{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:13:11Z","timestamp":1767856391727,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2005,9,22]],"date-time":"2005-09-22T00:00:00Z","timestamp":1127347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Methods"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1038\/nmeth791","type":"journal-article","created":{"date-parts":[[2005,9,22]],"date-time":"2005-09-22T19:53:50Z","timestamp":1127418830000},"page":"743-749","source":"Crossref","is-referenced-by-count":320,"title":["Correlated light and electron microscopic imaging of multiple endogenous proteins using Quantum dots"],"prefix":"10.1038","volume":"2","author":[{"given":"Ben N G","family":"Giepmans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J","family":"Deerinck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin L","family":"Smarr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Z","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H","family":"Ellisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,9,22]]},"reference":[{"key":"BFnmeth791_CR1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1177\/42.1.7505301","volume":"42","author":"KD Anderson","year":"1994","unstructured":"Anderson, K.D., Karle, E.J. & Reiner, A. A pre-embedding triple-label electron microscopic immunohistochemical method as applied to the study of multiple inputs to defined tegmental neurons. J. Histochem. Cytochem. 42, 49\u201356 (1994).","journal-title":"J. Histochem. Cytochem."},{"key":"BFnmeth791_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1177\/002215540405200102","volume":"52","author":"R Nisman","year":"2004","unstructured":"Nisman, R., Dellaire, G., Ren, Y., Li, R. & Bazett-Jones, D.P. Application of quantum dots as probes for correlative fluorescence, conventional, and energy-filtered transmission electron microscopy. J. Histochem. Cytochem. 52, 13\u201318 (2004).","journal-title":"J. Histochem. Cytochem."},{"key":"BFnmeth791_CR3","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1177\/002215549804601001","volume":"46","author":"T Takizawa","year":"1998","unstructured":"Takizawa, T., Suzuki, K. & Robinson, J.M. Correlative microscopy using FluoroNanogold on ultrathin cryosections. Proof of principle. J. Histochem. Cytochem. 46, 1097\u20131102 (1998).","journal-title":"J. Histochem. Cytochem."},{"key":"BFnmeth791_CR4","first-page":"2816","volume":"60","author":"YH Shiao","year":"2000","unstructured":"Shiao, Y.H., Resau, J.H., Nagashima, K., Anderson, L.M. & Ramakrishna, G. The von Hippel-Lindau tumor suppressor targets to mitochondria. Cancer Res. 60, 2816\u20132819 (2000).","journal-title":"Cancer Res."},{"key":"BFnmeth791_CR5","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1083\/jcb.126.4.901","volume":"126","author":"TJ Deerinck","year":"1994","unstructured":"Deerinck, T.J. et al. Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy. J. Cell Biol. 126, 901\u2013910 (1994).","journal-title":"J. Cell Biol."},{"key":"BFnmeth791_CR6","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1126\/science.1068793","volume":"296","author":"G Gaietta","year":"2002","unstructured":"Gaietta, G. et al. Multicolor and electron microscopic imaging of connexin trafficking. Science 296, 503\u2013507 (2002).","journal-title":"Science"},{"key":"BFnmeth791_CR7","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1126\/science.281.5385.2016","volume":"281","author":"WC Chan","year":"1998","unstructured":"Chan, W.C. & Nie, S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281, 2016\u20132018 (1998).","journal-title":"Science"},{"key":"BFnmeth791_CR8","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1126\/science.1104274","volume":"307","author":"X Michalet","year":"2005","unstructured":"Michalet, X. et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307, 538\u2013544 (2005).","journal-title":"Science"},{"key":"BFnmeth791_CR9","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/90228","volume":"19","author":"M Han","year":"2001","unstructured":"Han, M., Gao, X., Su, J.Z. & Nie, S. Quantum dot\u2013tagged microbeads for multiplexed optical coding of biomolecules. Nat. Biotechnol. 19, 631\u2013635 (2001).","journal-title":"Nat. Biotechnol."},{"key":"BFnmeth791_CR10","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S0958-1669(02)00282-3","volume":"13","author":"WC Chan","year":"2002","unstructured":"Chan, W.C. et al. Luminescent quantum dots for multiplexed biological detection and imaging. Curr. Opin. Biotechnol. 13, 40\u201346 (2002).","journal-title":"Curr. Opin. Biotechnol."},{"key":"BFnmeth791_CR11","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/nm1096","volume":"10","author":"EB Voura","year":"2004","unstructured":"Voura, E.B., Jaiswal, J.K., Mattoussi, H. & Simon, S.M. Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy. Nat. Med. 10, 993\u2013998 (2004).","journal-title":"Nat. Med."},{"key":"BFnmeth791_CR12","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/jemt.20129","volume":"65","author":"HE Grecco","year":"2004","unstructured":"Grecco, H.E. et al. Ensemble and single particle photophysical properties (two-photon excitation, anisotropy, FRET, lifetime, spectral conversion) of commercial quantum dots in solution and in live cells. Microsc. Res. Tech. 65, 169\u2013179 (2004).","journal-title":"Microsc. Res. Tech."},{"key":"BFnmeth791_CR13","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1046\/j.1365-2818.2000.00729.x","volume":"199","author":"C Liu","year":"2000","unstructured":"Liu, C., Miller, P.D., Henstrom, W.L. & Gibson, J.M. Transmission electron microscopy of semiconductor quantum dots. J. Microsc. 199, 130\u2013140 (2000).","journal-title":"J. Microsc."},{"key":"BFnmeth791_CR14","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.bbamem.2003.10.022","volume":"1662","author":"JC Herve","year":"2004","unstructured":"Herve, J.C., Bourmeyster, N. & Sarrouilhe, D. Diversity in protein-protein interactions of connexins: emerging roles. Biochim. Biophys. Acta 1662, 22\u201341 (2004).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnmeth791_CR15","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.cardiores.2003.12.009","volume":"62","author":"BN Giepmans","year":"2004","unstructured":"Giepmans, B.N. Gap junctions and connexin-interacting proteins. Cardiovasc. Res. 62, 233\u2013245 (2004).","journal-title":"Cardiovasc. Res."},{"key":"BFnmeth791_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/(SICI)1097-0029(19980701)42:1<43::AID-JEMT6>3.0.CO;2-S","volume":"42","author":"BM Humbel","year":"1998","unstructured":"Humbel, B.M., de Jong, M.D., Muller, W.H. & Verkleij, A.J. Pre-embedding immunolabeling for electron microscopy: an evaluation of permeabilization methods and markers. Microsc. Res. Tech. 42, 43\u201358 (1998).","journal-title":"Microsc. Res. Tech."},{"key":"BFnmeth791_CR17","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1179\/his.2000.23.3.261","volume":"23","author":"ME Martone","year":"2000","unstructured":"Martone, M.E., Deerinck, T.J., Yamada, N., Bushong, E. & Ellisman, M.H. Correlated 3D light and electron microscopy: use of high voltage electron microscopy and electron tomography for imaging large biological structures. J. Histotechnology 23, 261\u2013270 (2000).","journal-title":"J. Histotechnology"},{"key":"BFnmeth791_CR18","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1177\/43.3.7532656","volume":"43","author":"KD Phend","year":"1995","unstructured":"Phend, K.D., Rustioni, A. & Weinberg, R.J. An osmium-free method of epon embedment that preserves both ultrastructure and antigenicity for post-embedding immunocytochemistry. J. Histochem. Cytochem. 43, 283\u2013292 (1995).","journal-title":"J. Histochem. Cytochem."},{"key":"BFnmeth791_CR19","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/BF00492765","volume":"80","author":"M Horisberger","year":"1984","unstructured":"Horisberger, M. & Vauthey, M. Labelling of colloidal gold with protein. A quantitative study using \u03b2-lactoglobulin. Histochemistry 80, 13\u201318 (1984).","journal-title":"Histochemistry"},{"key":"BFnmeth791_CR20","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.bbrc.2003.12.133","volume":"314","author":"A Mansson","year":"2004","unstructured":"Mansson, A. et al. In vitro sliding of actin filaments labelled with single quantum dots. Biochem. Biophys. Res. Commun. 314, 529\u2013534 (2004).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnmeth791_CR21","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/S0006-291X(03)00211-0","volume":"302","author":"K Hanaki","year":"2003","unstructured":"Hanaki, K. et al. Semiconductor quantum dot\/albumin complex is a long-life and highly photostable endosome marker. Biochem. Biophys. Res. Commun. 302, 496\u2013501 (2003).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnmeth791_CR22","doi-asserted-by":"publisher","first-page":"12617","DOI":"10.1073\/pnas.152463399","volume":"99","author":"ME Akerman","year":"2002","unstructured":"Akerman, M.E., Chan, W.C., Laakkonen, P., Bhatia, S.N. & Ruoslahti, E. Nanocrystal targeting in vivo. Proc. Natl. Acad. Sci. USA 99, 12617\u201312621 (2002).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnmeth791_CR23","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/nbt994","volume":"22","author":"X Gao","year":"2004","unstructured":"Gao, X., Cui, Y., Levenson, R.M., Chung, L.W. & Nie, S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 22, 969\u2013976 (2004).","journal-title":"Nat. Biotechnol."},{"key":"BFnmeth791_CR24","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/nbt0804-959","volume":"22","author":"RK Jain","year":"2004","unstructured":"Jain, R.K. & Stroh, M. Zooming in and out with quantum dots. Nat. Biotechnol. 22, 959\u2013960 (2004).","journal-title":"Nat. Biotechnol."},{"key":"BFnmeth791_CR25","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.brainres.2004.07.088","volume":"1026","author":"M Bobik","year":"2004","unstructured":"Bobik, M., Ellisman, M.H., Rudy, B. & Martone, M.E. Potassium channel subunit Kv3.2 and the water channel aquaporin-4 are selectively localized to cerebellar pinceau. Brain Res. 1026, 168\u2013178 (2004).","journal-title":"Brain Res."},{"key":"BFnmeth791_CR26","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/nbt929","volume":"22","author":"DS Lidke","year":"2004","unstructured":"Lidke, D.S. et al. Quantum dot ligands provide new insights into erbB\/HER receptor-mediated signal transduction. Nat. Biotechnol. 22, 198\u2013203 (2004).","journal-title":"Nat. Biotechnol."},{"key":"BFnmeth791_CR27","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/nrm976","volume":"3","author":"J Zhang","year":"2002","unstructured":"Zhang, J., Campbell, R.E., Ting, A.Y. & Tsien, R.Y. Creating new fluorescent probes for cell biology. Nat. Rev. Mol. Cell Biol. 3, 906\u2013918 (2002).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFnmeth791_CR28","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1038\/nbt914","volume":"21","author":"O Tour","year":"2003","unstructured":"Tour, O., Meijer, R.M., Zacharias, D.A., Adams, S.R. & Tsien, R.Y. Genetically targeted chromophore-assisted light inactivation. Nat. Biotechnol. 21, 1505\u20131508 (2003).","journal-title":"Nat. Biotechnol."}],"container-title":["Nature Methods"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nmeth791.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nmeth791","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nmeth791.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:59:13Z","timestamp":1684454353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nmeth791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,22]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["BFnmeth791"],"URL":"https:\/\/doi.org\/10.1038\/nmeth791","relation":{},"ISSN":["1548-7091","1548-7105"],"issn-type":[{"value":"1548-7091","type":"print"},{"value":"1548-7105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,22]]}}}