201352 (1989).","journal-title":"Science"},{"key":"BFnm12961386_CR14","doi-asserted-by":"publisher","first-page":"7706","DOI":"10.1073\/pnas.86.20.7706","volume":"86","author":"JA Jaeger","year":"1989","unstructured":"Jaeger, J.A., Turner, D.H. & Zuker, M. Improved predictions of secondary structures for RNA. Proc. Natl. Acad. Sci. USA 86, 7706\u20137710 (1989).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm12961386_CR15","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0076-6879(90)83019-6","volume":"183","author":"JA Jaeger","year":"1989","unstructured":"Jaeger, J.A., Turner, D.H. & Zuker, M. Predicting optimal and suboptimal secondary structure for RNA. Methods Enzymol. 183, 281\u2013306 (1989).","journal-title":"Methods Enzymol."},{"key":"BFnm12961386_CR16","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1101\/gad.9.12.1445","volume":"9","author":"RJ Duronio","year":"1995","unstructured":"Duronio, R.J., O\u00b4Farrell, P.H., Xie, J.-E., Brook, A. & Dyson, N. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 9, 1445\u20131455 (1995).","journal-title":"Genes Dev."},{"key":"BFnm12961386_CR17","first-page":"2605","volume":"9","author":"SF Dobrowolski","year":"1994","unstructured":"Dobrowolski, S.F., Stacey, D.W., Harter, M.L., Stine, J.T. & Hiebert, S.W. An E2F dominant negative mutant blocks E1A induced cell cycle progression. Oncogene 9, 2605\u20132612 (1994).","journal-title":"Oncogene"},{"key":"BFnm12961386_CR18","doi-asserted-by":"publisher","first-page":"3698","DOI":"10.1128\/MCB.16.7.3698","volume":"16","author":"C-L Wu","year":"1996","unstructured":"Wu, C.-L., Classon, M., Dyson, N. & Harlow, E. Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1 . Mol. Cell. Biol. 16, 3698\u20133706 (1996).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm12961386_CR19","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1101\/gad.10.11.1422","volume":"10","author":"M Asano","year":"1996","unstructured":"Asano, M., Nevins, J.R. & Wharton, R.P. Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev. 10, 1422\u20131432 (1996).","journal-title":"Genes Dev."},{"key":"BFnm12961386_CR20","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1101\/gad.9.23.2873","volume":"9","author":"J DeGregori","year":"1995","unstructured":"DeGregori, J., Leone, G., Ohtani, K., Miron, A. & Nevins, J.R. E2F1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev. 9, 2873\u20132887 (1995).","journal-title":"Genes Dev."},{"key":"BFnm12961386_CR21","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/365349a0","volume":"365","author":"DG Johnson","year":"1993","unstructured":"Johnson, D.G., Schwarz, J.K., Cress, W.D. & Nevins, J.R. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365, 349\u2013352 (1993).","journal-title":"Nature"},{"key":"BFnm12961386_CR22","doi-asserted-by":"publisher","first-page":"10918","DOI":"10.1073\/pnas.91.23.10918","volume":"91","author":"X-Q Qin","year":"1994","unstructured":"Qin, X.-Q., Livingston, D.M., Kaelin, W.G. & Adams, P.D. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91, 10918\u201310922 (1994).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm12961386_CR23","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0092-8674(00)81254-4","volume":"85","author":"L Yamasaki","year":"1996","unstructured":"Yamasaki, L. et al Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85, 537\u2013548 (1996).","journal-title":"Cell"},{"key":"BFnm12961386_CR24","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S0092-8674(00)81255-6","volume":"85","author":"SJ Field","year":"1996","unstructured":"Field, S.J. et al. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85, 549\u2013561 (1996).","journal-title":"Cell"},{"key":"BFnm12961386_CR25","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1073\/pnas.92.6.2355","volume":"92","author":"JA Doudna","year":"1995","unstructured":"Doudna, J.A., Cech, T.R. & Sullenger, B. Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. Proc. Natl. Acad. Sci. USA 92, 2355\u20132359 (1995).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm12961386_CR26","doi-asserted-by":"publisher","first-page":"3215","DOI":"10.1073\/pnas.93.8.3215","volume":"93","author":"M-A Ikeda","year":"1996","unstructured":"Ikeda, M.-A., Jakoi, L. & Nevins, J.R. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc. Natl. Acad. Sci. USA 93, 3215\u20133220 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm12961386_CR27","doi-asserted-by":"publisher","first-page":"26750","DOI":"10.1074\/jbc.270.45.26750","volume":"270","author":"J-M Li","year":"1995","unstructured":"Li, J.-M., Nichols, M.A., Chandrasekharan, S., Xiong, Y. & Wang, X.-F. Transforming growth factor activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site. J. Biol. Chem. 270, 26750\u201326753 (1995).","journal-title":"J. Biol. Chem."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm1296-1386","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1296-1386.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1296-1386.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:23:39Z","timestamp":1684448619000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm1296-1386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1996,12]]}},"alternative-id":["BFnm12961386"],"URL":"https:\/\/doi.org\/10.1038\/nm1296-1386","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,12]]}}}