{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T07:52:26Z","timestamp":1768636346257,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2001,8,13]],"date-time":"2001-08-13T00:00:00Z","timestamp":997660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,8,13]],"date-time":"2001-08-13T00:00:00Z","timestamp":997660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2001,9]]},"DOI":"10.1038\/nn0901-908","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:43:33Z","timestamp":1027673013000},"page":"908-916","source":"Crossref","is-referenced-by-count":187,"title":["GABAA receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1"],"prefix":"10.1038","volume":"4","author":[{"given":"Fiona K.","family":"Bedford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef T.","family":"Kittler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Muller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia M.","family":"Uren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Merlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Wisden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Triller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor G.","family":"Smart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Moss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2001,8,13]]},"reference":[{"key":"BFnn0901908_CR1","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1146\/annurev.ne.17.030194.003033","volume":"17","author":"RL Macdonald","year":"1994","unstructured":"Macdonald, R. L. & Olsen, R. W. GABAA receptor channels. Annu. Rev. Neurosci. 17, 569\u2013602 (1994).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnn0901908_CR2","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/syn.890210302","volume":"21","author":"LE Rabow","year":"1995","unstructured":"Rabow, L. E., Russek, S. J. & Farb, D. H. From ion currents to genomic analysis: recent advances in GABAA receptor research. Synapse 21, 189\u2013274 (1995).","journal-title":"Synapse"},{"key":"BFnn0901908_CR3","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/385820a0","volume":"385","author":"PA Davies","year":"1997","unstructured":"Davies, P. A., Hanna, M. C., Hales, T. G. & Kirkness, E. F. Insensitivity to anaesthetic agents conferred by a class of GABAA receptor subunit. Nature 385, 820\u2013823 (1997).","journal-title":"Nature"},{"key":"BFnn0901908_CR4","doi-asserted-by":"publisher","first-page":"9891","DOI":"10.1073\/pnas.96.17.9891","volume":"96","author":"TP Bonnert","year":"1999","unstructured":"Bonnert, T. P. et al. Theta, a novel \u03b3-aminobutyric acid type A receptor subunit. Proc. Natl. Acad. Sci. USA 96, 9891\u20139896 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn0901908_CR5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0092-8674(05)80026-1","volume":"72","author":"N Unwin","year":"1993","unstructured":"Unwin, N. Neurotransmitter action: opening of ligand-gated ion channels. Cell Suppl. 72, 31\u201341 (1993).","journal-title":"Cell Suppl."},{"key":"BFnn0901908_CR6","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/2798","volume":"1","author":"C Essrich","year":"1998","unstructured":"Essrich, C., Lorez, M., Benson, J. A., Fritschy, J. M. & Luscher, B. Postsynaptic clustering of major GABAA receptor subtypes requires the \u03b32 subunit and gephyrin. Nat. Neurosci. 1, 563\u2013571 (1998).","journal-title":"Nat. Neurosci."},{"key":"BFnn0901908_CR7","doi-asserted-by":"publisher","first-page":"9289","DOI":"10.1523\/JNEUROSCI.19-21-09289.1999","volume":"19","author":"M Kneussel","year":"1999","unstructured":"Kneussel, M. et al. Loss of postsynaptic GABAA receptor clustering in gephyrin-deficient mice. J. Neurosci. 19, 9289\u20139297 (1999).","journal-title":"J. Neurosci."},{"key":"BFnn0901908_CR8","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1126\/science.282.5392.1321","volume":"282","author":"G Feng","year":"1998","unstructured":"Feng, G. et al. Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. Science 282, 1321\u20131324 (1998).","journal-title":"Science"},{"key":"BFnn0901908_CR9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1006\/mcne.2001.1005","volume":"18","author":"JT Kittler","year":"2001","unstructured":"Kittler, J. T. et al. The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABAA receptors. Mol. Cell Neurosci. 18, 13\u201325 (2001).","journal-title":"Mol. Cell Neurosci."},{"key":"BFnn0901908_CR10","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/16264","volume":"397","author":"HB Wang","year":"1999","unstructured":"Wang, H. B., Bedford, F. K., Brandon, N. J., Moss, S. J. & Olsen, R. W. GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton. Nature 397, 69\u201372 (1999).","journal-title":"Nature"},{"key":"BFnn0901908_CR11","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/41792","volume":"388","author":"Q Wan","year":"1997","unstructured":"Wan Q, et al. Recruitment of functional GABAA receptors to postsynaptic domains by insulin. Nature 388, 686\u2013689 (1997).","journal-title":"Nature"},{"key":"BFnn0901908_CR12","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/25999","volume":"395","author":"Z Nusser","year":"1998","unstructured":"Nusser, Z., Hajos, N., Somogyi, P. & Mody, I. Increased number of synaptic GABAA receptors underlies potentiation at hippocampal inhibitory. Nature 395, 172\u2013177 (1998).","journal-title":"Nature"},{"key":"BFnn0901908_CR13","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/S0896-6273(00)80382-7","volume":"19","author":"Z Nusser","year":"1997","unstructured":"Nusser, Z., Cull-Candy, S. & Farrant, M. Differences in synaptic GABAA receptor number underlie variation in GABA mini amplitude. Neuron 19, 697\u2013709 (1997).","journal-title":"Neuron"},{"key":"BFnn0901908_CR14","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/35067500","volume":"2","author":"SJ Moss","year":"2001","unstructured":"Moss, S. J. & Smart, T. G. Constructing inhibitory synapses. Nat. Rev. Neurosci. 2, 241\u2013250 (2001).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn0901908_CR15","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1006\/mcne.1999.0746","volume":"13","author":"CN Connolly","year":"1999","unstructured":"Connolly, C. N. et al. Subcellular localization and endocytosis of homomeric \u03b32 subunit splice variants of \u03b3-aminobutyric acid type A receptors. Mol. Cell Neurosci. 13, 259\u2013271 (1999).","journal-title":"Mol. Cell Neurosci."},{"key":"BFnn0901908_CR16","doi-asserted-by":"publisher","first-page":"36565","DOI":"10.1074\/jbc.274.51.36565","volume":"274","author":"CN Connolly","year":"1999","unstructured":"Connolly, C. N. et al. Cell surface stability of \u03b3-aminobutyric acid type A receptors. Dependence on protein kinase C activity and subunit composition. J. Biol. Chem. 274, 36565\u201336572 (1999).","journal-title":"J. Biol. Chem."},{"key":"BFnn0901908_CR17","doi-asserted-by":"publisher","first-page":"7972","DOI":"10.1523\/JNEUROSCI.20-21-07972.2000","volume":"20","author":"JT Kittler","year":"2000","unstructured":"Kittler, J. T. et al. Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J. Neurosci. 20, 7972\u20137977 (2000).","journal-title":"J. Neurosci."},{"key":"BFnn0901908_CR18","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1006\/mcne.2000.0882","volume":"16","author":"JT Kittler","year":"2000","unstructured":"Kittler, J. T. et al. Analysis of GABAA receptor assembly in mammalian cell lines and hippocampal neurons using \u03b32 subunit green fluorescent protein chimeras. Mol. Cell Neurosci. 16, 440\u2013452 (2000).","journal-title":"Mol. Cell Neurosci."},{"key":"BFnn0901908_CR19","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1126\/science.285.5425.215","volume":"285","author":"M Marsh","year":"1999","unstructured":"Marsh, M. & McMahon, H. T. The structural era of endocytosis. Science 285, 215\u2013220 (1999).","journal-title":"Science"},{"key":"BFnn0901908_CR20","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S1097-2765(00)80212-9","volume":"4","author":"AL Wu","year":"1999","unstructured":"Wu, A. L., Wang, J., Zheleznyak, A. & Brown, E. J. Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. Mol. Cell 4, 619\u2013625 (1999).","journal-title":"Mol. Cell"},{"key":"BFnn0901908_CR21","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S1097-2765(00)00040-X","volume":"6","author":"MF Kleijnen","year":"2000","unstructured":"Kleijnen, M. F. et al. The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. Mol. Cell 6, 409\u2013401 (2000).","journal-title":"Mol. Cell"},{"key":"BFnn0901908_CR22","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/340245a0","volume":"340","author":"S Field.","year":"1989","unstructured":"Field., S. & Song, O. A novel genetic system to detect protein\u2013protein interactions. Nature 340, 245\u2013246 (1989).","journal-title":"Nature"},{"key":"BFnn0901908_CR23","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/386279a0","volume":"386","author":"H Dong","year":"1997","unstructured":"Dong, H. et al. GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature 386, 279\u2013284 (1997).","journal-title":"Nature"},{"key":"BFnn0901908_CR24","doi-asserted-by":"publisher","first-page":"5009","DOI":"10.1093\/emboj\/18.18.5009","volume":"18","author":"M Funakoshi","year":"1999","unstructured":"Funakoshi, M., Geley, S., Hunt, T., Nishimoto, T. & Kobayashi, H. Identification of XDRP1; a Xenopus protein related to yeast Dsk2p binds to the N-terminus of cyclin A and inhibits its degradation. EMBO J. 18, 5009\u20135018 (1999).","journal-title":"EMBO J."},{"key":"BFnn0901908_CR25","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0962-8924(00)01785-2","volume":"10","author":"S Jentsch","year":"2000","unstructured":"Jentsch, S. & Pyrowolakis, G. Ubiquitin and its kin: how close are the family ties? Trends Cell Biol. 10, 335\u2013341 (2000).","journal-title":"Trends Cell Biol."},{"key":"BFnn0901908_CR26","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S0968-0004(96)30015-7","volume":"21","author":"K Hofmann","year":"1996","unstructured":"Hofmann, K. & Bucher, P. The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. Trends Biochem. Sci. 21, 172\u2013173 (1996).","journal-title":"Trends Biochem. Sci."},{"key":"BFnn0901908_CR27","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/16258","volume":"397","author":"JG Hanley","year":"1999","unstructured":"Hanley, J. G., Koulen, P., Bedford, F., Gordon-Weeks, P. R. & Moss, S. J. The protein MAP-1B links GABAC receptors to the cytoskeleton at retinal synapses. Nature 397, 66\u201390 (1999).","journal-title":"Nature"},{"key":"BFnn0901908_CR28","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0378-1119(88)90005-4","volume":"67","author":"DB Smith","year":"1988","unstructured":"Smith, D. B. & Johnson, K. S. Single step purification of polypeptides expressed in E. Coli as fusions with glutathione S-transferase. Gene 67, 31\u201340 (1988).","journal-title":"Gene"},{"key":"BFnn0901908_CR29","doi-asserted-by":"crossref","first-page":"27100","DOI":"10.1016\/S0021-9258(18)47131-1","volume":"269","author":"D Benke","year":"1994","unstructured":"Benke, D., Fritschy, J. M., Trzeciak, A., Bannwarth, W. & Mohler, H. Distribution, prevalence, and drug binding profile of gamma-aminobutyric acid type A receptor subtypes differing in the beta-subunit variant. J. Biol. Chem. 269, 27100\u201327107 (1994).","journal-title":"J. Biol. Chem."},{"key":"BFnn0901908_CR30","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1111\/j.1460-9568.1997.tb01641.x","volume":"9","author":"JR Wooltorton","year":"1997","unstructured":"Wooltorton, J. R., Moss, S. J. & Smart, T. G. Pharmacological and physiological characterization of murine homomeric \u03b23 GABAA receptors. Eur. J. Neurosci. 9, 2225\u20132235 (1997).","journal-title":"Eur. J. Neurosci."},{"key":"BFnn0901908_CR31","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1074\/jbc.271.1.89","volume":"271","author":"CN Connolly","year":"1996","unstructured":"Connolly, C. N., McDonald, B. M., Krishek, B. J., Smart, T. G. & Moss, S. J. Assembly and cell surface expression of heteromeric and homomeric GABAA receptors. J. Biol. Chem. 271, 89\u201397 (1996).","journal-title":"J. Biol. Chem."},{"key":"BFnn0901908_CR32","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1523\/JNEUROSCI.16-03-00974.1996","volume":"16","author":"AJ Todd","year":"1996","unstructured":"Todd, A. J., Watt, C., Spike, R. C. & Sieghart, W. Co-localization of GABA, glycine, and their receptors at synapses in the rat spinal cord. J. Neurosci. 16, 974\u2013982 (1996).","journal-title":"J. Neurosci."},{"key":"BFnn0901908_CR33","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1523\/JNEUROSCI.19-01-00168.1999","volume":"19","author":"A Gardiol","year":"1999","unstructured":"Gardiol, A., Racca, C. & Triller, A. Dendritic and postsynaptic protein synthetic machinery. J. Neurosci. 19, 168\u2013179 (1999).","journal-title":"J. Neurosci."},{"key":"BFnn0901908_CR34","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0896-6273(00)80786-2","volume":"23","author":"J Noel","year":"1999","unstructured":"Noel, J. et al. Surface expression of AMPA receptors in hippocampal neurons is regulated by a NSF-dependent mechanism. Neuron 23, 365\u2013376 (1999).","journal-title":"Neuron"},{"key":"BFnn0901908_CR35","doi-asserted-by":"publisher","first-page":"22349","DOI":"10.1074\/jbc.272.35.22349","volume":"272","author":"EJ Williams","year":"1997","unstructured":"Williams, E. J. et al. Selective inhibition of growth factor-stimulated mitogenesis by a cell-permeable Grb2-binding peptide. J. Biol. Chem. 272, 22349\u201322354 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFnn0901908_CR36","doi-asserted-by":"publisher","first-page":"6360","DOI":"10.1523\/JNEUROSCI.19-15-06360.1999","volume":"19","author":"PM Taylor","year":"1999","unstructured":"Taylor, P. M. et al. Identification of amino acid residues within GABAA receptor \u03b2 subunits that mediate both homomeric and heteromeric receptor expression. J. Neurosci. 19, 6360\u20136371 (1999).","journal-title":"J. Neurosci."},{"key":"BFnn0901908_CR37","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1523\/JNEUROSCI.20-04-01297.2000","volume":"20","author":"PM Taylor","year":"2000","unstructured":"Taylor, P. M. et al. Identification of residues within GABAA receptor alpha subunits that mediate specific assembly with receptor beta subunits. J. Neurosci. 20, 1297\u20131306 (2000).","journal-title":"J. Neurosci."},{"key":"BFnn0901908_CR38","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/S0962-8924(00)01783-9","volume":"10","author":"CC Garner","year":"2000","unstructured":"Garner, C. C., Nash, J. & Huganir, R. L. PDZ domains in synapse assembly and signaling. Trends Cell Biol. 10, 274\u2013280 (2000).","journal-title":"Trends Cell Biol."},{"key":"BFnn0901908_CR39","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1083\/jcb.151.4.847","volume":"151","author":"AL Mah","year":"2000","unstructured":"Mah, A. L., Perry, G., Smith, M. A. & Monteiro, M. J. Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. J. Cell Biol. 151, 847\u2013862 (2000).","journal-title":"J. Cell Biol."},{"key":"BFnn0901908_CR40","doi-asserted-by":"publisher","first-page":"6587","DOI":"10.1523\/JNEUROSCI.17-17-06587.1997","volume":"17","author":"GH Gorrie","year":"1997","unstructured":"Gorrie, G. H. et al. Assembly of GABAA receptors composed of \u03b11 and \u03b22 subunits in both cultured neurones and fibroblasts. J. Neurosci. 17, 6587\u20136588 (1997).","journal-title":"J. Neurosci."},{"key":"BFnn0901908_CR41","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/(SICI)1096-9861(19980831)398:3<359::AID-CNE5>3.0.CO;2-Z","volume":"398","author":"I Colin","year":"1998","unstructured":"Colin, I., Rostaing, P., Augustin, A. & Triller, A. Localization of components of glycinergic synapses during rat spinal cord development. J. Comp. Neurol. 398, 359\u2013372 (1998).","journal-title":"J. Comp. Neurol."},{"key":"BFnn0901908_CR42","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1083\/jcb.101.2.683","volume":"101","author":"A Triller","year":"1985","unstructured":"Triller, A., Cluzeaud, F., Pfeiffer, F., Betz, H. & Korn, H. Distribution of glycine receptors at central synapses: an immunoelectron microscopy study. Cell Biol. 101, 683\u2013688 (1985).","journal-title":"Cell Biol."},{"key":"BFnn0901908_CR43","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/978-3-642-70690-5_20","volume-title":"Molecular Aspects of Neurobiology","author":"A Triller","year":"1986","unstructured":"Triller, A., Cluzeaud, F., Pfeiffer, F. & Korn, H. in Molecular Aspects of Neurobiology (eds. Levi Montalcini, R. et al.) 101\u2013105 (Springer, Berlin, Heidelberg, 1986)."}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn0901-908.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn0901-908","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn0901-908.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T11:50:40Z","timestamp":1704282640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn0901-908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8,13]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["BFnn0901908"],"URL":"https:\/\/doi.org\/10.1038\/nn0901-908","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8,13]]}}}