{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:59:07Z","timestamp":1778745547493,"version":"3.51.4"},"reference-count":116,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Immunol"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1038\/nri2657","type":"journal-article","created":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T09:29:47Z","timestamp":1259141387000},"page":"823-832","source":"Crossref","is-referenced-by-count":313,"title":["Naive T cell homeostasis: from awareness of space to a sense of place"],"prefix":"10.1038","volume":"9","author":[{"given":"Kensuke","family":"Takada","sequence":"first","affiliation":[]},{"given":"Stephen C.","family":"Jameson","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFnri2657_CR1","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/S1286-4579(02)01571-X","volume":"4","author":"JR Dorfman","year":"2002","unstructured":"Dorfman, J. R. & Germain, R. N. MHC-dependent survival of naive T cells? A complicated answer to a simple question. Microbes Infect. 4, 547\u2013554 (2002).","journal-title":"Microbes Infect."},{"key":"BFnri2657_CR2","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nri853","volume":"2","author":"SC Jameson","year":"2002","unstructured":"Jameson, S. C. Maintaining the norm: T-cell homeostasis. Nature Rev. Immunol. 2, 547\u2013556 (2002).","journal-title":"Nature Rev. Immunol."},{"key":"BFnri2657_CR3","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.smim.2005.02.002","volume":"17","author":"AR Almeida","year":"2005","unstructured":"Almeida, A. R., Rocha, B., Freitas, A. A. & Tanchot, C. Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells. Semin. Immunol. 17, 239\u2013249 (2005).","journal-title":"Semin. Immunol."},{"key":"BFnri2657_CR4","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","volume":"29","author":"CD Surh","year":"2008","unstructured":"Surh, C. D. & Sprent, J. Homeostasis of naive and memory T cells. Immunity 29, 848\u2013862 (2008).","journal-title":"Immunity"},{"key":"BFnri2657_CR5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1146\/annurev.immunol.21.120601.141107","volume":"21","author":"TK Starr","year":"2003","unstructured":"Starr, T. K., Jameson, S. C. & Hogquist, K. A. Positive and negative selection of T cells. Annu. Rev. Immunol. 21, 139\u2013176 (2003).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnri2657_CR6","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1084\/jem.188.10.1867","volume":"188","author":"GM Davey","year":"1998","unstructured":"Davey, G. M. et al. Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells. J. Exp. Med. 188, 1867\u20131874 (1998).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR7","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S1074-7613(00)80036-9","volume":"10","author":"B Lucas","year":"1999","unstructured":"Lucas, B., Stefanova, I., Yasutomo, K., Dautigny, N. & Germain, R. N. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. Immunity 10, 367\u2013376 (1999).","journal-title":"Immunity"},{"key":"BFnri2657_CR8","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/1074-7613(94)90038-8","volume":"1","author":"NS van Oers","year":"1994","unstructured":"van Oers, N. S., Killeen, N. & Weiss, A. ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR\u03b6 in murine thymocytes and lymph node T cells. Immunity 1, 675\u2013685 (1994).","journal-title":"Immunity"},{"key":"BFnri2657_CR9","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/79783","volume":"1","author":"JR Dorfman","year":"2000","unstructured":"Dorfman, J. R., Stefanova, I., Yasutomo, K. & Germain, R. N. CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling. Nature Immunol. 1, 329\u2013335 (2000).","journal-title":"Nature Immunol."},{"key":"BFnri2657_CR10","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1084\/jem.191.2.355","volume":"191","author":"D Witherden","year":"2000","unstructured":"Witherden, D. et al. Tetracycline-controllable selection of CD4+ T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules. J. Exp. Med. 191, 355\u2013364 (2000).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR11","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1084\/jem.186.8.1223","volume":"186","author":"T Brocker","year":"1997","unstructured":"Brocker, T. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J. Exp. Med. 186, 1223\u20131232 (1997).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR12","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1084\/jem.186.8.1269","volume":"186","author":"J Kirberg","year":"1997","unstructured":"Kirberg, J., Berns, A. & von Boehmer, H. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J. Exp. Med. 186, 1269\u20131275 (1997).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR13","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.4049\/jimmunol.160.8.3705","volume":"160","author":"D Nesic","year":"1998","unstructured":"Nesic, D. & Vukmanovic, S. MHC class I is required for peripheral accumulation of CD8+ thymic emigrants. J. Immunol. 160, 3705\u20133712 (1998).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR14","doi-asserted-by":"publisher","first-page":"2917","DOI":"10.1002\/eji.200324273","volume":"33","author":"MA Markiewicz","year":"2003","unstructured":"Markiewicz, M. A., Brown, I. & Gajewski, T. F. Death of peripheral CD8+ T cells in the absence of MHC class I is Fas-dependent and not blocked by Bcl-xL . Eur. J. Immunol. 33, 2917\u20132926 (2003).","journal-title":"Eur. J. Immunol."},{"key":"BFnri2657_CR15","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1073\/pnas.95.6.3065","volume":"95","author":"MA Markiewicz","year":"1998","unstructured":"Markiewicz, M. A. et al. Long-term T cell memory requires the surface expression of self-peptide\/major histocompatibility complex molecules. Proc. Natl Acad. Sci. USA 95, 3065\u20133070 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2657_CR16","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1126\/science.286.5443.1377","volume":"286","author":"K Murali-Krishna","year":"1999","unstructured":"Murali-Krishna, K. et al. Persistence of memory CD8 T cells in MHC class I-deficient mice. Science 286, 1377\u20131381 (1999).","journal-title":"Science"},{"key":"BFnri2657_CR17","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S1074-7613(00)80317-9","volume":"5","author":"S Takeda","year":"1996","unstructured":"Takeda, S., Rodewald, H. R., Arakawa, H., Bluethmann, H. & Shimizu, T. MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span. Immunity 5, 217\u2013228 (1996).","journal-title":"Immunity"},{"key":"BFnri2657_CR18","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1126\/science.276.5321.2057","volume":"276","author":"C Tanchot","year":"1997","unstructured":"Tanchot, C., Lemonnier, F. A., Perarnau, B., Freitas, A. A. & Rocha, B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276, 2057\u20132062 (1997). References 17 and 18 set the stage for appreciating a role for self-peptide\u2013MHC complexes in maintaining naive T cell homeostasis.","journal-title":"Science"},{"key":"BFnri2657_CR19","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1084\/jem.20030963","volume":"198","author":"I Grandjean","year":"2003","unstructured":"Grandjean, I. et al. Are major histocompatibility complex molecules involved in the survival of naive CD4+ T cells? J. Exp. Med. 198, 1089\u20131102 (2003).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR20","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.4049\/jimmunol.165.5.2458","volume":"165","author":"SR Clarke","year":"2000","unstructured":"Clarke, S. R. & Rudensky, A. Y. Survival and homeostatic proliferation of naive peripheral CD4+ T cells in the absence of self peptide:MHC complexes. J. Immunol. 165, 2458\u20132464 (2000).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR21","doi-asserted-by":"publisher","first-page":"7181","DOI":"10.1073\/pnas.0608299104","volume":"104","author":"UB Fischer","year":"2007","unstructured":"Fischer, U. B. et al. MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo. Proc. Natl Acad. Sci. USA 104, 7181\u20137186 (2007).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2657_CR22","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1182\/blood-2006-01-0017","volume":"108","author":"B Martin","year":"2006","unstructured":"Martin, B., Becourt, C., Bienvenu, B. & Lucas, B. Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment. Blood 108, 270\u2013277 (2006).","journal-title":"Blood"},{"key":"BFnri2657_CR23","doi-asserted-by":"publisher","first-page":"12492","DOI":"10.1073\/pnas.95.21.12492","volume":"95","author":"Y Vugmeyster","year":"1998","unstructured":"Vugmeyster, Y. et al. Major histocompatibility complex (MHC) class I KbDb\u2212\/\u2212 deficient mice possess functional CD8+ T cells and natural killer cells. Proc. Natl Acad. Sci. USA 95, 12492\u201312497 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2657_CR24","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1084\/jem.20082553","volume":"206","author":"K Takada","year":"2009","unstructured":"Takada, K. & Jameson, S. C. Self class-I MHC molecules support survival of na\u00efve CD8 T cells but depress their functional sensitivity through regulation of CD8 expression levels. J. Exp. Med. 206, 2253\u20132269 (2009).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR25","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1126\/science.1124228","volume":"312","author":"J Hataye","year":"2006","unstructured":"Hataye, J., Moon, J. J., Khoruts, A., Reilly, C. & Jenkins, M. K. Naive and memory CD4+ T cell survival controlled by clonal abundance. Science 312, 114\u2013116 (2006). A pioneering study that described the effects of precursor cell number on the maintenance of naive and memory T cells in non-lymphopenic hosts.","journal-title":"Science"},{"key":"BFnri2657_CR26","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1073\/pnas.0334572100","volume":"100","author":"CT Moses","year":"2003","unstructured":"Moses, C. T., Thorstenson, K. M., Jameson, S. C. & Khoruts, A. Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells. Proc. Natl Acad. Sci. USA 100, 1185\u20131190 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2657_CR27","doi-asserted-by":"publisher","first-page":"3874","DOI":"10.1073\/pnas.0400606101","volume":"101","author":"B Min","year":"2004","unstructured":"Min, B., Foucras, G., Meier-Schellersheim, M. & Paul, W. E. Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire. Proc. Natl Acad. Sci. USA 101, 3874\u20133879 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2657_CR28","doi-asserted-by":"publisher","first-page":"672","DOI":"10.4049\/jimmunol.170.2.672","volume":"170","author":"AE Troy","year":"2003","unstructured":"Troy, A. E. & Shen, H. Cutting edge: homeostatic proliferation of peripheral T lymphocytes is regulated by clonal competition. J. Immunol. 170, 672\u2013676 (2003).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR29","doi-asserted-by":"publisher","first-page":"5232","DOI":"10.4049\/jimmunol.0804071","volume":"182","author":"C Leitao","year":"2009","unstructured":"Leitao, C., Freitas, A. A. & Garcia, S. The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool. J. Immunol. 182, 5232\u20135239 (2009).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR30","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.immuni.2007.07.007","volume":"27","author":"JJ Moon","year":"2007","unstructured":"Moon, J. J. et al. Naive CD4+ T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27, 203\u2013213 (2007).","journal-title":"Immunity"},{"key":"BFnri2657_CR31","doi-asserted-by":"publisher","first-page":"40","DOI":"10.4049\/jimmunol.172.1.40","volume":"172","author":"WC Kieper","year":"2004","unstructured":"Kieper, W. C., Burghardt, J. T. & Surh, C. D. A role for TCR affinity in regulating naive T cell homeostasis. J. Immunol. 172, 40\u201344 (2004).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR32","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1084\/jem.20052174","volume":"203","author":"Y Hao","year":"2006","unstructured":"Hao, Y., Legrand, N. & Freitas, A. A. The clone size of peripheral CD8 T cells is regulated by TCR promiscuity. J. Exp. Med. 203, 1643\u20131649 (2006).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR33","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1084\/jem.20070467","volume":"205","author":"F Agenes","year":"2008","unstructured":"Agenes, F., Dangy, J. P. & Kirberg, J. T cell receptor contact to restricting MHC molecules is a prerequisite for peripheral interclonal T cell competition. J. Exp. Med. 205, 2735\u20132743 (2008).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR34","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1084\/jem.194.9.1253","volume":"194","author":"K Smith","year":"2001","unstructured":"Smith, K. et al. Sensory adaptation in naive peripheral CD4 T cells. J. Exp. Med. 194, 1253\u20131261 (2001).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR35","doi-asserted-by":"publisher","first-page":"5464","DOI":"10.4049\/jimmunol.166.9.5464","volume":"166","author":"HS Azzam","year":"2001","unstructured":"Azzam, H. S. et al. Fine tuning of TCR signaling by CD5. J. Immunol. 166, 5464\u20135472 (2001).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR36","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1074-7613(01)00170-4","volume":"15","author":"N Labrecque","year":"2001","unstructured":"Labrecque, N. et al. How much TCR does a T cell need? Immunity 15, 71\u201382 (2001).","journal-title":"Immunity"},{"key":"BFnri2657_CR37","doi-asserted-by":"publisher","first-page":"8744","DOI":"10.1073\/pnas.141218898","volume":"98","author":"B Polic","year":"2001","unstructured":"Polic, B., Kunkel, D., Scheffold, A. & Rajewsky, K. How \u03b1\u03b2 T cells deal with induced TCR\u03b1 ablation. Proc. Natl Acad. Sci. USA 98, 8744\u20138749 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2657_CR38","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1126\/science.290.5489.127","volume":"290","author":"B Seddon","year":"2000","unstructured":"Seddon, B., Legname, G., Tomlinson, P. & Zamoyska, R. Long-term survival but impaired homeostatic proliferation of naive T cells in the absence of p56lck. Science 290, 127\u2013131 (2000). References 36\u201338 helped to dissect the role of TCR interactions in promoting T cell maintenance and LIP.","journal-title":"Science"},{"key":"BFnri2657_CR39","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.4049\/jimmunol.169.6.2997","volume":"169","author":"B Seddon","year":"2002","unstructured":"Seddon, B. & Zamoyska, R. TCR signals mediated by Src family kinases are essential for the survival of naive T cells. J. Immunol. 169, 2997\u20133005 (2002).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR40","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nature01146","volume":"420","author":"I Stefanova","year":"2002","unstructured":"Stefanova, I., Dorfman, J. R. & Germain, R. N. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature 420, 429\u2013434 (2002).","journal-title":"Nature"},{"key":"BFnri2657_CR41","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature03391","volume":"434","author":"M Krogsgaard","year":"2005","unstructured":"Krogsgaard, M. et al. Agonist\/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature 434, 238\u2013243 (2005).","journal-title":"Nature"},{"key":"BFnri2657_CR42","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1084\/jem.20062610","volume":"204","author":"PP Yachi","year":"2007","unstructured":"Yachi, P. P., Lotz, C., Ampudia, J. & Gascoigne, N. R. T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J. Exp. Med. 204, 2747\u20132757 (2007).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR43","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1126\/science.7542801","volume":"269","author":"A Tarakhovsky","year":"1995","unstructured":"Tarakhovsky, A. et al. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269, 535\u2013537 (1995).","journal-title":"Science"},{"key":"BFnri2657_CR44","doi-asserted-by":"publisher","first-page":"4829","DOI":"10.4049\/jimmunol.175.8.4829","volume":"175","author":"A Jabbari","year":"2005","unstructured":"Jabbari, A. & Harty, J. T. Cutting edge: differential self-peptide\/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation. J. Immunol. 175, 4829\u20134833 (2005).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR45","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S1074-7613(02)00417-X","volume":"17","author":"A Bhandoola","year":"2002","unstructured":"Bhandoola, A. et al. Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4+ T cells: evidence from a lymphopenic T cell model. Immunity 17, 425\u2013436 (2002).","journal-title":"Immunity"},{"key":"BFnri2657_CR46","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1146\/annurev.immunol.22.012703.104554","volume":"22","author":"P Marrack","year":"2004","unstructured":"Marrack, P. & Kappler, J. Control of T cell viability. Annu. Rev. Immunol. 22, 765\u2013787 (2004).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnri2657_CR47","doi-asserted-by":"publisher","first-page":"6869","DOI":"10.4049\/jimmunol.167.12.6869","volume":"167","author":"JC Rathmell","year":"2001","unstructured":"Rathmell, J. C., Farkash, E. A., Gao, W. & Thompson, C. B. IL-7 enhances the survival and maintains the size of naive T cells. J. Immunol. 167, 6869\u20136876 (2001).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR48","doi-asserted-by":"publisher","first-page":"7699","DOI":"10.4049\/jimmunol.181.11.7699","volume":"181","author":"Y Rochman","year":"2008","unstructured":"Rochman, Y. & Leonard, W. J. The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis. J. Immunol. 181, 7699\u20137705 (2008).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR49","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1093\/intimm\/13.6.763","volume":"13","author":"L Vivien","year":"2001","unstructured":"Vivien, L., Benoist, C. & Mathis, D. T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo. Int. Immunol. 13, 763\u2013768 (2001).","journal-title":"Int. Immunol."},{"key":"BFnri2657_CR50","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/80868","volume":"1","author":"KS Schluns","year":"2000","unstructured":"Schluns, K. S., Kieper, W. C., Jameson, S. C. & Lefrancois, L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nature Immunol. 1, 426\u2013432 (2000).","journal-title":"Nature Immunol."},{"key":"BFnri2657_CR51","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1002\/(SICI)1521-4141(199810)28:10<3057::AID-IMMU3057>3.0.CO;2-Z","volume":"28","author":"J Hassan","year":"1998","unstructured":"Hassan, J. & Reen, D. J. IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells. Eur. J. Immunol. 28, 3057\u20133065 (1998).","journal-title":"Eur. J. Immunol."},{"key":"BFnri2657_CR52","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1084\/jem.20030735","volume":"198","author":"RM Kondrack","year":"2003","unstructured":"Kondrack, R. M. et al. Interleukin 7 regulates the survival and generation of memory CD4 cells. J. Exp. Med. 198, 1797\u20131806 (2003).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR53","doi-asserted-by":"publisher","first-page":"8732","DOI":"10.1073\/pnas.161126098","volume":"98","author":"JT Tan","year":"2001","unstructured":"Tan, J. T. et al. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc. Natl Acad. Sci. USA 98, 8732\u20138737 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2657_CR54","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1093\/intimm\/7.3.401","volume":"7","author":"E Mertsching","year":"1995","unstructured":"Mertsching, E., Burdet, C. & Ceredig, R. IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro. Int. Immunol. 7, 401\u2013414 (1995).","journal-title":"Int. Immunol."},{"key":"BFnri2657_CR55","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1084\/jem.20020067","volume":"195","author":"WC Kieper","year":"2002","unstructured":"Kieper, W. C. et al. Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J. Exp. Med. 195, 1533\u20131539 (2002).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR56","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nri2580","volume":"9","author":"Y Rochman","year":"2009","unstructured":"Rochman, Y., Spolski, R. & Leonard, W. J. New insights into the regulation of T cells by \u03b3c family cytokines. Nature Rev. Immunol. 9, 480\u2013490 (2009).","journal-title":"Nature Rev. Immunol."},{"key":"BFnri2657_CR57","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.cytogfr.2005.05.004","volume":"16","author":"Q Jiang","year":"2005","unstructured":"Jiang, Q. et al. Cell biology of IL-7, a key lymphotrophin. Cytokine Growth Factor Rev. 16, 513\u2013533 (2005).","journal-title":"Cytokine Growth Factor Rev."},{"key":"BFnri2657_CR58","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1084\/jem.20070618","volume":"204","author":"S Wojciechowski","year":"2007","unstructured":"Wojciechowski, S. et al. Bim\/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J. Exp. Med. 204, 1665\u20131675 (2007).","journal-title":"Exp. Med."},{"key":"BFnri2657_CR59","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S0092-8674(00)80291-3","volume":"89","author":"K Akashi","year":"1997","unstructured":"Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R. & Weissman, I. L. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89, 1033\u20131041 (1997).","journal-title":"Cell"},{"key":"BFnri2657_CR60","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/S0092-8674(00)80289-5","volume":"89","author":"E Maraskovsky","year":"1997","unstructured":"Maraskovsky, E. et al. Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1\u2212\/\u2212 mice. Cell 89, 1011\u20131019 (1997).","journal-title":"Cell"},{"key":"BFnri2657_CR61","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1084\/jem.20041328","volume":"200","author":"M Pellegrini","year":"2004","unstructured":"Pellegrini, M. et al. Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice. J. Exp. Med. 200, 1189\u20131195 (2004).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR62","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1182\/blood-2007-06-096297","volume":"111","author":"JA Wofford","year":"2008","unstructured":"Wofford, J. A., Wieman, H. L., Jacobs, S. R., Zhao, Y. & Rathmell, J. C. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood 111, 2101\u20132111 (2008).","journal-title":"Blood"},{"key":"BFnri2657_CR63","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1038\/onc.2008.29","volume":"27","author":"BM Burgering","year":"2008","unstructured":"Burgering, B. M. A brief introduction to FOXOlogy. Oncogene 27, 2258\u20132262 (2008).","journal-title":"Oncogene"},{"key":"BFnri2657_CR64","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nature04882","volume":"442","author":"CM Carlson","year":"2006","unstructured":"Carlson, C. M. et al. Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature 442, 299\u2013302 (2006).","journal-title":"Nature"},{"key":"BFnri2657_CR65","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/ni.1603","volume":"9","author":"LV Sinclair","year":"2008","unstructured":"Sinclair, L. V. et al. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nature Immunol. 9, 513\u2013521 (2008).","journal-title":"Nature Immunol."},{"key":"BFnri2657_CR66","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/ni.1689","volume":"10","author":"YM Kerdiles","year":"2009","unstructured":"Kerdiles, Y. M. et al. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nature Immunol. 10, 176\u2013184 (2009).","journal-title":"Nature Immunol."},{"key":"BFnri2657_CR67","doi-asserted-by":"publisher","first-page":"6571","DOI":"10.4049\/jimmunol.174.11.6571","volume":"174","author":"TJ Fry","year":"2005","unstructured":"Fry, T. J. & Mackall, C. L. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J. Immunol. 174, 6571\u20136576 (2005).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR68","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1084\/jem.20020033","volume":"195","author":"AW Goldrath","year":"2002","unstructured":"Goldrath, A. W. et al. Cytokine requirements for acute and basal homeostatic proliferation of naive and memory CD8+ T cells. J. Exp. Med. 195, 1515\u20131522 (2002).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR69","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1084\/jem.20071681","volume":"205","author":"C Sportes","year":"2008","unstructured":"Sportes, C. et al. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J. Exp. Med. 205, 1701\u20131714 (2008).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR70","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.4049\/jimmunol.167.4.1970","volume":"167","author":"J Hassan","year":"2001","unstructured":"Hassan, J. & Reen, D. J. Human recent thymic emigrants \u2014 identification, expansion, and survival characteristics. J. Immunol. 167, 1970\u20131976 (2001).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR71","doi-asserted-by":"publisher","first-page":"9277","DOI":"10.1073\/pnas.161272698","volume":"98","author":"V Dardalhon","year":"2001","unstructured":"Dardalhon, V. et al. IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells. Proc. Natl Acad. Sci. USA 98, 9277\u20139282 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2657_CR72","doi-asserted-by":"publisher","first-page":"5635","DOI":"10.1182\/blood-2008-08-173658","volume":"113","author":"SJ Opiela","year":"2009","unstructured":"Opiela, S. J., Koru-Sengul, T. & Adkins, B. Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants. Blood 113, 5635\u20135643 (2009).","journal-title":"Blood"},{"key":"BFnri2657_CR73","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1084\/jem.20051520","volume":"203","author":"WQ Li","year":"2006","unstructured":"Li, W. Q. et al. IL-7 promotes T cell proliferation through destabilization of p27Kip1. J. Exp. Med. 203, 573\u2013582 (2006).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR74","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1182\/blood-2006-06-027912","volume":"109","author":"L Swainson","year":"2007","unstructured":"Swainson, L. et al. IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway. Blood 109, 1034\u20131042 (2007).","journal-title":"Blood"},{"key":"BFnri2657_CR75","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.immuni.2004.07.016","volume":"21","author":"JH Park","year":"2004","unstructured":"Park, J. H. et al. Suppression of IL7R\u03b1 transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 21, 289\u2013302 (2004).","journal-title":"Immunity"},{"key":"BFnri2657_CR76","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1038\/ni1512","volume":"8","author":"JH Park","year":"2007","unstructured":"Park, J. H. et al. 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nature Immunol. 8, 1049\u20131059 (2007). References 75 and 76 revealed the influence that IL-7R signalling has on its own expression and that of the T cell co-receptor CD8.","journal-title":"Nature Immunol."},{"key":"BFnri2657_CR77","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1038\/ng2106","volume":"39","author":"F Lundmark","year":"2007","unstructured":"Lundmark, F. et al. Variation in interleukin 7 receptor \u03b1 chain (IL7R) influences risk of multiple sclerosis. Nature Genet. 39, 1108\u20131113 (2007).","journal-title":"Nature Genet."},{"key":"BFnri2657_CR78","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1084\/jem.20021417","volume":"197","author":"R Yucel","year":"2003","unstructured":"Yucel, R., Karsunky, H., Klein-Hitpass, L. & Moroy, T. The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4\/CD8 lineage decision in the thymus. J. Exp. Med. 197, 831\u2013844 (2003).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR79","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.immuni.2009.02.003","volume":"30","author":"W Ouyang","year":"2009","unstructured":"Ouyang, W., Beckett, O., Flavell, R. A. & Li, M. O. An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity 30, 358\u2013371 (2009). Along with references 65 and 66, this study revealed a key role for FOXO1 and PI3K activation (which negatively regulates FOXO1 expression) in T cell trafficking and IL-7 reactivity.","journal-title":"Immunity"},{"key":"BFnri2657_CR80","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nrg1879","volume":"7","author":"JA Engelman","year":"2006","unstructured":"Engelman, J. A., Luo, J. & Cantley, L. C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nature Rev. Genet. 7, 606\u2013619 (2006).","journal-title":"Nature Rev. Genet."},{"key":"BFnri2657_CR81","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1084\/jem.20070740","volume":"204","author":"JH Cho","year":"2007","unstructured":"Cho, J. H. et al. An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2. J. Exp. Med. 204, 1787\u20131801 (2007).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR82","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.immuni.2006.10.011","volume":"25","author":"M Bajenoff","year":"2006","unstructured":"Bajenoff, M. et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25, 989\u20131001 (2006).","journal-title":"Immunity"},{"key":"BFnri2657_CR83","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/nri2588","volume":"9","author":"SN Mueller","year":"2009","unstructured":"Mueller, S. N. & Germain, R. N. Stromal cell contributions to the homeostasis and functionality of the immune system. Nature Rev. Immunol. 9, 618\u2013629 (2009).","journal-title":"Nature Rev. Immunol."},{"key":"BFnri2657_CR84","doi-asserted-by":"publisher","first-page":"6711","DOI":"10.4049\/jimmunol.167.12.6711","volume":"167","author":"Z Dai","year":"2001","unstructured":"Dai, Z. & Lakkis, F. G. Cutting edge: Secondary lymphoid organs are essential for maintaining the CD4, but not CD8, naive T cell pool. J. Immunol. 167, 6711\u20136715 (2001).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR85","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.4049\/jimmunol.166.4.2460","volume":"166","author":"W Dummer","year":"2001","unstructured":"Dummer, W., Ernst, B., LeRoy, E., Lee, D. & Surh, C. Autologous regulation of naive T cell homeostasis within the T cell compartment. J. Immunol. 166, 2460\u20132468 (2001).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR86","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/ni1513","volume":"8","author":"A Link","year":"2007","unstructured":"Link, A. et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nature Immunol. 8, 1255\u20131265 (2007). This groundbreaking report revealed the central role of the FRC network in naive T cell maintenance.","journal-title":"Nature Immunol."},{"key":"BFnri2657_CR87","doi-asserted-by":"publisher","first-page":"12694","DOI":"10.1073\/pnas.97.23.12694","volume":"97","author":"SA Luther","year":"2000","unstructured":"Luther, S. A., Tang, H. L., Hyman, P. L., Farr, A. G. & Cyster, J. G. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt\/plt mouse. Proc. Natl Acad. Sci. USA 97, 12694\u201312699 (2000).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2657_CR88","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.4049\/jimmunol.178.5.2973","volume":"178","author":"T Okada","year":"2007","unstructured":"Okada, T. & Cyster, J. G. CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J. Immunol. 178, 2973\u20132978 (2007).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR89","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1084\/jem.20061706","volume":"204","author":"T Worbs","year":"2007","unstructured":"Worbs, T., Mempel, T. R., Bolter, J., von Andrian, U. H. & Forster, R. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J. Exp. Med. 204, 489\u2013495 (2007).","journal-title":"Exp. Med."},{"key":"BFnri2657_CR90","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev.immunol.23.021704.115628","volume":"23","author":"JG Cyster","year":"2004","unstructured":"Cyster, J. G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23, 127\u2013159 (2004).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnri2657_CR91","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.immuni.2007.11.017","volume":"28","author":"TH Pham","year":"2008","unstructured":"Pham, T. H., Okada, T., Matloubian, M., Lo, C. G. & Cyster, J. G. S1P1 receptor signaling overrides retention mediated by G\u03b1i-coupled receptors to promote T cell egress. Immunity 28, 122\u2013133 (2008).","journal-title":"Immunity"},{"key":"BFnri2657_CR92","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1073\/pnas.0809559106","volume":"106","author":"NL Alves","year":"2009","unstructured":"Alves, N. L. et al. Characterization of the thymic IL-7 niche in vivo. Proc. Natl Acad. Sci. USA 106, 1512\u20131517 (2009).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2657_CR93","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/ni.1695","volume":"10","author":"M Guimond","year":"2009","unstructured":"Guimond, M. et al. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nature Immunol. 10, 149\u2013157 (2009). This report uncovered surprising differences in the cell types that produce IL-7 for sustaining CD4+ versus CD8+ T cells and regulatory feedback loops in IL-7 production.","journal-title":"Nature Immunol."},{"key":"BFnri2657_CR94","doi-asserted-by":"publisher","first-page":"7901","DOI":"10.1158\/1078-0432.CCR-05-1346","volume":"11","author":"JW Kim","year":"2005","unstructured":"Kim, J. W., Ferris, R. L. & Whiteside, T. L. Chemokine C receptor 7 expression and protection of circulating CD8+ T lymphocytes from apoptosis. Clin. Cancer Res. 11, 7901\u20137910 (2005).","journal-title":"Clin. Cancer Res."},{"key":"BFnri2657_CR95","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1002\/eji.200425729","volume":"35","author":"RM Cinalli","year":"2005","unstructured":"Cinalli, R. M. et al. T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. Eur. J. Immunol. 35, 786\u2013795 (2005).","journal-title":"Eur. J. Immunol."},{"key":"BFnri2657_CR96","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1006\/cyto.1995.0041","volume":"7","author":"D Clarke","year":"1995","unstructured":"Clarke, D., Katoh, O., Gibbs, R. V., Griffiths, S. D. & Gordon, M. Y. Interaction of interleukin 7 (IL-7) with glycosaminoglycans and its biological relevance. Cytokine 7, 325\u2013330 (1995).","journal-title":"Cytokine"},{"key":"BFnri2657_CR97","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1182\/blood.V93.1.140","volume":"93","author":"LA Borghesi","year":"1999","unstructured":"Borghesi, L. A., Yamashita, Y. & Kincade, P. W. Heparan sulfate proteoglycans mediate interleukin-7-dependent B lymphopoiesis. Blood 93, 140\u2013148 (1999).","journal-title":"Blood"},{"key":"BFnri2657_CR98","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1146\/annurev.immunol.22.012703.104543","volume":"22","author":"A Rot","year":"2004","unstructured":"Rot, A. & von Andrian, U. H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu. Rev. Immunol. 22, 891\u2013928 (2004).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnri2657_CR99","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev.immunol.23.021704.115628","volume":"23","author":"JG Cyster","year":"2005","unstructured":"Cyster, J. G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23, 127\u2013159 (2005).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnri2657_CR100","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.immuni.2006.11.002","volume":"25","author":"TR Mempel","year":"2006","unstructured":"Mempel, T. R., Junt, T. & von Andrian, U. H. Rulers over randomness: stroma cells guide lymphocyte migration in lymph nodes. Immunity 25, 867\u2013869 (2006).","journal-title":"Immunity"},{"key":"BFnri2657_CR101","doi-asserted-by":"publisher","first-page":"15430","DOI":"10.1073\/pnas.0702579104","volume":"104","author":"SN Mueller","year":"2007","unstructured":"Mueller, S. N. et al. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc. Natl Acad. Sci. USA 104, 15430\u201315435 (2007).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2657_CR102","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1126\/science.1144830","volume":"317","author":"SN Mueller","year":"2007","unstructured":"Mueller, S. N. et al. Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science 317, 670\u2013674 (2007). This study revealed how inflammatory immune responses lead to loss of homeostatic chemokine expression in lymphoid sites, with a resulting breakdown in naive T cell trafficking.","journal-title":"Science"},{"key":"BFnri2657_CR103","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/j.1600-065X.2008.00657.x","volume":"224","author":"SN Mueller","year":"2008","unstructured":"Mueller, S. N. & Ahmed, R. Lymphoid stroma in the initiation and control of immune responses. Immunol. Rev. 224, 284\u2013294 (2008).","journal-title":"Immunol. Rev."},{"key":"BFnri2657_CR104","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/ni.1605","volume":"9","author":"E Scandella","year":"2008","unstructured":"Scandella, E. et al. Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nature Immunol. 9, 667\u2013675 (2008).","journal-title":"Nature Immunol."},{"key":"BFnri2657_CR105","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.it.2007.05.004","volume":"28","author":"MH Cheng","year":"2007","unstructured":"Cheng, M. H., Shum, A. K. & Anderson, M. S. What's new in the Aire? Trends Immunol. 28, 321\u2013327 (2007).","journal-title":"Trends Immunol."},{"key":"BFnri2657_CR106","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/ni1427","volume":"8","author":"JW Lee","year":"2007","unstructured":"Lee, J. W. et al. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nature Immunol. 8, 181\u2013190 (2007).","journal-title":"Nature Immunol."},{"key":"BFnri2657_CR107","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1126\/science.1159407","volume":"321","author":"JM Gardner","year":"2008","unstructured":"Gardner, J. M. et al. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science 321, 843\u2013847 (2008).","journal-title":"Science"},{"key":"BFnri2657_CR108","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1084\/jem.187.11.1839","volume":"187","author":"SP Berzins","year":"1998","unstructured":"Berzins, S. P., Boyd, R. L. & Miller, J. F. The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool. J. Exp. Med. 187, 1839\u20131848 (1998).","journal-title":"J. Exp. Med."},{"key":"BFnri2657_CR109","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.4049\/jimmunol.175.4.2270","volume":"175","author":"FJ Schnell","year":"2005","unstructured":"Schnell, F. J. & Kersh, G. J. Control of recent thymic emigrant survival by positive selection signals and early growth response gene 1. J. Immunol. 175, 2270\u20132277 (2005).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR110","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1172\/JCI200522492","volume":"115","author":"FT Hakim","year":"2005","unstructured":"Hakim, F. T. et al. Age-dependent incidence, time course, and consequences of thymic renewal in adults. J. Clin. Invest. 115, 930\u2013939 (2005).","journal-title":"J. Clin. Invest."},{"key":"BFnri2657_CR111","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nri1292","volume":"4","author":"J Nikolich-Zugich","year":"2004","unstructured":"Nikolich-Zugich, J., Slifka, M. K. & Messaoudi, I. The many important facets of T-cell repertoire diversity. Nature Rev. Immunol. 4, 123\u2013132 (2004).","journal-title":"Nature Rev. Immunol."},{"key":"BFnri2657_CR112","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/83381","volume":"7","author":"LA Napolitano","year":"2001","unstructured":"Napolitano, L. A. et al. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nature Med. 7, 73\u201379 (2001).","journal-title":"Nature Med."},{"key":"BFnri2657_CR113","doi-asserted-by":"publisher","first-page":"7265","DOI":"10.4049\/jimmunol.180.11.7265","volume":"180","author":"O Boyman","year":"2008","unstructured":"Boyman, O., Ramsey, C., Kim, D. M., Sprent, J. & Surh, C. D. IL-7\/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia. J. Immunol. 180, 7265\u20137275 (2008).","journal-title":"J. Immunol."},{"key":"BFnri2657_CR114","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.coi.2007.04.015","volume":"19","author":"O Boyman","year":"2007","unstructured":"Boyman, O., Purton, J. F., Surh, C. D. & Sprent, J. Cytokines and T-cell homeostasis. Curr. Opin. Immunol. 19, 320\u2013326 (2007).","journal-title":"Curr. Opin. Immunol."},{"key":"BFnri2657_CR115","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/j.1365-2796.2009.02085.x","volume":"266","author":"CM Capitini","year":"2009","unstructured":"Capitini, C. M., Chisti, A. A. & Mackall, C. L. Modulating T-cell homeostasis with IL-7: preclinical and clinical studies. J. Intern. Med. 266, 141\u2013153 (2009).","journal-title":"J. Intern. Med."},{"key":"BFnri2657_CR116","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1073\/pnas.0712135105","volume":"105","author":"T Calzascia","year":"2008","unstructured":"Calzascia, T. et al. CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proc. Natl Acad. Sci. USA 105, 2999\u20133004 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Nature Reviews Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nri2657.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nri2657","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nri2657.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T17:25:44Z","timestamp":1685208344000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nri2657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":116,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["BFnri2657"],"URL":"https:\/\/doi.org\/10.1038\/nri2657","relation":{},"ISSN":["1474-1733","1474-1741"],"issn-type":[{"value":"1474-1733","type":"print"},{"value":"1474-1741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}