{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:10:07Z","timestamp":1773288607901,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Mol Cell Biol"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1038\/nrm905","type":"journal-article","created":{"date-parts":[[2002,9,3]],"date-time":"2002-09-03T20:33:31Z","timestamp":1031085211000},"page":"697-702","source":"Crossref","is-referenced-by-count":120,"title":["Signalling shortcuts: cell-surface receptors in the nucleus?"],"prefix":"10.1038","volume":"3","author":[{"given":"Alan","family":"Wells","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Marti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFnrm905_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0092-8674(00)81688-8","volume":"100","author":"T Hunter","year":"2000","unstructured":"Hunter, T. Signaling \u2014 2000 and beyond. Cell 100, 113\u2013127 (2000).","journal-title":"Cell"},{"key":"BFnrm905_CR2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)00114-8","volume":"103","author":"J Schlessinger","year":"2000","unstructured":"Schlessinger, J. Cell signaling by receptor tyrosine kinases. Cell 103, 211\u2013225 (2000).","journal-title":"Cell"},{"key":"BFnrm905_CR3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-1-4757-3600-7_4","volume-title":"Hormone Signalling","author":"A Wells","year":"2002","unstructured":"Wells, A. in Hormone Signalling (eds Goffin, V. & Kelly, P. A.) 57\u201380 (Kluwer Academic, Norwell, Massachusetts, 2002)."},{"key":"BFnrm905_CR4","doi-asserted-by":"publisher","first-page":"9185","DOI":"10.1074\/jbc.271.16.9185","volume":"271","author":"M David","year":"1996","unstructured":"David, M. et al. STAT activation by epidermal growth factor (EGF) and amphiregulin: requirement for the EGF receptor kinase but not for tyrosine phosphorylation sites or JAK1. J. Biol. Chem. 271, 9185\u20139188 (1996).","journal-title":"J. Biol. Chem."},{"key":"BFnrm905_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1006\/mcbr.2000.0177","volume":"3","author":"U Marti","year":"2000","unstructured":"Marti, U. & Wells, A. The nuclear accumulation of a variant epidermal growth factor receptor (EGFR) lacking the transmembrane domain requires co-expression of a full length EGFR. Mol. Cell Biol. Res. Commun. 3, 8\u201314 (2000).","journal-title":"Mol. Cell Biol. Res. Commun."},{"key":"BFnrm905_CR6","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/ncb0901-802","volume":"3","author":"SY Lin","year":"2001","unstructured":"Lin, S. Y. et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nature Cell Biol. 3, 802\u2013808 (2001).","journal-title":"Nature Cell Biol."},{"key":"BFnrm905_CR7","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1083\/jcb.152.6.1307","volume":"152","author":"JF Reilly","year":"2001","unstructured":"Reilly, J. F. & Maher, P. A. Importin \u03b2-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation. J. Cell Biol. 152, 1307\u20131312 (2001).","journal-title":"J. Cell Biol."},{"key":"BFnrm905_CR8","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1083\/jcb.200109033","volume":"6","author":"M Offterdinger","year":"2002","unstructured":"Offterdinger, M., Schofer, C., Weipoltshammer, K. & Grunt, T. W. c-erbB-3: a nuclear protein in mammary epithelial cells. J. Cell Biol. 6, 929\u2013940 (2002).","journal-title":"J. Cell Biol."},{"key":"BFnrm905_CR9","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1126\/science.1065412","volume":"294","author":"C-Y Ni","year":"2001","unstructured":"Ni, C.-Y., Murphy, M. P., Golde, T. E. & Carpenter, G. \u03b3-Secretase cleavage and nuclear localization of erbB-4 receptor tyrosine kinase. Science 294, 2179\u20132184 (2001).","journal-title":"Science"},{"key":"BFnrm905_CR10","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/311477a0","volume":"311","author":"M Basu","year":"1984","unstructured":"Basu, M., Biswas, R. & Das, M. 42,000-molecular weight EGF receptor has protein kinase activity. Nature 311, 477\u2013480 (1984).","journal-title":"Nature"},{"key":"BFnrm905_CR11","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/309270a0","volume":"309","author":"B Mroczkowski","year":"1984","unstructured":"Mroczkowski, B., Mosig, G. & Cohen, S. ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA. Nature 309, 270\u2013273 (1984).","journal-title":"Nature"},{"key":"BFnrm905_CR12","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/316640a0","volume":"316","author":"M Basu","year":"1985","unstructured":"Basu, M. et al. EGF receptor-associated DNA-nicking activity is due to a Mr-100,000 dissociable protein. Nature 316, 640\u2013641 (1985).","journal-title":"Nature"},{"key":"BFnrm905_CR13","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/S0016-5085(87)91084-5","volume":"92","author":"SE Raper","year":"1987","unstructured":"Raper, S. E., Burwen, S. J., Barker, M. E. & Jones, A. L. Translocation of epidermal growth factor to the hepatocyte nucleus during rat liver regeneration. Gastroenterology 92, 1243\u20131250 (1987).","journal-title":"Gastroenterology"},{"key":"BFnrm905_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/hep.1840130104","volume":"13","author":"U Marti","year":"1991","unstructured":"Marti, U. et al. Localization of epidermal growth factor receptor in hepatocyte nuclei. Hepatology 13, 15\u201320 (1991).","journal-title":"Hepatology"},{"key":"BFnrm905_CR15","doi-asserted-by":"publisher","first-page":"2960","DOI":"10.1073\/pnas.89.7.2960","volume":"89","author":"M Katoh","year":"1992","unstructured":"Katoh, M. et al. K-sam encodes secreted as well as transmembrane receptor tyrosine kinase. Proc. Natl Acad. Sci. USA 89, 2960\u20132964 (1992).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrm905_CR16","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1089\/105072501300042785","volume":"11","author":"U Marti","year":"2001","unstructured":"Marti, U. et al. Nuclear localization of epidermal growth factor and epidermal growth factor receptors in human thyroid tissues. Thyroid 11, 137\u2013145 (2001).","journal-title":"Thyroid"},{"key":"BFnrm905_CR17","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/0092-8674(86)90779-8","volume":"45","author":"CI Bargmann","year":"1986","unstructured":"Bargmann, C. I., Hung, M. C. & Weinberg, R. A. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell 45, 649\u2013657 (1986).","journal-title":"Cell"},{"key":"BFnrm905_CR18","doi-asserted-by":"crossref","first-page":"12416","DOI":"10.1016\/S0021-9258(18)42290-9","volume":"267","author":"N Longo","year":"1992","unstructured":"Longo, N. et al. Activation of insulin receptor signaling by a single amino acid substitution in the transmembrane domain. J. Biol. Chem. 267, 12416\u201312419 (1992).","journal-title":"J. Biol. Chem."},{"key":"BFnrm905_CR19","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1006\/bbrc.1994.2368","volume":"203","author":"Y Xie","year":"1994","unstructured":"Xie, Y. & Hung, M.-C. Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation. Biochem. Biophys. Res. Commun. 203, 1589\u20131598 (1994).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnrm905_CR20","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1126\/science.1067628","volume":"294","author":"C-H Heldin","year":"2001","unstructured":"Heldin, C.-H. & Ericsson, J. RIPping tyrosine kinase receptors apart. Science 294, 2111\u20132113 (2001).","journal-title":"Science"},{"key":"BFnrm905_CR21","first-page":"318","volume":"23","author":"U Marti","year":"1995","unstructured":"Marti, U. & Hug, M. Acinar and cellular distribution and mRNA expression of the epidermal growth factor receptor are changed during liver regeneration. J. Hepatol. 23, 318\u2013327 (1995).","journal-title":"J. Hepatol."},{"key":"BFnrm905_CR22","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1091\/mbc.12.6.1897","volume":"12","author":"P Burke","year":"2001","unstructured":"Burke, P., Schooler, K. & Wiley, H. S. Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol. Biol. Cell 12, 1897\u20131910 (2001).","journal-title":"Mol. Biol. Cell"},{"key":"BFnrm905_CR23","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S1357-2725(99)00015-1","volume":"31","author":"A Wells","year":"1999","unstructured":"Wells, A. Molecule in focus: EGF receptor. Int. J. Biochem. Cell Biol. 31, 637\u2013643 (1999).","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"BFnrm905_CR24","doi-asserted-by":"publisher","first-page":"E22","DOI":"10.1038\/ncb0202-e22a","volume":"4","author":"M Oksvold","year":"2002","unstructured":"Oksvold, M., Huitfeldt, H., Stang, E. & Madshus, I. Localizing the EGF receptor. Nature Cell Biol. 4, E22 (2002).","journal-title":"Nature Cell Biol."},{"key":"BFnrm905_CR25","doi-asserted-by":"publisher","first-page":"E209","DOI":"10.1038\/ncb0901-e209","volume":"3","author":"MG Waugh","year":"2001","unstructured":"Waugh, M. G. & Hsuan, J. J. EGF receptors as transcription factors: ridiculous or sublime. Nature Cell Biol. 3, E209\u2013E211 (2001).","journal-title":"Nature Cell Biol."},{"key":"BFnrm905_CR26","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1083\/jcb.143.2.279","volume":"143","author":"T Pederson","year":"1998","unstructured":"Pederson, T. Growth factors in the nucleolus. J. Cell Biol. 143, 279\u2013281 (1998).","journal-title":"J. Cell Biol."},{"key":"BFnrm905_CR27","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1083\/jcb.200103103","volume":"154","author":"CS Swindle","year":"2001","unstructured":"Swindle, C. S. et al. Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. J. Cell Biol. 154, 459\u2013468 (2001).","journal-title":"J. Cell Biol."},{"key":"BFnrm905_CR28","doi-asserted-by":"publisher","first-page":"6318","DOI":"10.1074\/jbc.M110371200","volume":"277","author":"HJ Lee","year":"2002","unstructured":"Lee, H. J. et al. Presenilin-dependent \u03b3-secretase-like intramembrane cleavage of ErbB4. J. Biol. Chem. 277, 6318\u20136323 (2002).","journal-title":"J. Biol. Chem."}],"container-title":["Nature Reviews Molecular Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrm905.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrm905","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrm905.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:11:11Z","timestamp":1684469471000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrm905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["BFnrm905"],"URL":"https:\/\/doi.org\/10.1038\/nrm905","relation":{},"ISSN":["1471-0072","1471-0080"],"issn-type":[{"value":"1471-0072","type":"print"},{"value":"1471-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}