{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:16:35Z","timestamp":1773166595368,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2005,9,25]],"date-time":"2005-09-25T00:00:00Z","timestamp":1127606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Struct Mol Biol"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1038\/nsmb995","type":"journal-article","created":{"date-parts":[[2005,9,26]],"date-time":"2005-09-26T14:13:42Z","timestamp":1127744022000},"page":"893-901","source":"Crossref","is-referenced-by-count":128,"title":["CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells"],"prefix":"10.1038","volume":"12","author":[{"given":"Nao","family":"Hosoda","sequence":"first","affiliation":[]},{"given":"Yoon Ki","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Fabrice","family":"Lejeune","sequence":"additional","affiliation":[]},{"given":"Lynne E","family":"Maquat","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2005,9,25]]},"reference":[{"key":"BFnsmb995_CR1","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/S0092-8674(01)00475-5","volume":"106","author":"Y Ishigaki","year":"2001","unstructured":"Ishigaki, Y., Li, X., Serin, G. & Maquat, L.E. Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell 106, 607\u2013617 (2001).","journal-title":"Cell"},{"key":"BFnsmb995_CR2","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1101\/gad.1170204","volume":"18","author":"SY Chiu","year":"2004","unstructured":"Chiu, S.Y., Lejeune, F., Ranganathan, A.C. & Maquat, L.E. The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex. Genes Dev. 18, 745\u2013754 (2004).","journal-title":"Genes Dev."},{"key":"BFnsmb995_CR3","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1038\/nsmb824","volume":"11","author":"F Lejeune","year":"2004","unstructured":"Lejeune, F., Ranganathan, A.C. & Maquat, L.E. eIF4G is required for the pioneer round of translation in mammalian cells. Nat. Struct. Mol. Biol. 11, 992\u20131000 (2004).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"BFnsmb995_CR4","doi-asserted-by":"publisher","first-page":"3536","DOI":"10.1093\/emboj\/cdf345","volume":"21","author":"F Lejeune","year":"2002","unstructured":"Lejeune, F., Ishigaki, Y., Li, X. & Maquat, L.E. The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO J. 21, 3536\u20133545 (2002).","journal-title":"EMBO J."},{"key":"BFnsmb995_CR5","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1126\/science.1062786","volume":"293","author":"J Lykke-Andersen","year":"2001","unstructured":"Lykke-Andersen, J., Shu, M.D. & Steitz, J.A. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science 293, 1836\u20131839 (2001).","journal-title":"Science"},{"key":"BFnsmb995_CR6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.cell.2004.11.050","volume":"120","author":"YK Kim","year":"2005","unstructured":"Kim, Y.K., Furic, L., Desgroseillers, L. & Maquat, L.E. Mammalian Staufen1 recruits Upf1 to specific mRNA 3\u2032UTRs so as to elicit mRNA decay. Cell 120, 195\u2013208 (2005).","journal-title":"Cell"},{"key":"BFnsmb995_CR7","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S1097-2765(03)00142-4","volume":"11","author":"NH Gehring","year":"2003","unstructured":"Gehring, N.H., Neu-Yilik, G., Schell, T., Hentze, M.W. & Kulozik, A.E. Y14 and hUpf3b form an NMD-activating complex. Mol. Cell 11, 939\u2013949 (2003).","journal-title":"Mol. Cell"},{"key":"BFnsmb995_CR8","doi-asserted-by":"publisher","first-page":"7009","DOI":"10.1074\/jbc.M307692200","volume":"279","author":"N Kataoka","year":"2004","unstructured":"Kataoka, N. & Dreyfuss, G. A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex. J. Biol. Chem. 279, 7009\u20137013 (2004).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb995_CR9","doi-asserted-by":"publisher","first-page":"17976","DOI":"10.1073\/pnas.0408435102","volume":"101","author":"T Hirose","year":"2004","unstructured":"Hirose, T., Shu, M.D. & Steitz, J.A. Splicing of U12-type introns deposits an exon junction complex competent to induce nonsense-mediated mRNA decay. Proc. Natl. Acad. Sci. USA 101, 17976\u201317981 (2004).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnsmb995_CR10","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S0968-0004(98)01208-0","volume":"23","author":"E Nagy","year":"1998","unstructured":"Nagy, E. & Maquat, L.E. A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. Trends Biochem. Sci. 23, 198\u2013199 (1998).","journal-title":"Trends Biochem. Sci."},{"key":"BFnsmb995_CR11","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nrm1310","volume":"5","author":"LE Maquat","year":"2004","unstructured":"Maquat, L.E. Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat. Rev. Mol. Cell Biol. 5, 89\u201399 (2004).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFnsmb995_CR12","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ceb.2004.03.012","volume":"16","author":"TO Tange","year":"2004","unstructured":"Tange, T.O., Nott, A. & Moore, M.J. The ever-increasing complexities of the exon junction complex. Curr. Opin. Cell Biol. 16, 279\u2013284 (2004).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFnsmb995_CR13","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/S0092-8674(00)00214-2","volume":"103","author":"J Lykke-Andersen","year":"2000","unstructured":"Lykke-Andersen, J., Shu, M.D. & Steitz, J.A. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103, 1121\u20131131 (2000).","journal-title":"Cell"},{"key":"BFnsmb995_CR14","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1017\/S1355838298971849","volume":"4","author":"J Zhang","year":"1998","unstructured":"Zhang, J., Sun, X., Qian, Y. & Maquat, L.E. Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm. RNA 4, 801\u2013815 (1998).","journal-title":"RNA"},{"key":"BFnsmb995_CR15","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1128\/MCB.18.5.2932","volume":"18","author":"PM Moriarty","year":"1998","unstructured":"Moriarty, P.M., Reddy, C.C. & Maquat, L.E. Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA. Mol. Cell. Biol. 18, 2932\u20132939 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"BFnsmb995_CR16","doi-asserted-by":"publisher","first-page":"6326","DOI":"10.1128\/MCB.14.9.6326","volume":"14","author":"P Belgrader","year":"1994","unstructured":"Belgrader, P. & Maquat, L.E. Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. Mol. Cell. Biol. 14, 6326\u20136336 (1994).","journal-title":"Mol. Cell. Biol."},{"key":"BFnsmb995_CR17","doi-asserted-by":"publisher","first-page":"9612","DOI":"10.1073\/pnas.89.20.9612","volume":"89","author":"F Lejbkowicz","year":"1992","unstructured":"Lejbkowicz, F. et al. A fraction of the mRNA 5\u2032 cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus. Proc. Natl. Acad. Sci. USA 89, 9612\u20139616 (1992).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnsmb995_CR18","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1083\/jcb.148.2.239","volume":"148","author":"J Dostie","year":"2000","unstructured":"Dostie, J., Lejbkowicz, F. & Sonenberg, N. Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles. J. Cell Biol. 148, 239\u2013247 (2000).","journal-title":"J. Cell Biol."},{"key":"BFnsmb995_CR19","doi-asserted-by":"publisher","first-page":"5701","DOI":"10.1002\/j.1460-2075.1995.tb00257.x","volume":"14","author":"A Haghighat","year":"1995","unstructured":"Haghighat, A., Mader, S., Pause, A. & Sonenberg, N. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J. 14, 5701\u20135709 (1995).","journal-title":"EMBO J."},{"key":"BFnsmb995_CR20","doi-asserted-by":"publisher","first-page":"4990","DOI":"10.1128\/MCB.15.9.4990","volume":"15","author":"S Mader","year":"1995","unstructured":"Mader, S., Lee, H., Pause, A. & Sonenberg, N. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol. Cell. Biol. 15, 4990\u20134997 (1995).","journal-title":"Mol. Cell. Biol."},{"key":"BFnsmb995_CR21","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/S1097-2765(01)80003-4","volume":"3","author":"J Marcotrigiano","year":"1999","unstructured":"Marcotrigiano, J., Gingras, A.C., Sonenberg, N. & Burley, S.K. Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol. Cell 3, 707\u2013716 (1999).","journal-title":"Mol. Cell"},{"key":"BFnsmb995_CR22","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1101\/gad.12.4.502","volume":"12","author":"AC Gingras","year":"1998","unstructured":"Gingras, A.C., Kennedy, S.G., O'Leary, M.A., Sonenberg, N. & Hay, N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway. Genes Dev. 12, 502\u2013513 (1998).","journal-title":"Genes Dev."},{"key":"BFnsmb995_CR23","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1017\/S1355838201000127","volume":"7","author":"M Pal","year":"2001","unstructured":"Pal, M., Ishigaki, Y., Nagy, E. & Maquat, L.E. Evidence that phosphorylation of human Upf1 protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway. RNA 7, 5\u201315 (2001).","journal-title":"RNA"},{"key":"BFnsmb995_CR24","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1017\/S1355838200000546","volume":"6","author":"A Bhattacharya","year":"2000","unstructured":"Bhattacharya, A. et al. Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. RNA 6, 1226\u20131235 (2000).","journal-title":"RNA"},{"key":"BFnsmb995_CR25","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S1097-2765(01)00299-4","volume":"8","author":"C Mazza","year":"2001","unstructured":"Mazza, C., Ohno, M., Segref, A., Mattaj, I.W. & Cusack, S. Crystal structure of the human nuclear cap binding complex. Mol. Cell 8, 383\u2013396 (2001).","journal-title":"Mol. Cell"},{"key":"BFnsmb995_CR26","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1128\/MCB.21.1.209-223.2001","volume":"21","author":"G Serin","year":"2001","unstructured":"Serin, G., Gersappe, A., Black, J.D., Aronoff, R. & Maquat, L.E. Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Mol. Cell. Biol. 21, 209\u2013223 (2001).","journal-title":"Mol. Cell. Biol."},{"key":"BFnsmb995_CR27","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1042\/bj20020263","volume":"365","author":"M Luo","year":"2002","unstructured":"Luo, M., Duchaine, T.F. & DesGroseillers, L. Molecular mapping of the determinants involved in human Staufen-ribosome association. Biochem. J. 365, 817\u2013824 (2002).","journal-title":"Biochem. J."},{"key":"BFnsmb995_CR28","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1126\/science.1074428","volume":"298","author":"JT Mendell","year":"2002","unstructured":"Mendell, J.T., ap Rhys, C.M. & Dietz, H.C. Separable roles for rent1\/hUpf1 in altered splicing and decay of nonsense transcripts. Science 298, 419\u2013422 (2002).","journal-title":"Science"},{"key":"BFnsmb995_CR29","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1242\/jcs.01701","volume":"118","author":"LE Maquat","year":"2005","unstructured":"Maquat, L.E. Nonsense-mediated mRNA decay in mammals. J. Cell Sci. 118, 1773\u20131776 (2005).","journal-title":"J. Cell Sci."},{"key":"BFnsmb995_CR30","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/S0960-9822(02)00902-8","volume":"12","author":"J Dostie","year":"2002","unstructured":"Dostie, J. & Dreyfuss, G. Translation is required to remove Y14 from mRNAs in the cytoplasm. Curr. Biol. 12, 1060\u20131067 (2002).","journal-title":"Curr. Biol."},{"key":"BFnsmb995_CR31","doi-asserted-by":"publisher","first-page":"4258","DOI":"10.1073\/pnas.0500684102","volume":"102","author":"Q Gao","year":"2005","unstructured":"Gao, Q., Das, B., Sherman, F. & Maquat, L.E. Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc. Natl. Acad. Sci. USA 102, 4258\u20134263 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnsmb995_CR32","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1017\/S1355838202021362","volume":"8","author":"D Castanotto","year":"2002","unstructured":"Castanotto, D., Li, H. & Rossi, J.J. Functional siRNA expression from transfected PCR products. RNA 8, 1454\u20131460 (2002).","journal-title":"RNA"},{"key":"BFnsmb995_CR33","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nsmb741","volume":"11","author":"J Kadlec","year":"2004","unstructured":"Kadlec, J., Izaurralde, E. & Cusack, S. The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat. Struct. Mol. Biol. 11, 330\u2013337 (2004).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"BFnsmb995_CR34","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/0092-8674(94)90530-4","volume":"78","author":"E Izaurralde","year":"1994","unstructured":"Izaurralde, E. et al. A nuclear cap binding protein complex involved in pre-mRNA splicing. Cell 78, 657\u2013668 (1994).","journal-title":"Cell"},{"key":"BFnsmb995_CR35","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1128\/MCB.19.3.2220","volume":"19","author":"L Wickham","year":"1999","unstructured":"Wickham, L., Duchaine, T., Luo, M., Nabi, I.R. & DesGroseillers, L. Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum. Mol. Cell. Biol. 19, 2220\u20132230 (1999).","journal-title":"Mol. Cell. Biol."},{"key":"BFnsmb995_CR36","doi-asserted-by":"publisher","first-page":"5578","DOI":"10.1073\/pnas.93.11.5578","volume":"93","author":"AC Gingras","year":"1996","unstructured":"Gingras, A.C., Svitkin, Y., Belsham, G.J., Pause, A. & Sonenberg, N. Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proc. Natl. Acad. Sci. USA 93, 5578\u20135583 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnsmb995_CR37","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1007\/BF00484578","volume":"19","author":"FG Berger","year":"1981","unstructured":"Berger, F.G. & Szoka, P. Biosynthesis of the major urinary proteins in mouse liver: a biochemical genetic study. Biochem. Genet. 19, 1261\u20131273 (1981).","journal-title":"Biochem. Genet."},{"key":"BFnsmb995_CR38","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S1097-2765(03)00349-6","volume":"12","author":"F Lejeune","year":"2003","unstructured":"Lejeune, F., Li, X. & Maquat, L.E. Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol. Cell 12, 675\u2013687 (2003).","journal-title":"Mol. Cell"}],"container-title":["Nature Structural & Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nsmb995.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nsmb995","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nsmb995.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:55:45Z","timestamp":1684472145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nsmb995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,25]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["BFnsmb995"],"URL":"https:\/\/doi.org\/10.1038\/nsmb995","relation":{},"ISSN":["1545-9993","1545-9985"],"issn-type":[{"value":"1545-9993","type":"print"},{"value":"1545-9985","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,25]]}}}