{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:43:44Z","timestamp":1768592624927,"version":"3.49.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Genet"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1038\/nrg2555","type":"journal-article","created":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T06:03:10Z","timestamp":1236664990000},"page":"269-276","source":"Crossref","is-referenced-by-count":61,"title":["Replication timing and epigenetic reprogramming of gene expression: a two-way relationship?"],"prefix":"10.1038","volume":"10","author":[{"given":"Anita","family":"G\u00f6nd\u00f6r","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Ohlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFnrg2555_CR1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nrg2143","volume":"8","author":"MI Aladjem","year":"2007","unstructured":"Aladjem, M. I. Replication in context: dynamic regulation of DNA replication patterns in metazoans. Nature Rev. Genet. 8, 588\u2013600 (2007).","journal-title":"Nature Rev. Genet."},{"key":"BFnrg2555_CR2","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/ng1046","volume":"32","author":"N Collins","year":"2002","unstructured":"Collins, N. et al. An ACF1\u2013ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Nature Genet. 32, 627\u2013632 (2002).","journal-title":"Nature Genet."},{"key":"BFnrg2555_CR3","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.cell.2007.01.030","volume":"128","author":"A Groth","year":"2007","unstructured":"Groth, A., Rocha, W., Verreault, A. & Almouzni, G. Chromatin challenges during DNA replication and repair. Cell 128, 721\u2013733 (2007).","journal-title":"Cell"},{"key":"BFnrg2555_CR4","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1101\/gr.6533407","volume":"17","author":"M Huvet","year":"2007","unstructured":"Huvet, M. et al. Human gene organization driven by the coordination of replication and transcription. Genome Res. 17, 1278\u20131285 (2007).","journal-title":"Genome Res."},{"key":"BFnrg2555_CR5","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s004120000080","volume":"109","author":"E Wintersberger","year":"2000","unstructured":"Wintersberger, E. Why is there late replication? Chromosoma 109, 300\u2013307 (2000).","journal-title":"Chromosoma"},{"key":"BFnrg2555_CR6","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1101\/gr.079566.108","volume":"18","author":"S Farkash-Amar","year":"2008","unstructured":"Farkash-Amar, S. et al. Global organization of replication time zones of the mouse genome. Genome Res. 18, 1562\u20131570 (2008).","journal-title":"Genome Res."},{"key":"BFnrg2555_CR7","doi-asserted-by":"publisher","first-page":"e245","DOI":"10.1371\/journal.pbio.0060245","volume":"6","author":"I Hiratani","year":"2008","unstructured":"Hiratani, I. et al. Global reorganization of replication domains during embryonic stem cell differentiation. PLoS Biol. 6, e245 (2008).","journal-title":"PLoS Biol."},{"key":"BFnrg2555_CR8","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/bies.10305","volume":"25","author":"AJ McNairn","year":"2003","unstructured":"McNairn, A. J. & Gilbert, D. M. Epigenomic replication: linking epigenetics to DNA replication. Bioessays 25, 647\u2013656 (2003).","journal-title":"Bioessays"},{"key":"BFnrg2555_CR9","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.coi.2008.02.002","volume":"20","author":"H Cedar","year":"2008","unstructured":"Cedar, H. & Bergman, Y. Choreography of Ig allelic exclusion. Curr. Opin. Immunol. 20, 308\u2013317 (2008).","journal-title":"Curr. Opin. Immunol."},{"key":"BFnrg2555_CR10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/978-3-540-69111-2_5","volume":"25","author":"B Horsthemke","year":"1999","unstructured":"Horsthemke, B., Surani, A., James, T. & Ohlsson, R. The mechanisms of genomic imprinting. Results Probl. Cell Differ. 25, 91\u2013118 (1999).","journal-title":"Results Probl. Cell Differ."},{"key":"BFnrg2555_CR11","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1101\/gad.254903","volume":"17","author":"V Pant","year":"2003","unstructured":"Pant, V. et al. The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains. Genes Dev. 17, 586\u2013590 (2003).","journal-title":"Genes Dev."},{"key":"BFnrg2555_CR12","doi-asserted-by":"publisher","first-page":"450","DOI":"10.4161\/cc.6.4.3854","volume":"6","author":"R Bergstrom","year":"2007","unstructured":"Bergstrom, R., Whitehead, J., Kurukuti, S. & Ohlsson, R. CTCF regulates asynchronous replication of the imprinted H19\/Igf2 domain. Cell Cycle 6, 450\u2013454 (2007).","journal-title":"Cell Cycle"},{"key":"BFnrg2555_CR13","doi-asserted-by":"publisher","first-page":"4322","DOI":"10.1128\/MCB.17.8.4322","volume":"17","author":"KD Tremblay","year":"1997","unstructured":"Tremblay, K. D., Duran, K. L. & Bartolomei, M. S. A 5\u2032 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development. Mol. Cell Biol. 17, 4322\u20134329 (1997).","journal-title":"Mol. Cell Biol."},{"key":"BFnrg2555_CR14","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/S0960-9822(00)00597-2","volume":"10","author":"C Kanduri","year":"2000","unstructured":"Kanduri, C. et al. Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr. Biol. 10, 853\u2013856 (2000).","journal-title":"Curr. Biol."},{"key":"BFnrg2555_CR15","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/S1097-2765(00)80227-0","volume":"4","author":"DS Dimitrova","year":"1999","unstructured":"Dimitrova, D. S. & Gilbert, D. M. The spatial position and replication timing of chromosomal domains are both established in early G1 phase. Mol. Cell 4, 983\u2013993 (1999).","journal-title":"Mol. Cell"},{"key":"BFnrg2555_CR16","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/S1097-2765(02)00702-5","volume":"10","author":"M Vogelauer","year":"2002","unstructured":"Vogelauer, M., Rubbi, L., Lucas, I., Brewer, B. J. & Grunstein, M. Histone acetylation regulates the time of replication origin firing. Mol. Cell 10, 1223\u20131233 (2002).","journal-title":"Mol. Cell"},{"key":"BFnrg2555_CR17","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1126\/science.8266072","volume":"262","author":"SP Bell","year":"1993","unstructured":"Bell, S. P., Kobayashi, R. & Stillman, B. Yeast origin recognition complex functions in transcription silencing and DNA replication. Science 262, 1844\u20131849 (1993).","journal-title":"Science"},{"key":"BFnrg2555_CR18","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.ceb.2006.04.001","volume":"18","author":"ML DePamphilis","year":"2006","unstructured":"DePamphilis, M. L. et al. Regulating the licensing of DNA replication origins in metazoa. Curr. Opin. Cell Biol. 18, 231\u2013239 (2006).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFnrg2555_CR19","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ceb.2007.04.007","volume":"19","author":"T Sasaki","year":"2007","unstructured":"Sasaki, T. & Gilbert, D. M. The many faces of the origin recognition complex. Curr. Opin. Cell Biol. 19, 337\u2013343 (2007).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFnrg2555_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-1119(03)00546-8","volume":"310","author":"ML DePamphilis","year":"2003","unstructured":"DePamphilis, M. L. The 'ORC cycle': a novel pathway for regulating eukaryotic DNA replication. Gene 310, 1\u201315 (2003).","journal-title":"Gene"},{"key":"BFnrg2555_CR21","doi-asserted-by":"publisher","first-page":"15837","DOI":"10.1073\/pnas.0805208105","volume":"105","author":"JC Cadoret","year":"2008","unstructured":"Cadoret, J. C. et al. Genome-wide studies highlight indirect links between human replication origins and gene regulation. Proc. Natl Acad. Sci. USA 105, 15837\u201315842 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrg2555_CR22","doi-asserted-by":"publisher","first-page":"6701","DOI":"10.1093\/nar\/gkm555","volume":"35","author":"E Zellner","year":"2007","unstructured":"Zellner, E., Herrmann, T., Schulz, C. & Grummt, F. Site-specific interaction of the murine pre-replicative complex with origin DNA: assembly and disassembly during cell cycle transit and differentiation. Nucleic Acids Res. 35, 6701\u20136713 (2007).","journal-title":"Nucleic Acids Res."},{"key":"BFnrg2555_CR23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0070-2153(06)76005-7","volume":"76","author":"AP Tabancay Jr","year":"2006","unstructured":"Tabancay, A. P. Jr & Forsburg, S. L. Eukaryotic DNA replication in a chromatin context. Curr. Top. Dev. Biol. 76, 129\u2013184 (2006).","journal-title":"Curr. Top. Dev. Biol."},{"key":"BFnrg2555_CR24","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/ncb1149","volume":"6","author":"E Danis","year":"2004","unstructured":"Danis, E. et al. Specification of a DNA replication origin by a transcription complex. Nature Cell Biol. 6, 721\u2013730 (2004).","journal-title":"Nature Cell Biol."},{"issue":"49","key":"BFnrg2555_CR25","doi-asserted-by":"publisher","first-page":"33803","DOI":"10.1074\/jbc.C800182200","volume":"283","author":"Junsuo Kan","year":"2008","unstructured":"Kan, J. et al. ORC mediates histone 3 lysine 4 methylation through cooperation with SPP1 in Saccharomyces cerevisiae. J. Biol. Chem. 9 Oct 2008 (doi:10.1074\/jbc.C800182200).","journal-title":"Journal of Biological Chemistry"},{"key":"BFnrg2555_CR26","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1101\/gad.1674108","volume":"22","author":"B Miotto","year":"2008","unstructured":"Miotto, B. & Struhl, K. HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1. Genes Dev. 22, 2633\u20132638 (2008).","journal-title":"Genes Dev."},{"key":"BFnrg2555_CR27","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1101\/gad.468308","volume":"22","author":"A Goren","year":"2008","unstructured":"Goren, A., Tabib, A., Hecht, M. & Cedar, H. DNA replication timing of the human \u03b2-globin domain is controlled by histone modification at the origin. Genes Dev. 22, 1319\u20131324 (2008).","journal-title":"Genes Dev."},{"key":"BFnrg2555_CR28","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1038\/sj.emboj.7600609","volume":"24","author":"J Zhou","year":"2005","unstructured":"Zhou, J. et al. Cell cycle regulation of chromatin at an origin of DNA replication. EMBO J. 24, 1406\u20131417 (2005).","journal-title":"EMBO J."},{"key":"BFnrg2555_CR29","doi-asserted-by":"publisher","first-page":"889","DOI":"10.4161\/cc.4.7.1823","volume":"4","author":"J Zhou","year":"2005","unstructured":"Zhou, J., Chau, C., Deng, Z., Stedman, W. & Lieberman, P. M. Epigenetic control of replication origins. Cell Cycle 4, 889\u2013892 (2005).","journal-title":"Cell Cycle"},{"key":"BFnrg2555_CR30","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.4161\/cc.3.12.1346","volume":"3","author":"P Perry","year":"2004","unstructured":"Perry, P. et al. A dynamic switch in the replication timing of key regulator genes in embryonic stem cells upon neural induction. Cell Cycle 3, 1645\u20131650 (2004).","journal-title":"Cell Cycle"},{"key":"BFnrg2555_CR31","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/nature01150","volume":"420","author":"J Zhang","year":"2002","unstructured":"Zhang, J., Xu, F., Hashimshony, T., Keshet, I. & Cedar, H. Establishment of transcriptional competence in early and late S phase. Nature 420, 198\u2013202 (2002).","journal-title":"Nature"},{"key":"BFnrg2555_CR32","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/35041601","volume":"408","author":"Z Zhang","year":"2000","unstructured":"Zhang, Z., Shibahara, K. & Stillman, B. PCNA connects DNA replication to epigenetic inheritance in yeast. Nature 408, 221\u2013225 (2000).","journal-title":"Nature"},{"key":"BFnrg2555_CR33","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.cell.2007.05.003","volume":"129","author":"GL Moldovan","year":"2007","unstructured":"Moldovan, G. L., Pfander, B. & Jentsch, S. PCNA, the maestro of the replication fork. Cell 129, 665\u2013679 (2007).","journal-title":"Cell"},{"key":"BFnrg2555_CR34","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/77023","volume":"25","author":"MR Rountree","year":"2000","unstructured":"Rountree, M. R., Bachman, K. E. & Baylin, S. B. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nature Genet. 25, 269\u2013277 (2000).","journal-title":"Nature Genet."},{"key":"BFnrg2555_CR35","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1101\/gad.1463706","volume":"20","author":"PO Esteve","year":"2006","unstructured":"Esteve, P. O. et al. Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication. Genes Dev. 20, 3089\u20133103 (2006).","journal-title":"Genes Dev."},{"key":"BFnrg2555_CR36","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1091\/mbc.e04-11-0997","volume":"16","author":"R Wu","year":"2005","unstructured":"Wu, R., Terry, A. V., Singh, P. B. & Gilbert, D. M. Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states. Mol. Biol. Cell 16, 2872\u20132881 (2005).","journal-title":"Mol. Biol. Cell"},{"key":"BFnrg2555_CR37","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1186\/gb-2007-8-8-r169","volume":"8","author":"HF Jorgensen","year":"2007","unstructured":"Jorgensen, H. F. et al. The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells. Genome Biol. 8, R169 (2007).","journal-title":"Genome Biol."},{"key":"BFnrg2555_CR38","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00412-007-0098-4","volume":"116","author":"K Kupper","year":"2007","unstructured":"Kupper, K. et al. Radial chromatin positioning is shaped by local gene density, not by gene expression. Chromosoma 116, 285\u2013306 (2007).","journal-title":"Chromosoma"},{"key":"BFnrg2555_CR39","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.gde.2007.08.008","volume":"17","author":"A Pombo","year":"2007","unstructured":"Pombo, A. & Branco, M. R. Functional organisation of the genome during interphase. Curr. Opin. Genet. Dev. 17, 451\u2013455 (2007).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFnrg2555_CR40","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1023\/A:1012495201697","volume":"9","author":"M Cremer","year":"2001","unstructured":"Cremer, M. et al. Non-random radial higher-order chromatin arrangements in nuclei of diploid human cells. Chromosome Res. 9, 541\u2013567 (2001).","journal-title":"Chromosome Res."},{"key":"BFnrg2555_CR41","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1091\/mbc.e06-08-0689","volume":"18","author":"C Conti","year":"2007","unstructured":"Conti, C. et al. Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells. Mol. Biol. Cell 18, 3059\u20133067 (2007).","journal-title":"Mol. Biol. Cell"},{"key":"BFnrg2555_CR42","doi-asserted-by":"publisher","first-page":"32569","DOI":"10.1074\/jbc.M314017200","volume":"279","author":"M Izumi","year":"2004","unstructured":"Izumi, M., Yatagai, F. & Hanaoka, F. Localization of human Mcm10 is spatially and temporally regulated during the S phase. J. Biol. Chem. 279, 32569\u201332577 (2004).","journal-title":"J. Biol. Chem."},{"key":"BFnrg2555_CR43","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1146\/annurev.genet.37.110801.142705","volume":"38","author":"A Taddei","year":"2004","unstructured":"Taddei, A., Hediger, F., Neumann, F. R. & Gasser, S. M. The function of nuclear architecture: a genetic approach. Annu. Rev. Genet. 38, 305\u2013345 (2004).","journal-title":"Annu. Rev. Genet."},{"key":"BFnrg2555_CR44","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s004120000077","volume":"109","author":"R Hancock","year":"2000","unstructured":"Hancock, R. A new look at the nuclear matrix. Chromosoma 109, 219\u2013225 (2000).","journal-title":"Chromosoma"},{"key":"BFnrg2555_CR45","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nature07233","volume":"455","author":"S Courbet","year":"2008","unstructured":"Courbet, S. et al. Replication fork movement sets chromatin loop size and origin choice in mammalian cells. Nature 455, 557\u2013560 (2008).","journal-title":"Nature"},{"key":"BFnrg2555_CR46","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.cell.2005.08.045","volume":"123","author":"JM Lemaitre","year":"2005","unstructured":"Lemaitre, J. M., Danis, E., Pasero, P., Vassetzky, Y. & Mechali, M. Mitotic remodeling of the replicon and chromosome structure. Cell 123, 787\u2013801 (2005).","journal-title":"Cell"},{"key":"BFnrg2555_CR47","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/298100a0","volume":"298","author":"M Buongiorno-Nardelli","year":"1982","unstructured":"Buongiorno-Nardelli, M., Micheli, G., Carri, M. T. & Marilley, M. A relationship between replicon size and supercoiled loop domains in the eukaryotic genome. Nature 298, 100\u2013102 (1982).","journal-title":"Nature"},{"key":"BFnrg2555_CR48","doi-asserted-by":"publisher","first-page":"3737","DOI":"10.1093\/emboj\/cdg352","volume":"22","author":"D Fisher","year":"2003","unstructured":"Fisher, D. & Mechali, M. Vertebrate HoxB gene expression requires DNA replication. EMBO J. 22, 3737\u20133748 (2003).","journal-title":"EMBO J."},{"key":"BFnrg2555_CR49","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nrg1688","volume":"6","author":"D Sproul","year":"2005","unstructured":"Sproul, D., Gilbert, N. & Bickmore, W. A. The role of chromatin structure in regulating the expression of clustered genes. Nature Rev. Genet. 6, 775\u2013781 (2005).","journal-title":"Nature Rev. Genet."},{"key":"BFnrg2555_CR50","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1074\/jbc.M707880200","volume":"283","author":"Y Johmura","year":"2008","unstructured":"Johmura, Y., Osada, S., Nishizuka, M. & Imagawa, M. FAD24 acts in concert with histone acetyltransferase HBO1 to promote adipogenesis by controlling DNA replication. J. Biol. Chem. 283, 2265\u20132274 (2008).","journal-title":"J. Biol. Chem."},{"key":"BFnrg2555_CR51","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/sj.emboj.7600492","volume":"24","author":"J Li","year":"2005","unstructured":"Li, J., Santoro, R., Koberna, K. & Grummt, I. The chromatin remodeling complex NoRC controls replication timing of rRNA genes. EMBO J. 24, 120\u2013127 (2005).","journal-title":"EMBO J."},{"key":"BFnrg2555_CR52","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1101\/gad.232902","volume":"16","author":"P Pasero","year":"2002","unstructured":"Pasero, P., Bensimon, A. & Schwob, E. Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus. Genes Dev. 16, 2479\u20132484 (2002).","journal-title":"Genes Dev."},{"key":"BFnrg2555_CR53","doi-asserted-by":"publisher","first-page":"3319","DOI":"10.1128\/MCB.26.8.3319-3326.2006","volume":"26","author":"E Petermann","year":"2006","unstructured":"Petermann, E. et al. Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase. Mol. Cell Biol. 26, 3319\u20133326 (2006).","journal-title":"Mol. Cell Biol."},{"key":"BFnrg2555_CR54","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/ncb1145","volume":"6","author":"D Shechter","year":"2004","unstructured":"Shechter, D., Costanzo, V. & Gautier, J. ATR and ATM regulate the timing of DNA replication origin firing. Nature Cell Biol. 6, 648\u2013655 (2004).","journal-title":"Nature Cell Biol."},{"key":"BFnrg2555_CR55","doi-asserted-by":"publisher","first-page":"32370","DOI":"10.1074\/jbc.M705905200","volume":"282","author":"K Siddiqui","year":"2007","unstructured":"Siddiqui, K. & Stillman, B. ATP-dependent assembly of the human origin recognition complex. J. Biol. Chem. 282, 32370\u201332383 (2007).","journal-title":"J. Biol. Chem."},{"key":"BFnrg2555_CR56","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1101\/gad.445108","volume":"22","author":"O Cuvier","year":"2008","unstructured":"Cuvier, O., Stanojcic, S., Lemaitre, J. M. & Mechali, M. A topoisomerase II-dependent mechanism for resetting replicons at the S\u2013M-phase transition. Genes Dev. 22, 860\u2013865 (2008).","journal-title":"Genes Dev."},{"key":"BFnrg2555_CR57","doi-asserted-by":"publisher","first-page":"5623","DOI":"10.1093\/nar\/gkn533","volume":"36","author":"H Labit","year":"2008","unstructured":"Labit, H., Perewoska, I., Germe, T., Hyrien, O. & Marheineke, K. DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts. Nucleic Acids Res. 36, 5623\u20135634 (2008).","journal-title":"Nucleic Acids Res."},{"key":"BFnrg2555_CR58","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nature05879","volume":"447","author":"D Egli","year":"2007","unstructured":"Egli, D., Rosains, J., Birkhoff, G. & Eggan, K. Developmental reprogramming after chromosome transfer into mitotic mouse zygotes. Nature 447, 679\u2013685 (2007).","journal-title":"Nature"},{"key":"BFnrg2555_CR59","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.cub.2008.03.016","volume":"18","author":"A Kloc","year":"2008","unstructured":"Kloc, A., Zaratiegui, M., Nora, E. & Martienssen, R. RNA interference guides histone modification during the S phase of chromosomal replication. Curr. Biol. 18, 490\u2013495 (2008).","journal-title":"Curr. Biol."},{"key":"BFnrg2555_CR60","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/nature06561","volume":"451","author":"ES Chen","year":"2008","unstructured":"Chen, E. S. et al. Cell cycle control of centromeric repeat transcription and heterochromatin assembly. Nature 451, 734\u2013737 (2008).","journal-title":"Nature"},{"key":"BFnrg2555_CR61","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1101\/gr.5427007","volume":"17","author":"N Karnani","year":"2007","unstructured":"Karnani, N., Taylor, C., Malhotra, A. & Dutta, A. Pan-S replication patterns and chromosomal domains defined by genome-tiling arrays of ENCODE genomic areas. Genome Res. 17, 865\u2013876 (2007).","journal-title":"Genome Res."},{"key":"BFnrg2555_CR62","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1126\/science.1148910","volume":"318","author":"A Gimelbrant","year":"2007","unstructured":"Gimelbrant, A., Hutchinson, J. N., Thompson, B. R. & Chess, A. Widespread monoallelic expression on human autosomes. Science 318, 1136\u20131140 (2007).","journal-title":"Science"},{"key":"BFnrg2555_CR63","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.4049\/jimmunol.165.6.2982","volume":"165","author":"BL Kelly","year":"2000","unstructured":"Kelly, B. L. & Locksley, R. M. Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns. J. Immunol. 165, 2982\u20132986 (2000).","journal-title":"J. Immunol."},{"key":"BFnrg2555_CR64","doi-asserted-by":"publisher","first-page":"4684","DOI":"10.1073\/pnas.0730775100","volume":"100","author":"MW State","year":"2003","unstructured":"State, M. W. et al. Epigenetic abnormalities associated with a chromosome 18(q21\u2013q22) inversion and a Gilles de la Tourette syndrome phenotype. Proc. Natl Acad. Sci. USA 100, 4684\u20134689 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrg2555_CR65","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.gene.2004.02.029","volume":"333","author":"S D'Antoni","year":"2004","unstructured":"D'Antoni, S. et al. Altered replication timing of the HIRA\/Tuple1 locus in the DiGeorge and Velocardiofacial syndromes. Gene 333, 111\u2013119 (2004).","journal-title":"Gene"},{"key":"BFnrg2555_CR66","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.bbrc.2007.09.136","volume":"364","author":"Y Watanabe","year":"2007","unstructured":"Watanabe, Y., Shibata, K., Sugimura, H. & Maekawa, M. p53-dependent change in replication timing of the human genome. Biochem. Biophys. Res. Commun. 364, 289\u2013293 (2007).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnrg2555_CR67","doi-asserted-by":"publisher","first-page":"3541","DOI":"10.1158\/0008-5472.CAN-05-2481","volume":"66","author":"KM McGarvey","year":"2006","unstructured":"McGarvey, K. M. et al. Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res. 66, 3541\u20133549 (2006).","journal-title":"Cancer Res."},{"key":"BFnrg2555_CR68","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/hmg\/11.1.13","volume":"11","author":"Y Watanabe","year":"2002","unstructured":"Watanabe, Y. et al. Chromosome-wide assessment of replication timing for human chromosomes 11q and 21q: disease-related genes in timing-switch regions. Hum. Mol. Genet. 11, 13\u201321 (2002).","journal-title":"Hum. Mol. Genet."},{"key":"BFnrg2555_CR69","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.ygeno.2004.08.001","volume":"84","author":"Y Watanabe","year":"2004","unstructured":"Watanabe, Y., Ikemura, T. & Sugimura, H. Amplicons on human chromosome 11q are located in the early\/late-switch regions of replication timing. Genomics 84, 796\u2013805 (2004).","journal-title":"Genomics"},{"key":"BFnrg2555_CR70","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1146\/annurev.genet.41.110306.130308","volume":"41","author":"RA Sclafani","year":"2007","unstructured":"Sclafani, R. A. & Holzen, T. M. Cell cycle regulation of DNA replication. Annu. Rev. Genet. 41, 237\u2013280 (2007).","journal-title":"Annu. Rev. Genet."},{"key":"BFnrg2555_CR71","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/35066610","volume":"410","author":"S Hasan","year":"2001","unstructured":"Hasan, S., Hassa, P. O., Imhof, R. & Hottiger, M. O. Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis. Nature 410, 387\u2013391 (2001).","journal-title":"Nature"},{"key":"BFnrg2555_CR72","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1083\/jcb.200706150","volume":"179","author":"S Jorgensen","year":"2007","unstructured":"Jorgensen, S. et al. The histone methyltransferase SET8 is required for S-phase progression. J. Cell Biol. 179, 1337\u20131345 (2007).","journal-title":"J. Cell Biol."}],"container-title":["Nature Reviews Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrg2555.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrg2555","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrg2555.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T03:19:58Z","timestamp":1684466398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrg2555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["BFnrg2555"],"URL":"https:\/\/doi.org\/10.1038\/nrg2555","relation":{},"ISSN":["1471-0056","1471-0064"],"issn-type":[{"value":"1471-0056","type":"print"},{"value":"1471-0064","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}