{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T20:27:25Z","timestamp":1778012845831,"version":"3.51.4"},"reference-count":127,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Mol Cell Biol"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1038\/nrm2105","type":"journal-article","created":{"date-parts":[[2007,1,24]],"date-time":"2007-01-24T11:18:54Z","timestamp":1169637534000},"page":"149-160","source":"Crossref","is-referenced-by-count":405,"title":["Multiple levels of cyclin specificity in cell-cycle control"],"prefix":"10.1038","volume":"8","author":[{"given":"Joanna","family":"Bloom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick R.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFnrm2105_CR1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1091\/mbc.01-05-0265","volume":"13","author":"FR Cross","year":"2002","unstructured":"Cross, F. R., Archambault, V., Miller, M. & Klovstad, M. Testing a mathematical model of the yeast cell cycle. Mol. Biol. Cell 13, 52\u201370 (2002).","journal-title":"Mol. Biol. Cell"},{"key":"BFnrm2105_CR2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature03329","volume":"434","author":"M Loog","year":"2005","unstructured":"Loog, M. & Morgan, D. O. Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature 434, 104\u2013108 (2005). Identifies Cdc28 substrates that are preferentially phosphorylated by Clb5-directed Cdc28.","journal-title":"Nature"},{"key":"BFnrm2105_CR3","first-page":"394","volume":"401","author":"SB Haase","year":"1999","unstructured":"Haase, S. B. & Reed, S. I. Evidence that a free-running oscillator drives G1 events in the budding yeast cell cycle. Nature 401, 394\u2013397 (1999).","journal-title":"Nature"},{"key":"BFnrm2105_CR4","doi-asserted-by":"crossref","first-page":"8910","DOI":"10.1073\/pnas.0406987102","volume":"102","author":"F Hu","year":"2005","unstructured":"Hu, F. & Aparicio, O. M. Swe1 regulation and transcriptional control restrict the activity of mitotic cyclins toward replication proteins in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA 102, 8910\u20138915 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm2105_CR5","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1101\/gad.6.9.1695","volume":"6","author":"CB Epstein","year":"1992","unstructured":"Epstein, C. B. & Cross, F. R. CLB5: a novel B cyclin from budding yeast with a role in S phase. Genes Dev. 6, 1695\u20131706 (1992).","journal-title":"Genes Dev."},{"key":"BFnrm2105_CR6","doi-asserted-by":"crossref","first-page":"7772","DOI":"10.1073\/pnas.93.15.7772","volume":"93","author":"M Tyers","year":"1996","unstructured":"Tyers, M. The cyclin-dependent kinase inhibitor p40SIC1 imposes the requirement for Cln G1 cyclin function at Start. Proc. Natl Acad. Sci. USA 93, 7772\u20137776 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm2105_CR7","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/j.1460-2075.1996.tb00420.x","volume":"15","author":"DL Fisher","year":"1996","unstructured":"Fisher, D. L. & Nurse, P. A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. EMBO J. 15, 850\u2013860 (1996).","journal-title":"EMBO J."},{"key":"BFnrm2105_CR8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1097-2765(00)80337-8","volume":"4","author":"K Levine","year":"1999","unstructured":"Levine, K., Kiang, L., Jacobson, M. D., Fisher, R. P. & Cross, F. R. Directed evolution to bypass cyclin requirements for the Cdc28p cyclin-dependent kinase. Mol. Cell 4, 353\u2013363 (1999).","journal-title":"Mol. Cell"},{"key":"BFnrm2105_CR9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1097-2765(00)80183-5","volume":"4","author":"FR Cross","year":"1999","unstructured":"Cross, F. R., Yuste-Rojas, M., Gray, S. & Jacobson, M. D. Specialization and targeting of B-type cyclins. Mol. Cell 4, 11\u201319 (1999).","journal-title":"Mol. Cell"},{"key":"BFnrm2105_CR10","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1128\/MCB.20.13.4483-4493.2000","volume":"20","author":"MD Jacobson","year":"2000","unstructured":"Jacobson, M. D., Gray, S., Yuste-Rojas, M. & Cross, F. R. Testing cyclin specificity in the exit from mitosis. Mol. Cell. Biol. 20, 4483\u20134493 (2000).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR11","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.molcel.2004.05.025","volume":"14","author":"V Archambault","year":"2004","unstructured":"Archambault, V. et al. Targeted proteomic study of the cyclin\u2013cdk module. Mol. Cell 14, 699\u2013711 (2004). Identifies upstream regulators and downstream targets of individual cyclin\u2013Cdc28 complexes by mass-spectrometric analysis.","journal-title":"Mol. Cell"},{"key":"BFnrm2105_CR12","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1128\/MCB.20.13.4782-4790.2000","volume":"20","author":"FR Cross","year":"2000","unstructured":"Cross, F. R. & Jacobson, M. D. Conservation and function of a potential substrate-binding domain in the yeast Clb5 B-type cyclin. Mol. Cell. Biol. 20, 4782\u20134790 (2000).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR13","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/0092-8674(91)90444-4","volume":"66","author":"K Nasmyth","year":"1991","unstructured":"Nasmyth, K. & Dirick, L. The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast. Cell 66, 995\u20131013 (1991).","journal-title":"Cell"},{"key":"BFnrm2105_CR14","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/0092-8674(91)90445-5","volume":"66","author":"J Ogas","year":"1991","unstructured":"Ogas, J., Andrews, B. J. & Herskowitz, I. Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription. Cell 66, 1015\u20131026 (1991).","journal-title":"Cell"},{"key":"BFnrm2105_CR15","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1101\/gad.7.7a.1160","volume":"7","author":"E Schwob","year":"1993","unstructured":"Schwob, E. & Nasmyth, K. CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Genes Dev. 7, 1160\u20131175 (1993).","journal-title":"Genes Dev."},{"key":"BFnrm2105_CR16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1534\/genetics.105.044560","volume":"171","author":"JM Bean","year":"2005","unstructured":"Bean, J. M., Siggia, E. D. & Cross, F. R. High functional overlap between MluI cell-cycle box binding factor and Swi4\/6 cell-cycle box binding factor in the G1\/S transcriptional program in Saccharomyces cerevisiae. Genetics 171, 49\u201361 (2005).","journal-title":"Genetics"},{"key":"BFnrm2105_CR17","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1002\/j.1460-2075.1993.tb05845.x","volume":"12","author":"M Tyers","year":"1993","unstructured":"Tyers, M., Tokiwa, G. & Futcher, B. Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins. EMBO J. 12, 1955\u20131968 (1993).","journal-title":"EMBO J."},{"key":"BFnrm2105_CR18","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1002\/j.1460-2075.1995.tb00162.x","volume":"14","author":"L Dirick","year":"1995","unstructured":"Dirick, L., Bohm, T. & Nasmyth, K. Roles and regulation of Cln\u2013Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. EMBO J. 14, 4803\u20134813 (1995).","journal-title":"EMBO J."},{"key":"BFnrm2105_CR19","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1101\/gad.9.22.2780","volume":"9","author":"D Stuart","year":"1995","unstructured":"Stuart, D. & Wittenberg, C. CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells. Genes Dev. 9, 2780\u20132794 (1995).","journal-title":"Genes Dev."},{"key":"BFnrm2105_CR20","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1128\/MCB.16.12.6794","volume":"16","author":"K Levine","year":"1996","unstructured":"Levine, K., Huang, K. & Cross, F. R. Saccharomyces cerevisiae G1 cyclins differ in their intrinsic functional specificities. Mol. Cell. Biol. 16, 6794\u20136803 (1996).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR21","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2004.05.025","volume":"117","author":"RA de Bruin","year":"2004","unstructured":"de Bruin, R. A., McDonald, W. H., Kalashnikova, T. I., Yates, J. 3rd & Wittenberg, C. Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5. Cell 117, 887\u2013898 (2004).","journal-title":"Cell"},{"key":"BFnrm2105_CR22","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.cell.2004.05.024","volume":"117","author":"M Costanzo","year":"2004","unstructured":"Costanzo, M. et al. CDK activity antagonizes Whi5, an inhibitor of G1\/S transcription in yeast. Cell 117, 899\u2013913 (2004). References 21 and 22 describe Cln\u2013Cdc28-dependent phosphorylation of the SBF inhibitor Whi5, which allows for the transcription of CLN1 and CLN2.","journal-title":"Cell"},{"key":"BFnrm2105_CR23","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0092-8674(91)90394-E","volume":"65","author":"FR Cross","year":"1991","unstructured":"Cross, F. R. & Tinkelenberg, A. H. A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle. Cell 65, 875\u2013883 (1991).","journal-title":"Cell"},{"key":"BFnrm2105_CR24","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/351754a0","volume":"351","author":"L Dirick","year":"1991","unstructured":"Dirick, L. & Nasmyth, K. Positive feedback in the activation of G1 cyclins in yeast. Nature 351, 754\u2013757 (1991).","journal-title":"Nature"},{"key":"BFnrm2105_CR25","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1128\/MCB.24.6.2277-2285.2004","volume":"24","author":"M Geymonat","year":"2004","unstructured":"Geymonat, M., Spanos, A., Wells, G. P., Smerdon, S. J. & Sedgwick, S. G. Clb6\/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6. Mol. Cell. Biol. 24, 2277\u20132285 (2004).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR26","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0092-8674(93)90722-3","volume":"74","author":"A Amon","year":"1993","unstructured":"Amon, A., Tyers, M., Futcher, B. & Nasmyth, K. Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins. Cell 74, 993\u20131007 (1993).","journal-title":"Cell"},{"key":"BFnrm2105_CR27","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1128\/MCB.16.6.2647","volume":"16","author":"RF Siegmund","year":"1996","unstructured":"Siegmund, R. F. & Nasmyth, K. A. The Saccharomyces cerevisiae Start-specific transcription factor Swi4 interacts through the ankyrin repeats with the mitotic Clb2\/Cdc28 kinase and through its conserved carboxy terminus with Swi6. Mol. Cell. Biol. 16, 2647\u20132655 (1996).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR28","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1091\/mbc.3.7.805","volume":"3","author":"I Fitch","year":"1992","unstructured":"Fitch, I. et al. Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae. Mol. Biol. Cell 3, 805\u2013818 (1992).","journal-title":"Mol. Biol. Cell"},{"key":"BFnrm2105_CR29","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1101\/gad.1074103","volume":"17","author":"D Reynolds","year":"2003","unstructured":"Reynolds, D. et al. Recruitment of Thr319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation. Genes Dev. 17, 1789\u20131802 (2003).","journal-title":"Genes Dev."},{"key":"BFnrm2105_CR30","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.cub.2003.08.053","volume":"13","author":"Z Darieva","year":"2003","unstructured":"Darieva, Z. et al. Cell cycle-regulated transcription through the FHA domain of Fkh2p and the coactivator Ndd1p. Curr. Biol. 13, 1740\u20131745 (2003).","journal-title":"Curr. Biol."},{"key":"BFnrm2105_CR31","doi-asserted-by":"crossref","first-page":"10036","DOI":"10.1128\/MCB.24.22.10036-10046.2004","volume":"24","author":"A Pic-Taylor","year":"2004","unstructured":"Pic-Taylor, A., Darieva, Z., Morgan, B. A. & Sharrocks, A. D. Regulation of cell cycle-specific gene expression through cyclin-dependent kinase-mediated phosphorylation of the forkhead transcription factor Fkh2p. Mol. Cell. Biol. 24, 10036\u201310046 (2004).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR32","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1101\/gad.9.4.399","volume":"9","author":"Y Barral","year":"1995","unstructured":"Barral, Y., Jentsch, S. & Mann, C. G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes Dev. 9, 399\u2013409 (1995).","journal-title":"Genes Dev."},{"key":"BFnrm2105_CR33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0092-8674(00)80403-1","volume":"91","author":"D Skowyra","year":"1997","unstructured":"Skowyra, D., Craig, K. L., Tyers, M., Elledge, S. J. & Harper, J. W. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209\u2013219 (1997).","journal-title":"Cell"},{"key":"BFnrm2105_CR34","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1128\/MCB.26.6.2456-2466.2006","volume":"26","author":"LP Jackson","year":"2006","unstructured":"Jackson, L. P., Reed, S. I. & Haase, S. B. Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6. Mol. Cell. Biol. 26, 2456\u20132466 (2006).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1097-2765(00)80127-6","volume":"2","author":"AD Donaldson","year":"1998","unstructured":"Donaldson, A. D. et al. CLB5-dependent activation of late replication origins in S. cerevisiae. Mol. Cell 2, 173\u2013182 (1998).","journal-title":"Mol. Cell"},{"key":"BFnrm2105_CR36","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nrm1988","volume":"7","author":"JM Peters","year":"2006","unstructured":"Peters, J. M. The anaphase promoting complex\/cyclosome: a machine designed to destroy. Nature Rev. Mol. Cell Biol. 7, 644\u2013656 (2006).","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"BFnrm2105_CR37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/46080","volume":"402","author":"M Shirayama","year":"1999","unstructured":"Shirayama, M., Toth, A., Galova, M. & Nasmyth, K. APCCdc20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5. Nature 402, 203\u2013207 (1999).","journal-title":"Nature"},{"key":"BFnrm2105_CR38","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature00856","volume":"418","author":"R Wasch","year":"2002","unstructured":"Wasch, R. & Cross, F. R. APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature 418, 556\u2013562 (2002).","journal-title":"Nature"},{"key":"BFnrm2105_CR39","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1083\/jcb.149.7.1377","volume":"149","author":"AD Rudner","year":"2000","unstructured":"Rudner, A. D. & Murray, A. W. Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex. J. Cell Biol. 149, 1377\u20131390 (2000).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR40","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.282.5394.1721","volume":"282","author":"W Zachariae","year":"1998","unstructured":"Zachariae, W., Schwab, M., Nasmyth, K. & Seufert, W. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex. Science 282, 1721\u20131724 (1998).","journal-title":"Science"},{"key":"BFnrm2105_CR41","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0960-9822(99)80111-0","volume":"9","author":"SL Jaspersen","year":"1999","unstructured":"Jaspersen, S. L., Charles, J. F. & Morgan, D. O. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr. Biol. 9, 227\u2013236 (1999).","journal-title":"Curr. Biol."},{"key":"BFnrm2105_CR42","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1128\/MCB.21.15.5071-5081.2001","volume":"21","author":"FM Yeong","year":"2001","unstructured":"Yeong, F. M., Lim, H. H., Wang, Y. & Surana, U. Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase. Mol. Cell. Biol. 21, 5071\u20135081 (2001).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR43","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1083\/jcb.200102007","volume":"154","author":"JN Huang","year":"2001","unstructured":"Huang, J. N., Park, I., Ellingson, E., Littlepage, L. E. & Pellman, D. Activity of the APCCdh1 form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p. J. Cell Biol. 154, 85\u201394 (2001).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR44","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0092-8674(94)90193-7","volume":"79","author":"E Schwob","year":"1994","unstructured":"Schwob, E., Bohm, T., Mendenhall, M. D. & Nasmyth, K. The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79, 233\u2013244 (1994).","journal-title":"Cell"},{"key":"BFnrm2105_CR45","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)80404-3","volume":"91","author":"RM Feldman","year":"1997","unstructured":"Feldman, R. M., Correll, C. C., Kaplan, K. B. & Deshaies, R. J. A complex of Cdc4p, Skp1p, and Cdc53p\/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91, 221\u2013230 (1997).","journal-title":"Cell"},{"key":"BFnrm2105_CR46","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1126\/science.278.5337.455","volume":"278","author":"R Verma","year":"1997","unstructured":"Verma, R. et al. Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278, 455\u2013460 (1997).","journal-title":"Science"},{"key":"BFnrm2105_CR47","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1128\/MCB.20.2.542-555.2000","volume":"20","author":"ME Miller","year":"2000","unstructured":"Miller, M. E. & Cross, F. R. Distinct subcellular localization patterns contribute to functional specificity of the Cln2 and Cln3 cyclins of Saccharomyces cerevisiae. Mol. Cell. Biol. 20, 542\u2013555 (2000).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR48","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1128\/MCB.21.18.6292-6311.2001","volume":"21","author":"ME Miller","year":"2001","unstructured":"Miller, M. E. & Cross, F. R. Mechanisms controlling subcellular localization of the G1 cyclins Cln2p and Cln3p in budding yeast. Mol. Cell. Biol. 21, 6292\u20136311 (2001).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR49","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1242\/jcs.114.24.4599","volume":"114","author":"NP Edgington","year":"2001","unstructured":"Edgington, N. P. & Futcher, B. Relationship between the function and the location of G1 cyclins in S. cerevisiae. J. Cell Sci. 114, 4599\u20134611 (2001).","journal-title":"J. Cell Sci."},{"key":"BFnrm2105_CR50","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1242\/jcs.00706","volume":"116","author":"E Bailly","year":"2003","unstructured":"Bailly, E., Cabantous, S., Sondaz, D., Bernadac, A. & Simon, M. N. Differential cellular localization among mitotic cyclins from Saccharomyces cerevisiae: a new role for the axial budding protein Bud3 in targeting Clb2 to the mother-bud neck. J. Cell Sci. 116, 4119\u20134130 (2003).","journal-title":"J. Cell Sci."},{"key":"BFnrm2105_CR51","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1242\/jcs.114.3.589","volume":"114","author":"JK Hood","year":"2001","unstructured":"Hood, J. K., Hwang, W. W. & Silver, P. A. The Saccharomyces cerevisiae cyclin Clb2p is targeted to multiple subcellular locations by cis- and trans-acting determinants. J. Cell Sci. 114, 589\u2013597 (2001).","journal-title":"J. Cell Sci."},{"key":"BFnrm2105_CR52","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1002\/j.1460-2075.1993.tb06016.x","volume":"12","author":"RN Booher","year":"1993","unstructured":"Booher, R. N., Deshaies, R. J. & Kirschner, M. W. Properties of Saccharomyces cerevisiae Wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J. 12, 3417\u20133426 (1993).","journal-title":"EMBO J."},{"key":"BFnrm2105_CR53","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/ncb1066","volume":"5","author":"BR Thornton","year":"2003","unstructured":"Thornton, B. R. & Toczyski, D. P. Securin and B-cyclin\/CDK are the only essential targets of the APC. Nature Cell Biol. 5, 1090\u20131094 (2003).","journal-title":"Nature Cell Biol."},{"key":"BFnrm2105_CR54","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1038\/sj.emboj.7600683","volume":"24","author":"S Asano","year":"2005","unstructured":"Asano, S. et al. Concerted mechanism of Swe1\/Wee1 regulation by multiple kinases in budding yeast. EMBO J. 24, 2194\u20132204 (2005).","journal-title":"EMBO J."},{"key":"BFnrm2105_CR55","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cell.2005.05.029","volume":"122","author":"SL Harvey","year":"2005","unstructured":"Harvey, S. L., Charlet, A., Haas, W., Gygi, S. P. & Kellogg, D. R. Cdk1-dependent regulation of the mitotic inhibitor Wee1. Cell 122, 407\u2013420 (2005).","journal-title":"Cell"},{"key":"BFnrm2105_CR56","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0962-8924(02)02284-5","volume":"12","author":"A Breitkreutz","year":"2002","unstructured":"Breitkreutz, A. & Tyers, M. MAPK signaling specificity: it takes two to tango. Trends Cell Biol. 12, 254\u2013257 (2002).","journal-title":"Trends Cell Biol."},{"key":"BFnrm2105_CR57","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1126\/science.8066461","volume":"265","author":"M Peter","year":"1994","unstructured":"Peter, M. & Herskowitz, I. Direct inhibition of the yeast cyclin-dependent kinase Cdc28\u2013Cln by Far1. Science 265, 1228\u20131231 (1994).","journal-title":"Science"},{"key":"BFnrm2105_CR58","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1128\/MCB.18.1.433","volume":"18","author":"DI Jeoung","year":"1998","unstructured":"Jeoung, D. I., Oehlen, L. J. & Cross, F. R. Cln3-associated kinase activity in Saccharomyces cerevisiae is regulated by the mating factor pathway. Mol. Cell. Biol. 18, 433\u2013441 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR59","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1128\/MCB.18.7.3681","volume":"18","author":"A Gartner","year":"1998","unstructured":"Gartner, A. et al. Pheromone-dependent G1 cell cycle arrest requires Far1 phosphorylation, but may not involve inhibition of Cdc28\u2013Cln2 kinase, in vivo. Mol. Cell. Biol. 18, 3681\u20133691 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR60","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1101\/gad.7.5.833","volume":"7","author":"JD McKinney","year":"1993","unstructured":"McKinney, J. D., Chang, F., Heintz, N. & Cross, F. R. Negative regulation of FAR1 at the Start of the yeast cell cycle. Genes Dev. 7, 833\u2013843 (1993).","journal-title":"Genes Dev."},{"key":"BFnrm2105_CR61","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1101\/gad.11.22.3046","volume":"11","author":"S Henchoz","year":"1997","unstructured":"Henchoz, S. et al. Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast. Genes Dev. 11, 3046\u20133060 (1997).","journal-title":"Genes Dev."},{"key":"BFnrm2105_CR62","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1128\/MCB.15.5.2509","volume":"15","author":"JD McKinney","year":"1995","unstructured":"McKinney, J. D. & Cross, F. R. FAR1 and the G1 phase specificity of cell cycle arrest by mating factor in Saccharomyces cerevisiae. Mol. Cell. Biol. 15, 2509\u20132516 (1995).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR63","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s004380050722","volume":"258","author":"LJ Oehlen","year":"1998","unstructured":"Oehlen, L. J., Jeoung, D. I. & Cross, F. R. Cyclin-specific START events and the G1-phase specificity of arrest by mating factor in budding yeast. Mol. Gen. Genet. 258, 183\u2013198 (1998).","journal-title":"Mol. Gen. Genet."},{"key":"BFnrm2105_CR64","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1101\/gad.8.9.1058","volume":"8","author":"LJ Oehlen","year":"1994","unstructured":"Oehlen, L. J. & Cross, F. R. G1 cyclins CLN1 and CLN2 repress the mating factor response pathway at Start in the yeast cell cycle. Genes Dev. 8, 1058\u20131070 (1994).","journal-title":"Genes Dev."},{"key":"BFnrm2105_CR65","doi-asserted-by":"crossref","first-page":"25089","DOI":"10.1074\/jbc.273.39.25089","volume":"273","author":"LJ Oehlen","year":"1998","unstructured":"Oehlen, L. J. & Cross, F. R. Potential regulation of Ste20 function by the Cln1\u2013Cdc28 and Cln2\u2013Cdc28 cyclin-dependent protein kinases. J. Biol. Chem. 273, 25089\u201325097 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFnrm2105_CR66","doi-asserted-by":"crossref","first-page":"28107","DOI":"10.1074\/jbc.273.43.28107","volume":"273","author":"C Wu","year":"1998","unstructured":"Wu, C., Leeuw, T., Leberer, E., Thomas, D. Y. & Whiteway, M. Cell cycle- and Cln2p\u2013Cdc28p-dependent phosphorylation of the yeast Ste20p protein kinase. J. Biol. Chem. 273, 28107\u201328115 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFnrm2105_CR67","doi-asserted-by":"crossref","first-page":"6591","DOI":"10.1073\/pnas.96.12.6591","volume":"96","author":"Y Oda","year":"1999","unstructured":"Oda, Y., Huang, K., Cross, F. R., Cowburn, D. & Chait, B. T. Accurate quantitation of protein expression and site-specific phosphorylation. Proc. Natl Acad. Sci. USA 96, 6591\u20136596 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm2105_CR68","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1083\/jcb.129.3.739","volume":"129","author":"DJ Lew","year":"1995","unstructured":"Lew, D. J. & Reed, S. I. A cell cycle checkpoint monitors cell morphogenesis in budding yeast. J. Cell Biol. 129, 739\u2013749 (1995).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR69","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1091\/mbc.7.11.1657","volume":"7","author":"RA Sia","year":"1996","unstructured":"Sia, R. A., Herald, H. A. & Lew, D. J. Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. Mol. Biol. Cell 7, 1657\u20131666 (1996).","journal-title":"Mol. Biol. Cell"},{"key":"BFnrm2105_CR70","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1016\/j.cub.2005.11.039","volume":"15","author":"JJ McNulty","year":"2005","unstructured":"McNulty, J. J. & Lew, D. J. Swe1p responds to cytoskeletal perturbation, not bud size, in S. cerevisiae. Curr. Biol. 15, 2190\u20132198 (2005).","journal-title":"Curr. Biol."},{"key":"BFnrm2105_CR71","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1128\/MCB.19.9.5981","volume":"19","author":"JN McMillan","year":"1999","unstructured":"McMillan, J. N., Sia, R. A., Bardes, E. S. & Lew, D. J. Phosphorylation-independent inhibition of Cdc28p by the tyrosine kinase Swe1p in the morphogenesis checkpoint. Mol. Cell. Biol. 19, 5981\u20135990 (1999).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR72","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1083\/jcb.141.5.1181","volume":"141","author":"JC Waters","year":"1998","unstructured":"Waters, J. C., Chen, R. H., Murray, A. W. & Salmon, E. D. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J. Cell Biol. 141, 1181\u20131191 (1998).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR73","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1091\/mbc.10.8.2607","volume":"10","author":"RH Chen","year":"1999","unstructured":"Chen, R. H., Brady, D. M., Smith, D., Murray, A. W. & Hardwick, K. G. The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins. Mol. Biol. Cell 10, 2607\u20132618 (1999).","journal-title":"Mol. Biol. Cell"},{"key":"BFnrm2105_CR74","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0960-9822(00)00515-7","volume":"10","author":"DM Brady","year":"2000","unstructured":"Brady, D. M. & Hardwick, K. G. Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function. Curr. Biol. 10, 675\u2013678 (2000).","journal-title":"Curr. Biol."},{"key":"BFnrm2105_CR75","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1126\/science.279.5353.1041","volume":"279","author":"LH Hwang","year":"1998","unstructured":"Hwang, L. H. et al. Budding yeast Cdc20: a target of the spindle checkpoint. Science 279, 1041\u20131044 (1998).","journal-title":"Science"},{"key":"BFnrm2105_CR76","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1097-2765(00)80286-5","volume":"2","author":"R Visintin","year":"1998","unstructured":"Visintin, R. et al. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol. Cell 2, 709\u2013718 (1998).","journal-title":"Mol. Cell"},{"key":"BFnrm2105_CR77","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0092-8674(00)00007-6","volume":"102","author":"AJ Bardin","year":"2000","unstructured":"Bardin, A. J., Visintin, R. & Amon, A. A mechanism for coupling exit from mitosis to partitioning of the nucleus. Cell 102, 21\u201331 (2000).","journal-title":"Cell"},{"key":"BFnrm2105_CR78","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1083\/jcb.145.5.979","volume":"145","author":"R Fraschini","year":"1999","unstructured":"Fraschini, R., Formenti, E., Lucchini, G. & Piatti, S. Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2. J. Cell Biol. 145, 979\u2013991 (1999).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR79","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1093\/emboj\/18.10.2707","volume":"18","author":"G Alexandru","year":"1999","unstructured":"Alexandru, G., Zachariae, W., Schleiffer, A. & Nasmyth, K. Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage. EMBO J. 18, 2707\u20132721 (1999).","journal-title":"EMBO J."},{"key":"BFnrm2105_CR80","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1083\/jcb.120.6.1305","volume":"120","author":"DJ Lew","year":"1993","unstructured":"Lew, D. J. & Reed, S. I. Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins. J. Cell Biol. 120, 1305\u20131320 (1993).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR81","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1002\/j.1460-2075.1993.tb06222.x","volume":"12","author":"BK Benton","year":"1993","unstructured":"Benton, B. K., Tinkelenberg, A. H., Jean, D., Plump, S. D. & Cross, F. R. Genetic analysis of Cln\u2013Cdc28 regulation of cell morphogenesis in budding yeast. EMBO J. 12, 5267\u20135275 (1993).","journal-title":"EMBO J."},{"key":"BFnrm2105_CR82","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1002\/j.1460-2075.1993.tb06223.x","volume":"12","author":"F Cvrckova","year":"1993","unstructured":"Cvrckova, F. & Nasmyth, K. Yeast G1 cyclins CLN1 and CLN2 and a GAP-like protein have a role in bud formation. EMBO J. 12, 5277\u20135286 (1993).","journal-title":"EMBO J."},{"key":"BFnrm2105_CR83","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/0092-8674(91)90015-Q","volume":"65","author":"J Chant","year":"1991","unstructured":"Chant, J. & Herskowitz, I. Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway. Cell 65, 1203\u20131212 (1991).","journal-title":"Cell"},{"key":"BFnrm2105_CR84","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/ncb1078","volume":"6","author":"J Moffat","year":"2004","unstructured":"Moffat, J. & Andrews, B. Late-G1 cyclin-CDK activity is essential for control of cell morphogenesis in budding yeast. Nature Cell Biol. 6, 59\u201366 (2004). Describes a Cln-specific role for budding and morphogenesis, but not other cell-cycle events such as DNA replication or SPB duplication.","journal-title":"Nature Cell Biol."},{"key":"BFnrm2105_CR85","doi-asserted-by":"crossref","first-page":"6327","DOI":"10.1128\/MCB.23.17.6327-6337.2003","volume":"23","author":"A Sreenivasan","year":"2003","unstructured":"Sreenivasan, A., Bishop, A. C., Shokat, K. M. & Kellogg, D. R. Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events. Mol. Cell. Biol. 23, 6327\u20136337 (2003).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR86","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1083\/jcb.138.1.119","volume":"138","author":"R Altman","year":"1997","unstructured":"Altman, R. & Kellogg, D. Control of mitotic events by Nap1 and the Gin4 kinase. J. Cell Biol. 138, 119\u2013130 (1997).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR87","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1083\/jcb.130.3.661","volume":"130","author":"DR Kellogg","year":"1995","unstructured":"Kellogg, D. R., Kikuchi, A., Fujii-Nakata, T., Turck, C. W. & Murray, A. W. Members of the NAP\/SET family of proteins interact specifically with B-type cyclins. J. Cell Biol. 130, 661\u2013673 (1995).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR88","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1083\/jcb.130.3.675","volume":"130","author":"DR Kellogg","year":"1995","unstructured":"Kellogg, D. R. & Murray, A. W. NAP1 acts with Clb1 to perform mitotic functions and to suppress polar bud growth in budding yeast. J. Cell Biol. 130, 675\u2013685 (1995).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR89","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1091\/mbc.01-10-0500","volume":"13","author":"EM Mortensen","year":"2002","unstructured":"Mortensen, E. M., McDonald, H., Yates, J. 3rd & Kellogg, D. R. Cell cycle-dependent assembly of a Gin4\u2013septin complex. Mol. Biol. Cell 13, 2091\u20132105 (2002).","journal-title":"Mol. Biol. Cell"},{"key":"BFnrm2105_CR90","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1128\/MCB.20.8.2809-2817.2000","volume":"20","author":"H Masumoto","year":"2000","unstructured":"Masumoto, H., Sugino, A. & Araki, H. Dpb11 controls the association between DNA polymerases \u03b1 and \u025b and the autonomously replicating sequence region of budding yeast. Mol. Cell. Biol. 20, 2809\u20132817 (2000).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrm2105_CR91","first-page":"651","volume-title":"Nature","author":"H Masumoto","year":"2002","unstructured":"Masumoto, H., Muramatsu, S., Kamimura, Y. & Araki, H. S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast. Nature 415, 651\u2013655 (2002). Describes the first identified essential substrate of Cdc28 that is targeted by S-phase Clb\u2013Cdc2 complexes and the phosphorylation of which is required for progression through S phase."},{"key":"BFnrm2105_CR92","doi-asserted-by":"crossref","first-page":"14245","DOI":"10.1074\/jbc.M313289200","volume":"279","author":"T Kesti","year":"2004","unstructured":"Kesti, T., McDonald, W. H., Yates, J. R., 3rd & Wittenberg, C. Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase. J. Biol. Chem. 279, 14245\u201314255 (2004).","journal-title":"J. Biol. Chem."},{"key":"BFnrm2105_CR93","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1091\/mbc.7.11.1723","volume":"7","author":"S Elsasser","year":"1996","unstructured":"Elsasser, S., Lou, F., Wang, B., Campbell, J. L. & Jong, A. Interaction between yeast Cdc6 protein and B-type cyclin\/Cdc28 kinases. Mol. Biol. Cell 7, 1723\u20131735 (1996).","journal-title":"Mol. Biol. Cell"},{"key":"BFnrm2105_CR94","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0960-9822(00)00355-9","volume":"10","author":"LS Drury","year":"2000","unstructured":"Drury, L. S., Perkins, G. & Diffley, J. F. The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle. Curr. Biol. 10, 231\u2013240 (2000).","journal-title":"Curr. Biol."},{"key":"BFnrm2105_CR95","doi-asserted-by":"crossref","first-page":"9734","DOI":"10.1074\/jbc.275.13.9734","volume":"275","author":"A Calzada","year":"2000","unstructured":"Calzada, A., Sanchez, M., Sanchez, E. & Bueno, A. The stability of the Cdc6 protein is regulated by cyclin-dependent kinase\/cyclin B complexes in Saccharomyces cerevisiae. J. Biol. Chem. 275, 9734\u20139741 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFnrm2105_CR96","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/nature03024","volume":"431","author":"S Mimura","year":"2004","unstructured":"Mimura, S., Seki, T., Tanaka, S. & Diffley, J. F. Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature 431, 1118\u20131123 (2004).","journal-title":"Nature"},{"key":"BFnrm2105_CR97","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/15649","volume":"1","author":"K Labib","year":"1999","unstructured":"Labib, K., Diffley, J. F. & Kearsey, S. E. G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Nature Cell Biol. 1, 415\u2013422 (1999).","journal-title":"Nature Cell Biol."},{"key":"BFnrm2105_CR98","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0960-9822(00)00337-7","volume":"10","author":"VQ Nguyen","year":"2000","unstructured":"Nguyen, V. Q., Co, C., Irie, K. & Li, J. J. Clb\/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2\u20137. Curr. Biol. 10, 195\u2013205 (2000).","journal-title":"Curr. Biol."},{"key":"BFnrm2105_CR99","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/35082600","volume":"411","author":"VQ Nguyen","year":"2001","unstructured":"Nguyen, V. Q., Co, C. & Li, J. J. Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature 411, 1068\u20131073 (2001).","journal-title":"Nature"},{"key":"BFnrm2105_CR100","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1101\/gad.1202304","volume":"18","author":"GM Wilmes","year":"2004","unstructured":"Wilmes, G. M. et al. Interaction of the S-phase cyclin Clb5 with an \u201cRXL\u201d docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch. Genes Dev. 18, 981\u2013991 (2004).","journal-title":"Genes Dev."},{"key":"BFnrm2105_CR101","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4161\/cc.4.1.1402","volume":"4","author":"V Archambault","year":"2005","unstructured":"Archambault, V., Buchler, N. E., Wilmes, G. M., Jacobson, M. D. & Cross, F. R. Two-faced cyclins with eyes on the targets. Cell Cycle 4, 125\u2013130 (2005).","journal-title":"Cell Cycle"},{"key":"BFnrm2105_CR102","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/35050543","volume":"3","author":"SB Haase","year":"2001","unstructured":"Haase, S. B., Winey, M. & Reed, S. I. Multi-step control of spindle pole body duplication by cyclin-dependent kinase. Nature Cell Biol. 3, 38\u201342 (2001). Describes the functions of different cyclin\u2013Cdc28 complexes in SPB duplication, maturation and separation.","journal-title":"Nature Cell Biol."},{"key":"BFnrm2105_CR103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.cellbio.20.022003.114106","volume":"20","author":"SL Jaspersen","year":"2004","unstructured":"Jaspersen, S. L. & Winey, M. The budding yeast spindle pole body: structure, duplication, and function. Annu. Rev. Cell. Dev. Biol. 20, 1\u201328 (2004).","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"key":"BFnrm2105_CR104","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.devcel.2004.07.006","volume":"7","author":"SL Jaspersen","year":"2004","unstructured":"Jaspersen, S. L. et al. Cdc28\/Cdk1 regulates spindle pole body duplication through phosphorylation of Spc42 and Mps1. Dev. Cell 7, 263\u2013274 (2004). Identifies substrates of Cln\u2013Cdc28 complexes that promote SPB duplication.","journal-title":"Dev. Cell"},{"key":"BFnrm2105_CR105","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1083\/jcb.200111025","volume":"156","author":"AR Castillo","year":"2002","unstructured":"Castillo, A. R., Meehl, J. B., Morgan, G., Schutz-Geschwender, A. & Winey, M. The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p. J. Cell Biol. 156, 453\u2013465 (2002).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR106","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nature02062","volume":"425","author":"JA Ubersax","year":"2003","unstructured":"Ubersax, J. A. et al. Targets of the cyclin-dependent kinase Cdk1. Nature 425, 859\u2013864 (2003).","journal-title":"Nature"},{"key":"BFnrm2105_CR107","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1083\/jcb.143.1.135","volume":"143","author":"M Segal","year":"1998","unstructured":"Segal, M., Clarke, D. J. & Reed, S. I. Clb5-associated kinase activity is required early in the spindle pathway for correct preanaphase nuclear positioning in Saccharomyces cerevisiae. J. Cell Biol. 143, 135\u2013145 (1998).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR108","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1083\/jcb.148.3.441","volume":"148","author":"M Segal","year":"2000","unstructured":"Segal, M. et al. Coordinated spindle assembly and orientation requires Clb5p-dependent kinase in budding yeast. J. Cell Biol. 148, 441\u2013452 (2000).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR109","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1093\/emboj\/20.22.6359","volume":"20","author":"G Pereira","year":"2001","unstructured":"Pereira, G., Tanaka, T. U., Nasmyth, K. & Schiebel, E. Modes of spindle pole body inheritance and segregation of the Bfa1p\u2013Bub2p checkpoint protein complex. EMBO J. 20, 6359\u20136370 (2001).","journal-title":"EMBO J."},{"key":"BFnrm2105_CR110","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1083\/jcb.140.2.377","volume":"140","author":"RK Miller","year":"1998","unstructured":"Miller, R. K. & Rose, M. D. Kar9p is a novel cortical protein required for cytoplasmic microtubule orientation in yeast. J. Cell Biol. 140, 377\u2013390 (1998).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR111","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1083\/jcb.144.5.963","volume":"144","author":"RK Miller","year":"1999","unstructured":"Miller, R. K., Matheos, D. & Rose, M. D. The cortical localization of the microtubule orientation protein, Kar9p, is dependent upon actin and proteins required for polarization. J. Cell Biol. 144, 963\u2013975 (1999).","journal-title":"J. Cell Biol."},{"key":"BFnrm2105_CR112","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/emboj\/cdg063","volume":"22","author":"H Maekawa","year":"2003","unstructured":"Maekawa, H., Usui, T., Knop, M. & Schiebel, E. Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions. EMBO J. 22, 438\u2013449 (2003).","journal-title":"EMBO J."},{"key":"BFnrm2105_CR113","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0092-8674(03)00119-3","volume":"112","author":"D Liakopoulos","year":"2003","unstructured":"Liakopoulos, D., Kusch, J., Grava, S., Vogel, J. & Barral, Y. Asymmetric loading of Kar9 onto spindle poles and microtubules ensures proper spindle alignment. Cell 112, 561\u2013574 (2003). Identifies a Clb4-specific role for orienting the mitotic spindle.","journal-title":"Cell"},{"key":"BFnrm2105_CR114","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1101\/gad.298704","volume":"18","author":"H Maekawa","year":"2004","unstructured":"Maekawa, H. & Schiebel, E. Cdk1\u2013Clb4 controls the interaction of astral microtubule plus ends with subdomains of the daughter cell cortex. Genes Dev. 18, 1709\u20131724 (2004).","journal-title":"Genes Dev."},{"key":"BFnrm2105_CR115","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1091\/mbc.e05-06-0565","volume":"17","author":"JK Moore","year":"2006","unstructured":"Moore, J. K., D'Silva, S. & Miller, R. K. The CLIP-170 homologue Bik1p promotes the phosphorylation and asymmetric localization of Kar9p. Mol. Biol. Cell 17, 178\u2013191 (2006).","journal-title":"Mol. Biol. Cell"},{"key":"BFnrm2105_CR116","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.devcel.2006.02.018","volume":"10","author":"S Grava","year":"2006","unstructured":"Grava, S., Schaerer, F., Faty, M., Philippsen, P. & Barral, Y. Asymmetric recruitment of dynein to spindle poles and microtubules promotes proper spindle orientation in yeast. Dev. Cell 10, 425\u2013439 (2006).","journal-title":"Dev. Cell"},{"key":"BFnrm2105_CR117","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0092-8674(00)80529-2","volume":"90","author":"M Schwab","year":"1997","unstructured":"Schwab, M., Lutum, A. S. & Seufert, W. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis. Cell 90, 683\u2013693 (1997).","journal-title":"Cell"},{"key":"BFnrm2105_CR118","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1091\/mbc.9.10.2803","volume":"9","author":"SL Jaspersen","year":"1998","unstructured":"Jaspersen, S. L., Charles, J. F., Tinker-Kulberg, R. L. & Morgan, D. O. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol. Biol. Cell 9, 2803\u20132817 (1998).","journal-title":"Mol. Biol. Cell"},{"key":"BFnrm2105_CR119","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/ncb940","volume":"5","author":"M Sullivan","year":"2003","unstructured":"Sullivan, M. & Uhlmann, F. A non-proteolytic function of separase links the onset of anaphase to mitotic exit. Nature Cell Biol. 5, 249\u2013254 (2003).","journal-title":"Nature Cell Biol."},{"key":"BFnrm2105_CR120","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.genet.37.042203.120656","volume":"37","author":"DJ Lew","year":"2003","unstructured":"Lew, D. J. & Burke, D. J. The spindle assembly and spindle position checkpoints. Annu. Rev. Genet. 37, 251\u2013282 (2003).","journal-title":"Annu. Rev. Genet."},{"key":"BFnrm2105_CR121","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0960-9822(00)00491-7","volume":"10","author":"SL Jaspersen","year":"2000","unstructured":"Jaspersen, S. L. & Morgan, D. O. Cdc14 activates Cdc15 to promote mitotic exit in budding yeast. Curr. Biol. 10, 615\u2013618 (2000).","journal-title":"Curr. Biol."},{"key":"BFnrm2105_CR122","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0092-8674(02)00618-9","volume":"108","author":"F Stegmeier","year":"2002","unstructured":"Stegmeier, F., Visintin, R. & Amon, A. Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell 108, 207\u2013220 (2002).","journal-title":"Cell"},{"key":"BFnrm2105_CR123","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1126\/science.1099402","volume":"305","author":"R Azzam","year":"2004","unstructured":"Azzam, R. et al. Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science 305, 516\u2013519 (2004).","journal-title":"Science"},{"key":"BFnrm2105_CR124","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.cell.2006.03.038","volume":"125","author":"E Queralt","year":"2006","unstructured":"Queralt, E., Lehane, C., Novak, B. & Uhlmann, F. Downregulation of PP2ACdc55 phosphatase by separase initiates mitotic exit in budding yeast. Cell 125, 719\u2013732 (2006).","journal-title":"Cell"},{"key":"BFnrm2105_CR125","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1097-2765(01)00291-X","volume":"8","author":"W Shou","year":"2001","unstructured":"Shou, W. et al. Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit. Mol. Cell 8, 45\u201355 (2001).","journal-title":"Mol. Cell"},{"key":"BFnrm2105_CR126","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1098\/rstb.1995.0113","volume":"349","author":"K Nasmyth","year":"1995","unstructured":"Nasmyth, K. Evolution of the cell cycle. Philos. Trans. R Soc. Lond. B Biol. Sci. 349, 271\u2013281 (1995).","journal-title":"Philos. Trans. R Soc. Lond. B Biol. Sci."},{"key":"BFnrm2105_CR127","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0168-9525(96)80016-3","volume":"12","author":"B Stern","year":"1996","unstructured":"Stern, B. & Nurse, P. A quantitative model for the Cdc2 control of S phase and mitosis in fission yeast. Trends Genet. 12, 345\u2013350 (1996).","journal-title":"Trends Genet."}],"container-title":["Nature Reviews Molecular Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrm2105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrm2105","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrm2105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T03:53:55Z","timestamp":1684468435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrm2105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":127,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["BFnrm2105"],"URL":"https:\/\/doi.org\/10.1038\/nrm2105","relation":{},"ISSN":["1471-0072","1471-0080"],"issn-type":[{"value":"1471-0072","type":"print"},{"value":"1471-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}