{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:03:26Z","timestamp":1781129006714,"version":"3.54.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2003,10,12]],"date-time":"2003-10-12T00:00:00Z","timestamp":1065916800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Struct Mol Biol"],"published-print":{"date-parts":[[2003,11]]},"DOI":"10.1038\/nsb1002","type":"journal-article","created":{"date-parts":[[2003,10,12]],"date-time":"2003-10-12T14:36:15Z","timestamp":1065969375000},"page":"913-921","source":"Crossref","is-referenced-by-count":187,"title":["Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation"],"prefix":"10.1038","volume":"10","author":[{"given":"Bin Y","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvana S","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hema","family":"Srinath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Delston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"Derynck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,10,12]]},"reference":[{"key":"BFnsb1002_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-1119(99)00262-0","volume":"237","author":"Y Mamane","year":"1999","unstructured":"Mamane, Y. et al. Interferon regulatory factors: the next generation. Gene 237, 1\u201314 (1999).","journal-title":"Gene"},{"key":"BFnsb1002_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1089\/107999002753452665","volume":"22","author":"B Barnes","year":"2002","unstructured":"Barnes, B., Lubyova, B. & Pitha, P.M. On the role of IRF in host defense. J. Interferon Cytokine Res. 22, 59\u201371 (2002).","journal-title":"J. Interferon Cytokine Res."},{"key":"BFnsb1002_CR3","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1146\/annurev.immunol.19.1.623","volume":"19","author":"T Taniguchi","year":"2001","unstructured":"Taniguchi, T., Ogasawara, K., Takaoka, A. & Tanaka, N. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19, 623\u2013655 (2001).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnsb1002_CR4","doi-asserted-by":"publisher","first-page":"5028","DOI":"10.1093\/emboj\/18.18.5028","volume":"18","author":"Y Fujii","year":"1999","unstructured":"Fujii, Y. et al. Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences. EMBO J. 18, 5028\u20135041 (1999).","journal-title":"EMBO J."},{"key":"BFnsb1002_CR5","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/34224","volume":"391","author":"CR Escalante","year":"1998","unstructured":"Escalante, C.R., Yie, J., Thanos, D. & Aggarwal, A.K. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation. Nature 391, 103\u2013106 (1998).","journal-title":"Nature"},{"key":"BFnsb1002_CR6","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1128\/MCB.19.4.2465","volume":"19","author":"R Lin","year":"1999","unstructured":"Lin, R., Mamane, Y. & Hiscott, J. Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains. Mol. Cell Biol. 19, 2465\u20132474 (1999).","journal-title":"Mol. Cell Biol."},{"key":"BFnsb1002_CR7","doi-asserted-by":"publisher","first-page":"34320","DOI":"10.1074\/jbc.M002814200","volume":"275","author":"R Lin","year":"2000","unstructured":"Lin, R., Mamane, Y. & Hiscott, J. Multiple regulatory domains control IRF-7 activity in response to virus infection. J. Biol. Chem. 275, 34320\u201334327 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFnsb1002_CR8","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/viro.2000.0782","volume":"280","author":"WC Au","year":"2001","unstructured":"Au, W.C., Yeow, W. & Pitha, P.M. Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3. Virology 280, 273\u2013282 (2001).","journal-title":"Virology"},{"key":"BFnsb1002_CR9","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1101\/gad.10.18.2335","volume":"10","author":"AL Brass","year":"1996","unstructured":"Brass, A.L., Kehrli, E., Eisenbeis, C.F., Storb, U. & Singh, H. Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1. Genes Dev. 10, 2335\u20132347 (1996).","journal-title":"Genes Dev."},{"key":"BFnsb1002_CR10","doi-asserted-by":"publisher","first-page":"5721","DOI":"10.1128\/MCB.22.16.5721-5740.2002","volume":"22","author":"BJ Barnes","year":"2002","unstructured":"Barnes, B.J., Kellum, M., Field, A.E. & Pitha, P.M. Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes. Mol. Cell. Biol. 22, 5721\u20135740 (2002).","journal-title":"Mol. Cell. Biol."},{"key":"BFnsb1002_CR11","doi-asserted-by":"publisher","first-page":"3659","DOI":"10.1128\/JVI.76.8.3659-3669.2002","volume":"76","author":"BR tenOever","year":"2002","unstructured":"tenOever, B.R., Servant, M.J., Grandvaux, N., Lin, R. & Hiscott, J. Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation. J. Virol. 76, 3659\u20133669 (2002).","journal-title":"J. Virol."},{"key":"BFnsb1002_CR12","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1046\/j.1365-2443.2001.00426.x","volume":"6","author":"T Iwamura","year":"2001","unstructured":"Iwamura, T. et al. Induction of IRF-3\/-7 kinase and NF-\u03baB in response to double-stranded RNA and virus infection: common and unique pathways. Genes Cells 6, 375\u2013388 (2001).","journal-title":"Genes Cells"},{"key":"BFnsb1002_CR13","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/S1074-7613(00)00053-4","volume":"13","author":"M Sato","year":"2000","unstructured":"Sato, M. et al. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-\u03b1\/\u03b2 gene induction. Immunity 13, 539\u2013548 (2000).","journal-title":"Immunity"},{"key":"BFnsb1002_CR14","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S1097-2765(00)80051-9","volume":"1","author":"MG Wathelet","year":"1998","unstructured":"Wathelet, M.G. et al. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-\u03b2 enhancer in vivo. Mol. Cell 1, 507\u2013518 (1998).","journal-title":"Mol. Cell"},{"key":"BFnsb1002_CR15","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1093\/emboj\/17.4.1087","volume":"17","author":"M Yoneyama","year":"1998","unstructured":"Yoneyama, M. et al. Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP\/p300. EMBO J. 17, 1087\u20131095 (1998).","journal-title":"EMBO J."},{"key":"BFnsb1002_CR16","doi-asserted-by":"publisher","first-page":"2986","DOI":"10.1128\/MCB.18.5.2986","volume":"18","author":"R Lin","year":"1998","unstructured":"Lin, R., Heylbroeck, C., Pitha, P.M. & Hiscott, J. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol. Cell Biol. 18, 2986\u20132996 (1998).","journal-title":"Mol. Cell Biol."},{"key":"BFnsb1002_CR17","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1074\/jbc.M007790200","volume":"276","author":"MJ Servant","year":"2001","unstructured":"Servant, M.J. et al. Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3. J. Biol. Chem. 276, 355\u2013363 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFnsb1002_CR18","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1126\/science.1081315","volume":"300","author":"S Sharma","year":"2003","unstructured":"Sharma, S. et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 300, 1148\u20131151 (2003).","journal-title":"Science"},{"key":"BFnsb1002_CR19","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/ni921","volume":"4","author":"KA Fitzgerald","year":"2003","unstructured":"Fitzgerald, K.A. et al. IKK\u03b5 and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491\u2013496 (2003).","journal-title":"Nat. Immunol."},{"key":"BFnsb1002_CR20","doi-asserted-by":"publisher","first-page":"29210","DOI":"10.1074\/jbc.273.44.29210","volume":"273","author":"WC Au","year":"1998","unstructured":"Au, W.C., Moore, P.A., LaFleur, D.W., Tombal, B. & Pitha, P.M. Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes. J. Biol. Chem. 273, 29210\u201329217 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFnsb1002_CR21","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1089\/107999002753452700","volume":"1","author":"L Zhang","year":"2002","unstructured":"Zhang, L. & Pagano, J.S. Structure and function of IRF-7. J. Interferon Cytokine Res. 1, 95\u2013101 (2002).","journal-title":"J. Interferon Cytokine Res."},{"key":"BFnsb1002_CR22","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1089\/107999002753452692","volume":"1","author":"DE Levy","year":"2002","unstructured":"Levy, D.E., Marie, I., Smith, E. & Prakash, A. Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback. J. Interferon Cytokine Res. 1, 87\u201393 (2002).","journal-title":"J. Interferon Cytokine Res."},{"key":"BFnsb1002_CR23","doi-asserted-by":"publisher","first-page":"6660","DOI":"10.1093\/emboj\/17.22.6660","volume":"17","author":"I Marie","year":"1998","unstructured":"Marie, I., Durbin, J.E. & Levy, D.E. Differential viral induction of distinct interferon-\u03b1 genes by positive feedback through interferon regulatory factor-7. EMBO J. 17, 6660\u20136669 (1998).","journal-title":"EMBO J."},{"key":"BFnsb1002_CR24","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s001090050369","volume":"77","author":"A Eroshkin","year":"1999","unstructured":"Eroshkin, A. & Mushegian, A. Conserved transactivation domain shared by interferon regulatory factors and Smad morphogens. J. Mol. Med. 77, 403\u2013405 (1999).","journal-title":"J. Mol. Med."},{"key":"BFnsb1002_CR25","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/383168a0","volume":"383","author":"Y Zhang","year":"1996","unstructured":"Zhang, Y., Feng, X.H., Wu, R.Y. & Derynck, R. Receptor-associated Mad homologues synergize as effectors of the TGF-\u03b2 response. Nature 383, 168\u2013172 (1996).","journal-title":"Nature"},{"key":"BFnsb1002_CR26","doi-asserted-by":"publisher","first-page":"4056","DOI":"10.1093\/emboj\/17.14.4056","volume":"17","author":"M Kawabata","year":"1998","unstructured":"Kawabata, M., Inoue, H., Hanyu, A., Imamura, T. & Miyazono, K. Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine\/threonine kinase receptors. EMBO J. 17, 4056\u20134065 (1998).","journal-title":"EMBO J."},{"key":"BFnsb1002_CR27","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/84995","volume":"8","author":"BM Chacko","year":"2001","unstructured":"Chacko, B.M. et al. The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization. Nat. Struct. Biol. 8, 248\u2013253 (2001).","journal-title":"Nat. Struct. Biol."},{"key":"BFnsb1002_CR28","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/S1097-2765(01)00417-8","volume":"8","author":"BY Qin","year":"2001","unstructured":"Qin, B.Y. et al. Structural basis of Smad1 activation by receptor kinase phosphorylation. Mol. Cell 8, 1303\u20131312 (2001).","journal-title":"Mol. Cell"},{"key":"BFnsb1002_CR29","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/S1097-2765(00)00114-3","volume":"6","author":"D Durocher","year":"2000","unstructured":"Durocher, D. et al. The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol. Cell 6, 1169\u20131182 (2000).","journal-title":"Mol. Cell"},{"key":"BFnsb1002_CR30","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1006\/jmbi.1999.3313","volume":"294","author":"H Liao","year":"1999","unstructured":"Liao, H., Byeon, I.J. & Tsai, M.D. Structure and function of a new phosphopeptide-binding domain containing the FHA2 of Rad53. J. Mol. Biol. 294, 1041\u20131049 (1999).","journal-title":"J. Mol. Biol."},{"key":"BFnsb1002_CR31","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.4049\/jimmunol.163.12.6468","volume":"163","author":"D Meraro","year":"1999","unstructured":"Meraro, D. et al. Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors. J. Immunol. 163, 6468\u20136478 (1999).","journal-title":"J. Immunol."},{"key":"BFnsb1002_CR32","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1089\/107999002753452764","volume":"22","author":"BZ Levi","year":"2002","unstructured":"Levi, B.Z., Hashmueli, S., Gleit-Kielmanowicz, M., Azriel, A. & Meraro, D. ICSBP\/IRF-8 transactivation: a tale of protein-protein interaction. J. Interferon Cytokine Res. 22, 153\u2013160 (2002).","journal-title":"J. Interferon Cytokine Res."},{"key":"BFnsb1002_CR33","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1101\/sqb.1998.63.609","volume":"63","author":"T Maniatis","year":"1998","unstructured":"Maniatis, T. et al. Structure and function of the interferon-\u03b2 enhanceosome. Cold Spring Harb. Symp. Quant. Biol. 63, 609\u2013620 (1998).","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"BFnsb1002_CR34","doi-asserted-by":"publisher","first-page":"9441","DOI":"10.1074\/jbc.M209851200","volume":"278","author":"MJ Servant","year":"2003","unstructured":"Servant, M.J. et al. Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. J. Biol. Chem. 278, 9441\u20139447 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnsb1002_CR35","doi-asserted-by":"publisher","first-page":"6142","DOI":"10.1046\/j.1432-1033.2002.03330.x","volume":"269","author":"H Yang","year":"2002","unstructured":"Yang, H. et al. Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions. Eur. J. Biochem. 269, 6142\u20136151 (2002).","journal-title":"Eur. J. Biochem."},{"key":"BFnsb1002_CR36","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S1097-2765(01)00332-X","volume":"8","author":"M Huse","year":"2001","unstructured":"Huse, M. et al. The TGF-\u03b2 receptor activation process: an inhibitor- to substrate-binding switch. Mol. Cell 8, 671\u2013682 (2001).","journal-title":"Mol. Cell"},{"key":"BFnsb1002_CR37","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/S1097-2765(01)00421-X","volume":"8","author":"JW Wu","year":"2001","unstructured":"Wu, J.W. et al. Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-\u03b2 signaling. Mol. Cell 8, 1277\u20131289 (2001).","journal-title":"Mol. Cell"},{"key":"BFnsb1002_CR38","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/S0092-8674(00)81701-8","volume":"95","author":"T Tsukazaki","year":"1998","unstructured":"Tsukazaki, T., Chiang, T.A., Davison, A.F., Attisano, L. & Wrana, J.L. SARA, a FYVE domain protein that recruits smad2 to the TGF-\u03b2 receptor. Cell 95, 779\u2013791 (1998).","journal-title":"Cell"},{"key":"BFnsb1002_CR39","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1126\/science.287.5450.92","volume":"287","author":"G Wu","year":"2000","unstructured":"Wu, G. et al. Structural basis of smad2 recognition by the smad anchor for receptor activation. Science 287, 92\u201397 (2000).","journal-title":"Science"},{"key":"BFnsb1002_CR40","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1101\/gad.1002002","volume":"16","author":"BY Qin","year":"2002","unstructured":"Qin, B.Y., Lam, S.S., Correia, J.J. & Lin, K. Smad3 allostery links TGF-\u03b2 receptor kinase activation to transcriptional control. Genes Dev. 16, 1950\u20131963 (2002).","journal-title":"Genes Dev."},{"key":"BFnsb1002_CR41","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1101\/gad.13.17.2196","volume":"13","author":"K Luo","year":"1999","unstructured":"Luo, K. et al. The Ski oncoprotein interacts with the Smad proteins to repress TGF\u03b2 signaling. Genes Dev. 13, 196\u2013206 (1999).","journal-title":"Genes Dev."},{"key":"BFnsb1002_CR42","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1126\/science.286.5449.2528","volume":"286","author":"DW Bell","year":"1999","unstructured":"Bell, D.W. et al. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286, 2528\u20132531 (1999).","journal-title":"Science"},{"key":"BFnsb1002_CR43","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1128\/MCB.18.3.1359","volume":"18","author":"BK Weaver","year":"1998","unstructured":"Weaver, B.K., Kumar, K.P. & Reich, N.C. Interferon regulatory factor 3 and CREB-binding protein\/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Mol. Cell Biol. 18, 1359\u20131368 (1998).","journal-title":"Mol. Cell Biol."},{"key":"BFnsb1002_CR44","doi-asserted-by":"crossref","unstructured":"Takahasi, K. et al. X-ray crystal structure of IRF-3 and its functional implications. Nat. Struct. Biol. advance online publication, 12 October 2003 (doi:10.1038\/nsb1001).","DOI":"10.1038\/nsb1001"},{"key":"BFnsb1002_CR45","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Z Otwinowski","year":"1997","unstructured":"Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation model. Methods Enzymol. 276, 307\u2013326 (1997).","journal-title":"Methods Enzymol."},{"key":"BFnsb1002_CR46","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"AT Brunger","year":"1998","unstructured":"Brunger, A.T. et al. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta. Crystallogr. D 54, 905\u2013921 (1998).","journal-title":"Acta. Crystallogr. D"},{"key":"BFnsb1002_CR47","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"47","author":"AT Jones","year":"1991","unstructured":"Jones, A.T., Zou, J.-Y., Cowan, S.W. & Kjeldgaard, M. Improved methods for building proteins models in electron-density maps and the location of errors in these models. Acta. Crystallogr. A 47, 110\u2013119 (1991).","journal-title":"Acta. Crystallogr. A"},{"key":"BFnsb1002_CR48","doi-asserted-by":"publisher","first-page":"16979","DOI":"10.1074\/jbc.M001526200","volume":"275","author":"Y Zhang","year":"2000","unstructured":"Zhang, Y. & Derynck, R. Transcriptional regulation of the transforming growth factor-\u03b2-inducible mouse germ line Ig \u03b1 constant region gene by functional cooperation of Smad, CREB, and AML family members. J. Biol. Chem. 275, 16979\u201316985 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFnsb1002_CR49","doi-asserted-by":"publisher","first-page":"24237","DOI":"10.1074\/jbc.270.41.24237","volume":"270","author":"XH Feng","year":"1995","unstructured":"Feng, X.H., Filvaroff, E.H. & Derynck, R. Transforming growth factor-\u03b2 (TGF-\u03b2)-induced down-regulation of cyclin A expression requires a functional TGF-\u03b2 receptor complex. Characterization of chimeric and truncated type I and type II receptors. J. Biol. Chem. 270, 24237\u201324245 (1995).","journal-title":"J. Biol. Chem."}],"container-title":["Nature Structural &amp; Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nsb1002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nsb1002","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nsb1002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:20:58Z","timestamp":1684455658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nsb1002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,12]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["BFnsb1002"],"URL":"https:\/\/doi.org\/10.1038\/nsb1002","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1016075.199807","asserted-by":"object"}]},"ISSN":["1545-9993","1545-9985"],"issn-type":[{"value":"1545-9993","type":"print"},{"value":"1545-9985","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,12]]}}}