{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:05:42Z","timestamp":1780538742229,"version":"3.54.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2003,4,21]],"date-time":"2003-04-21T00:00:00Z","timestamp":1050883200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2003,5]]},"DOI":"10.1038\/nn1048","type":"journal-article","created":{"date-parts":[[2003,4,25]],"date-time":"2003-04-25T17:20:54Z","timestamp":1051291254000},"page":"507-518","source":"Crossref","is-referenced-by-count":669,"title":["Becoming a new neuron in the adult olfactory bulb"],"prefix":"10.1038","volume":"6","author":[{"given":"Alan","family":"Carleton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldo T.","family":"Petreanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusty","family":"Lansford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Alvarez-Buylla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Marie","family":"Lledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,4,21]]},"reference":[{"key":"BFnn1048_CR1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1523\/JNEUROSCI.22-03-00629.2002","volume":"22","author":"A Alvarez-Buylla","year":"2002","unstructured":"Alvarez-Buylla, A. & Garcia-Verdugo, J.M. Neurogenesis in adult subventricular zone. J. Neurosci. 22, 629\u2013634 (2002).","journal-title":"J. Neurosci."},{"key":"BFnn1048_CR2","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1523\/JNEUROSCI.22-03-00612.2002","volume":"22","author":"FH Gage","year":"2002","unstructured":"Gage, F.H. Neurogenesis in the adult brain. J. Neurosci. 22, 612\u2013613 (2002).","journal-title":"J. Neurosci."},{"key":"BFnn1048_CR3","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1523\/JNEUROSCI.22-03-00624.2002","volume":"22","author":"F Nottebohm","year":"2002","unstructured":"Nottebohm, F. Why are some neurons replaced in adult brain? J. Neurosci. 22, 624\u2013628 (2002).","journal-title":"J. Neurosci."},{"key":"BFnn1048_CR4","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1242\/dev.128.19.3759","volume":"128","author":"H Wichterle","year":"2001","unstructured":"Wichterle, H., Turnbull, D.H., Nery, S., Fishell, G. & Alvarez-Buylla, A. In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain. Development 128, 3759\u20133771 (2001).","journal-title":"Development"},{"key":"BFnn1048_CR5","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0896-6273(93)90281-U","volume":"11","author":"MB Luskin","year":"1993","unstructured":"Luskin, M.B. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 11, 173\u2013189 (1993).","journal-title":"Neuron"},{"key":"BFnn1048_CR6","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1126\/science.8178174","volume":"264","author":"C Lois","year":"1994","unstructured":"Lois. C. & Alvarez-Buylla, A. Long-distance neuronal migration in the adult mammalian brain. Science 264, 1145\u20131148 (1994).","journal-title":"Science"},{"key":"BFnn1048_CR7","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/cne.902580109","volume":"258","author":"K Kishi","year":"1987","unstructured":"Kishi K. Golgi studies on the development of granule cells of the rat olfactory bulb with reference to migration in the subependymal layer. J. Comp. Neurol. 258, 112\u2013124 (1987).","journal-title":"J. Comp. Neurol."},{"key":"BFnn1048_CR8","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/neu.10012","volume":"49","author":"S De Marchis","year":"2001","unstructured":"De Marchis, S., Fasolo, A., Shipley, M. & Puche, A. Unique neuronal tracers show migration and differentiation of SVZ progenitors in organotypic slices. J. Neurobiol. 49, 326\u2013338 (2001).","journal-title":"J. Neurobiol."},{"key":"BFnn1048_CR9","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/S0960-9822(02)00771-6","volume":"12","author":"M Carl\u00e9n","year":"2002","unstructured":"Carl\u00e9n, M. et al. Functional integration of adult-born neurons. Curr. Biol. 12, 606\u2013608 (2002).","journal-title":"Curr. Biol."},{"key":"BFnn1048_CR10","doi-asserted-by":"publisher","first-page":"6106","DOI":"10.1523\/JNEUROSCI.22-14-06106.2002","volume":"22","author":"L Petreanu","year":"2002","unstructured":"Petreanu, L. & Alvarez-Buylla, A. Maturation and death of adult-born olfactory bulb granule neurons: role of olfaction. J. Neurosci. 22, 6106\u20136113 (2002).","journal-title":"J. Neurosci."},{"key":"BFnn1048_CR11","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1126\/science.6474166","volume":"225","author":"JA Paton","year":"1984","unstructured":"Paton, J.A. & Nottebohm, F.N. Neurons generated in the adult brain are recruited into functional circuits. Science 225, 1046\u20131048 (1984).","journal-title":"Science"},{"key":"BFnn1048_CR12","first-page":"159","volume-title":"The Synaptic Organization of the Brain","author":"GM Shepherd","year":"1998","unstructured":"Shepherd, G.M. & Greer, C.A. Olfactory bulb. in The Synaptic Organization of the Brain (ed. Shepherd, G.M.) 159\u2013203 (Oxford Univ. Press, New York, 1998)."},{"key":"BFnn1048_CR13","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1073\/pnas.97.4.1823","volume":"97","author":"G Gheusi","year":"2000","unstructured":"Gheusi, G. et al. Importance of newly generated neurons in the adult olfactory bulb for odor discrimination. Proc. Natl. Acad. Sci. USA 97, 1823\u20131828 (2000).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn1048_CR14","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1023\/A:1012849801892","volume":"11","author":"GA Cecchi","year":"2001","unstructured":"Cecchi, G.A., Petreanu, L.T., Alvarez-Buylla, A. & Magnasco, M.O. Unsupervised learning and adaptation in a model of adult neurogenesis. J. Comput. Neurosci. 11, 175\u2013182 (2001).","journal-title":"J. Comput. Neurosci."},{"key":"BFnn1048_CR15","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1006\/exnr.1999.7033","volume":"156","author":"A Okada","year":"1999","unstructured":"Okada, A., Lansford, R., Weimann, J.M., Fraser, S.E. & McConnell, S.K. Imaging cells in the developing nervous system with retrovirus expressing modified green fluorescent protein. Exp. Neurol. 156, 394\u2013406 (1999).","journal-title":"Exp. Neurol."},{"key":"BFnn1048_CR16","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/76536","volume":"18","author":"SH Lee","year":"2000","unstructured":"Lee, S.H., Lumelsky, N., Studer, L., Auerbach, J.M. & McKay, R.D. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat. Biotechnol. 18, 675\u2013679 (2000).","journal-title":"Nat. Biotechnol."},{"key":"BFnn1048_CR17","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1038\/4151030a","volume":"415","author":"H van Praag","year":"2002","unstructured":"van Praag, H. et al. Functional neurogenesis in the adult hippocampus. Nature 415, 1030\u20131034 (2002).","journal-title":"Nature"},{"key":"BFnn1048_CR18","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/nn844","volume":"5","author":"HJ Song","year":"2002","unstructured":"Song, H.J., Stevens, C.F. & Gage, F.H. Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat. Neurosci. 5, 438\u2013445 (2002).","journal-title":"Nat. Neurosci."},{"key":"BFnn1048_CR19","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1006\/exnr.1999.7078","volume":"158","author":"RH Liu","year":"1999","unstructured":"Liu, R.H., Morassutti, D.J., Whittemore, S.R., Sosnowski, J.S. & Magnuson, D.S. Electrophysiological properties of mitogen-expanded adult rat spinal cord and subventricular zone neural precursor cells. Exp. Neurol. 158, 143\u2013154 (1999).","journal-title":"Exp. Neurol."},{"key":"BFnn1048_CR20","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1152\/jn.1999.81.1.95","volume":"81","author":"RR Stewart","year":"1999","unstructured":"Stewart, R.R., Zigova, T. & Luskin, M.B. K+ currents in precursor cells isolated from the anterior subventricular zone of the neonatal rat forebrain. J. Neurophysiol. 81, 95\u2013102 (1999).","journal-title":"J. Neurophysiol."},{"key":"BFnn1048_CR21","doi-asserted-by":"publisher","first-page":"9180","DOI":"10.1523\/JNEUROSCI.19-21-09180.1999","volume":"19","author":"PE Castillo","year":"1999","unstructured":"Castillo, P.E., Carleton, A., Vincent, J.D. & Lledo, P.-M. Multiple and opposing roles of cholinergic transmission in the main olfactory bulb. J. Neurosci. 19, 9180\u20139191 (1999).","journal-title":"J. Neurosci."},{"key":"BFnn1048_CR22","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1152\/jn.2001.86.6.2823","volume":"86","author":"Z Nusser","year":"2001","unstructured":"Nusser, Z., Kay, L.M., Laurent, G., Homanics, G.E. & Mody, I. Disruption of GABAA receptors on GABAergic interneurons leads to increased oscillatory power in the olfactory bulb network. J. Neurophysiol. 86, 2823\u20132833 (2001).","journal-title":"J. Neurophysiol."},{"key":"BFnn1048_CR23","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/73119","volume":"6","author":"NS Roy","year":"2000","unstructured":"Roy, N.S. et al. In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat. Med. 6, 271\u2013277 (2000).","journal-title":"Nat. Med."},{"key":"BFnn1048_CR24","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/neu.10038","volume":"50","author":"RR Stewart","year":"2002","unstructured":"Stewart, R.R., Hoge, G.J., Zigova, T. & Luskin, M.B. Neural progenitor cells of the neonatal rat anterior SVZ express functional GABAA receptors. J. Neurobiol. 50, 305\u2013322 (2002).","journal-title":"J. Neurobiol."},{"key":"BFnn1048_CR25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/381071a0","volume":"381","author":"GM Durand","year":"1996","unstructured":"Durand, G.M., Kovalchuk, Y. & Konnerth, A. Long-term potentiation and functional synapse induction in developing hippocampus. Nature 381, 71\u201375 (1996).","journal-title":"Nature"},{"key":"BFnn1048_CR26","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/(SICI)1097-4695(199810)37:1<110::AID-NEU9>3.0.CO;2-C","volume":"37","author":"H Komuro","year":"1998","unstructured":"Komuro, H. & Rakic, P. Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations. J. Neurobiol. 37, 110\u2013130 (1998).","journal-title":"J. Neurobiol."},{"key":"BFnn1048_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1152\/jn.1992.68.1.55","volume":"68","author":"I Spigelman","year":"1992","unstructured":"Spigelman, I., Zhang, L. & Carlen, P.L. Patch-clamp study of postnatal development of CA1 neurons in rat hippocampal slices: membrane excitability and K+ currents. J. Neurophysiol. 68, 55\u201369 (1992).","journal-title":"J. Neurophysiol."},{"key":"BFnn1048_CR28","doi-asserted-by":"publisher","first-page":"5428","DOI":"10.1523\/JNEUROSCI.17-14-05428.1997","volume":"17","author":"M Pirchio","year":"1997","unstructured":"Pirchio, M., Turner, J.P., Williams, S.R., Asprodini, E. & Crunelli, V. Postnatal development of membrane properties and delta oscillations in thalamocortical neurons of the cat dorsal lateral geniculate nucleus. J. Neurosci. 17, 5428\u20135444 (1997).","journal-title":"J. Neurosci."},{"key":"BFnn1048_CR29","first-page":"81","volume-title":"Principles of Neural Science","author":"J Koestner","year":"1991","unstructured":"Koestner, J. Membrane potential. in Principles of Neural Science (eds. Kandel, E.R., Schwartz, J.H. & Jessell T.H.) 81\u201394 (Elsevier, New York, 1991)."},{"key":"BFnn1048_CR30","doi-asserted-by":"publisher","first-page":"10372","DOI":"10.1523\/JNEUROSCI.19-23-10372.1999","volume":"19","author":"R Tyzio","year":"1999","unstructured":"Tyzio, R. et al. The establishment of GABAergic and glutamatergic synapses on CA1 pyramidal neurons is sequential and correlates with the development of the apical dendrite. J. Neurosci. 19, 10372\u201310382 (1999).","journal-title":"J. Neurosci."},{"key":"BFnn1048_CR31","doi-asserted-by":"publisher","first-page":"9770","DOI":"10.1523\/JNEUROSCI.21-24-09770.2001","volume":"21","author":"R Khazipov","year":"2001","unstructured":"Khazipov, R. et al. Early development of neuronal activity in the primate hippocampus in utero. J. Neurosci. 21, 9770\u20139781 (2001).","journal-title":"J. Neurosci."},{"key":"BFnn1048_CR32","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/S0959-4388(00)00182-3","volume":"11","author":"HT Cline","year":"2001","unstructured":"Cline, H.T. Dendritic arbor development and synaptogenesis. Curr. Opin. Neurobiol. 11, 118\u2013126 (2001).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn1048_CR33","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/nrn919","volume":"3","author":"DF Owens","year":"2002","unstructured":"Owens, D.F. & Kriegstein, A.J. Is there more to GABA than synaptic inhibition? Nat. Rev. Neurosci. 3, 715\u2013727 (2002).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn1048_CR34","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/nrn920","volume":"3","author":"Y Ben-Ari","year":"2002","unstructured":"Ben-Ari, Y. Excitatory actions of GABA during development: the nature of the nurture. Nat. Rev. Neurosci. 3, 728\u2013739 (2002).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn1048_CR35","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0092-8674(01)00341-5","volume":"105","author":"K Ganguly","year":"2001","unstructured":"Ganguly, K., Schinder, A.F., Wong, S.T. & Poo, M.M. GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition. Cell 105, 521\u2013532 (2001).","journal-title":"Cell"},{"key":"BFnn1048_CR36","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1002\/(SICI)1096-9861(19990322)405:4<508::AID-CNE5>3.0.CO;2-5","volume":"405","author":"G Alonso","year":"1999","unstructured":"Alonso, G., Prieto, M. & Chauvet, N. Tangential migration of young neurons arising from the subventricular zone of adult rats is impaired by surgical lesions passing through their natural migratory pathway. J. Comp. Neurol. 405, 508\u2013528 (1999).","journal-title":"J. Comp. Neurol."},{"key":"BFnn1048_CR37","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1126\/science.271.5251.978","volume":"271","author":"C Lois","year":"1996","unstructured":"Lois, C., Garcia-Verdugo, J.M. & Alvarez-Buylla, A. Chain migration of neuronal precursors. Science 271, 978\u2013981 (1996).","journal-title":"Science"},{"key":"BFnn1048_CR38","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1038\/nn753","volume":"4","author":"LI Zhang","year":"2001","unstructured":"Zhang, L.I. & Poo, M.M. Electrical activity and development of neural circuits. Nat. Neurosci. 4, 1207\u20131214 (2001).","journal-title":"Nat. Neurosci."},{"key":"BFnn1048_CR39","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1152\/jn.2001.85.6.2423","volume":"85","author":"JS Snyder","year":"2001","unstructured":"Snyder, J.S., Kee, N. & Wojtowicz, J.M. Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. J. Neurophysiol. 85, 2423\u20132431 (2001).","journal-title":"J. Neurophysiol."},{"key":"BFnn1048_CR40","doi-asserted-by":"publisher","first-page":"11032","DOI":"10.1073\/pnas.97.20.11032","volume":"97","author":"V Lemaire","year":"2000","unstructured":"Lemaire, V., Koehl, M., Le Moal, M. & Abrous, D.N. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc. Natl. Acad. Sci. USA 97, 11032\u201311037 (2000).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn1048_CR41","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/6365","volume":"2","author":"E Gould","year":"1999","unstructured":"Gould, E., Beylin, A., Tanapat, P., Reeves, A. & Shors, T.J. Learning enhances adult neurogenesis in the hippocampal formation. Nat. Neurosci. 2, 260\u2013265 (1999).","journal-title":"Nat. Neurosci."},{"key":"BFnn1048_CR42","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/6368","volume":"2","author":"H van Praag","year":"1999","unstructured":"van Praag, H., Kempermann, G. & Gage, F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 2, 266\u2013270 (1999).","journal-title":"Nat. Neurosci."},{"key":"BFnn1048_CR43","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1523\/JNEUROSCI.22-07-02679.2002","volume":"22","author":"C Rochefort","year":"2002","unstructured":"Rochefort, C., Gheusi, G., Vincent, J.D. & Lledo, P.-M. Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory. J. Neurosci. 22, 2679\u20132689 (2002).","journal-title":"J. Neurosci."},{"key":"BFnn1048_CR44","doi-asserted-by":"publisher","first-page":"6441","DOI":"10.1073\/pnas.101126398","volume":"98","author":"A Didier","year":"2001","unstructured":"Didier, A. et al. A dendro-dendritic reciprocal synapse provides a recurrent excitatory connection in the olfactory bulb. Proc. Natl. Acad. Sci. USA 98, 6441\u20136446 (2001).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn1048_CR45","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/S0896-6273(01)00245-8","volume":"29","author":"MC Walker","year":"2001","unstructured":"Walker, M.C., Ruiz, A. & Kullmann, D.M. Monosynaptic GABAergic signaling from dentate to CA3 with a pharmacological and physiological profile typical of mossy fiber synapses. Neuron 29, 703\u2013715 (2001).","journal-title":"Neuron"},{"key":"BFnn1048_CR46","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1152\/jn.2002.87.5.2562","volume":"87","author":"R Guti\u00e9rrez","year":"2002","unstructured":"Guti\u00e9rrez, R. Activity-dependent expression of simultaneous glutamatergic and GABAergic neurotransmission from the mossy fibers in vitro. J. Neurophysiol. 87, 2562\u20132570 (2002).","journal-title":"J. Neurophysiol."},{"key":"BFnn1048_CR47","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0960-9822(98)70156-3","volume":"8","author":"T Kanda","year":"1998","unstructured":"Kanda, T., Sullivan, K.F. & Wahl, G.M. Histone\u2013GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr. Biol. 8, 377\u2013385 (1998).","journal-title":"Curr. Biol."}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn1048","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn1048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn1048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:48:16Z","timestamp":1684453696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn1048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,21]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["BFnn1048"],"URL":"https:\/\/doi.org\/10.1038\/nn1048","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,21]]}}}