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Rogers, C. Cheah, C. Steward, E.B., K. Tate, N. Lench and R. Prathalingam are employees of Congenica; B. Tolhuis, J. Findhammer, J.K., M.V. and T. Karten are employees of GENALICE; C. Colombo, C. Geoghegan, C.J.B., C. Rees, D.R.B., J.F.P., J. Hughes, R.J.G., S. Humphray, S. Hunter and T.S.A.G. are employees of Illumina Cambridge; C.V.-G. is the holder of the Bayer and Norbert Heimburger (CSL Behring) Chair; K.J.M. previously received funding for research and is currently on the scientific advisory board of Gemini Therapeutics; M.C.S. received travel and accommodation fees from NovoNordisk; D.M.L. serves on advisory boards for Agios, Novartis and Cerus; M.I.M. serves on advisory panels for Pfizer, NovoNordisk and Zoe Global, has received honoraria from Pfizer, NovoNordisk and Eli Lilly, has stock options in Zoe Global, and has received research funding from Abbvie, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, NovoNordisk, Pfizer, Roche, Sanofi Aventis, Servier and Takeda;\u00a0DLB has acted as a consultant on behalf of Oxford Innovation in the last 2 years for the following companies: Amgen, CODA therapeutic, Bristows, Lilly, Mundipharma, Regeneron and Theranexus, he holds an MRC Industrial Partnership grant with Astra Zeneca. 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