{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:38:32Z","timestamp":1772134712383,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2004,1,4]],"date-time":"2004-01-04T00:00:00Z","timestamp":1073174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1038\/nn1174","type":"journal-article","created":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T13:09:54Z","timestamp":1072962594000},"page":"113-117","source":"Crossref","is-referenced-by-count":463,"title":["Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway"],"prefix":"10.1038","volume":"7","author":[{"given":"Peng","family":"Jin","sequence":"first","affiliation":[]},{"given":"Daniela C","family":"Zarnescu","sequence":"additional","affiliation":[]},{"given":"Stephanie","family":"Ceman","sequence":"additional","affiliation":[]},{"given":"Mika","family":"Nakamoto","sequence":"additional","affiliation":[]},{"given":"Julie","family":"Mowrey","sequence":"additional","affiliation":[]},{"given":"Thomas A","family":"Jongens","sequence":"additional","affiliation":[]},{"given":"David L","family":"Nelson","sequence":"additional","affiliation":[]},{"given":"Kevin","family":"Moses","sequence":"additional","affiliation":[]},{"given":"Stephen T","family":"Warren","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2004,1,4]]},"reference":[{"key":"BFnn1174_CR1","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1146\/annurev.neuro.25.112701.142909","volume":"25","author":"WT O'Donnell","year":"2002","unstructured":"O'Donnell, W.T. & Warren, S.T. A decade of molecular studies of fragile X syndrome. Annu. Rev. Neurosci. 25, 315\u2013338 (2002).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnn1174_CR2","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1002\/j.1460-2075.1995.tb07237.x","volume":"14","author":"MC Siomi","year":"1995","unstructured":"Siomi, M.C. et al. FXR1, an autosomal homolog of the fragile X mental retardation gene. Embo J. 14, 2401\u20132408 (1995).","journal-title":"Embo J."},{"key":"BFnn1174_CR3","doi-asserted-by":"publisher","first-page":"5358","DOI":"10.1002\/j.1460-2075.1995.tb00220.x","volume":"14","author":"Y Zhang","year":"1995","unstructured":"Zhang, Y. et al. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. Embo J. 14, 5358\u20135366 (1995).","journal-title":"Embo J."},{"key":"BFnn1174_CR4","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1093\/nar\/29.11.2276","volume":"29","author":"Z Li","year":"2001","unstructured":"Li, Z. et al. The fragile X mental retardation protein inhibits translation via interacting with mRNA. Nucleic Acids Res. 29, 2276\u20132283 (2001).","journal-title":"Nucleic Acids Res."},{"key":"BFnn1174_CR5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1093\/hmg\/10.4.329","volume":"10","author":"B Laggerbauer","year":"2001","unstructured":"Laggerbauer, B., Ostareck, D., Keidel, E.M., Ostareck-Lederer, A. & Fischer, U. Evidence that fragile X mental retardation protein is a negative regulator of translation. Hum. Mol. Genet. 10, 329\u2013338 (2001).","journal-title":"Hum. Mol. Genet."},{"key":"BFnn1174_CR6","doi-asserted-by":"publisher","first-page":"5401","DOI":"10.1073\/pnas.94.10.5401","volume":"94","author":"TA Comery","year":"1997","unstructured":"Comery, T.A. et al. Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits. Proc. Natl. Acad. Sci. USA 94, 5401\u20135404 (1997).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn1174_CR7","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/ajmg.1320410306","volume":"41","author":"VJ Hinton","year":"1991","unstructured":"Hinton, V.J., Brown, W.T., Wisniewski, K. & Rudelli, R.D. Analysis of neocortex in three males with the fragile X syndrome. Am. J. Med. Genet. 41, 289\u2013294 (1991).","journal-title":"Am. J. Med. Genet."},{"key":"BFnn1174_CR8","doi-asserted-by":"publisher","first-page":"5139","DOI":"10.1523\/JNEUROSCI.21-14-05139.2001","volume":"21","author":"EA Nimchinsky","year":"2001","unstructured":"Nimchinsky, E.A., Oberlander, A.M. & Svoboda, K. Abnormal development of dendritic spines in FMR1 knock-out mice. J. Neurosci. 21, 5139\u20135146 (2001).","journal-title":"J. Neurosci."},{"key":"BFnn1174_CR9","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1523\/JNEUROSCI.17-05-01539.1997","volume":"17","author":"Y Feng","year":"1997","unstructured":"Feng, Y. et al. Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes. J. Neurosci. 17, 1539\u20131547 (1997).","journal-title":"J. Neurosci."},{"key":"BFnn1174_CR10","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S0959-437X(02)00300-3","volume":"12","author":"B Bardoni","year":"2002","unstructured":"Bardoni, B. & Mandel, J.L. Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes. Curr. Opin. Genet. Dev. 12, 284\u2013293 (2002).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFnn1174_CR11","doi-asserted-by":"publisher","first-page":"7746","DOI":"10.1073\/pnas.122205699","volume":"99","author":"KM Huber","year":"2002","unstructured":"Huber, K.M., Gallagher, S.M., Warren, S.T. & Bear, M.F. Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc. Natl. Acad. Sci. USA 99, 7746\u20137750 (2002).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn1174_CR12","doi-asserted-by":"publisher","first-page":"4803","DOI":"10.1093\/emboj\/20.17.4803","volume":"20","author":"C Schaeffer","year":"2001","unstructured":"Schaeffer, C. et al. The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif. Embo J. 20, 4803\u20134813 (2001).","journal-title":"Embo J."},{"key":"BFnn1174_CR13","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0092-8674(01)00568-2","volume":"107","author":"V Brown","year":"2001","unstructured":"Brown, V. et al. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 107, 477\u2013487 (2001).","journal-title":"Cell"},{"key":"BFnn1174_CR14","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0092-8674(01)00566-9","volume":"107","author":"JC Darnell","year":"2001","unstructured":"Darnell, J.C. et al. Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 107, 489\u2013499 (2001).","journal-title":"Cell"},{"key":"BFnn1174_CR15","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0896-6273(03)00034-5","volume":"37","author":"KY Miyashiro","year":"2003","unstructured":"Miyashiro, K.Y. et al. RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron 37, 417\u2013431 (2003).","journal-title":"Neuron"},{"key":"BFnn1174_CR16","doi-asserted-by":"publisher","first-page":"15669","DOI":"10.1074\/jbc.M211117200","volume":"278","author":"YJ Sung","year":"2003","unstructured":"Sung, Y.J. et al. The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo. J. Biol. Chem. 278, 15669\u201315678 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnn1174_CR17","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S0092-8674(03)00079-5","volume":"112","author":"F Zalfa","year":"2003","unstructured":"Zalfa, F. et al. The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses. Cell 112, 317\u2013327 (2003).","journal-title":"Cell"},{"key":"BFnn1174_CR18","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1093\/hmg\/ddg350","volume":"12","author":"S Ceman","year":"2003","unstructured":"Ceman, S. et al. Phosphorylation influences the translation state of FMRP-associated polyribosomes. Hum. Mol. Genet. 12, 3295\u20133305 (2003).","journal-title":"Hum. Mol. Genet."},{"key":"BFnn1174_CR19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0168-9525(02)00010-0","volume":"19","author":"H Cerutti","year":"2003","unstructured":"Cerutti, H. RNA interference: traveling in the cell and gaining functions? Trends Genet. 19, 39\u201346 (2003).","journal-title":"Trends Genet."},{"key":"BFnn1174_CR20","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/35052556","volume":"2","author":"SM Hammond","year":"2001","unstructured":"Hammond, S.M., Caudy, A.A. & Hannon, G.J. Post-transcriptional gene silencing by double-stranded RNA. Nat. Rev. Genet. 2, 110\u2013119 (2001).","journal-title":"Nat. Rev. Genet."},{"key":"BFnn1174_CR21","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1146\/annurev.cellbio.18.012502.105832","volume":"18","author":"AE Pasquinelli","year":"2002","unstructured":"Pasquinelli, A.E. & Ruvkun, G. Control of developmental timing by microRNAs and their targets. Annu. Rev. Cell Dev. Biol. 18, 495\u2013513 (2002).","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"BFnn1174_CR22","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/nrg908","volume":"3","author":"MT McManus","year":"2002","unstructured":"McManus, M.T. & Sharp, P.A. Gene silencing in mammals by small interfering RNAs. Nat. Rev. Genet. 3, 737\u2013747 (2002).","journal-title":"Nat. Rev. Genet."},{"key":"BFnn1174_CR23","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/35053110","volume":"409","author":"E Bernstein","year":"2001","unstructured":"Bernstein, E., Caudy, A.A., Hammond, S.M. & Hannon, G.J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363\u2013366 (2001).","journal-title":"Nature"},{"key":"BFnn1174_CR24","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1101\/gad.1026102","volume":"16","author":"MA Carmell","year":"2002","unstructured":"Carmell, M.A., Xuan, Z., Zhang, M.Q. & Hannon, G.J. The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 16, 2733\u20132742 (2002).","journal-title":"Genes Dev."},{"key":"BFnn1174_CR25","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.1101\/gad.1022002","volume":"16","author":"A Ishizuka","year":"2002","unstructured":"Ishizuka, A., Siomi, M.C. & Siomi, H. A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev. 16, 2497\u20132508 (2002).","journal-title":"Genes Dev."},{"key":"BFnn1174_CR26","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1101\/gad.1025202","volume":"16","author":"AA Caudy","year":"2002","unstructured":"Caudy, A.A., Myers, M., Hannon, G.J. & Hammond, S.M. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev. 16, 2491\u20132496 (2002).","journal-title":"Genes Dev."},{"key":"BFnn1174_CR27","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/S0968-0004(03)00033-1","volume":"28","author":"P Jin","year":"2003","unstructured":"Jin, P. & Warren, S.T. New insights into fragile X syndrome: from molecules to neurobehaviors. Trends Biochem. Sci. 28, 152\u2013158 (2003).","journal-title":"Trends Biochem. Sci."},{"key":"BFnn1174_CR28","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1126\/science.1064023","volume":"293","author":"SM Hammond","year":"2001","unstructured":"Hammond, S.M., Boettcher, S., Caudy, A.A., Kobayashi, R. & Hannon, G.J. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293, 1146\u20131150 (2001).","journal-title":"Science"},{"key":"BFnn1174_CR29","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1101\/gad.974702","volume":"16","author":"Z Mourelatos","year":"2002","unstructured":"Mourelatos, Z. et al. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev. 16, 720\u2013728 (2002).","journal-title":"Genes Dev."},{"key":"BFnn1174_CR30","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1093\/hmg\/11.5.487","volume":"11","author":"CJ Bontekoe","year":"2002","unstructured":"Bontekoe, C.J. et al. Knockout mouse model for Fxr2: a model for mental retardation. Hum. Mol. Genet. 11, 487\u2013498 (2002).","journal-title":"Hum. Mol. Genet."},{"key":"BFnn1174_CR31","doi-asserted-by":"crossref","unstructured":"The Dutch-Belgian Fragile X Consortium. Fmr1 knockout mice: a model to study fragile X mental retardation. Cell 78, 23\u201333 (1994).","DOI":"10.1016\/0092-8674(94)90569-X"},{"key":"BFnn1174_CR32","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0960-9822(02)01394-5","volume":"13","author":"N Doi","year":"2003","unstructured":"Doi, N. et al. Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr. Biol. 13, 41\u201346 (2003).","journal-title":"Curr. Biol."},{"key":"BFnn1174_CR33","doi-asserted-by":"publisher","first-page":"8536","DOI":"10.1128\/MCB.20.22.8536-8547.2000","volume":"20","author":"L Wan","year":"2000","unstructured":"Wan, L., Dockendorff, T.C., Jongens, T.A. & Dreyfuss, G. Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. Mol. Cell. Biol. 20, 8536\u20138547 (2000).","journal-title":"Mol. Cell. Biol."},{"key":"BFnn1174_CR34","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/S0092-8674(01)00589-X","volume":"107","author":"YQ Zhang","year":"2001","unstructured":"Zhang, Y.Q. et al. Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell 107, 591\u2013603 (2001).","journal-title":"Cell"},{"key":"BFnn1174_CR35","doi-asserted-by":"publisher","first-page":"6889","DOI":"10.1073\/pnas.072190799","volume":"99","author":"RW Williams","year":"2002","unstructured":"Williams, R.W. & Rubin, G.M. ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos. Proc. Natl. Acad. Sci. USA 99, 6889\u20136894 (2002).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn1174_CR36","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1046\/j.1365-2443.2001.00427.x","volume":"6","author":"Y Kataoka","year":"2001","unstructured":"Kataoka, Y., Takeichi, M. & Uemura, T. Developmental roles and molecular characterization of a Drosophila homologue of Arabidopsis Argonaute1, the founder of a novel gene superfamily. Genes Cells 6, 313\u2013325 (2001).","journal-title":"Genes Cells"},{"key":"BFnn1174_CR37","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S0896-6273(02)00724-9","volume":"34","author":"TC Dockendorff","year":"2002","unstructured":"Dockendorff, T.C. et al. Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Neuron 34, 973\u2013984 (2002).","journal-title":"Neuron"},{"key":"BFnn1174_CR38","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nrn942","volume":"3","author":"KC Martin","year":"2002","unstructured":"Martin, K.C. & Kosik, K.S. Synaptic tagging\u2014who's it? Nat. Rev. Neurosci. 3, 813\u2013820 (2002).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn1174_CR39","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S0896-6273(03)00090-4","volume":"37","author":"LN Antar","year":"2003","unstructured":"Antar, L.N. & Bassell, G.J. Sunrise at the synapse: the FMRP mRNP shaping the synaptic interface. Neuron 37, 555\u2013558 (2003).","journal-title":"Neuron"}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn1174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn1174","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn1174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:50:47Z","timestamp":1684439447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn1174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,4]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["BFnn1174"],"URL":"https:\/\/doi.org\/10.1038\/nn1174","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1017715.203385","asserted-by":"object"}]},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,4]]}}}