{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:45:48Z","timestamp":1776923148610,"version":"3.51.2"},"reference-count":145,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Immunol"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1038\/nri2567","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T05:36:54Z","timestamp":1244180214000},"page":"581-593","source":"Crossref","is-referenced-by-count":3341,"title":["Membrane vesicles as conveyors of immune responses"],"prefix":"10.1038","volume":"9","author":[{"given":"Clotilde","family":"Th\u00e9ry","sequence":"first","affiliation":[]},{"given":"Matias","family":"Ostrowski","sequence":"additional","affiliation":[]},{"given":"Elodie","family":"Segura","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"BFnri2567_CR1","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.4049\/jimmunol.126.4.1327","volume":"126","author":"SO Sharrow","year":"1981","unstructured":"Sharrow, S. O., Mathieson, B. J. & Singer, A. Cell surface appearance of unexpected host MHC determinants on thymocytes from radiation bone marrow chimeras. J. Immunol. 126, 1327\u20131335 (1981).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR2","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nri2020","volume":"7","author":"DM Davis","year":"2007","unstructured":"Davis, D. M. Intercellular transfer of cell-surface proteins is common and can affect many stages of an immune response. Nature Rev. Immunol. 7, 238\u2013243 (2007).","journal-title":"Nature Rev. Immunol."},{"key":"BFnri2567_CR3","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1182\/blood.V94.11.3791","volume":"94","author":"HF Heijnen","year":"1999","unstructured":"Heijnen, H. F., Schiel, A. E., Fijnheer, R., Geuze, H. J. & Sixma, J. J. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and \u03b1-granules. Blood 94, 3791\u20133799 (1999).","journal-title":"Blood"},{"key":"BFnri2567_CR4","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/ncb1725","volume":"10","author":"K Al-Nedawi","year":"2008","unstructured":"Al-Nedawi, K. et al. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nature Cell Biol. 10, 619\u2013624 (2008). This is the first demonstration that oncogenic activity can be transferred between tumour cells by fusion of microvesicles with their plasma membrane.","journal-title":"Nature Cell Biol."},{"key":"BFnri2567_CR5","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4049\/jimmunol.134.1.138","volume":"134","author":"DD Poutsiaka","year":"1985","unstructured":"Poutsiaka, D. D., Schroder, E. W., Taylor, D. D., Levy, E. M. & Black, P. H. Membrane vesicles shed by murine melanoma cells selectively inhibit the expression of Ia antigen by macrophages. J. Immunol. 134, 138\u2013144 (1985).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR6","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.4049\/jimmunol.163.8.4564","volume":"163","author":"C Hess","year":"1999","unstructured":"Hess, C., Sadallah, S., Hefti, A., Landmann, R. & Schifferli, J. A. Ectosomes released by human neutrophils are specialized functional units. J. Immunol. 163, 4564\u20134573 (1999).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR7","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.2353\/ajpath.2006.060453","volume":"169","author":"C Obregon","year":"2006","unstructured":"Obregon, C., Rothen-Rutishauser, B., Gitahi, S. K., Gehr, P. & Nicod, L. P. Exovesicles from human activated dendritic cells fuse with resting dendritic cells, allowing them to present alloantigens. Am. J. Pathol. 169, 2127\u20132136 (2006).","journal-title":"Am. J. Pathol."},{"key":"BFnri2567_CR8","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.1242\/jcs.02439","volume":"118","author":"AM Marzesco","year":"2005","unstructured":"Marzesco, A. M. et al. Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells. J. Cell Sci. 118, 2849\u20132858 (2005).","journal-title":"J. Cell Sci."},{"key":"BFnri2567_CR9","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1083\/jcb.200508014","volume":"172","author":"AM Booth","year":"2006","unstructured":"Booth, A. M. et al. Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J. Cell Biol. 172, 923\u2013935 (2006).","journal-title":"J. Cell Biol."},{"key":"BFnri2567_CR10","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1083\/jcb.97.2.329","volume":"97","author":"C Harding","year":"1983","unstructured":"Harding, C., Heuser, J. & Stahl, P. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J. Cell Biol. 97, 329\u2013339 (1983).","journal-title":"J. Cell Biol."},{"key":"BFnri2567_CR11","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1083\/jcb.101.3.942","volume":"101","author":"BT Pan","year":"1985","unstructured":"Pan, B. T., Teng, K., Wu, C., Adam, M. & Johnstone, R. M. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J. Cell Biol. 101, 942\u2013948 (1985).","journal-title":"J. Cell Biol."},{"key":"BFnri2567_CR12","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1053\/j.gastro.2005.03.045","volume":"128","author":"V Huber","year":"2005","unstructured":"Huber, V. et al. Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape. Gastroenterology 128, 1796\u20131804 (2005).","journal-title":"Gastroenterology"},{"key":"BFnri2567_CR13","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1084\/jem.20011624","volume":"195","author":"G Andreola","year":"2002","unstructured":"Andreola, G. et al. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J. Exp. Med. 195, 1303\u20131316 (2002).","journal-title":"J. Exp. Med."},{"key":"BFnri2567_CR14","doi-asserted-by":"publisher","first-page":"6736","DOI":"10.4049\/jimmunol.167.12.6736","volume":"167","author":"I Monleon","year":"2001","unstructured":"Monleon, I. et al. Differential secretion of Fas ligand- or APO2 ligand\/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells. J. Immunol. 167, 6736\u20136744 (2001).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR15","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/sj.bjc.6602316","volume":"92","author":"DD Taylor","year":"2005","unstructured":"Taylor, D. D. & Gercel-Taylor, C. Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br. J. Cancer 92, 305\u2013311 (2005).","journal-title":"Br. J. Cancer"},{"key":"BFnri2567_CR16","doi-asserted-by":"publisher","first-page":"3358","DOI":"10.1096\/fj.07-102855","volume":"22","author":"E Ristorcelli","year":"2008","unstructured":"Ristorcelli, E. et al. Human tumor nanoparticles induce apoptosis of pancreatic cancer cells. FASEB J. 22, 3358\u20133369 (2008).","journal-title":"FASEB J."},{"key":"BFnri2567_CR17","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1073\/pnas.0307981100","volume":"101","author":"FI Hawari","year":"2004","unstructured":"Hawari, F. I. et al. Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors. Proc. Natl Acad. Sci. USA 101, 1297\u20131302 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2567_CR18","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1126\/science.1153124","volume":"319","author":"K Trajkovic","year":"2008","unstructured":"Trajkovic, K. et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319, 1244\u20131247 (2008).","journal-title":"Science"},{"key":"BFnri2567_CR19","first-page":"22","volume":"20","author":"B Hugel","year":"2005","unstructured":"Hugel, B., Martinez, M. C., Kunzelmann, C. & Freyssinet, J. M. Membrane microparticles: two sides of the coin. Physiology (Bethesda) 20, 22\u201327 (2005).","journal-title":"Physiology (Bethesda)"},{"key":"BFnri2567_CR20","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/S1074-7613(01)00229-1","volume":"15","author":"A MacKenzie","year":"2001","unstructured":"MacKenzie, A. et al. Rapid secretion of interleukin-1\u03b2 by microvesicle shedding. Immunity 15, 825\u2013835 (2001).","journal-title":"Immunity"},{"key":"BFnri2567_CR21","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1002\/eji.1830190819","volume":"19","author":"PJ Peters","year":"1989","unstructured":"Peters, P. J. et al. Molecules relevant for T cell-target cell interaction are present in cytolytic granules of human T lymphocytes. Eur. J. Immunol. 19, 1469\u20131475 (1989).","journal-title":"Eur. J. Immunol."},{"key":"BFnri2567_CR22","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.4049\/jimmunol.168.7.3235","volume":"168","author":"N Blanchard","year":"2002","unstructured":"Blanchard, N. et al. TCR activation of human T cells induces the production of exosomes bearing the TCR\/CD3\/\u03b6 complex. J. Immunol. 168, 3235\u20133241 (2002).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR23","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1091\/mbc.8.12.2631","volume":"8","author":"G Raposo","year":"1997","unstructured":"Raposo, G. et al. Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation. Mol. Biol. Cell 8, 2631\u20132645 (1997).","journal-title":"Mol. Biol. Cell"},{"key":"BFnri2567_CR24","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1042\/BC20060027","volume":"98","author":"P Rialland","year":"2006","unstructured":"Rialland, P., Lankar, D., Raposo, G., Bonnerot, C. & Hubert, P. BCR-bound antigen is targeted to exosomes in human follicular lymphoma B-cells. Biol. Cell 98, 491\u2013501 (2006).","journal-title":"Biol. Cell"},{"key":"BFnri2567_CR25","doi-asserted-by":"publisher","first-page":"8146","DOI":"10.4049\/jimmunol.180.12.8146","volume":"180","author":"SC Saunderson","year":"2008","unstructured":"Saunderson, S. C. et al. Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor. J. Immunol. 180, 8146\u20138152 (2008).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR26","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1002\/eji.200737694","volume":"38","author":"S Arita","year":"2008","unstructured":"Arita, S. et al. B cell activation regulates exosomal HLA production. Eur. J. Immunol. 38, 1423\u20131434 (2008).","journal-title":"Eur. J. Immunol."},{"key":"BFnri2567_CR27","doi-asserted-by":"publisher","first-page":"4263","DOI":"10.1038\/sj.emboj.7601842","volume":"26","author":"A Muntasell","year":"2007","unstructured":"Muntasell, A., Berger, A. C. & Roche, P. A. T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes. EMBO J. 26, 4263\u20134272 (2007).","journal-title":"EMBO J."},{"key":"BFnri2567_CR28","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1084\/jem.183.3.1161","volume":"183","author":"G Raposo","year":"1996","unstructured":"Raposo, G. et al. B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 183, 1161\u20131172 (1996). This is the first description of exosomes bearing functional peptide\u2013MHC complexes secreted by APCs. This paper sparked renewed interest in exosomes, although the atypical secretion described was not immediately accepted by the entire scientific community.","journal-title":"J. Exp. Med."},{"key":"BFnri2567_CR29","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nm0598-594","volume":"4","author":"L Zitvogel","year":"1998","unstructured":"Zitvogel, L. et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nature Med. 4, 594\u2013600 (1998). This description of exosomes secreted by DCs and their ability to promote antitumour immune responses in vivo prompted both basic and clinical studies exploring the application of exosomes for therapeutic purposes.","journal-title":"Nature Med."},{"key":"BFnri2567_CR30","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.1182\/blood-2007-03-079152","volume":"110","author":"S Bhatnagar","year":"2007","unstructured":"Bhatnagar, S., Shinagawa, K., Castellino, F. J. & Schorey, J. S. Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood 110, 3234\u20133244 (2007).","journal-title":"Blood"},{"key":"BFnri2567_CR31","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1083\/jcb.147.3.599","volume":"147","author":"C Thery","year":"1999","unstructured":"Thery, C. et al. Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. J. Cell Biol. 147, 599\u2013610 (1999).","journal-title":"J. Cell Biol."},{"key":"BFnri2567_CR32","doi-asserted-by":"publisher","first-page":"3757","DOI":"10.4049\/jimmunol.177.6.3757","volume":"177","author":"J Colino","year":"2006","unstructured":"Colino, J. & Snapper, C. M. Exosomes from bone marrow dendritic cells pulsed with diphtheria toxoid preferentially induce type 1 antigen-specific IgG responses in naive recipients in the absence of free antigen. J. Immunol. 177, 3757\u20133762 (2006).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR33","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1182\/blood-2005-01-0220","volume":"106","author":"E Segura","year":"2005","unstructured":"Segura, E. et al. ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T cell priming. Blood 106, 216\u2013223 (2005).","journal-title":"Blood"},{"key":"BFnri2567_CR34","doi-asserted-by":"publisher","first-page":"4795","DOI":"10.1158\/0008-5472.CAN-05-4579","volume":"66","author":"X Yu","year":"2006","unstructured":"Yu, X., Harris, S. L. & Levine, A. J. The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res. 66, 4795\u20134801 (2006).","journal-title":"Cancer Res."},{"key":"BFnri2567_CR35","doi-asserted-by":"publisher","first-page":"7864","DOI":"10.1158\/0008-5472.CAN-07-6538","volume":"68","author":"BD Lehmann","year":"2008","unstructured":"Lehmann, B. D. et al. Senescence-associated exosome release from human prostate cancer cells. Cancer Res. 68, 7864\u20137871 (2008).","journal-title":"Cancer Res."},{"key":"BFnri2567_CR36","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1038\/cdd.2008.104","volume":"15","author":"A Lespagnol","year":"2008","unstructured":"Lespagnol, A. et al. Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6\/Steap3-null mice. Cell Death Differ. 15, 1723\u20131733 (2008).","journal-title":"Cell Death Differ."},{"key":"BFnri2567_CR37","doi-asserted-by":"publisher","first-page":"28439","DOI":"10.1074\/jbc.M501112200","volume":"280","author":"R Alonso","year":"2005","unstructured":"Alonso, R. et al. Diacylglycerol kinase \u03b1 regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes. J. Biol. Chem. 280, 28439\u201328450 (2005).","journal-title":"J. Biol. Chem."},{"key":"BFnri2567_CR38","doi-asserted-by":"publisher","first-page":"9591","DOI":"10.1074\/jbc.M607122200","volume":"282","author":"A Islam","year":"2007","unstructured":"Islam, A. et al. The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles. J. Biol. Chem. 282, 9591\u20139599 (2007).","journal-title":"J. Biol. Chem."},{"key":"BFnri2567_CR39","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1242\/jcs.115.12.2505","volume":"115","author":"A Savina","year":"2002","unstructured":"Savina, A., Vidal, M. & Colombo, M. I. The exosome pathway in K562 cells is regulated by Rab11. J. Cell Sci. 115, 2505\u20132515 (2002).","journal-title":"J. Cell Sci."},{"key":"BFnri2567_CR40","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.4049\/jimmunol.165.3.1259","volume":"165","author":"K Denzer","year":"2000","unstructured":"Denzer, K. et al. Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface. J. Immunol. 165, 1259\u20131265 (2000).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR41","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1093\/intimm\/dxh267","volume":"17","author":"MP Caby","year":"2005","unstructured":"Caby, M. P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G. & Bonnerot, C. Exosomal-like vesicles are present in human blood plasma. Int. Immunol. 17, 879\u2013887 (2005).","journal-title":"Int. Immunol."},{"key":"BFnri2567_CR42","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.4049\/jimmunol.176.3.1534","volume":"176","author":"DD Taylor","year":"2006","unstructured":"Taylor, D. D., Akyol, S. & Gercel-Taylor, C. Pregnancy-associated exosomes and their modulation of T cell signaling. J. Immunol. 176, 1534\u20131542 (2006). This study provides support for a physiological role of in vivo -secreted exosomes, showing that exosomes with T cell-inhibiting activity are increased in pregnant women who deliver at full term compared with women who deliver pre-term.","journal-title":"J. Immunol."},{"key":"BFnri2567_CR43","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ygyno.2008.04.033","volume":"110","author":"DD Taylor","year":"2008","unstructured":"Taylor, D. D. & Gercel-Taylor, C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol. Oncol. 110, 13\u201321 (2008).","journal-title":"Gynecol. Oncol."},{"key":"BFnri2567_CR44","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1183\/09031936.03.00041703","volume":"22","author":"C Admyre","year":"2003","unstructured":"Admyre, C. et al. Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur. Respir. J. 22, 578\u2013583 (2003).","journal-title":"Eur. Respir. J."},{"key":"BFnri2567_CR45","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.4049\/jimmunol.181.2.1519","volume":"181","author":"N Prado","year":"2008","unstructured":"Prado, N. et al. Exosomes from bronchoalveolar fluid of tolerized mice prevent allergic reaction. J. Immunol. 181, 1519\u20131525 (2008).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR46","doi-asserted-by":"publisher","first-page":"13368","DOI":"10.1073\/pnas.0403453101","volume":"101","author":"T Pisitkun","year":"2004","unstructured":"Pisitkun, T., Shen, R. F. & Knepper, M. A. Identification and proteomic profiling of exosomes in human urine. Proc. Natl Acad. Sci. USA 101, 13368\u201313373 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2567_CR47","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0140-6736(02)09552-1","volume":"360","author":"F Andre","year":"2002","unstructured":"Andre, F. et al. Malignant effusions and immunogenic tumour-derived exosomes. Lancet 360, 295\u2013305 (2002).","journal-title":"Lancet"},{"key":"BFnri2567_CR48","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1095\/biolreprod.104.036426","volume":"72","author":"JL Gatti","year":"2005","unstructured":"Gatti, J. L., Metayer, S., Belghazi, M., Dacheux, F. & Dacheux, J. L. Identification, proteomic profiling, and origin of ram epididymal fluid exosome-like vesicles. Biol. Reprod. 72, 1452\u20131465 (2005).","journal-title":"Biol. Reprod."},{"key":"BFnri2567_CR49","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jri.2008.06.001","volume":"79","author":"A Asea","year":"2008","unstructured":"Asea, A. et al. Heat shock protein-containing exosomes in mid-trimester amniotic fluids. J. Reprod. Immunol. 79, 12\u201317 (2008).","journal-title":"J. Reprod. Immunol."},{"key":"BFnri2567_CR50","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.4049\/jimmunol.179.3.1969","volume":"179","author":"C Admyre","year":"2007","unstructured":"Admyre, C. et al. Exosomes with immune modulatory features are present in human breast milk. J. Immunol. 179, 1969\u20131978 (2007).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR51","doi-asserted-by":"publisher","first-page":"5441","DOI":"10.1021\/bi963119m","volume":"36","author":"MH Andersen","year":"1997","unstructured":"Andersen, M. H., Berglund, L., Rasmussen, J. T. & Petersen, T. E. Bovine PAS-6\/7 binds \u03b1v\u03b25 integrins and anionic phospholipids through two domains. Biochemistry 36, 5441\u20135446 (1997).","journal-title":"Biochemistry"},{"key":"BFnri2567_CR52","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1182\/blood-2004-03-0824","volume":"104","author":"AE Morelli","year":"2004","unstructured":"Morelli, A. E. et al. Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood 104, 3257\u20133266 (2004).","journal-title":"Blood"},{"key":"BFnri2567_CR53","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.4049\/jimmunol.179.3.1489","volume":"179","author":"E Segura","year":"2007","unstructured":"Segura, E., Guerin, C., Hogg, N., Amigorena, S. & Thery, C. CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo. J. Immunol. 179, 1489\u20131496 (2007). This paper identifies LFA1 as a specific receptor for exosomes on DCs and demonstrates the preferential capture of exosomes by cross-presenting CD8+ DCs. LFA1 was subsequently also shown to be required for exosome capture by activated T cells.","journal-title":"J. Immunol."},{"key":"BFnri2567_CR54","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1182\/blood-2008-08-174094","volume":"113","author":"EN Nolte-'t Hoen","year":"2009","unstructured":"Nolte-'t Hoen, E. N., Buschow, S. I., Anderton, S. M., Stoorvogel, W. & Wauben, M. H. Activated T-cells recruit exosomes secreted by dendritic cells via LFA-1. Blood 113, 1977\u20131981 (2009).","journal-title":"Blood"},{"key":"BFnri2567_CR55","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1128\/JVI.72.3.2105-2112.1998","volume":"72","author":"JF Fortin","year":"1998","unstructured":"Fortin, J. F., Cantin, R. & Tremblay, M. J. T cells expressing activated LFA-1 are more susceptible to infection with human immunodeficiency virus type 1 particles bearing host-encoded ICAM-1. J. Virol. 72, 2105\u20132112 (1998).","journal-title":"J. Virol."},{"key":"BFnri2567_CR56","doi-asserted-by":"publisher","first-page":"926","DOI":"10.4049\/jimmunol.175.2.926","volume":"175","author":"MR Tardif","year":"2005","unstructured":"Tardif, M. R. & Tremblay, M. J. Regulation of LFA-1 activity through cytoskeleton remodeling and signaling components modulates the efficiency of HIV type-1 entry in activated CD4+ T lymphocytes. J. Immunol. 175, 926\u2013935 (2005).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR57","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1096\/fj.03-1094fje","volume":"18","author":"A Clayton","year":"2004","unstructured":"Clayton, A. et al. Adhesion and signaling by B cell-derived exosomes: the role of integrins. FASEB J. 18, 977\u2013979 (2004).","journal-title":"FASEB J."},{"key":"BFnri2567_CR58","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1046\/j.1432-1327.2000.01036.x","volume":"267","author":"S Rieu","year":"2000","unstructured":"Rieu, S., Geminard, C., Rabesandratana, H., Sainte-Marie, J. & Vidal, M. Exosomes released during reticulocyte maturation bind to fibronectin via integrin \u03b14\u03b21. Eur. J. Biochem. 267, 583\u2013590 (2000).","journal-title":"Eur. J. Biochem."},{"key":"BFnri2567_CR59","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nature06307","volume":"450","author":"M Miyanishi","year":"2007","unstructured":"Miyanishi, M. et al. Identification of Tim4 as a phosphatidylserine receptor. Nature 450, 435\u2013439 (2007).","journal-title":"Nature"},{"key":"BFnri2567_CR60","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/417182a","volume":"417","author":"R Hanayama","year":"2002","unstructured":"Hanayama, R. et al. Identification of a factor that links apoptotic cells to phagocytes. Nature 417, 182\u2013187 (2002).","journal-title":"Nature"},{"key":"BFnri2567_CR61","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.bcmd.2005.05.001","volume":"35","author":"P Veron","year":"2005","unstructured":"Veron, P., Segura, E., Sugano, G., Amigorena, S. & Thery, C. Accumulation of MFG-E8\/lactadherin on exosomes from immature dendritic cells. Blood Cells Mol. Dis. 35, 81\u201388 (2005).","journal-title":"Blood Cells Mol. Dis."},{"key":"BFnri2567_CR62","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/sj.leu.2404132","volume":"20","author":"J Ratajczak","year":"2006","unstructured":"Ratajczak, J. et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 20, 847\u2013856 (2006).","journal-title":"Leukemia"},{"key":"BFnri2567_CR63","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/ncb1800","volume":"10","author":"J Skog","year":"2008","unstructured":"Skog, J. et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nature Cell Biol. 10, 1470\u20131476 (2008).","journal-title":"Nature Cell Biol."},{"key":"BFnri2567_CR64","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi, H. et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nature Cell Biol. 9, 654\u2013659 (2007). This study is the first to show that mRNA and microRNA are present in exosomes and transferred and translated in recipient cells (whether this also occurs in vivo remains unknown).","journal-title":"Nature Cell Biol."},{"key":"BFnri2567_CR65","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/85438","volume":"7","author":"J Wolfers","year":"2001","unstructured":"Wolfers, J. et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nature Med. 7, 297\u2013303 (2001).","journal-title":"Nature Med."},{"key":"BFnri2567_CR66","doi-asserted-by":"publisher","first-page":"e2461","DOI":"10.1371\/journal.pone.0002461","volume":"3","author":"PK Giri","year":"2008","unstructured":"Giri, P. K. & Schorey, J. S. Exosomes derived from M. bovis BCG infected macrophages activate antigen-specific CD4+ and CD8+ T cells in vitro and in vivo. PLoS ONE 3, e2461 (2008).","journal-title":"PLoS ONE"},{"key":"BFnri2567_CR67","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.4049\/jimmunol.182.3.1548","volume":"182","author":"JD Walker","year":"2009","unstructured":"Walker, J. D., Maier, C. L. & Pober, J. S. Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomes. J. Immunol. 182, 1548\u20131559 (2009).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR68","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.4049\/jimmunol.0802578","volume":"182","author":"K Coppieters","year":"2009","unstructured":"Coppieters, K. et al. No significant CTL cross-priming by dendritic cell-derived exosomes during murine lymphocytic choriomeningitis virus infection. J. Immunol. 182, 2213\u20132220 (2009).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR69","doi-asserted-by":"publisher","first-page":"5024","DOI":"10.4049\/jimmunol.179.8.5024","volume":"179","author":"L Luketic","year":"2007","unstructured":"Luketic, L. et al. Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL. J. Immunol. 179, 5024\u20135032 (2007).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR70","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1002\/eji.200535615","volume":"36","author":"C Admyre","year":"2006","unstructured":"Admyre, C., Johansson, S. M., Paulie, S. & Gabrielsson, S. Direct exosome stimulation of peripheral human T cells detected by ELISPOT. Eur. J. Immunol. 36, 1772\u20131781 (2006).","journal-title":"Eur. J. Immunol."},{"key":"BFnri2567_CR71","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0165-2478(03)00128-7","volume":"89","author":"S Utsugi-Kobukai","year":"2003","unstructured":"Utsugi-Kobukai, S., Fujimaki, H., Hotta, C., Nakazawa, M. & Minami, M. MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells. Immunol. Lett. 89, 125\u2013131 (2003).","journal-title":"Immunol. Lett."},{"key":"BFnri2567_CR72","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1097\/00002371-200309000-00007","volume":"26","author":"DH Hsu","year":"2003","unstructured":"Hsu, D. H. et al. Exosomes as a tumor vaccine: enhancing potency through direct loading of antigenic peptides. J. Immunother. 26, 440\u2013450 (2003).","journal-title":"J. Immunother."},{"key":"BFnri2567_CR73","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.4049\/jimmunol.172.4.2137","volume":"172","author":"N Chaput","year":"2004","unstructured":"Chaput, N. et al. Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection. J. Immunol. 172, 2137\u20132146 (2004).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR74","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1038\/ni854","volume":"3","author":"C Thery","year":"2002","unstructured":"Thery, C. et al. Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Nature Immunol. 3, 1156\u20131162 (2002).","journal-title":"Nature Immunol."},{"key":"BFnri2567_CR75","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.4049\/jimmunol.180.5.3081","volume":"180","author":"A Montecalvo","year":"2008","unstructured":"Montecalvo, A. et al. Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition. J. Immunol. 180, 3081\u20133090 (2008).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR76","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1053\/j.gastro.2007.02.043","volume":"132","author":"J Mallegol","year":"2007","unstructured":"Mallegol, J. et al. T84-intestinal epithelial exosomes bear MHC class II\/peptide complexes potentiating antigen presentation by dendritic cells. Gastroenterology 132, 1866\u20131876 (2007).","journal-title":"Gastroenterology"},{"key":"BFnri2567_CR77","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/intimm\/11.11.1739","volume":"11","author":"P Bedford","year":"1999","unstructured":"Bedford, P., Garner, K. & Knight, S. C. MHC class II molecules transferred between allogeneic dendritic cells stimulate primary mixed leukocyte reactions. Int. Immunol. 11, 1739\u20131744 (1999).","journal-title":"Int. Immunol."},{"key":"BFnri2567_CR78","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1182\/blood-2008-02-142596","volume":"113","author":"J Klibi","year":"2009","unstructured":"Klibi, J. et al. Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein\u2013Barr virus-infected nasopharyngeal carcinoma cells. Blood 113, 1957\u20131966 (2009).","journal-title":"Blood"},{"key":"BFnri2567_CR79","doi-asserted-by":"publisher","first-page":"7458","DOI":"10.1158\/0008-5472.CAN-06-3456","volume":"67","author":"A Clayton","year":"2007","unstructured":"Clayton, A., Mitchell, J. P., Court, J., Mason, M. D. & Tabi, Z. Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Cancer Res. 67, 7458\u20137466 (2007).","journal-title":"Cancer Res."},{"key":"BFnri2567_CR80","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.4049\/jimmunol.176.3.1375","volume":"176","author":"C Liu","year":"2006","unstructured":"Liu, C. et al. Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J. Immunol. 176, 1375\u20131385 (2006).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR81","doi-asserted-by":"publisher","first-page":"7249","DOI":"10.4049\/jimmunol.180.11.7249","volume":"180","author":"A Clayton","year":"2008","unstructured":"Clayton, A. et al. Human tumor-derived exosomes down-modulate NKG2D expression. J. Immunol. 180, 7249\u20137258 (2008).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR82","doi-asserted-by":"publisher","first-page":"6867","DOI":"10.4049\/jimmunol.178.11.6867","volume":"178","author":"S Yu","year":"2007","unstructured":"Yu, S. et al. Tumor exosomes inhibit differentiation of bone marrow dendritic cells. J. Immunol. 178, 6867\u20136875 (2007).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR83","doi-asserted-by":"publisher","first-page":"9290","DOI":"10.1158\/0008-5472.CAN-06-1819","volume":"66","author":"R Valenti","year":"2006","unstructured":"Valenti, R. et al. Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-\u03b2-mediated suppressive activity on T lymphocytes. Cancer Res. 66, 9290\u20139298 (2006).","journal-title":"Cancer Res."},{"key":"BFnri2567_CR84","doi-asserted-by":"publisher","first-page":"5242","DOI":"10.4049\/jimmunol.181.8.5242","volume":"181","author":"GJ Wang","year":"2008","unstructured":"Wang, G. J. et al. Thymus exosomes-like particles induce regulatory T cells. J. Immunol. 181, 5242\u20135248 (2008).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR85","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1002\/ijc.24249","volume":"124","author":"X Xiang","year":"2009","unstructured":"Xiang, X. et al. Induction of myeloid-derived suppressor cells by tumor exosomes. Int. J. Cancer 124, 2621\u20132633 (2009).","journal-title":"Int. J. Cancer"},{"key":"BFnri2567_CR86","doi-asserted-by":"publisher","first-page":"817","DOI":"10.4049\/jimmunol.180.2.817","volume":"180","author":"C Eken","year":"2008","unstructured":"Eken, C. et al. Polymorphonuclear neutrophil-derived ectosomes interfere with the maturation of monocyte-derived dendritic cells. J. Immunol. 180, 817\u2013824 (2008).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR87","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/S0301-472X(02)00791-9","volume":"30","author":"M Baj-Krzyworzeka","year":"2002","unstructured":"Baj-Krzyworzeka, M. et al. Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells. Exp. Hematol. 30, 450\u2013459 (2002).","journal-title":"Exp. Hematol."},{"key":"BFnri2567_CR88","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.imlet.2007.07.014","volume":"113","author":"M Baj-Krzyworzeka","year":"2007","unstructured":"Baj-Krzyworzeka, M., Szatanek, R., Weglarczyk, K., Baran, J. & Zembala, M. Tumour-derived microvesicles modulate biological activity of human monocytes. Immunol. Lett. 113, 76\u201382 (2007).","journal-title":"Immunol. Lett."},{"key":"BFnri2567_CR89","doi-asserted-by":"publisher","first-page":"5028","DOI":"10.1182\/blood-2007-06-097410","volume":"111","author":"DL Sprague","year":"2008","unstructured":"Sprague, D. L. et al. Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles. Blood 111, 5028\u20135036 (2008).","journal-title":"Blood"},{"key":"BFnri2567_CR90","doi-asserted-by":"publisher","first-page":"25779","DOI":"10.1074\/jbc.M702277200","volume":"282","author":"S Bhatnagar","year":"2007","unstructured":"Bhatnagar, S. & Schorey, J. S. Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory. J. Biol. Chem. 282, 25779\u201325789 (2007).","journal-title":"J. Biol. Chem."},{"key":"BFnri2567_CR91","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1189\/jlb.0507277","volume":"82","author":"BJ Quah","year":"2007","unstructured":"Quah, B. J. & O'Neill, H. C. Mycoplasma contaminants present in exosome preparations induce polyclonal B cell responses. J. Leukoc. Biol. 82, 1070\u20131082 (2007).","journal-title":"J. Leukoc. Biol."},{"key":"BFnri2567_CR92","doi-asserted-by":"publisher","first-page":"e3377","DOI":"10.1371\/journal.pone.0003377","volume":"3","author":"VR Simhadri","year":"2008","unstructured":"Simhadri, V. R. et al. Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function. PLoS ONE 3, e3377 (2008).","journal-title":"PLoS ONE"},{"key":"BFnri2567_CR93","doi-asserted-by":"publisher","first-page":"e4942","DOI":"10.1371\/journal.pone.0004942","volume":"4","author":"S Viaud","year":"2009","unstructured":"Viaud, S. et al. Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15R\u03b1. PLoS ONE 4, e4942 (2009).","journal-title":"PLoS ONE"},{"key":"BFnri2567_CR94","doi-asserted-by":"publisher","first-page":"5238","DOI":"10.1158\/0008-5472.CAN-04-3804","volume":"65","author":"R Gastpar","year":"2005","unstructured":"Gastpar, R. et al. Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res. 65, 5238\u20135247 (2005).","journal-title":"Cancer Res."},{"key":"BFnri2567_CR95","doi-asserted-by":"publisher","first-page":"4299","DOI":"10.4049\/jimmunol.180.6.4299","volume":"180","author":"VL Vega","year":"2008","unstructured":"Vega, V. L. et al. Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. J. Immunol. 180, 4299\u20134307 (2008).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR96","doi-asserted-by":"publisher","first-page":"7554","DOI":"10.1158\/1078-0432.CCR-05-0810","volume":"11","author":"S Dai","year":"2005","unstructured":"Dai, S. et al. More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells. Clin. Cancer Res. 11, 7554\u20137563 (2005).","journal-title":"Clin. Cancer Res."},{"key":"BFnri2567_CR97","doi-asserted-by":"publisher","first-page":"7385","DOI":"10.4049\/jimmunol.176.12.7385","volume":"176","author":"HG Zhang","year":"2006","unstructured":"Zhang, H. G. et al. A membrane form of TNF-\u03b1 presented by exosomes delays T cell activation-induced cell death. J. Immunol. 176, 7385\u20137393 (2006).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR98","doi-asserted-by":"publisher","first-page":"4127","DOI":"10.1128\/IAI.72.7.4127-4137.2004","volume":"72","author":"F Aline","year":"2004","unstructured":"Aline, F., Bout, D., Amigorena, S., Roingeard, P. & Dimier-Poisson, I. Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T. gondii infection. Infect. Immun. 72, 4127\u20134137 (2004).","journal-title":"Infect. Immun."},{"key":"BFnri2567_CR99","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1097\/01.TP.0000092494.75313.38","volume":"76","author":"H Peche","year":"2003","unstructured":"Peche, H., Heslan, M., Usal, C., Amigorena, S. & Cuturi, M. C. Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection. Transplantation 76, 1503\u20131510 (2003).","journal-title":"Transplantation"},{"key":"BFnri2567_CR100","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1097\/01.shk.0000209533.22941.d0","volume":"25","author":"M Miksa","year":"2006","unstructured":"Miksa, M. et al. Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis. Shock 25, 586\u2013593 (2006).","journal-title":"Shock"},{"key":"BFnri2567_CR101","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.4049\/jimmunol.179.4.2242","volume":"179","author":"SH Kim","year":"2007","unstructured":"Kim, S. H., Bianco, N. R., Shufesky, W. J., Morelli, A. E. & Robbins, P. D. Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4. J. Immunol. 179, 2242\u20132249 (2007).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR102","doi-asserted-by":"publisher","first-page":"6440","DOI":"10.4049\/jimmunol.174.10.6440","volume":"174","author":"SH Kim","year":"2005","unstructured":"Kim, S. H. et al. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J. Immunol. 174, 6440\u20136448 (2005).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR103","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.canlet.2008.10.021","volume":"275","author":"JA Cho","year":"2009","unstructured":"Cho, J. A., Lee, Y. S., Kim, S. H., Ko, J. K. & Kim, C. W. MHC independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models. Cancer Lett. 275, 256\u2013265 (2009).","journal-title":"Cancer Lett."},{"key":"BFnri2567_CR104","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s00109-006-0102-0","volume":"84","author":"S Dai","year":"2006","unstructured":"Dai, S. et al. Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8+ CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells. J. Mol. Med. 84, 1067\u20131076 (2006).","journal-title":"J. Mol. Med."},{"key":"BFnri2567_CR105","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1002\/1521-4141(2001010)31:10<2892::AID-IMMU2892>3.0.CO;2-I","volume":"31","author":"M Karlsson","year":"2001","unstructured":"Karlsson, M. et al. \u201cTolerosomes\u201d are produced by intestinal epithelial cells. Eur. J. Immunol. 31, 2892\u20132900 (2001).","journal-title":"Eur. J. Immunol."},{"key":"BFnri2567_CR106","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1136\/gut.52.12.1690","volume":"52","author":"G Van Niel","year":"2003","unstructured":"Van Niel, G. et al. Intestinal epithelial exosomes carry MHC class II\/peptides able to inform the immune system in mice. Gut 52, 1690\u20131697 (2003).","journal-title":"Gut"},{"key":"BFnri2567_CR107","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1479-5876-6-63","volume":"6","author":"V Huber","year":"2008","unstructured":"Huber, V., Filipazzi, P., Iero, M., Fais, S. & Rivoltini, L. More insights into the immunosuppressive potential of tumor exosomes. J. Transl. Med. 6, 63 (2008).","journal-title":"J. Transl. Med."},{"key":"BFnri2567_CR108","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1158\/0008-5472.CAN-07-3163","volume":"68","author":"IS Zeelenberg","year":"2008","unstructured":"Zeelenberg, I. S. et al. Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Cancer Res. 68, 1228\u20131235 (2008). In this study, in vivo secretion of antigen-containing vesicles by tumour cells or by tissue cells is shown to promote antigen-specific immune responses and thereby control tumour growth.","journal-title":"Cancer Res."},{"key":"BFnri2567_CR109","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1084\/jem.20020991","volume":"196","author":"C Scheinecker","year":"2002","unstructured":"Scheinecker, C., McHugh, R., Shevach, E. M. & Germain, R. N. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med. 196, 1079\u20131090 (2002).","journal-title":"J. Exp. Med."},{"key":"BFnri2567_CR110","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1084\/jem.20041132","volume":"200","author":"MN Fleeton","year":"2004","unstructured":"Fleeton, M. N. et al. Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice. J. Exp. Med. 200, 235\u2013245 (2004).","journal-title":"J. Exp. Med."},{"key":"BFnri2567_CR111","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.immuni.2006.04.017","volume":"25","author":"RS Allan","year":"2006","unstructured":"Allan, R. S. et al. Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. Immunity 25, 153\u2013162 (2006).","journal-title":"Immunity"},{"key":"BFnri2567_CR112","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1084\/jem.20071365","volume":"205","author":"CH GeurtsvanKessel","year":"2008","unstructured":"GeurtsvanKessel, C. H. et al. Clearance of influenza virus from the lung depends on migratory langerin+CD11b\u2212 but not plasmacytoid dendritic cells. J. Exp. Med. 205, 1621\u20131634 (2008).","journal-title":"J. Exp. Med."},{"key":"BFnri2567_CR113","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1365-2567.2008.02812.x","volume":"125","author":"N Almqvist","year":"2008","unstructured":"Almqvist, N., Lonnqvist, A., Hultkrantz, S., Rask, C. & Telemo, E. Serum-derived exosomes from antigen-fed mice prevent allergic sensitization in a model of allergic asthma. Immunology 125, 21\u201327 (2008).","journal-title":"Immunology"},{"key":"BFnri2567_CR114","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.4049\/jimmunol.163.10.5201","volume":"163","author":"DM Patel","year":"1999","unstructured":"Patel, D. M., Arnold, P. Y., White, G. A., Nardella, J. P. & Mannie, M. D. Class II MHC\/peptide complexes are released from APC and are acquired by T cell responders during specific antigen recognition. J. Immunol. 163, 5201\u20135210 (1999).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR115","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1182\/blood-2007-09-114389","volume":"112","author":"J Helft","year":"2008","unstructured":"Helft, J. et al. Antigen-specific T\u2013T interactions regulate CD4 T-cell expansion. Blood 112, 1249\u20131258 (2008).","journal-title":"Blood"},{"key":"BFnri2567_CR116","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1479-5876-3-10","volume":"3","author":"B Escudier","year":"2005","unstructured":"Escudier, B. et al. Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial. J. Transl. Med. 3, 10 (2005).","journal-title":"J. Transl. Med."},{"key":"BFnri2567_CR117","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1479-5876-3-9","volume":"3","author":"MA Morse","year":"2005","unstructured":"Morse, M. A. et al. A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J. Transl. Med. 3, 9 (2005).","journal-title":"J. Transl. Med."},{"key":"BFnri2567_CR118","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0022-1759(02)00330-7","volume":"270","author":"HG Lamparski","year":"2002","unstructured":"Lamparski, H. G. et al. Production and characterization of clinical grade exosomes derived from dendritic cells. J. Immunol. Methods 270, 211\u2013226 (2002).","journal-title":"J. Immunol. Methods"},{"key":"BFnri2567_CR119","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/mt.2008.1","volume":"16","author":"S Dai","year":"2008","unstructured":"Dai, S. et al. Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol. Ther. 16, 782\u2013790 (2008).","journal-title":"Mol. Ther."},{"key":"BFnri2567_CR120","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1016\/j.vaccine.2005.04.017","volume":"23","author":"M Adams","year":"2005","unstructured":"Adams, M. et al. The rationale for combined chemo\/immunotherapy using a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes in advanced ovarian cancer. Vaccine 23, 2374\u20132378 (2005).","journal-title":"Vaccine"},{"key":"BFnri2567_CR121","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.4049\/jimmunol.176.5.2722","volume":"176","author":"J Taieb","year":"2006","unstructured":"Taieb, J. et al. Chemoimmunotherapy of tumors: cyclophosphamide synergizes with exosome based vaccines. J. Immunol. 176, 2722\u20132729 (2006).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR122","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00109-006-0154-1","volume":"85","author":"F Xiu","year":"2007","unstructured":"Xiu, F. et al. Surface anchorage of superantigen SEA promotes induction of specific antitumor immune response by tumor-derived exosomes. J. Mol. Med. 85, 511\u2013521 (2007).","journal-title":"J. Mol. Med."},{"key":"BFnri2567_CR123","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1016\/j.vaccine.2005.11.034","volume":"24","author":"B Bellier","year":"2006","unstructured":"Bellier, B. et al. DNA vaccines encoding retrovirus-based virus-like particles induce efficient immune responses without adjuvant. Vaccine 24, 2643\u20132655 (2006).","journal-title":"Vaccine"},{"key":"BFnri2567_CR124","doi-asserted-by":"publisher","first-page":"4336","DOI":"10.1182\/blood-2003-03-0871","volume":"102","author":"A de Gassart","year":"2003","unstructured":"de Gassart, A., Geminard, C., Fevrier, B., Raposo, G. & Vidal, M. Lipid raft-associated protein sorting in exosomes. Blood 102, 4336\u20134344 (2003).","journal-title":"Blood"},{"key":"BFnri2567_CR125","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/immu.200310028","volume":"33","author":"A Clayton","year":"2003","unstructured":"Clayton, A., Harris, C. L., Court, J., Mason, M. D. & Morgan, B. P. Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur. J. Immunol. 33, 522\u2013531 (2003).","journal-title":"Eur. J. Immunol."},{"key":"BFnri2567_CR126","doi-asserted-by":"publisher","first-page":"8666","DOI":"10.1128\/JVI.00682-07","volume":"81","author":"HJ Kueng","year":"2007","unstructured":"Kueng, H. J. et al. General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines. J. Virol. 81, 8666\u20138676 (2007).","journal-title":"J. Virol."},{"key":"BFnri2567_CR127","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0005-2736(81)90512-5","volume":"645","author":"EG Trams","year":"1981","unstructured":"Trams, E. G., Lauter, C. J., Salem, N. Jr & Heine, U. Exfoliation of membrane ecto-enzymes in the form of micro-vesicles. Biochim. Biophys. Acta 645, 63\u201370 (1981).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnri2567_CR128","doi-asserted-by":"publisher","first-page":"10592","DOI":"10.1073\/pnas.1831413100","volume":"100","author":"SJ Gould","year":"2003","unstructured":"Gould, S. J., Booth, A. M. & Hildreth, J. E. The Trojan exosome hypothesis. Proc. Natl Acad. Sci. USA 100, 10592\u201310597 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2567_CR129","doi-asserted-by":"publisher","first-page":"9683","DOI":"10.1073\/pnas.0308413101","volume":"101","author":"B Fevrier","year":"2004","unstructured":"Fevrier, B. et al. Cells release prions in association with exosomes. Proc. Natl Acad. Sci. USA 101, 9683\u20139688 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2567_CR130","doi-asserted-by":"publisher","first-page":"11172","DOI":"10.1073\/pnas.0603838103","volume":"103","author":"L Rajendran","year":"2006","unstructured":"Rajendran, L. et al. Alzheimer's disease \u03b2-amyloid peptides are released in association with exosomes. Proc. Natl Acad. Sci. USA 103, 11172\u201311177 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2567_CR131","doi-asserted-by":"publisher","first-page":"3850","DOI":"10.1210\/en.2006-1479","volume":"148","author":"N Aoki","year":"2007","unstructured":"Aoki, N. et al. Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redox- and hormone-dependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles. Endocrinology 148, 3850\u20133862 (2007).","journal-title":"Endocrinology"},{"key":"BFnri2567_CR132","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1189\/jlb.0206094","volume":"80","author":"N Chaput","year":"2006","unstructured":"Chaput, N. et al. Dendritic cell derived-exosomes: biology and clinical implementations. J. Leukoc. Biol. 80, 471\u2013478 (2006).","journal-title":"J. Leukoc. Biol."},{"key":"BFnri2567_CR133","doi-asserted-by":"publisher","first-page":"4646","DOI":"10.1021\/pr070192y","volume":"6","author":"DS Choi","year":"2007","unstructured":"Choi, D. S. et al. Proteomic analysis of microvesicles derived from human colorectal cancer cells. J. Proteome Res. 6, 4646\u20134655 (2007).","journal-title":"J. Proteome Res."},{"key":"BFnri2567_CR134","doi-asserted-by":"publisher","first-page":"5157","DOI":"10.1021\/pr8004887","volume":"7","author":"J Conde-Vancells","year":"2008","unstructured":"Conde-Vancells, J. et al. Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J. Proteome Res. 7, 5157\u20135166 (2008).","journal-title":"J. Proteome Res."},{"key":"BFnri2567_CR135","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.mcn.2005.12.003","volume":"31","author":"J Faure","year":"2006","unstructured":"Faure, J. et al. Exosomes are released by cultured cortical neurones. Mol. Cell. Neurosci. 31, 642\u2013648 (2006).","journal-title":"Mol. Cell. Neurosci."},{"key":"BFnri2567_CR136","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.4049\/jimmunol.175.4.2237","volume":"175","author":"I Potolicchio","year":"2005","unstructured":"Potolicchio, I. et al. Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism. J. Immunol. 175, 2237\u20132243 (2005).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR137","doi-asserted-by":"publisher","first-page":"4019","DOI":"10.1002\/pmic.200400876","volume":"4","author":"R Mears","year":"2004","unstructured":"Mears, R. et al. Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Proteomics 4, 4019\u20134031 (2004).","journal-title":"Proteomics"},{"key":"BFnri2567_CR138","doi-asserted-by":"publisher","first-page":"868","DOI":"10.4049\/jimmunol.166.2.868","volume":"166","author":"D Skokos","year":"2001","unstructured":"Skokos, D. et al. Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes. J. Immunol. 166, 868\u2013876 (2001).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR139","doi-asserted-by":"publisher","first-page":"10963","DOI":"10.1074\/jbc.M207550200","volume":"278","author":"R Wubbolts","year":"2003","unstructured":"Wubbolts, R. et al. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J. Biol. Chem. 278, 10963\u201310972 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnri2567_CR140","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1016\/S0002-9440(10)63739-X","volume":"164","author":"JP Hegmans","year":"2004","unstructured":"Hegmans, J. P. et al. Proteomic analysis of exosomes secreted by human mesothelioma cells. Am. J. Pathol. 164, 1807\u20131815 (2004).","journal-title":"Am. J. Pathol."},{"key":"BFnri2567_CR141","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1165\/rcmb.2003-0238OC","volume":"31","author":"MP Bard","year":"2004","unstructured":"Bard, M. P. et al. Proteomic analysis of exosomes isolated from human malignant pleural effusions. Am. J. Respir. Cell Mol. Biol. 31, 114\u2013121 (2004).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"BFnri2567_CR142","doi-asserted-by":"crossref","unstructured":"Thery, C., Amigorena, S., Raposo, G. & Clayton, A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc. Cell Biol. Chapter 3, Unit 3 22 (2006).","DOI":"10.1002\/0471143030.cb0322s30"},{"key":"BFnri2567_CR143","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0014-4827(03)00055-7","volume":"285","author":"O Gasser","year":"2003","unstructured":"Gasser, O. et al. Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils. Exp. Cell Res. 285, 243\u2013257 (2003).","journal-title":"Exp. Cell Res."},{"key":"BFnri2567_CR144","doi-asserted-by":"publisher","first-page":"7309","DOI":"10.4049\/jimmunol.166.12.7309","volume":"166","author":"C Thery","year":"2001","unstructured":"Thery, C. et al. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J. Immunol. 166, 7309\u20137318 (2001).","journal-title":"J. Immunol."},{"key":"BFnri2567_CR145","unstructured":"Buschow, S. I. et al. MHC II in dendritic cells is sorted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways. Traffic (in the press)."}],"container-title":["Nature Reviews Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nri2567.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nri2567","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nri2567.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T06:42:39Z","timestamp":1710398559000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nri2567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,5]]},"references-count":145,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["BFnri2567"],"URL":"https:\/\/doi.org\/10.1038\/nri2567","relation":{},"ISSN":["1474-1733","1474-1741"],"issn-type":[{"value":"1474-1733","type":"print"},{"value":"1474-1741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,5]]}}}