{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:03:31Z","timestamp":1774677811648,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2001,10,9]],"date-time":"2001-10-09T00:00:00Z","timestamp":1002585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1038\/nn734","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:34:56Z","timestamp":1027672496000},"page":"1071-1078","source":"Crossref","is-referenced-by-count":156,"title":["GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons"],"prefix":"10.1038","volume":"4","author":[{"given":"Feng","family":"Yang","sequence":"first","affiliation":[]},{"given":"Linyin","family":"Feng","sequence":"additional","affiliation":[]},{"given":"Fang","family":"Zheng","sequence":"additional","affiliation":[]},{"given":"Steven W.","family":"Johnson","sequence":"additional","affiliation":[]},{"given":"Jing","family":"Du","sequence":"additional","affiliation":[]},{"given":"Liya","family":"Shen","sequence":"additional","affiliation":[]},{"given":"Chien-ping","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Bai","family":"Lu","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2001,10,9]]},"reference":[{"key":"BFnn734_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1006\/mcne.1999.0754","volume":"13","author":"MS Airaksinen","year":"1999","unstructured":"Airaksinen, M. S., Titievsky, A. & Saarma, M. GDNF family neurotrophic factor signaling: four masters, one servant? Mol. Cell. Neurosci. 13, 313\u2013325 (1999).","journal-title":"Mol. Cell. Neurosci."},{"key":"BFnn734_CR2","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0959-4388(99)00048-3","volume":"10","author":"RH Baloh","year":"2000","unstructured":"Baloh, R. H., Enomoto, H., Johnson, E. M. Jr. & Milbrandt, J. The GDNF family ligands and receptors\u2014implications for neural development. Curr. Opin. Neurobiol. 10, 103\u2013110 (2000).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn734_CR3","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/381789a0","volume":"381","author":"P Durbec","year":"1996","unstructured":"Durbec, P. et al. GDNF signalling through the Ret receptor tyrosine kinase. Nature 381, 789\u2013793 (1996).","journal-title":"Nature"},{"key":"BFnn734_CR4","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/S0092-8674(00)81311-2","volume":"85","author":"S Jing","year":"1996","unstructured":"Jing, S. et al. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell 85, 1113\u20131124 (1996).","journal-title":"Cell"},{"key":"BFnn734_CR5","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/382080a0","volume":"382","author":"JJ Treanor","year":"1996","unstructured":"Treanor, J. J. et al. Characterization of a multicomponent receptor for GDNF. Nature 382, 80\u201383 (1996).","journal-title":"Nature"},{"key":"BFnn734_CR6","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/381785a0","volume":"381","author":"M Trupp","year":"1996","unstructured":"Trupp, M. et al. Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature 381, 785\u2013788 (1996).","journal-title":"Nature"},{"key":"BFnn734_CR7","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0306-4522(99)00129-3","volume":"93","author":"L Feng","year":"1999","unstructured":"Feng, L. et al. Differential signaling of glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons. Neuroscience 93, 265\u2013273 (1999).","journal-title":"Neuroscience"},{"key":"BFnn734_CR8","doi-asserted-by":"publisher","first-page":"9160","DOI":"10.1523\/JNEUROSCI.19-21-09160.1999","volume":"19","author":"RM Soler","year":"1999","unstructured":"Soler, R. M. et al. Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons. J. Neurosci. 19, 9160\u20139169 (1999).","journal-title":"J. Neurosci."},{"key":"BFnn734_CR9","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1126\/science.8493557","volume":"260","author":"LF Lin","year":"1993","unstructured":"Lin, L. F., Doherty, D. H., Lile, J. D., Bektesh, S. & Collins, F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260, 1130\u20131132 (1993).","journal-title":"Science"},{"key":"BFnn734_CR10","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/373335a0","volume":"373","author":"A Tomac","year":"1995","unstructured":"Tomac, A. et al. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373, 335\u2013339 (1995).","journal-title":"Nature"},{"key":"BFnn734_CR11","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/380252a0","volume":"380","author":"DM Gash","year":"1996","unstructured":"Gash, D. M. et al. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 380, 252\u2013255 (1996).","journal-title":"Nature"},{"key":"BFnn734_CR12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0304-3940(94)90218-6","volume":"182","author":"BJ Hoffer","year":"1994","unstructured":"Hoffer, B. J. et al. Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Neurosci. Lett. 182, 107\u2013111 (1994).","journal-title":"Neurosci. Lett."},{"key":"BFnn734_CR13","doi-asserted-by":"publisher","first-page":"8935","DOI":"10.1073\/pnas.92.19.8935","volume":"92","author":"H Sauer","year":"1995","unstructured":"Sauer, H., Rosenblad, C. & Bjorklund, A. Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion. Proc. Natl. Acad. Sci. USA 92, 8935\u20138939 (1995).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn734_CR14","doi-asserted-by":"publisher","first-page":"8132","DOI":"10.1523\/JNEUROSCI.16-24-08132.1996","volume":"16","author":"WA Cass","year":"1996","unstructured":"Cass, W. A. GDNF selectively protects dopamine neurons over serotonin neurons against the neurotoxic effects of methamphetamine. J. Neurosci. 16, 8132\u20138139 (1996).","journal-title":"J. Neurosci."},{"key":"BFnn734_CR15","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/373339a0","volume":"373","author":"KD Beck","year":"1995","unstructured":"Beck, K. D. et al. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373, 339\u2013341 (1995).","journal-title":"Nature"},{"key":"BFnn734_CR16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1006\/exnr.1993.1181","volume":"124","author":"RM Lindsay","year":"1993","unstructured":"Lindsay, R. M., Altar, C. A., Cedarbaum, J. M., Hyman, C. & Wiegand, S. J. The therapeutic potential of neurotrophic factors in the treatment of Parkinson's disease. Exp. Neurol. 124, 103\u2013118 (1993).","journal-title":"Exp. Neurol."},{"key":"BFnn734_CR17","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1517\/13543776.7.4.325","volume":"7","author":"W Gao","year":"1997","unstructured":"Gao, W., Dugich-Djordjevic, M. M., Weil, R. J. & Lu, B. Therapeutical usage of neurotrophic factors: patent analysis. Expert Opin. Therap. Patents 7, 325\u2013338 (1997).","journal-title":"Expert Opin. Therap. Patents"},{"key":"BFnn734_CR18","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/(SICI)1097-4547(19991001)58:1<76::AID-JNR8>3.0.CO;2-0","volume":"58","author":"B Lu","year":"1999","unstructured":"Lu, B. & Chow, A. Neurotrophins and hippocampal synaptic plasticity. J. Neurosci. Res. 58, 76\u201387 (1999).","journal-title":"J. Neurosci. Res."},{"key":"BFnn734_CR19","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1146\/annurev.neuro.22.1.295","volume":"22","author":"AM McAllister","year":"1999","unstructured":"McAllister, A. M., Katz, L. C. & Lo, D. C. Neurotrophins and synaptic plasticity. Annu. Rev. Neurosci. 22, 295\u2013318 (1999).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnn734_CR20","doi-asserted-by":"publisher","first-page":"9092","DOI":"10.1073\/pnas.92.20.9092","volume":"92","author":"HT Mount","year":"1995","unstructured":"Mount, H. T., Dean, D. O., Alberch, J., Dreyfus, C. F. & Black, I. B. Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells. Proc. Natl. Acad. Sci. USA 92, 9092\u20139096 (1995).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn734_CR21","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1083\/jcb.130.1.137","volume":"130","author":"M Trupp","year":"1995","unstructured":"Trupp, M. et al. Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian perioheral neurons. J. Cell Biol. 130, 137\u2013148 (1995).","journal-title":"J. Cell Biol."},{"key":"BFnn734_CR22","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.1523\/JNEUROSCI.20-13-05001.2000","volume":"20","author":"RW Oppenheim","year":"2000","unstructured":"Oppenheim, R. W. et al. Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: regulation of programmed cell death among motoneuron subtypes. J. Neurosci. 20, 5001\u20135011 (2000).","journal-title":"J. Neurosci."},{"key":"BFnn734_CR23","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1126\/science.279.5357.1725","volume":"279","author":"QT Nguyen","year":"1998","unstructured":"Nguyen, Q. T., Parsadanian, A. S., Snider, W. D. & Lichtman, J. W. Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle. Science 279, 1725\u20131729 (1998).","journal-title":"Science"},{"key":"BFnn734_CR24","unstructured":"Wang, C. et al. Ca2+-binding protein frequenin mediates GDNF-induced synaptic facilitation by potentiating Ca2+ channels. Neuron (in press)."},{"key":"BFnn734_CR25","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1113\/jphysiol.1984.sp015154","volume":"349","author":"H Jahnsen","year":"1984","unstructured":"Jahnsen, H. & Llinas, R. Ionic basis for the electro-responsiveness and oscillatory properties of guinea-pig thalamic neurones in vitro. J. Physiol. (Lond.) 349, 227\u2013247 (1984).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn734_CR26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/S0169-328X(99)00015-7","volume":"66","author":"L Feng","year":"1999","unstructured":"Feng, L. et al. Differential effects of GDNF and BDNF on cultured ventral mesencephalic neurons. Mol. Brain Res. 66, 62\u201370 (1999).","journal-title":"Mol. Brain Res."},{"key":"BFnn734_CR27","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1523\/JNEUROSCI.09-04-01233.1989","volume":"9","author":"MG Lacey","year":"1989","unstructured":"Lacey, M. G., Mercuri, N. B. & North, R. A. Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids. J. Neurosci. 9, 1233\u20131241 (1989).","journal-title":"J. Neurosci."},{"key":"BFnn734_CR28","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1113\/jphysiol.1971.sp009366","volume":"213","author":"JA Connor","year":"1971","unstructured":"Connor, J. A. & Stevens, C. F. Prediction of repetitive firing behaviour from voltage clamp data on an isolated neurone soma. J. Physiol. (Lond.) 213, 31\u201353 (1971).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn734_CR29","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1126\/science.3059497","volume":"242","author":"R Llinas","year":"1988","unstructured":"Llinas, R. The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science 242, 1654\u20131664 (1988).","journal-title":"Science"},{"key":"BFnn734_CR30","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1152\/jn.1992.68.4.1384","volume":"68","author":"DA McCormick","year":"1992","unstructured":"McCormick, D. A. & Huguenard, J. R. A model of the electrophysiological properties of thalamocortical relay neurons. J. Neurophysiol. 68, 1384\u2013400 (1992).","journal-title":"J. Neurophysiol."},{"key":"BFnn734_CR31","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1113\/jphysiol.1995.sp020998","volume":"488","author":"L Zhang","year":"1995","unstructured":"Zhang, L. & McBain, C. J. Potassium conductances underlying repolarization and after-hyperpolarization in rat CA1 hippocampal interneurones. J. Physiol. (Lond.) 488, 661\u2013672 (1995).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn734_CR32","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1046\/j.1471-4159.2000.0752277.x","volume":"75","author":"JP Adams","year":"2000","unstructured":"Adams, J. P. et al. The A-type potassium channel kv4.2 is a substrate for the mitogen-activated protein kinase ERK. J. Neurochem. 75, 2277\u20132287 (2000).","journal-title":"J. Neurochem."},{"key":"BFnn734_CR33","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1113\/jphysiol.1992.sp019136","volume":"450","author":"SW Johnson","year":"1992","unstructured":"Johnson, S. W. & North, R. A. Two types of neurons in the rat ventral tegmental area and their synaptic inputs. J. Physiol. (Lond.) 450, 455\u2013468 (1992).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn734_CR34","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1038\/44847","volume":"401","author":"KW Kafitz","year":"1999","unstructured":"Kafitz, K. W., Rose, C. R., Thoenen, H. & Konnerth, A. Neurotrophin-evoked rapid excitation through TrkB receptors. Nature 401, 918\u2013921 (1999).","journal-title":"Nature"},{"key":"BFnn734_CR35","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0896-6273(00)80838-7","volume":"24","author":"HS Li","year":"1999","unstructured":"Li, H. S., Xu, X. Z. & Montell, C. Activation of a TRPC3-dependent cation current through the neurotrophin BDNF. Neuron 24, 261\u2013273 (1999).","journal-title":"Neuron"},{"key":"BFnn734_CR36","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1152\/jn.1998.79.2.1081","volume":"79","author":"P Serodio","year":"1998","unstructured":"Serodio, P. & Rudy, B. Differential expression of Kv4 K+ channel subunits mediating subthreshold transient K+ (A-type) currents in rat brain. J. Neurophysiol. 79, 1081\u20131091 (1998).","journal-title":"J. Neurophysiol."},{"key":"BFnn734_CR37","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/S0006-8993(00)02586-5","volume":"875","author":"YH Chung","year":"2000","unstructured":"Chung, Y. H., Shin, C., Kim, M. J. & Cha, C. I. Immunohistochemical study on the distribution of six members of the Kv1 channel subunits in the rat basal ganglia. Brain Res. 875, 164\u2013170 (2000).","journal-title":"Brain Res."},{"key":"BFnn734_CR38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0168-0102(99)00039-5","volume":"34","author":"H Washio","year":"1999","unstructured":"Washio, H., Takigachi-Hayashi, K. & Konishi, S. Early postnatal development of substantia nigra neurons in rat midbrain slices: hyperpolarization-activated inward current and dopamine-activated current. Neurosci. Res. 34, 91\u2013101 (1999).","journal-title":"Neurosci. Res."},{"key":"BFnn734_CR39","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1111\/j.1460-9568.1995.tb00342.x","volume":"7","author":"NB Mercuri","year":"1995","unstructured":"Mercuri, N. B., Bonci, A., Calabresi, P., Stefani, A. & Bernardi, G. Properties of the hyperpolarization-activated cation current Ih in rat midbrain dopaminergic neurons. Eur. J. Neurosci. 7, 462\u2013469 (1995).","journal-title":"Eur. J. Neurosci."},{"key":"BFnn734_CR40","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/382076a0","volume":"382","author":"MW Moore","year":"1996","unstructured":"Moore, M. W. et al. Renal and neuronal abnormalities in mice lacking GDNF. Nature 382, 76\u201379 (1996).","journal-title":"Nature"},{"key":"BFnn734_CR41","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/382070a0","volume":"382","author":"MP Sanchez","year":"1996","unstructured":"Sanchez, M. P. et al. Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382, 70\u201373 (1996).","journal-title":"Nature"},{"key":"BFnn734_CR42","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0896-6273(00)80514-0","volume":"21","author":"G Cacalano","year":"1998","unstructured":"Cacalano, G. et al. GFR\u03b11 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron 21, 53\u201362 (1998).","journal-title":"Neuron"},{"key":"BFnn734_CR43","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.1523\/JNEUROSCI.20-09-03182.2000","volume":"20","author":"AC Granholm","year":"2000","unstructured":"Granholm, A. C. et al. Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons. J. Neurosci. 20, 3182\u20133190 (2000).","journal-title":"J. Neurosci."},{"key":"BFnn734_CR44","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/cne.903550402","volume":"355","author":"KE Bowenkamp","year":"1995","unstructured":"Bowenkamp, K. E. et al. Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. J. Comp. Neurol. 355, 479\u2013489 (1995).","journal-title":"J. Comp. Neurol."},{"key":"BFnn734_CR45","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/S0896-6273(00)80085-9","volume":"16","author":"KD Beck","year":"1996","unstructured":"Beck, K. D. et al. GDNF Induces a dystonia-like state in neonatal rats and stimulates dopamine and serotonin synthesis. Neuron 16, 665\u2013673 (1996).","journal-title":"Neuron"},{"key":"BFnn734_CR46","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/0361-9230(94)00224-O","volume":"36","author":"J Hudson","year":"1995","unstructured":"Hudson, J. et al. Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo. Brain Res. Bull. 36, 425\u2013432 (1995).","journal-title":"Brain Res. Bull."},{"key":"BFnn734_CR47","first-page":"1181","volume":"279","author":"MA Herbert","year":"1996","unstructured":"Herbert, M. A., Horne, C. G. V., Hoffer, B. J. & Gerhardt, G. A. Functional effects of GDNF in normal rat striatum: presynaptic studies using in vivo electrochemistry and microdialysis. J. Pharmcol. Exp. Ther. 279, 1181\u20131190 (1996).","journal-title":"J. Pharmcol. Exp. Ther."},{"key":"BFnn734_CR48","doi-asserted-by":"publisher","first-page":"12341","DOI":"10.1073\/pnas.91.25.12341","volume":"91","author":"HG Kim","year":"1994","unstructured":"Kim, H. G., Wang, T., Olafsson, P. & Lu, B. Neurotrophin 3 potentiates neuronal activity and inhibits g-aminobutyratergic synaptic transmission in cortical neurons. Proc. Natl. Acad. Sci. USA 91, 12341\u201312345 (1994).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn734_CR49","doi-asserted-by":"publisher","first-page":"9573","DOI":"10.1523\/JNEUROSCI.18-23-09573.1998","volume":"18","author":"TD Plant","year":"1998","unstructured":"Plant, T. D., Schirra, C., Katz, E., Uchitel, O. D. & Konnerth, A. Single-cell RT-PCR and functional characterization of Ca2+ channels in motoneurons of the rat facial nucleus. J. Neurosci. 18, 9573\u20139584 (1998).","journal-title":"J. Neurosci."},{"key":"BFnn734_CR50","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1113\/jphysiol.1987.sp016425","volume":"383","author":"P Anderson","year":"1987","unstructured":"Anderson, P., Storm, J. & Wheal, H. V. Thresholds of action potentials evoked by synapses on the dendrites of pyramidal cells in the rat hippocampus in vitro. J. Physiol. (Lond.) 383, 509\u2013526 (1987).","journal-title":"J. Physiol. (Lond.)"}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn734.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn734","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn734.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:02:04Z","timestamp":1684454524000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,9]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["BFnn734"],"URL":"https:\/\/doi.org\/10.1038\/nn734","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10,9]]}}}