{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T04:35:19Z","timestamp":1772685319502,"version":"3.50.1"},"reference-count":107,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Mol Cell Biol"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1038\/nrm1711","type":"journal-article","created":{"date-parts":[[2006,9,26]],"date-time":"2006-09-26T15:07:03Z","timestamp":1159283223000},"page":"702-714","source":"Crossref","is-referenced-by-count":343,"title":["Proteomics of organelles and large cellular structures"],"prefix":"10.1038","volume":"6","author":[{"given":"John R.","family":"Yates III","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalyn","family":"Gilchrist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn E.","family":"Howell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J. M.","family":"Bergeron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFnrm1711_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1146\/annurev.biophys.33.111502.082538","volume":"33","author":"JR Yates 3rd.","year":"2004","unstructured":"Yates, J. R. 3rd. Mass spectral analysis in proteomics. Annu. Rev. Biophys. Biomol. Struct. 33, 297\u2013316 (2004).","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"BFnrm1711_CR2","doi-asserted-by":"publisher","first-page":"917","DOI":"10.2144\/04366TE01","volume":"36","author":"JR Yates 3rd.","year":"2004","unstructured":"Yates, J. R. 3rd. Mass spectrometry as an emerging tool for systems biology. Biotechniques 36, 917\u2013919 (2004).","journal-title":"Biotechniques"},{"key":"BFnrm1711_CR3","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/13690","volume":"17","author":"SP Gygi","year":"1999","unstructured":"Gygi, S. P. et al. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nature Biotechnol. 17, 994\u2013999 (1999).","journal-title":"Nature Biotechnol."},{"key":"BFnrm1711_CR4","doi-asserted-by":"publisher","first-page":"6591","DOI":"10.1073\/pnas.96.12.6591","volume":"96","author":"Y Oda","year":"1999","unstructured":"Oda, Y., Huang, K., Cross, F. R., Cowburn, D. & Chait, B. T. Accurate quantitation of protein expression and site-specific phosphorylation. Proc. Natl Acad. Sci. USA 96, 6591\u20136596 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm1711_CR5","doi-asserted-by":"publisher","first-page":"4951","DOI":"10.1021\/ac049208j","volume":"76","author":"CC Wu","year":"2004","unstructured":"Wu, C. C., MacCoss, M. J., Howell, K. E., Matthews, D. E. & Yates, J. R. 3rd. Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis. Anal. Chem. 76, 4951\u20134959 (2004).","journal-title":"Anal. Chem."},{"key":"BFnrm1711_CR6","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/85686","volume":"19","author":"MP Washburn","year":"2001","unstructured":"Washburn, M. P., Wolters, D. & Yates, J. R. 3rd. Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nature Biotechnol. 19, 242\u2013247 (2001).","journal-title":"Nature Biotechnol."},{"key":"BFnrm1711_CR7","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/nbt819","volume":"21","author":"CC Wu","year":"2003","unstructured":"Wu, C. C., MacCoss, M. J., Howell, K. E. & Yates, J. R. 3rd. A method for the comprehensive proteomic analysis of membrane proteins. Nature Biotechnol. 21, 532\u2013538 (2003).","journal-title":"Nature Biotechnol."},{"key":"BFnrm1711_CR8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1021\/pr0255248","volume":"1","author":"J Blonder","year":"2002","unstructured":"Blonder, J. et al. Enrichment of integral membrane proteins for proteomic analysis using liquid chromatography\u2013tandem mass spectrometry. J. Proteome Res. 1, 351\u2013360 (2002).","journal-title":"J. Proteome Res."},{"key":"BFnrm1711_CR9","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.tcb.2003.10.006","volume":"13","author":"S Brunet","year":"2003","unstructured":"Brunet, S. et al. Organelle proteomics: looking at less to see more. Trends Cell Biol. 13, 629\u2013638 (2003).","journal-title":"Trends Cell Biol."},{"key":"BFnrm1711_CR10","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1097\/01.TP.0000092494.75313.38","volume":"76","author":"H Peche","year":"2003","unstructured":"Peche, H., Heslan, M., Usal, C., Amigorena, S. & Cuturi, M. C. Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection. Transplantation 76, 1503\u20131510 (2003).","journal-title":"Transplantation"},{"key":"BFnrm1711_CR11","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1084\/jem.183.3.1161","volume":"183","author":"G Raposo","year":"1996","unstructured":"Raposo, G. et al. B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 183, 1161\u20131172 (1996).","journal-title":"J. Exp. Med."},{"key":"BFnrm1711_CR12","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.humimm.2003.08.344","volume":"64","author":"B Riteau","year":"2003","unstructured":"Riteau, B. et al. Exosomes bearing HLA-G are released by melanoma cells. Hum. Immunol. 64, 1064\u20131072 (2003).","journal-title":"Hum. Immunol."},{"key":"BFnrm1711_CR13","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nm0598-594","volume":"4","author":"L Zitvogel","year":"1998","unstructured":"Zitvogel, L. et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nature Med. 4, 594\u2013600 (1998).","journal-title":"Nature Med."},{"key":"BFnrm1711_CR14","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nri855","volume":"2","author":"C Thery","year":"2002","unstructured":"Thery, C., Zitvogel, L. & Amigorena, S. Exosomes: composition, biogenesis and function. Nature Rev. Immunol. 2, 569\u2013579 (2002).","journal-title":"Nature Rev. Immunol."},{"key":"BFnrm1711_CR15","doi-asserted-by":"publisher","first-page":"4019","DOI":"10.1002\/pmic.200400876","volume":"4","author":"R Mears","year":"2004","unstructured":"Mears, R. et al. Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Proteomics 4, 4019\u20134031 (2004).","journal-title":"Proteomics"},{"key":"BFnrm1711_CR16","doi-asserted-by":"publisher","first-page":"13368","DOI":"10.1073\/pnas.0403453101","volume":"101","author":"T Pisitkun","year":"2004","unstructured":"Pisitkun, T., Shen, R. F. & Knepper, M. A. Identification and proteomic profiling of exosomes in human urine. Proc. Natl Acad. Sci. USA 101, 13368\u201313373 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm1711_CR17","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0092-8674(02)00797-3","volume":"110","author":"E Gagnon","year":"2002","unstructured":"Gagnon, E. et al. Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages. Cell 110, 119\u2013131 (2002).","journal-title":"Cell"},{"key":"BFnrm1711_CR18","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/nri1053","volume":"3","author":"M Desjardins","year":"2003","unstructured":"Desjardins, M. ER-mediated phagocytosis: a new membrane for new functions. Nature Rev. Immunol. 3, 280\u2013291 (2003).","journal-title":"Nature Rev. Immunol."},{"key":"BFnrm1711_CR19","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/nature01912","volume":"425","author":"M Houde","year":"2003","unstructured":"Houde, M. et al. Phagosomes are competent organelles for antigen cross-presentation. Nature 425, 402\u2013406 (2003). This study validated the presence of ER proteins in the phagolysosome proteome, which led to a link between ER recruitment and the phenomenon of antigen cross-presentation.","journal-title":"Nature"},{"key":"BFnrm1711_CR20","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.bbrc.2004.05.054","volume":"319","author":"JD Ng Yan Hing","year":"2004","unstructured":"Ng Yan Hing, J. D., Desjardins, M. & Descoteaux, A. Proteomic analysis reveals a role for protein kinase C-a in phagosome maturation. Biochem. Biophys. Res. Commun. 319, 810\u2013816 (2004).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnrm1711_CR21","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1083\/jcb.200205078","volume":"158","author":"S Wasiak","year":"2002","unstructured":"Wasiak, S. et al. Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. J. Cell Biol. 158, 855\u2013862 (2002).","journal-title":"J. Cell Biol."},{"key":"BFnrm1711_CR22","doi-asserted-by":"publisher","first-page":"3833","DOI":"10.1073\/pnas.0308186101","volume":"101","author":"F Blondeau","year":"2004","unstructured":"Blondeau, F. et al. Tandem MS analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling. Proc. Natl Acad. Sci. USA 101, 3833\u20133838 (2004). These authors showed an important function for brain CCVs in recycling synaptic vesicles, which supports a full-fusion model for synaptic vesicle exocytosis. They also identified the novel protein enthoprotin, which has a known link to schizophrenia.","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm1711_CR23","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/sj.embor.7400004","volume":"4","author":"B Ritter","year":"2003","unstructured":"Ritter, B. et al. Identification of a family of endocytic proteins that define a new a-adaptin ear-binding motif. EMBO Rep. 4, 1089\u20131095 (2003).","journal-title":"EMBO Rep."},{"key":"BFnrm1711_CR24","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1038\/sj.emboj.7600378","volume":"23","author":"B Ritter","year":"2004","unstructured":"Ritter, B. et al. Two WXXF-based motifs in NECAPs define the specificity of accessory protein binding to AP-1 and AP-2. EMBO J. 23, 3701\u20133710 (2004).","journal-title":"EMBO J."},{"key":"BFnrm1711_CR25","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1086\/430095","volume":"76","author":"J Pimm","year":"2005","unstructured":"Pimm, J. et al. The epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia. Am. J. Hum. Genet. 76, 902\u2013907 (2005).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrm1711_CR26","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/nbt793","volume":"21","author":"SW Taylor","year":"2003","unstructured":"Taylor, S. W. et al. Characterization of the human heart mitochondrial proteome. Nature Biotechnol. 21, 281\u2013286 (2003).","journal-title":"Nature Biotechnol."},{"key":"BFnrm1711_CR27","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1021\/pr034102a","volume":"3","author":"SP Gaucher","year":"2004","unstructured":"Gaucher, S. P. et al. Expanded coverage of the human heart mitochondrial proteome using multidimensional liquid chromatography coupled with tandem mass spectrometry. J. Proteome Res. 3, 495\u2013505 (2004).","journal-title":"J. Proteome Res."},{"key":"BFnrm1711_CR28","doi-asserted-by":"publisher","first-page":"13207","DOI":"10.1073\/pnas.2135385100","volume":"100","author":"A Sickmann","year":"2003","unstructured":"Sickmann, A. et al. The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl Acad. Sci. USA 100, 13207\u201313212 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm1711_CR29","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0092-8674(03)00926-7","volume":"115","author":"VK Mootha","year":"2003","unstructured":"Mootha, V. K. et al. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115, 629\u2013640 (2003).","journal-title":"Cell"},{"key":"BFnrm1711_CR30","doi-asserted-by":"publisher","first-page":"e160","DOI":"10.1371\/journal.pbio.0020160","volume":"2","author":"H Prokisch","year":"2004","unstructured":"Prokisch, H. et al. Integrative analysis of the mitochondrial proteome in yeast. PLoS Biol. 2, e160 (2004).","journal-title":"PLoS Biol."},{"key":"BFnrm1711_CR31","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1073\/pnas.242716699","volume":"100","author":"VK Mootha","year":"2003","unstructured":"Mootha, V. K. et al. Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics. Proc. Natl Acad. Sci. USA 100, 605\u2013610 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm1711_CR32","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1083\/jcb.200404119","volume":"167","author":"M Marelli","year":"2004","unstructured":"Marelli, M. et al. Quantitative mass spectrometry reveals a role for the GTPase Rho1p in actin organization on the peroxisome membrane. J. Cell Biol. 167, 1099\u20131112 (2004).","journal-title":"J. Cell Biol."},{"key":"BFnrm1711_CR33","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1074\/mcp.M300053-MCP200","volume":"2","author":"B Knoblach","year":"2003","unstructured":"Knoblach, B. et al. ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins. Mol. Cell. Proteomics 2, 1104\u20131119 (2003).","journal-title":"Mol. Cell. Proteomics"},{"key":"BFnrm1711_CR34","doi-asserted-by":"publisher","first-page":"47242","DOI":"10.1074\/jbc.M406644200","volume":"279","author":"L Breuza","year":"2004","unstructured":"Breuza, L. et al. Proteomics of endoplasmic reticulum\u2013Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. J. Biol. Chem. 279, 47242\u201347253 (2004).","journal-title":"J. Biol. Chem."},{"key":"BFnrm1711_CR35","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1083\/jcb.152.3.503","volume":"152","author":"S Otte","year":"2001","unstructured":"Otte, S. et al. Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J. Cell Biol. 152, 503\u2013518 (2001).","journal-title":"J. Cell Biol."},{"key":"BFnrm1711_CR36","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1126\/science.1065224","volume":"294","author":"WJ Belden","year":"2001","unstructured":"Belden, W. J. & Barlowe, C. Role of Erv29p in collecting soluble secretory proteins into ER-derived transport vesicles. Science 294, 1528\u20131531 (2001).","journal-title":"Science"},{"key":"BFnrm1711_CR37","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1002\/1522-2683(20001001)21:16<3441::AID-ELPS3441>3.0.CO;2-G","volume":"21","author":"RS Taylor","year":"2000","unstructured":"Taylor, R. S. et al. Proteomics of rat liver Golgi complex: minor proteins are identified through sequential fractionation. Electrophoresis 21, 3441\u20133459 (2000).","journal-title":"Electrophoresis"},{"key":"BFnrm1711_CR38","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1034\/j.1600-0854.2000.011004.x","volume":"1","author":"CC Wu","year":"2000","unstructured":"Wu, C. C., Yates, J. R. 3rd, Neville, M. C. & Howell, K. E. Proteomic analysis of two functional states of the Golgi complex in mammary epithelial cells. Traffic 1, 769\u2013782 (2000).","journal-title":"Traffic"},{"key":"BFnrm1711_CR39","doi-asserted-by":"publisher","first-page":"5152","DOI":"10.1074\/jbc.M006143200","volume":"276","author":"AW Bell","year":"2001","unstructured":"Bell, A. W. et al. Proteomics characterization of abundant Golgi membrane proteins. J. Biol. Chem. 276, 5152\u20135165 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFnrm1711_CR40","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1091\/mbc.e04-02-0101","volume":"15","author":"CC Wu","year":"2004","unstructured":"Wu, C. C. et al. Organellar proteomics reveals Golgi arginine dimethylation. Mol. Biol. Cell 15, 2907\u20132919 (2004). These authors used MudPIT to study the Golgi proteome, and identified arginine dimethylation as a novel cytoplasmic post-translational modification.","journal-title":"Mol. Biol. Cell"},{"key":"BFnrm1711_CR41","first-page":"963","volume":"1","author":"CC Wu","year":"2000","unstructured":"Wu, C. C. et al. GMx33: a novel family of trans-Golgi proteins identified by proteomics. Traffic 1, 963\u2013975 (2000).","journal-title":"Traffic"},{"key":"BFnrm1711_CR42","first-page":"1010","volume":"23","author":"AB Novikoff","year":"1964","unstructured":"Novikoff, A. B., Essner, E. & Quintana, N. Golgi apparatus and lysosomes. Fed. Proc. 23, 1010\u20131022 (1964).","journal-title":"Fed. Proc."},{"key":"BFnrm1711_CR43","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1083\/jcb.144.6.1135","volume":"144","author":"MS Ladinsky","year":"1999","unstructured":"Ladinsky, M. S., Mastronarde, D. N., McIntosh, J. R., Howell, K. E. & Staehelin, L. A. Golgi structure in three dimensions: functional insights from the normal rat kidney cell. J. Cell Biol. 144, 1135\u20131149 (1999).","journal-title":"J. Cell Biol."},{"key":"BFnrm1711_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0079-6336(11)80025-2","volume":"21","author":"CE Smith","year":"1990","unstructured":"Smith, C. E., Hermo, L., Fazel, A., Lalli, M. F. & Bergeron, J. J. Ultrastructural distribution of NADPase within the Golgi apparatus and lysosomes of mammalian cells. Prog. Histochem. Cytochem. 21, 1\u2013120 (1990).","journal-title":"Prog. Histochem. Cytochem."},{"key":"BFnrm1711_CR45","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nature02188","volume":"426","author":"K Hanada","year":"2003","unstructured":"Hanada, K. et al. Molecular machinery for non-vesicular trafficking of ceramide. Nature 426, 803\u2013809 (2003).","journal-title":"Nature"},{"key":"BFnrm1711_CR46","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1074\/mcp.M300030-MCP200","volume":"2","author":"M Ferro","year":"2003","unstructured":"Ferro, M. et al. Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana. Mol. Cell. Proteomics 2, 325\u2013345 (2003).","journal-title":"Mol. Cell. Proteomics"},{"key":"BFnrm1711_CR47","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1074\/mcp.M400128-MCP200","volume":"4","author":"RD Bagshaw","year":"2005","unstructured":"Bagshaw, R. D., Mahuran, D. J. & Callahan, J. W. A proteomics analysis of lysosomal integral-membrane proteins reveals the diverse composition of the organelle. Mol. Cell. Proteomics 4, 133\u2013143 (2005).","journal-title":"Mol. Cell. Proteomics"},{"key":"BFnrm1711_CR48","doi-asserted-by":"publisher","first-page":"18507","DOI":"10.1074\/jbc.M101113200","volume":"276","author":"JF Dermine","year":"2001","unstructured":"Dermine, J. F. et al. Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes. J. Biol. Chem. 276, 18507\u201318512 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFnrm1711_CR49","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1083\/jcb.148.4.635","volume":"148","author":"MP Rout","year":"2000","unstructured":"Rout, M. P. et al. The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148, 635\u2013651 (2000). One of the pioneering organelle proteomics studies. Discovered a Brownian-affinity-gating mechanism for nucleocytoplasmic transport.","journal-title":"J. Cell Biol."},{"key":"BFnrm1711_CR50","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1083\/jcb.200206106","volume":"158","author":"JM Cronshaw","year":"2002","unstructured":"Cronshaw, J. M., Krutchinsky, A. N., Zhang, W., Chait, B. T. & Matunis, M. J. Proteomic analysis of the mammalian nuclear pore complex. J. Cell Biol. 158, 915\u2013927 (2002).","journal-title":"J. Cell Biol."},{"key":"BFnrm1711_CR51","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1126\/science.1088176","volume":"301","author":"EC Schirmer","year":"2003","unstructured":"Schirmer, E. C., Florens, L., Guan, T., Yates, J. R. 3rd & Gerace, L. Nuclear membrane proteins with potential disease links found by subtractive proteomics. Science 301, 1380\u20131382 (2003).","journal-title":"Science"},{"key":"BFnrm1711_CR52","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nature03207","volume":"433","author":"JS Andersen","year":"2005","unstructured":"Andersen, J. S. et al. Nucleolar proteome dynamics. Nature 433, 77\u201383 (2005). A quantitative temporal proteomics study, which identified proteins that are recruited to or lost from the nucleolus following transcription or proteasome inhibition.","journal-title":"Nature"},{"key":"BFnrm1711_CR53","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/nature02026","volume":"425","author":"WK Huh","year":"2003","unstructured":"Huh, W. K. et al. Global analysis of protein localization in budding yeast. Nature 425, 686\u2013691 (2003).","journal-title":"Nature"},{"key":"BFnrm1711_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0960-9822(01)00650-9","volume":"12","author":"JS Andersen","year":"2002","unstructured":"Andersen, J. S. et al. Directed proteomic analysis of the human nucleolus. Curr. Biol. 12, 1\u201311 (2002).","journal-title":"Curr. Biol."},{"key":"BFnrm1711_CR55","doi-asserted-by":"publisher","first-page":"12130","DOI":"10.1073\/pnas.0404720101","volume":"101","author":"SA Beausoleil","year":"2004","unstructured":"Beausoleil, S. A. et al. Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc. Natl Acad. Sci. USA 101, 12130\u201312135 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm1711_CR56","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nature02580","volume":"429","author":"P Oh","year":"2004","unstructured":"Oh, P. et al. Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature 429, 629\u2013635 (2004). A silica-coated-bead methodology was used to isolate the plasma membrane of lung endothelial cells. Two proteins were shown to be lung endothelium specific and cell-surface exposed. Annexin A1 was identified as a novel target for cancer treatment.","journal-title":"Nature"},{"key":"BFnrm1711_CR57","doi-asserted-by":"publisher","first-page":"7607","DOI":"10.1074\/jbc.M210455200","volume":"278","author":"BK Shin","year":"2003","unstructured":"Shin, B. K. et al. Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J. Biol. Chem. 278, 7607\u20137616 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnrm1711_CR58","doi-asserted-by":"publisher","first-page":"6917","DOI":"10.1073\/pnas.0305862101","volume":"101","author":"EM Tam","year":"2004","unstructured":"Tam, E. M., Morrison, C. J., Wu, Y. I., Stack, M. S. & Overall, C. M. Membrane protease proteomics: isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates. Proc. Natl Acad. Sci. USA 101, 6917\u20136922 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm1711_CR59","doi-asserted-by":"publisher","first-page":"2855","DOI":"10.1002\/elps.200305569","volume":"24","author":"W Zhang","year":"2003","unstructured":"Zhang, W., Zhou, G., Zhao, Y. & White, M. A. Affinity enrichment of plasma membrane for proteomics analysis. Electrophoresis 24, 2855\u20132863 (2003).","journal-title":"Electrophoresis"},{"key":"BFnrm1711_CR60","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1105\/tpc.104.023150","volume":"16","author":"TS Nuhse","year":"2004","unstructured":"Nuhse, T. S., Stensballe, A., Jensen, O. N. & Peck, S. C. Phosphoproteomics of the Arabidopsis plasma membrane and a new phosphorylation site database. Plant Cell 16, 2394\u20132405 (2004).","journal-title":"Plant Cell"},{"key":"BFnrm1711_CR61","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1074\/mcp.T500002-MCP200","volume":"4","author":"PA Nielsen","year":"2005","unstructured":"Nielsen, P. A. et al. Proteomic mapping of brain plasma membrane proteins. Mol. Cell. Proteomics 4, 402\u2013408 (2005).","journal-title":"Mol. Cell. Proteomics"},{"key":"BFnrm1711_CR62","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1083\/jcb.61.1.201","volume":"61","author":"A Amar-Costesec","year":"1974","unstructured":"Amar-Costesec, A. et al. Analytical study of microsomes and isolated subcellular membranes from rat liver. II. Preparation and composition of the microsomal fraction. J. Cell Biol. 61, 201\u2013212 (1974).","journal-title":"J. Cell Biol."},{"key":"BFnrm1711_CR63","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0092-8674(03)00882-1","volume":"115","author":"S Munro","year":"2003","unstructured":"Munro, S. Lipid rafts: elusive or illusive? Cell 115, 377\u201388 (2003).","journal-title":"Cell"},{"key":"BFnrm1711_CR64","doi-asserted-by":"publisher","first-page":"5813","DOI":"10.1073\/pnas.0631608100","volume":"100","author":"LJ Foster","year":"2003","unstructured":"Foster, L. J., De Hoog, C. L. & Mann, M. Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors. Proc. Natl Acad. Sci. USA 100, 5813\u20135818 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm1711_CR65","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1002\/pmic.200400832","volume":"4","author":"N Li","year":"2004","unstructured":"Li, N., Shaw, A. R., Zhang, N., Mak, A. & Li, L. Lipid raft proteomics: analysis of in-solution digest of sodium dodecyl sulfate-solubilized lipid raft proteins by liquid chromatography\u2013matrix-assisted laser desorption\/ionization tandem mass spectrometry. Proteomics 4, 3156\u20133166 (2004).","journal-title":"Proteomics"},{"key":"BFnrm1711_CR66","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1042\/bj20020503","volume":"369","author":"L Bini","year":"2003","unstructured":"Bini, L. et al. Extensive temporally regulated reorganization of the lipid raft proteome following T-cell antigen receptor triggering. Biochem. J. 369, 301\u2013309 (2003).","journal-title":"Biochem. J."},{"key":"BFnrm1711_CR67","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1074\/mcp.M400053-MCP200","volume":"3","author":"SD Chuong","year":"2004","unstructured":"Chuong, S. D. et al. Large-scale identification of tubulin-binding proteins provides insight on subcellular trafficking, metabolic channeling, and signaling in plant cells. Mol. Cell. Proteomics 3, 970\u2013983 (2004).","journal-title":"Mol. Cell. Proteomics"},{"key":"BFnrm1711_CR68","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1242\/jcs.01171","volume":"117","author":"MK Dougherty","year":"2004","unstructured":"Dougherty, M. K. & Morrison, D. K. Unlocking the code of 14-3-3. J. Cell Sci. 117, 1875\u20131884 (2004).","journal-title":"J. Cell Sci."},{"key":"BFnrm1711_CR69","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/j.cub.2004.07.051","volume":"14","author":"J Jin","year":"2004","unstructured":"Jin, J. et al. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr. Biol. 14, 1436\u20131450 (2004).","journal-title":"Curr. Biol."},{"key":"BFnrm1711_CR70","doi-asserted-by":"publisher","first-page":"43399","DOI":"10.1074\/jbc.M205386200","volume":"277","author":"T Nebl","year":"2002","unstructured":"Nebl, T. et al. Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. J. Biol. Chem. 277, 43399\u201343409 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFnrm1711_CR71","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/nature02166","volume":"426","author":"JS Andersen","year":"2003","unstructured":"Andersen, J. S. et al. Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426, 570\u2013574 (2003).","journal-title":"Nature"},{"key":"BFnrm1711_CR72","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1074\/mcp.M400158-MCP200","volume":"4","author":"G Sauer","year":"2005","unstructured":"Sauer, G. et al. Proteome analysis of the human mitotic spindle. Mol. Cell. Proteomics 4, 35\u201343 (2005).","journal-title":"Mol. Cell. Proteomics"},{"key":"BFnrm1711_CR73","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1126\/science.1097931","volume":"305","author":"AR Skop","year":"2004","unstructured":"Skop, A. R., Liu, H., Yates, J. 3rd., Meyer, B. J. & Heald, R. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305, 61\u201366 (2004). Identified novel proteins that have a role in cytokinesis, and indicated a role for the ER chaperone GRP94 in chromosome segregation.","journal-title":"Science"},{"key":"BFnrm1711_CR74","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.1002\/j.1460-2075.1985.tb04054.x","volume":"4","author":"E Devaney","year":"1985","unstructured":"Devaney, E. & Howell, K. E. Immuno-isolation of a plasma membrane fraction from the Fao cell. EMBO J. 4, 3123\u20133130 (1985).","journal-title":"EMBO J."},{"key":"BFnrm1711_CR75","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1515\/bchm2.1984.365.1.539","volume":"365","author":"FJ Kamrath","year":"1984","unstructured":"Kamrath, F. J., Dodt, G., Debuch, H. & Uhlenbruck, G. The isolation of lysosomes from normal rat liver by affinity chromatography. Hoppe Seyler's Z. Physiol. Chem. 365, 539\u2013547 (1984).","journal-title":"Hoppe Seyler's Z. Physiol. Chem."},{"key":"BFnrm1711_CR76","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/S0955-0674(03)00083-8","volume":"15","author":"M Desjardins","year":"2003","unstructured":"Desjardins, M. & Griffiths, G. Phagocytosis: latex leads the way. Curr. Opin. Cell Biol. 15, 498\u2013503 (2003).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFnrm1711_CR77","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/nbt993","volume":"22","author":"E Durr","year":"2004","unstructured":"Durr, E. et al. Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture. Nature Biotechnol. 22, 985\u2013992 (2004).","journal-title":"Nature Biotechnol."},{"key":"BFnrm1711_CR78","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nature02426","volume":"428","author":"RA Gibbs","year":"2004","unstructured":"Gibbs, R. A. et al. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428, 493\u2013521 (2004).","journal-title":"Nature"},{"key":"BFnrm1711_CR79","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/nature01262","volume":"420","author":"RH Waterston","year":"2002","unstructured":"Waterston, R. H. et al. Initial sequencing and comparative analysis of the mouse genome. Nature 420, 520\u2013562 (2002).","journal-title":"Nature"},{"key":"BFnrm1711_CR80","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1126\/science.1058040","volume":"291","author":"JC Venter","year":"2001","unstructured":"Venter, J. C. et al. The sequence of the human genome. Science 291, 1304\u20131351 (2001).","journal-title":"Science"},{"key":"BFnrm1711_CR81","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/35057062","volume":"409","author":"ES Lander","year":"2001","unstructured":"Lander, E. S. et al. Initial sequencing and analysis of the human genome. Nature 409, 860\u2013921 (2001).","journal-title":"Nature"},{"key":"BFnrm1711_CR82","doi-asserted-by":"crossref","unstructured":"International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature 431, 931\u2013945 (2004).","DOI":"10.1038\/nature03001"},{"key":"BFnrm1711_CR83","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1126\/science.287.5461.2185","volume":"287","author":"MD Adams","year":"2000","unstructured":"Adams, M. D. et al. The genome sequence of Drosophila melanogaster. Science 287, 2185\u20132195 (2000).","journal-title":"Science"},{"key":"BFnrm1711_CR84","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1126\/science.274.5287.546","volume":"274","author":"A Goffeau","year":"1996","unstructured":"Goffeau, A. et al. Life with 6000 genes. Science 274, 563\u2013567 (1996).","journal-title":"Science"},{"key":"BFnrm1711_CR85","doi-asserted-by":"crossref","unstructured":"The C. elegans sequencing consortium. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282, 2012\u20132018 (1998).","DOI":"10.1126\/science.282.5396.2012"},{"key":"BFnrm1711_CR86","doi-asserted-by":"publisher","first-page":"5011","DOI":"10.1073\/pnas.90.11.5011","volume":"90","author":"WJ Henzel","year":"1993","unstructured":"Henzel, W. J. et al. Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases. Proc. Natl Acad. Sci. USA 90, 5011\u20135015 (1993).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm1711_CR87","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1006\/abio.1993.1514","volume":"214","author":"JR Yates 3rd.","year":"1993","unstructured":"Yates, J. R. 3rd., Speicher, S., Griffin, P. R. & Hunkapiller, T. Peptide mass maps: a highly informative approach to protein identification. Anal. Biochem. 214, 397\u2013408 (1993).","journal-title":"Anal. Biochem."},{"key":"BFnrm1711_CR88","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1006\/bbrc.1993.2009","volume":"195","author":"P James","year":"1993","unstructured":"James, P., Quadroni, M., Carafoli, E. & Gonnet, G. Protein identification by mass profile fingerprinting. Biochem.Biophys. Res. Commun. 195, 58\u201364 (1993).","journal-title":"Biochem.Biophys. Res. Commun."},{"key":"BFnrm1711_CR89","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0960-9822(93)90195-T","volume":"3","author":"DJ Pappin","year":"1993","unstructured":"Pappin, D. J., Hojrup, P. & Bleasby, A. J. Rapid identification of proteins by peptide-mass fingerprinting. Curr. Biol. 3, 327\u2013332 (1993).","journal-title":"Curr. Biol."},{"key":"BFnrm1711_CR90","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1002\/bms.1200220605","volume":"22","author":"M Mann","year":"1993","unstructured":"Mann, M., Hojrup, P. & Roepstorff, P. Use of mass spectrometric molecular weight information to identify proteins in sequence databases. Biol. Mass Spectrom. 22, 338\u2013345 (1993).","journal-title":"Biol. Mass Spectrom."},{"key":"BFnrm1711_CR91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1570-9639(02)00546-0","volume":"1646","author":"D Lin","year":"2003","unstructured":"Lin, D., Tabb, D. L. & Yates, J. R. 3rd. Large-scale protein identification using mass spectrometry. Biochim. Biophys. Acta 1646, 1\u201310 (2003).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnrm1711_CR92","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nmeth725","volume":"1","author":"R Sadygov","year":"2004","unstructured":"Sadygov, R., Cociorva, D. & Yates, J. R. 3rd. Large-scale database searching using tandem mass spectra: looking up the answer in the back of the book. Nature Methods 1, 195\u2013202 (2004).","journal-title":"Nature Methods"},{"key":"BFnrm1711_CR93","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1002\/elps.11501601175","volume":"16","author":"J Klose","year":"1995","unstructured":"Klose, J. & Kobalz, U. Two-dimensional electrophoresis of proteins: an updated protocol and implications for a functional analysis of the genome. Electrophoresis 16, 1034\u20131059 (1995).","journal-title":"Electrophoresis"},{"key":"BFnrm1711_CR94","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1002\/elps.1150190539","volume":"19","author":"MP Molloy","year":"1998","unstructured":"Molloy, M. P. et al. Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis. Electrophoresis 19, 837\u2013844 (1998).","journal-title":"Electrophoresis"},{"key":"BFnrm1711_CR95","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1046\/j.1432-1327.2000.01296.x","volume":"267","author":"MP Molloy","year":"2000","unstructured":"Molloy, M. P. et al. Proteomic analysis of the Escherichia coli outer membrane. Eur. J. Biochem. 267, 2871\u20132881 (2000).","journal-title":"Eur. J. Biochem."},{"key":"BFnrm1711_CR96","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/1044-0305(94)80016-2","volume":"5","author":"JK Eng","year":"1994","unstructured":"Eng, J. K., McCormack, A. L. & Yates, J. R. 3rd. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J. Am. Soc.Mass Spectrom. 5, 976\u2013989 (1994).","journal-title":"J. Am. Soc.Mass Spectrom."},{"key":"BFnrm1711_CR97","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/76615","volume":"3","author":"H Husi","year":"2000","unstructured":"Husi, H., Ward, M. A., Choudhary, J. S., Blackstock, W. P. & Grant, S. G. Proteomic analysis of NMDA receptor\u2013adhesion protein signaling complexes. Nature Neurosci. 3, 661\u2013669 (2000).","journal-title":"Nature Neurosci."},{"key":"BFnrm1711_CR98","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1002\/elps.1150180808","volume":"18","author":"AJ Link","year":"1997","unstructured":"Link, A. J., Hays, L. G., Carmack, E. B. & Yates, J. R. 3rd. Identifying the major components of Haemophilus influenzae type-strain NCTC 8143. Electrophoresis 18, 1314\u20131334 (1997).","journal-title":"Electrophoresis"},{"key":"BFnrm1711_CR99","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1021\/ac960799q","volume":"69","author":"AL McCormack","year":"1997","unstructured":"McCormack, A. L. et al. Direct analysis and identification of proteins in mixtures by LC\/MS\/MS and database searching at the low-femtomole level. Anal. Chem. 69, 767\u2013776 (1997).","journal-title":"Anal. Chem."},{"key":"BFnrm1711_CR100","doi-asserted-by":"publisher","first-page":"4193","DOI":"10.1021\/ac0498563","volume":"76","author":"H Liu","year":"2004","unstructured":"Liu, H., Sadygov, R. G. & Yates, J. R. 3rd. A model for random sampling and estimation of relative protein abundance in shotgun proteomics. Anal. Chem. 76, 4193\u20134201 (2004).","journal-title":"Anal. Chem."},{"key":"BFnrm1711_CR101","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/10890","volume":"17","author":"AJ Link","year":"1999","unstructured":"Link, A. J. et al. Direct analysis of protein complexes using mass spectrometry. Nature Biotechnol. 17, 676\u2013682 (1999).","journal-title":"Nature Biotechnol."},{"key":"BFnrm1711_CR102","doi-asserted-by":"publisher","first-page":"5683","DOI":"10.1021\/ac010617e","volume":"73","author":"DA Wolters","year":"2001","unstructured":"Wolters, D. A., Washburn, M. P. & Yates, J. R. 3rd. An automated multidimensional protein identification technology for shotgun proteomics. Anal. Chem. 73, 5683\u20135690 (2001).","journal-title":"Anal. Chem."},{"key":"BFnrm1711_CR103","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1002\/elps.1150190604","volume":"19","author":"JR Yates 3rd.","year":"1998","unstructured":"Yates, J. R. 3rd. Database searching using mass spectrometry data. Electrophoresis 19, 893\u2013900 (1998).","journal-title":"Electrophoresis"},{"key":"BFnrm1711_CR104","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1002\/1615-9861(200212)2:12<1682::AID-PROT1682>3.0.CO;2-Y","volume":"2","author":"JX Yan","year":"2002","unstructured":"Yan, J. X. et al. Fluorescence two-dimensional difference gel electrophoresis and mass spectrometry based proteomic analysis of Escherichia coli. Proteomics 2, 1682\u20131698 (2002).","journal-title":"Proteomics"},{"key":"BFnrm1711_CR105","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1021\/pr049926m","volume":"3","author":"TY Sam-Yellowe","year":"2004","unstructured":"Sam-Yellowe, T. Y. et al. Proteome analysis of rhoptry-enriched fractions isolated from Plasmodium merozoites. J. Proteome Res. 3, 995\u20131001 (2004).","journal-title":"J. Proteome Res."},{"key":"BFnrm1711_CR106","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/nature01107","volume":"419","author":"L Florens","year":"2002","unstructured":"Florens, L. et al. A proteomic view of the Plasmodium falciparum life cycle. Nature 419, 520\u2013526 (2002).","journal-title":"Nature"},{"key":"BFnrm1711_CR107","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1083\/jcb.152.1.165","volume":"152","author":"J Garin","year":"2001","unstructured":"Garin, J. et al. The phagosome proteome: insight into phagosome functions. J. Cell Biol. 152, 165\u2013180 (2001).","journal-title":"J. Cell Biol."}],"container-title":["Nature Reviews Molecular Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrm1711.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrm1711","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrm1711.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T03:50:35Z","timestamp":1684468235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrm1711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":107,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["BFnrm1711"],"URL":"https:\/\/doi.org\/10.1038\/nrm1711","relation":{},"ISSN":["1471-0072","1471-0080"],"issn-type":[{"value":"1471-0072","type":"print"},{"value":"1471-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}