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This paper is important in understanding TOP2 checkpoints as it was the first to use a catalytic inhibitor of TOP2 rather than an agent that induces TOP2-mediated DNA damage.","journal-title":"Nature"},{"key":"BFnrc2608_CR84","doi-asserted-by":"crossref","first-page":"12044","DOI":"10.1073\/pnas.221430898","volume":"98","author":"PB Deming","year":"2001","unstructured":"Deming, P. B. et al. The human decatenation checkpoint. Proc. Natl Acad. Sci. USA 98, 12044\u201312049 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrc2608_CR85","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.molcel.2004.08.018","volume":"15","author":"DA Skoufias","year":"2004","unstructured":"Skoufias, D. A., Lacroix, F. B., Andreassen, P. R., Wilson, L. & Margolis, R. L. Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase. Mol. Cell 15, 977\u2013990 (2004).","journal-title":"Mol. 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