{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:52:27Z","timestamp":1775595147277,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2007,6,10]],"date-time":"2007-06-10T00:00:00Z","timestamp":1181433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Struct Mol Biol"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1038\/nsmb1250","type":"journal-article","created":{"date-parts":[[2007,6,10]],"date-time":"2007-06-10T13:38:41Z","timestamp":1181482721000},"page":"591-596","source":"Crossref","is-referenced-by-count":462,"title":["The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a"],"prefix":"10.1038","volume":"14","author":[{"given":"Sonia","family":"Guil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier F","family":"C\u00e1ceres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,6,10]]},"reference":[{"key":"BFnsmb1250_CR1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nrm760","volume":"3","author":"G Dreyfuss","year":"2002","unstructured":"Dreyfuss, G., Kim, V.N. & Kataoka, N. Messenger-RNA-binding proteins and the messages they carry. Nat. Rev. Mol. Cell Biol. 3, 195\u2013205 (2002).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFnsmb1250_CR2","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/0092-8674(92)90477-T","volume":"68","author":"A Mayeda","year":"1992","unstructured":"Mayeda, A. & Krainer, A.R. Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell 68, 365\u2013375 (1992).","journal-title":"Cell"},{"key":"BFnsmb1250_CR3","doi-asserted-by":"publisher","first-page":"5483","DOI":"10.1002\/j.1460-2075.1994.tb06883.x","volume":"13","author":"A Mayeda","year":"1994","unstructured":"Mayeda, A., Munroe, S.H., Caceres, J.F. & Krainer, A.R. Function of conserved domains of hnRNP A1 and other hnRNP A\/B proteins. EMBO J. 13, 5483\u20135495 (1994).","journal-title":"EMBO J."},{"key":"BFnsmb1250_CR4","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1126\/science.8085156","volume":"265","author":"JF Caceres","year":"1994","unstructured":"Caceres, J.F., Stamm, S., Helfman, D.M. & Krainer, A.R. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science 265, 1706\u20131709 (1994).","journal-title":"Science"},{"key":"BFnsmb1250_CR5","doi-asserted-by":"publisher","first-page":"6924","DOI":"10.1073\/pnas.91.15.6924","volume":"91","author":"X Yang","year":"1994","unstructured":"Yang, X. et al. The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5\u2032 splice site selection in vivo. Proc. Natl. Acad. Sci. USA 91, 6924\u20136928 (1994).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnsmb1250_CR6","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1371\/journal.pbio.0040021","volume":"4","author":"R Martinez-Contreras","year":"2006","unstructured":"Martinez-Contreras, R. et al. Intronic binding sites for hnRNP A\/B and hnRNP F\/H proteins stimulate pre-mRNA splicing. PLoS Biol. 4, e21 (2006).","journal-title":"PLoS Biol."},{"key":"BFnsmb1250_CR7","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/355730a0","volume":"355","author":"S Pinol-Roma","year":"1992","unstructured":"Pinol-Roma, S. & Dreyfuss, G. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature 355, 730\u2013732 (1992).","journal-title":"Nature"},{"key":"BFnsmb1250_CR8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1083\/jcb.137.1.27","volume":"137","author":"E Izaurralde","year":"1997","unstructured":"Izaurralde, E. et al. A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J. Cell Biol. 137, 27\u201335 (1997).","journal-title":"J. Cell Biol."},{"key":"BFnsmb1250_CR9","doi-asserted-by":"publisher","first-page":"4144","DOI":"10.1074\/jbc.M411492200","volume":"280","author":"S Bonnal","year":"2005","unstructured":"Bonnal, S. et al. Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA. J. Biol. Chem. 280, 4144\u20134153 (2005).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb1250_CR10","doi-asserted-by":"publisher","first-page":"28732","DOI":"10.1074\/jbc.272.45.28732","volume":"272","author":"BJ Hamilton","year":"1997","unstructured":"Hamilton, B.J., Burns, C.M., Nichols, R.C. & Rigby, W.F. Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes. The roles of cytoplasmic location, transcription, and phosphorylation. J. Biol. Chem. 272, 28732\u201328741 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb1250_CR11","doi-asserted-by":"publisher","first-page":"4060","DOI":"10.1093\/emboj\/18.14.4060","volume":"18","author":"M Caputi","year":"1999","unstructured":"Caputi, M., Mayeda, A., Krainer, A.R. & Zahler, A.M. hnRNP A\/B proteins are required for inhibition of HIV-1 pre-mRNA splicing. EMBO J. 18, 4060\u20134067 (1999).","journal-title":"EMBO J."},{"key":"BFnsmb1250_CR12","doi-asserted-by":"publisher","first-page":"35353","DOI":"10.1074\/jbc.M004692200","volume":"275","author":"N Matter","year":"2000","unstructured":"Matter, N. et al. Heterogeneous ribonucleoprotein A1 is part of an exon-specific splice- silencing complex controlled by oncogenic signaling pathways. J. Biol. Chem. 275, 35353\u201335360 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb1250_CR13","doi-asserted-by":"publisher","first-page":"6195","DOI":"10.1093\/emboj\/cdf625","volume":"21","author":"VC Hou","year":"2002","unstructured":"Hou, V.C. et al. Decrease in hnRNP A\/B expression during erythropoiesis mediates a pre- mRNA splicing switch. EMBO J. 21, 6195\u20136204 (2002).","journal-title":"EMBO J."},{"key":"BFnsmb1250_CR14","doi-asserted-by":"publisher","first-page":"15241","DOI":"10.1074\/jbc.M109046200","volume":"277","author":"AJ Pollard","year":"2002","unstructured":"Pollard, A.J., Krainer, A.R., Robson, S.C. & Europe-Finner, G.N. Alternative splicing of the adenylyl cyclase stimulatory G-protein G alpha(s) is regulated by SF2\/ASF and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and involves the use of an unusual TG 3\u2032- splice site. J. Biol. Chem. 277, 15241\u201315251 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb1250_CR15","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1128\/MCB.23.8.2927-2941.2003","volume":"23","author":"S Guil","year":"2003","unstructured":"Guil, S. et al. Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation. Mol. Cell. Biol. 23, 2927\u20132941 (2003).","journal-title":"Mol. Cell. Biol."},{"key":"BFnsmb1250_CR16","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1128\/MCB.23.6.1874-1884.2003","volume":"23","author":"N Rooke","year":"2003","unstructured":"Rooke, N., Markovtsov, V., Cagavi, E. & Black, D.L. Roles for SR proteins and hnRNP A1 in the regulation of c-src exon N1. Mol. Cell. Biol. 23, 1874\u20131884 (2003).","journal-title":"Mol. Cell. Biol."},{"key":"BFnsmb1250_CR17","doi-asserted-by":"publisher","first-page":"10888","DOI":"10.1128\/JVI.78.20.10888-10905.2004","volume":"78","author":"X Zhao","year":"2004","unstructured":"Zhao, X., Rush, M. & Schwartz, S. Identification of an hnRNP A1-dependent splicing silencer in the human papillomavirus type 16 L1 coding region that prevents premature expression of the late L1 gene. J. Virol. 78, 10888\u201310905 (2004).","journal-title":"J. Virol."},{"key":"BFnsmb1250_CR18","doi-asserted-by":"publisher","first-page":"e158","DOI":"10.1371\/journal.pbio.0030158","volume":"3","author":"K Han","year":"2005","unstructured":"Han, K., Yeo, G., An, P., Burge, C.B. & Grabowski, P.J. A combinatorial code for splicing silencing: UAGG and GGGG motifs. PLoS Biol. 3, e158 (2005).","journal-title":"PLoS Biol."},{"key":"BFnsmb1250_CR19","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1002\/j.1460-2075.1994.tb06369.x","volume":"13","author":"CG Burd","year":"1994","unstructured":"Burd, C.G. & Dreyfuss, G. RNA binding specificity of hnRNP A1: significance of hnRNP A1 high- affinity binding sites in pre-mRNA splicing. EMBO J. 13, 1197\u20131204 (1994).","journal-title":"EMBO J."},{"key":"BFnsmb1250_CR20","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1126\/science.1090095","volume":"302","author":"J Ule","year":"2003","unstructured":"Ule, J. et al. CLIP identifies Nova-regulated RNA networks in the brain. Science 302, 1212\u20131215 (2003).","journal-title":"Science"},{"key":"BFnsmb1250_CR21","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.ymeth.2005.07.018","volume":"37","author":"J Ule","year":"2005","unstructured":"Ule, J., Jensen, K., Mele, A. & Darnell, R.B. CLIP: a method for identifying protein-RNA interaction sites in living cells. Methods 37, 376\u2013386 (2005).","journal-title":"Methods"},{"key":"BFnsmb1250_CR22","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature02871","volume":"431","author":"V Ambros","year":"2004","unstructured":"Ambros, V. The functions of animal microRNAs. Nature 431, 350\u2013355 (2004).","journal-title":"Nature"},{"key":"BFnsmb1250_CR23","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.1101\/gad.1262504","volume":"18","author":"J Han","year":"2004","unstructured":"Han, J. et al. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 18, 3016\u20133027 (2004).","journal-title":"Genes Dev."},{"key":"BFnsmb1250_CR24","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/sj.emboj.7600491","volume":"24","author":"Y Zeng","year":"2005","unstructured":"Zeng, Y., Yi, R. & Cullen, B.R. Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha. EMBO J. 24, 138\u2013148 (2005).","journal-title":"EMBO J."},{"key":"BFnsmb1250_CR25","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1126\/science.1090599","volume":"303","author":"E Lund","year":"2004","unstructured":"Lund, E., Guttinger, S., Calado, A., Dahlberg, J.E. & Kutay, U. Nuclear export of microRNA precursors. Science 303, 95\u201398 (2004).","journal-title":"Science"},{"key":"BFnsmb1250_CR26","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1101\/gad.927801","volume":"15","author":"RF Ketting","year":"2001","unstructured":"Ketting, R.F. et al. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15, 2654\u20132659 (2001).","journal-title":"Genes Dev."},{"key":"BFnsmb1250_CR27","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1126\/science.1062039","volume":"293","author":"SW Knight","year":"2001","unstructured":"Knight, S.W. & Bass, B.L. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science 293, 2269\u20132271 (2001).","journal-title":"Science"},{"key":"BFnsmb1250_CR28","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1101\/gr.2722704","volume":"14","author":"A Rodriguez","year":"2004","unstructured":"Rodriguez, A., Griffiths-Jones, S., Ashurst, J.L. & Bradley, A. Identification of mammalian microRNA host genes and transcription units. Genome Res. 14, 1902\u20131910 (2004).","journal-title":"Genome Res."},{"key":"BFnsmb1250_CR29","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jmb.2004.03.065","volume":"339","author":"A Tanzer","year":"2004","unstructured":"Tanzer, A. & Stadler, P.F. Molecular evolution of a microRNA cluster. J. Mol. Biol. 339, 327\u2013335 (2004).","journal-title":"J. Mol. Biol."},{"key":"BFnsmb1250_CR30","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1158\/0008-5472.CAN-03-3773","volume":"64","author":"A Ota","year":"2004","unstructured":"Ota, A. et al. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Res. 64, 3087\u20133095 (2004).","journal-title":"Cancer Res."},{"key":"BFnsmb1250_CR31","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1038\/ng1855","volume":"38","author":"M Dews","year":"2006","unstructured":"Dews, M. et al. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat. Genet. 38, 1060\u20131065 (2006).","journal-title":"Nat. Genet."},{"key":"BFnsmb1250_CR32","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/nature03552","volume":"435","author":"L He","year":"2005","unstructured":"He, L. et al. A microRNA polycistron as a potential human oncogene. Nature 435, 828\u2013833 (2005).","journal-title":"Nature"},{"key":"BFnsmb1250_CR33","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1126\/science.1064921","volume":"294","author":"M Lagos-Quintana","year":"2001","unstructured":"Lagos-Quintana, M., Rauhut, R., Lendeckel, W. & Tuschl, T. Identification of novel genes coding for small expressed RNAs. Science 294, 853\u2013858 (2001).","journal-title":"Science"},{"key":"BFnsmb1250_CR34","doi-asserted-by":"publisher","first-page":"4663","DOI":"10.1093\/emboj\/cdf476","volume":"21","author":"Y Lee","year":"2002","unstructured":"Lee, Y., Jeon, K., Lee, J.T., Kim, S. & Kim, V.N. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 21, 4663\u20134670 (2002).","journal-title":"EMBO J."},{"key":"BFnsmb1250_CR35","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.cell.2006.03.043","volume":"125","author":"J Han","year":"2006","unstructured":"Han, J. et al. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 125, 887\u2013901 (2006).","journal-title":"Cell"},{"key":"BFnsmb1250_CR36","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1101\/gad.1444406","volume":"20","author":"JM Thomson","year":"2006","unstructured":"Thomson, J.M. et al. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 20, 2202\u20132207 (2006).","journal-title":"Genes Dev."},{"key":"BFnsmb1250_CR37","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1261\/rna.2322506","volume":"12","author":"G Obernosterer","year":"2006","unstructured":"Obernosterer, G., Leuschner, P.J., Alenius, M. & Martinez, J. Post-transcriptional regulation of microRNA expression. RNA 12, 1161\u20131167 (2006).","journal-title":"RNA"},{"key":"BFnsmb1250_CR38","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1083\/jcb.138.2.225","volume":"138","author":"JF Caceres","year":"1997","unstructured":"Caceres, J.F., Misteli, T., Screaton, G.R., Spector, D.L. & Krainer, A.R. Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. J. Cell Biol. 138, 225\u2013238 (1997).","journal-title":"J. Cell Biol."},{"key":"BFnsmb1250_CR39","doi-asserted-by":"publisher","first-page":"5744","DOI":"10.1128\/MCB.00224-06","volume":"26","author":"S Guil","year":"2006","unstructured":"Guil, S., Long, J.C. & Caceres, J.F. hnRNP A1 relocalization to the stress granules reflects a role in the stress response. Mol. Cell. Biol. 26, 5744\u20135758 (2006).","journal-title":"Mol. Cell. Biol."},{"key":"BFnsmb1250_CR40","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1101\/gad.286404","volume":"18","author":"JR Sanford","year":"2004","unstructured":"Sanford, J.R., Gray, N.K., Beckmann, K. & Caceres, J.F. A novel role for shuttling SR proteins in mRNA translation. Genes Dev. 18, 755\u2013768 (2004).","journal-title":"Genes Dev."},{"key":"BFnsmb1250_CR41","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.1073\/pnas.0409889102","volume":"102","author":"E Allemand","year":"2005","unstructured":"Allemand, E. et al. Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock. Proc. Natl. Acad. Sci. USA 102, 3605\u20133610 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnsmb1250_CR42","first-page":"430","volume":"4","author":"A Hanamura","year":"1998","unstructured":"Hanamura, A., Caceres, J.F., Mayeda, A., Franza, B.R. & Krainer, A.R. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA 4, 430\u2013444 (1998).","journal-title":"RNA"}],"container-title":["Nature Structural & Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nsmb1250.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nsmb1250","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nsmb1250.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:51:04Z","timestamp":1684457464000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nsmb1250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,10]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["BFnsmb1250"],"URL":"https:\/\/doi.org\/10.1038\/nsmb1250","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1089727.545013","asserted-by":"object"}]},"ISSN":["1545-9993","1545-9985"],"issn-type":[{"value":"1545-9993","type":"print"},{"value":"1545-9985","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,10]]}}}